Both Amyloid-β Peptide and Tau Protein Are Affected by an Anti-Amyloid-β Antibody Fragment in Elderly 3xTg-AD Mice

APP Maturation and Intracellular Localization Are Controlled by a Specific Inhibitor of 37/67 kDa Laminin-1 Receptor in Neuronal Cells

(2020) Antaripa Bhattacharya et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Progression of Alzheimer's disease and effect of scFv‐h3D6 immunotherapy in the 3xTg‐AD mouse model: An in vivo longitudinal study using Magnetic Resonance Imaging and Spectroscopy

(2020) J. Güell‐Bosch et al.   NMR IN BIOMEDICINE

New Insights into the Molecular Bases of Familial Alzheimer’s Disease

(2020) Valeria D’Argenio et al.   Journal of Personalized Medicine

Amyloid-β Immunotherapy for Alzheimer's Disease - Is It Now A Long Shot…?

(2019) Francesco Panza et al.   ANNALS OF NEUROLOGY

Scientists rise up against statistical significance

(2019) Valentin Amrhein et al.   NATURE

Treatment with scFv-h3D6 Prevented Neuronal Loss and Improved Spatial Memory in Young 3xTg-AD Mice by Reducing the Intracellular Amyloid-β Burden

(2019) Gisela Esquerda-Canals et al.   JOURNAL OF ALZHEIMERS DISEASE

Pharmacokinetic parameters and mechanism of action of an efficient anti-Aβ single chain antibody fragment

(2019) Gisela Esquerda-Canals et al.   PLoS One

Differential effects of apoE and apoJ mimetic peptides on the action of an anti-Aβ scFv in 3xTg-AD mice

(2018) Laia Montoliu-Gaya et al.   BIOCHEMICAL PHARMACOLOGY

Phos-tau peptide immunization of amyloid-tg-mice reduced non-mutant phos-tau pathology, improved cognition and reduced amyloid plaques

(2018) Sandrine Benhamron et al.   EXPERIMENTAL NEUROLOGY

Differences Between Women and Men in Incidence Rates of Dementia and Alzheimer’s Disease

(2018) Christopher R. Beam et al.   JOURNAL OF ALZHEIMERS DISEASE

Aβ-oligomer uptake and the resulting inflammatory response in adult human astrocytes are precluded by an anti-Aβ single chain variable fragment in combination with an apoE mimetic peptide

(2018) Laia Montoliu-Gaya et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Tau-targeting therapies for Alzheimer disease

(2018) Erin E. Congdon et al.   Nature Reviews Neurology

Efficient clearance of Aβ protofibrils in AβPP-transgenic mice treated with a brain-penetrating bifunctional antibody

(2018) Stina Syvänen et al.   Alzheimers Research & Therapy

Immunotherapy to improve cognition and reduce pathological species in an Alzheimer’s disease mouse model

(2018) Krystal Herline et al.   Alzheimers Research & Therapy

Sex Differences in Healthspan Predict Lifespan in the 3xTg-AD Mouse Model of Alzheimer’s Disease

(2018) Alice E. Kane et al.   Frontiers in Aging Neuroscience

Alzheimer's Disease: Evidence for the Expression of Interleukin-33 and Its Receptor ST2 in the Brain

(2018) Zhi Xiong et al.   JOURNAL OF ALZHEIMERS DISEASE

Evidence of intraneuronal Aβ accumulation preceding tau pathology in the entorhinal cortex

(2018) Lindsay A. Welikovitch et al.   ACTA NEUROPATHOLOGICA

Attempt to Untangle the Prion-Like Misfolding Mechanism for Neurodegenerative Diseases

(2018) Daniela Sarnataro   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of Glial Cells and Synapse Loss in Mouse Models of Alzheimer’s Disease

(2018) Stephanie Ziegler-Waldkirch et al.   Frontiers in Cellular Neuroscience

Active full-length DNA Aβ42 immunization in 3xTg-AD mice reduces not only amyloid deposition but also tau pathology

(2018) Roger N. Rosenberg et al.   Alzheimers Research & Therapy

An Intracellular Amyloid-β/AβPP Epitope Correlates with Neurodegeneration in those Neuronal Populations Early Involved in Alzheimer’s Disease

(2017) Gisela Esquerda-Canals et al.   JOURNAL OF ALZHEIMERS DISEASE

Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease

(2017) Zhuoran Yin et al.   NEUROBIOLOGY OF AGING

Prevalencia e incidencia de la enfermedad de Alzheimer en Europa: metaanálisis

(2017) H. Niu et al.   NEUROLOGIA

Tau passive immunization inhibits not only tau but also Aβ pathology

(2017) Chun-ling Dai et al.   Alzheimers Research & Therapy

Interleukin33 deficiency causes tau abnormality and neurodegeneration with Alzheimer-like symptoms in aged mice

