Aβ-Immunotherapeutic strategies: a wide range of approaches for Alzheimer's disease treatment

Modified Immunotherapies Against Alzheimer's Disease: Toward Safer and Effective Amyloid-β Clearance

(2017) Yan-Jiang Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Vanutide Cridificar and the QS-21 Adjuvant in Japanese Subjects with Mild to Moderate Alzheimer’ s Disease: Results from Two Phase 2 Studies

(2015) Heii Arai et al.   Current Alzheimer Research

Mutational approaches to improve the biophysical properties of human single-domain antibodies

(2014) Dae Young Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle

(2014) Jens Niewoehner et al.   NEURON

Study of the transcytosis of an anti-transferrin receptor antibody with a Fab′ cargo across the blood–brain barrier in mice

(2013) Gemma Manich et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Intravenous immunoglobulin and Alzheimer’s disease: what now?

(2013) David A Loeffler   Journal of Neuroinflammation

Early intervention in the 3xTg-AD mice with an amyloid β-antibody fragment ameliorates first hallmarks of Alzheimer disease

(2013) Lydia Giménez-Llort et al.   mAbs

Immunotherapy for Alzheimer’s disease: hoops and hurdles

(2013) Cynthia A Lemere   Molecular Neurodegeneration

Developing Therapeutic Antibodies for Neurodegenerative Disease

(2013) Y. Joy Yu et al.   Neurotherapeutics

Prophylaxis and Treatment of Alzheimer's Disease by Delivery of an Adeno-Associated Virus Encoding a Monoclonal Antibody Targeting the Amyloid Beta Protein

(2013) Masaru Shimada et al.   PLoS One

Engineered antibody approaches for Alzheimer’s disease immunotherapy

(2012) Remy Robert et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Epitope structure and binding affinity of single chain llama anti-β-amyloid antibodies revealed by proteolytic excision affinity-mass spectrometry

(2012) Gabriela Paraschiv et al.   JOURNAL OF MOLECULAR RECOGNITION

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Immunotherapeutic Strategies for Alzheimer's Disease Treatment

(2011) Beka Solomon   TheScientificWorldJOURNAL

Targeted Hydrolysis of Beta-Amyloid with Engineered Antibody Fragments

(2010) S. Kasturirangan et al.   Current Alzheimer Research

Intravenous Immunoglobulins as a Treatment for Alzheimerʼs Disease

(2010) Richard Dodel et al.   DRUGS

Human intravenous immunoglobulin provides protection against Aβ toxicity by multiple mechanisms in a mouse model of Alzheimer's disease

(2010) Johanna Magga et al.   Journal of Neuroinflammation

Effect of IVIG administration on complement activation and HLA antibody levels

(2010) Takafumi Machimoto et al.   TRANSPLANT INTERNATIONAL

Antibody concentrations to Aβ1–42 monomer and soluble oligomers in untreated and antibody–antigen-dissociated intravenous immunoglobulin preparations

(2009) Andrea C. Klaver et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Direct in Vivo Intracellular Selection of Conformation-sensitive Antibody Domains Targeting Alzheimer's Amyloid-β Oligomers

(2009) Giovanni Meli et al.   JOURNAL OF MOLECULAR BIOLOGY

Therapeutic activities of intravenous immunoglobulins in multiple sclerosis involve modulation of chemokine expression

(2009) Nadine Pigard et al.   JOURNAL OF NEUROIMMUNOLOGY

Development of AFFITOPE vaccines for Alzheimer’s disease (AD) — From concept to clinical testing

(2009) A. Schneeberger et al.   Journal of Nutrition Health & Aging

Generating Differentially Targeted Amyloid-β Specific Intrabodies as a Passive Vaccination Strategy for Alzheimer's Disease

(2009) Kelly L Sudol et al.   MOLECULAR THERAPY

Immune therapy for age-related diseases

(2009) Marc E. Weksler et al.   TRENDS IN IMMUNOLOGY

Natural human antibodies to amyloid beta peptide

(2008) Paul Szabo et al.   AUTOIMMUNITY REVIEWS

Catalytic antibodies to amyloid β peptide in defense against Alzheimer disease

(2008) Hiroaki Taguchi et al.   AUTOIMMUNITY REVIEWS

The Role of the Cell Surface LRP and Soluble LRP in Blood-Brain Barrier Aβ Clearance in Alzheimers Disease

(2008) R. Deane et al.   CURRENT PHARMACEUTICAL DESIGN

Exceptional Amyloid β Peptide Hydrolyzing Activity of Nonphysiological Immunoglobulin Variable Domain Scaffolds

(2008) Hiroaki Taguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-domain antibodies recognize selectively small oligomeric forms of amyloid β, prevent Aβ-induced neurotoxicity and inhibit fibril formation

(2008) Pierre Lafaye et al.   MOLECULAR IMMUNOLOGY

Intramuscular delivery of a single chain antibody gene reduces brain Aβ burden in a mouse model of Alzheimer's disease

(2007) Yan-Jiang Wang et al.   NEUROBIOLOGY OF AGING