New roles for Fc receptors in neurodegeneration-the impact on Immunotherapy for Alzheimer's Disease

Epigenetic suppression of neuroligin 1 underlies amyloid-induced memory deficiency

(2014) Bihua Bie et al.   NATURE NEUROSCIENCE

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

(2014) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inflammatory components in human Alzheimer’s disease and after active amyloid-β42 immunization

(2013) Elina Zotova et al.   BRAIN

Antibody Uptake into Neurons Occurs Primarily via Clathrin-dependent Fcγ Receptor Endocytosis and Is a Prerequisite for Acute Tau Protein Clearance

(2013) Erin E. Congdon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer’s disease

(2013) Tae-In Kam et al.   JOURNAL OF CLINICAL INVESTIGATION

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Evidence on the pathogenic role of auto-antibodies in acute cardiovascular diseases

(2013) Federico Carbone et al.   THROMBOSIS AND HAEMOSTASIS

Intracerebral immune complex formation induces inflammation in the brain that depends on Fc receptor interaction

(2012) Jessica L. Teeling et al.   ACTA NEUROPATHOLOGICA

Immunoglobulin G Fc receptor deficiency prevents Alzheimer-like pathology and cognitive impairment in mice

(2012) P. Fernandez-Vizarra et al.   BRAIN

Chronic Administration of an Aglycosylated Murine Antibody of Ponezumab Does Not Worsen Microhemorrhages in Aged Tg2576 Mice

(2012) Gary B. Freeman et al.   Current Alzheimer Research

Long-term impact of systemic bacterial infection on the cerebral vasculature and microglia

(2012) Ursula Püntener et al.   Journal of Neuroinflammation

The gamma chain subunit of Fc receptors is required for alpha-synuclein-induced pro-inflammatory signaling in microglia

(2012) Shuwen Cao et al.   Journal of Neuroinflammation

Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

(2012) David H Cribbs et al.   Journal of Neuroinflammation

An Effector-Reduced Anti- -Amyloid (A ) Antibody with Unique A  Binding Properties Promotes Neuroprotection and Glial Engulfment of A 

(2012) O. Adolfsson et al.   JOURNAL OF NEUROSCIENCE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diverse Inflammatory Responses in Transgenic Mouse Models of Alzheimer's Disease and the Effect of Immunotherapy on These Responses

(2011) Donna M Wilcock et al.   ASN Neuro

Age related changes in microglial phenotype vary between CNS regions: Grey versus white matter differences

(2011) Adam D. Hart et al.   BRAIN BEHAVIOR AND IMMUNITY

Activation and Control of CNS Innate Immune Responses in Health and Diseases: A Balancing Act Finely Tuned by Neuroimmune Regulators (NIReg)

(2011) Jean-Jacques Hoarau et al.   CNS & Neurological Disorders-Drug Targets

Systemic Inflammation Modulates Fc Receptor Expression on Microglia during Chronic Neurodegeneration

(2011) K. Lunnon et al.   JOURNAL OF IMMUNOLOGY

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Proinflammatory cytokines, sickness behavior, and Alzheimer disease

(2011) C. Holmes et al.   NEUROLOGY

11C-PiB PET assessment of change in fibrillar amyloid-β load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study

(2010) Juha O Rinne et al.   LANCET NEUROLOGY

Fcγ receptors are required for NF-κB signaling, microglial activation and dopaminergic neurodegeneration in an AAV-synuclein mouse model of Parkinson's disease

(2010) Shuwen Cao et al.   Molecular Neurodegeneration

Can Alzheimer disease be prevented by amyloid-β immunotherapy?

(2010) Cynthia A. Lemere et al.   Nature Reviews Neurology

A PHASE 2 MULTIPLE ASCENDING DOSE TRIAL OF BAPINEUZUMAB IN MILD TO MODERATE ALZHEIMER DISEASE

(2010) D. T. Laskowitz et al.   NEUROLOGY

The Role of Microglia in Antibody-Mediated Clearance of Amyloid-Beta from the Brain

(2009) Dave Morgan   CNS & Neurological Disorders-Drug Targets

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Active and Passive Immunotherapy for Neurodegenerative Disorders

(2008) David L. Brody et al.   Annual Review of Neuroscience

Specificity and affinity of human Fc  receptors and their polymorphic variants for human IgG subclasses

(2008) P. Bruhns et al.   BLOOD

Monomeric IgG Is Neuroprotective via Enhancing Microglial Recycling Endocytosis and TNF- 

(2008) R. E. Hulse et al.   JOURNAL OF NEUROSCIENCE

Alterations of Fc gamma receptor I and Toll-like receptor 4 mediate the antiinflammatory actions of microglia and astrocytes after adrenaline-induced blood-brain barrier opening in rats

(2008) Ying-Na Li et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Targeting β-amyloid pathology in Alzheimer’s disease with Aβ immunotherapy

(2008) Roger M. Nitsch et al.   Neurotherapeutics