(2017) C Carlock et al.   Translational Psychiatry

Production of an anti-Aβ antibody fragment in Pichia pastoris and in vitro and in vivo validation of its therapeutic effect

(2017) Laia Montoliu-Gaya et al.   PLoS One

Effects of an Aβ-antibody fragment on Aβ aggregation and astrocytic uptake are modulated by apolipoprotein E and J mimetic peptides

(2017) Laia Montoliu-Gaya et al.   PLoS One

Alzheimer’s disease: experimental models and reality

(2016) Eleanor Drummond et al.   ACTA NEUROPATHOLOGICA

Intracellular A? and its Pathological Role in Alzheimer's Disease: Lessons from Cellular to Animal Models

(2016) Lina Ji et al.   Current Alzheimer Research

CSF, blood-brain barrier, and brain drug delivery

(2016) William M. Pardridge   Expert Opinion on Drug Delivery

Aβ-Immunotherapeutic strategies: a wide range of approaches for Alzheimer's disease treatment

(2016) Laia Montoliu-Gaya et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

TREM2 variants: new keys to decipher Alzheimer disease pathogenesis

(2016) Marco Colonna et al.   NATURE REVIEWS NEUROSCIENCE

IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline

(2016) Amy K. Y. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Tau Protein Mediates APP Intracellular Domain (AICD)-Induced Alzheimer’s-Like Pathological Features in Mice

(2016) Kaushik Ghosal et al.   PLoS One

Dealing with Danger in the CNS: The Response of the Immune System to Injury

(2015) Sachin P. Gadani et al.   NEURON

Tau Oligomers: The Toxic Player at Synapses in Alzheimer’s Disease

(2015) Marcos J. Guerrero-Muñoz et al.   Frontiers in Cellular Neuroscience

Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers

(2014) Christiane Reitz et al.   BIOCHEMICAL PHARMACOLOGY

Abundance of Aβ5-x like immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer’s disease

(2014) Erika Guzmán et al.   Molecular Neurodegeneration

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

New roles for Fc receptors in neurodegeneration-the impact on Immunotherapy for Alzheimer's Disease

(2014) James P. Fuller et al.   Frontiers in Neuroscience

Systemic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing Aβ deposition and tau pathology in 3xTg-AD mice

(2013) Suhail Rasool et al.   JOURNAL OF NEUROCHEMISTRY

Elongation of the C-terminal domain of an anti-amyloid β single-chain variable fragment increases its thermodynamic stability and decreases its aggregation tendency

(2013) Geovanny Rivera-Hernández et al.   mAbs

Loss of deep cerebellar nuclei neurons in the 3xTg-AD mice and protection by an anti-amyloid β antibody fragment

(2013) Gisela Esquerda-Canals et al.   mAbs

Early intervention in the 3xTg-AD mice with an amyloid β-antibody fragment ameliorates first hallmarks of Alzheimer disease

(2013) Lydia Giménez-Llort et al.   mAbs

Engineered antibody approaches for Alzheimer’s disease immunotherapy

(2012) Remy Robert et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Effect of Immunotherapy With Bapineuzumab on Cerebrospinal Fluid Biomarker Levels in Patients With Mild to Moderate Alzheimer Disease

(2012) Henrik Zetterberg   ARCHIVES OF NEUROLOGY

The immunology of neurodegeneration

(2012) Eva Czirr et al.   JOURNAL OF CLINICAL INVESTIGATION

Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis

(2012) Reisa Sperling et al.   LANCET NEUROLOGY

Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody

(2012) Katherine L Youmans et al.   Molecular Neurodegeneration

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

An anti-Aβ (amyloid β) single-chain variable fragment prevents amyloid fibril formation and cytotoxicity by withdrawing Aβ oligomers from the amyloid pathway

(2011) Marta Marín-Argany et al.   BIOCHEMICAL JOURNAL

Monoclonal antibodies against β-amyloid (Aβ) for the treatment of Alzheimer's disease: the Aβ target at a crossroads

(2011) Francesco Panza et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Sex differences in β-amyloid accumulation in 3xTg-AD mice: Role of neonatal sex steroid hormone exposure

(2010) Jenna C. Carroll et al.   BRAIN RESEARCH

Bapineuzumab

(2010) Geoffrey A Kerchner et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Bapineuzumab: anti-β-amyloid monoclonal antibodies for the treatment of Alzheimer’s disease

(2010) Francesco Panza et al.   Immunotherapy

Clearance of Amyloid-β Peptide Across the Blood-Brain Barrier: Implication for Therapies in Alzheimers Disease

(2009) R. Deane et al.   CNS & Neurological Disorders-Drug Targets

Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain

(2009) K. Ghosal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunotherapy Reduces Vascular Amyloid-  in PDAPP Mice

(2008) S. Schroeter et al.   JOURNAL OF NEUROSCIENCE