Inhibition of HDAC3 reverses Alzheimer’s disease-related pathologies in vitro and in the 3xTg-AD mouse model

Dysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease

(2018) Raffaella Nativio et al.   NATURE NEUROSCIENCE

NAAG Peptidase Inhibitors Act via mGluR3: Animal Models of Memory, Alzheimer’s, and Ethanol Intoxication

(2017) Rafal T. Olszewski et al.   NEUROCHEMICAL RESEARCH

Neurons derived from sporadic Alzheimer’s disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation

(2017) Anna Ochalek et al.   Alzheimers Research & Therapy

The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease

(2016) Marco Magistri et al.   Current Alzheimer Research

Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-κB-mediated inflammation

(2016) Niek GJ Leus et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Intrinsic Tau Acetylation Is Coupled to Auto-Proteolytic Tau Fragmentation

(2016) Todd J. Cohen et al.   PLoS One

The Effects of Pharmacological Inhibition of Histone Deacetylase 3 (HDAC3) in Huntington’s Disease Mice

(2016) Haiqun Jia et al.   PLoS One

2015 Alzheimer's disease facts and figures

(2015)   Alzheimers & Dementia

Increased Acetylation of Histone H4 at Lysine 12 (H4K12) in Monocytes of Transgenic Alzheimer’s Mice and in Human Patients

(2015) Barbara Plagg et al.   Current Alzheimer Research

Epigenetic Readers of Lysine Acetylation Regulate Cocaine-Induced Plasticity

(2015) G. C. Sartor et al.   JOURNAL OF NEUROSCIENCE

Pharmacological Selectivity Within Class I Histone Deacetylases Predicts Effects on Synaptic Function and Memory Rescue

(2015) Gavin Rumbaugh et al.   NEUROPSYCHOPHARMACOLOGY

Histone Acetylation Modifiers in the Pathogenesis of Alzheimer’s Disease

(2015) Xi Lu et al.   Frontiers in Cellular Neuroscience

Amyloid-beta and Alzheimer’s disease: the role of neprilysin-2 in amyloid-beta clearance

(2014) Robert A. Marr et al.   Frontiers in Aging Neuroscience

Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation

(2013) Lea Tenenholz Grinberg et al.   ACTA NEUROPATHOLOGICA

The Potential of HDAC Inhibitors as Cognitive Enhancers

(2013) Johannes Gräff et al.   Annual Review of Pharmacology and Toxicology

Impairment of nesting behaviour in 3xTg-AD mice

(2013) Virginia Torres-Lista et al.   BEHAVIOURAL BRAIN RESEARCH

Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

(2013) Takayuki Kondo et al.   Cell Stem Cell

Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies

(2012) David J. Irwin et al.   BRAIN

Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

(2012) Mason A. Israel et al.   NATURE

HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity

(2012) Mitsumasa Kurita et al.   NATURE NEUROSCIENCE

The acetylation of tau inhibits its function and promotes pathological tau aggregation

(2011) Todd J. Cohen et al.   Nature Communications

Hdac3 Is Essential for the Maintenance of Chromatin Structure and Genome Stability

(2010) Srividya Bhaskara et al.   CANCER CELL

CD40/CD40L interaction induces Aβ production and increases γ-secretase activity independently of tumor necrosis factor receptor associated factor (TRAF) signaling

(2009) Claude-Henry Volmar et al.   EXPERIMENTAL CELL RESEARCH

HDAC2 negatively regulates memory formation and synaptic plasticity

(2009) Ji-Song Guan et al.   NATURE

Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease

(2009) Mark Kilgore et al.   NEUROPSYCHOPHARMACOLOGY

Targeting Histone Deacetylases as a Multifaceted Approach to Treat the Diverse Outcomes of Stroke

(2009) Brett Langley et al.   STROKE

Hyperphosphorylation of Microtubule-Associated Protein Tau: A Promising Therapeutic Target for Alzheimer Disease

(2008) C.-X. Gong et al.   CURRENT MEDICINAL CHEMISTRY

Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders

(2008) T ABEL et al.   CURRENT OPINION IN PHARMACOLOGY

The granulocyte macrophage colony stimulating factor (GM-CSF) regulates amyloid β (Aβ) production

(2008) Claude-Henry Volmar et al.   CYTOKINE

Blocking A 42 Accumulation Delays the Onset and Progression of Tau Pathology via the C Terminus of Heat Shock Protein70-Interacting Protein: A Mechanistic Link between A  and Tau Pathology

(2008) S. Oddo et al.   JOURNAL OF NEUROSCIENCE

Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of β-secretase

(2008) Mohammad Ali Faghihi et al.   NATURE MEDICINE