Systemic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing Aβ deposition and tau pathology in 3xTg-AD mice

Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice

(2012) Suhail Rasool et al.   Molecular Neurodegeneration

Tau Protein Is Required for Amyloid  -Induced Impairment of Hippocampal Long-Term Potentiation

(2011) O. A. Shipton et al.   JOURNAL OF NEUROSCIENCE

Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers

(2011) Rakez Kayed et al.   Molecular Neurodegeneration

Soluble amyloid  -protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

(2011) M. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A  Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

(2010) H. Zempel et al.   JOURNAL OF NEUROSCIENCE

Immunotherapy Targeting Pathological Tau Prevents Cognitive Decline in a New Tangle Mouse Model

(2010) A. Boutajangout et al.   JOURNAL OF NEUROSCIENCE

Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport: Fig. 1

(2010) Keith A. Vossel et al.   SCIENCE

Amyloid Reduction by Amyloid-  Vaccination Also Reduces Mouse Tau Pathology and Protects from Neuron Loss in Two Mouse Models of Alzheimer's Disease

(2009) D. M. Wilcock et al.   JOURNAL OF NEUROSCIENCE

An amyloid-β protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease

(2009) Anna Lord et al.   NEUROBIOLOGY OF DISEASE

Active and Passive Immunotherapy for Neurodegenerative Disorders

(2008) David L. Brody et al.   Annual Review of Neuroscience

Limited Clearance of Pre-Existing Amyloid Plaques After Intracerebral Injection of Aβ Antibodies in Two Mouse Models of Alzheimer Disease

(2008) Stina M. Fangmark Tucker et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Reduced Pathology and Improved Behavioral Performance in Alzheimer's Disease Mice Vaccinated With HSV Amplicons Expressing Amyloid-β and Interleukin-4

(2008) Maria E Frazer et al.   MOLECULAR THERAPY

A highly insoluble state of Aβ similar to that of Alzheimer's disease brain is found in Arctic APP transgenic mice

(2008) Ola Philipson et al.   NEUROBIOLOGY OF AGING