Developing Effective Alzheimer’s Disease Therapies: Clinical Experience and Future Directions

Effect of Idalopirdine as Adjunct to Cholinesterase Inhibitors on Change in Cognition in Patients With Alzheimer Disease

(2018) Alireza Atri et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease

(2018) Joseph Park et al.   NATURE NEUROSCIENCE

A Phase 2 clinical trial of PF-05212377 (SAM-760) in subjects with mild to moderate Alzheimer’s disease with existing neuropsychiatric symptoms on a stable daily dose of donepezil

(2018) Terence Fullerton et al.   Alzheimers Research & Therapy

Evidence for the Efficacy of Latrepirdine (Dimebon) Treatment for Improvement of Cognitive Function: A Meta-Analysis

(2018) Nieves Cano-Cuenca et al.   JOURNAL OF ALZHEIMERS DISEASE

A Randomized Study of H3 Antagonist ABT-288 in Mild-To-Moderate Alzheimer's Dementia1

(2018) George M. Haig et al.   JOURNAL OF ALZHEIMERS DISEASE

Sembragiline in Moderate Alzheimer’s Disease: Results of a Randomized, Double-Blind, Placebo-Controlled Phase II Trial (MAyflOwer RoAD)

(2017) Stephane Nave et al.   JOURNAL OF ALZHEIMERS DISEASE

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease

(2017) Kuan-lin Huang et al.   NATURE NEUROSCIENCE

A phase 3 trial of IV immunoglobulin for Alzheimer disease

(2017) Norman R. Relkin et al.   NEUROLOGY

Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer’s disease

(2017) Dragan Gamberger et al.   Scientific Reports

A phase III randomized trial of gantenerumab in prodromal Alzheimer’s disease

(2017) Susanne Ostrowitzki et al.   Alzheimers Research & Therapy

Why Do So Many Drugs for Alzheimer's Disease Fail in Development? Time for New Methods and New Practices?

(2017) Robert E. Becker et al.   JOURNAL OF ALZHEIMERS DISEASE

PHASE 3 TRIAL OF THE TAU AGGREGATION INHIBITOR LEUCO-METHYLTHIONINIUM-BIS (HYDROMETHANESULFONATE) (LMTM) IN MILD TO MODERATE ALZHEIMER'S DISEASE

(2016) Serge Gauthier et al.   Alzheimers & Dementia

Synaptic Amyloid-β Oligomers Precede p-Tau and Differentiate High Pathology Control Cases

(2016) Tina Bilousova et al.   AMERICAN JOURNAL OF PATHOLOGY

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Double-blind, placebo-controlled, proof-of-concept trial of bexarotene in moderate Alzheimer’s disease

(2016) Jeffrey L. Cummings et al.   Alzheimers Research & Therapy

First-In-Human safety and long-term exposure data for AAB-003 (PF-05236812) and biomarkers after intravenous infusions of escalating doses in patients with mild to moderate Alzheimer’s disease

(2016) Marielle Delnomdedieu et al.   Alzheimers Research & Therapy

Bapineuzumab for mild to moderate Alzheimer’s disease in two global, randomized, phase 3 trials

(2016) Rik Vandenberghe et al.   Alzheimers Research & Therapy

Donepezil decreases annual rate of hippocampal atrophy in suspected prodromal Alzheimer's disease

(2015) Bruno Dubois et al.   Alzheimers & Dementia

Tau positron emission tomographic imaging in aging and early Alzheimer disease

(2015) Keith A. Johnson et al.   ANNALS OF NEUROLOGY

Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia

(2015) Willemijn J. Jansen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

IVIG treatment of mild cognitive impairment due to Alzheimer's disease: a randomised double-blinded exploratory study of the effect on brain atrophy, cognition and conversion to dementia

(2015) Shawn Kile et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Etanercept in Alzheimer disease: A randomized, placebo-controlled, double-blind, phase 2 trial

(2015) J. Butchart et al.   NEUROLOGY

A Randomized, Double-Blind, Placebo-Controlled, 16-Week Study of the H3 Receptor Antagonist, GSK239512 as a Monotherapy in Subjects with Mild-to-Moderate Alzheimer’s Disease

(2014) Richard Grove et al.   Current Alzheimer Research

Targeting microglia for the treatment of Alzheimer’s disease

(2014) Patrick L McGeer et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

A Food and Drug Administration-approved Asthma Therapeutic Agent Impacts Amyloid β in the Brain in a Transgenic Model of Alzheimer Disease

(2014) Yukiko Hori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

Clinical trial of an inhibitor of RAGE-A  interactions in Alzheimer disease

(2014) D. Galasko et al.   NEUROLOGY

A brief overview of amyloids and Alzheimer's disease

(2014) Sian-Yang Ow et al.   PROTEIN SCIENCE

BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease

(2014) Robert Vassar   Alzheimers Research & Therapy

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

Biomarker Modeling of Alzheimer’s Disease

(2013) Clifford R. Jack et al.   NEURON

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

(2013) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Genetics of Alzheimer Disease

(2013) R. E. Tanzi   Cold Spring Harbor Perspectives in Medicine

Progression of Alzheimer’s disease as measured by Clinical Dementia Rating Sum of Boxes scores

(2012) Monique M. Williams et al.   Alzheimers & Dementia

EHT0202 in Alzheimers Disease: A 3-Month, Randomized, Placebo- Controlled, Double-Blind Study

(2012) B. Vellas et al.   Current Alzheimer Research

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Marilyn S. Albert et al.   Alzheimers & Dementia

Disease-modifying treatments for Alzheimer’s disease

(2011) Daniela Galimberti et al.   Therapeutic Advances in Neurological Disorders

Diabetes mellitus and Alzheimer's disease: shared pathology and treatment?

(2010) Kawser Akter et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Alzheimer's disease: clinical trials and drug development

(2010) Francesca Mangialasche et al.   LANCET NEUROLOGY

The Genetics of Alzheimer Disease: Back to the Future

(2010) Lars Bertram et al.   NEURON

Mechanisms of tau-induced neurodegeneration

(2009) Khalid Iqbal et al.   ACTA NEUROPATHOLOGICA

Atomoxetine Augmentation of Cholinesterase Inhibitor Therapy in Patients With Alzheimer Disease: 6-Month, Randomized, Double-Blind, Placebo-Controlled, Parallel-Trial Study

(2009) Richard C. Mohs et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Translational Medicine Lessons from Flurizan's Failure in Alzheimer's Disease (AD) Trial: Implication for Future Drug Discovery and Development for AD

(2009) Hong I. Wan et al.   CTS-Clinical and Translational Science

Effect of Tarenflurbil on Cognitive Decline and Activities of Daily Living in Patients With Mild Alzheimer DiseaseA Randomized Controlled Trial

(2009) Robert C. Green   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease

(2009) S. Salloway et al.   NEUROLOGY

Donepezil treatment of patients with MCI: A 48-week randomized, placebo-controlled trial

(2009) R. S. Doody et al.   NEUROLOGY

Gain in Brain Immunity in the Oldest-Old Differentiates Cognitively Normal from Demented Individuals

(2009) Pavel Katsel et al.   PLoS One

Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE

(2008) Lars Bertram et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Risk-reducing effect of education in Alzheimer's disease

(2008) Sigrid Botne Sando et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Tau-based treatment strategies in neurodegenerative diseases

(2008) Anja Schneider et al.   Neurotherapeutics