Attempt to Untangle the Prion-Like Misfolding Mechanism for Neurodegenerative Diseases

Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity

(2018) Franziska Kundel et al.   ACS Chemical Biology

Cause and consequence of Aβ – Lipid interactions in Alzheimer disease pathogenesis

(2018) Vijayaraghavan Rangachari et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Prion-like Spreading in Tauopathies

(2018) Jacob I. Ayers et al.   BIOLOGICAL PSYCHIATRY

Synaptotoxic Amyloid-β Oligomers: A Molecular Basis for the Cause, Diagnosis, and Treatment of Alzheimer's Disease?

(2018) William L. Klein   JOURNAL OF ALZHEIMERS DISEASE

Distinct differences in prion-like seeding and aggregation between Tau protein variants provide mechanistic insights into tauopathies

(2017) Kevin H. Strang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Physico-Pathologic Mechanisms Involved in Neurodegeneration: Misfolded Protein-Plasma Membrane Interactions

(2017) Amulya Nidhi Shrivastava et al.   NEURON

Chaperones as Suppressors of Protein Misfolded Oligomer Toxicity

(2017) Benedetta Mannini et al.   Frontiers in Molecular Neuroscience

Tau Phosphorylation by cdk5 and Fyn in Response to Amyloid Peptide Aβ25–35: Involvement of Lipid Rafts

(2017) Paula Hernandez et al.   JOURNAL OF ALZHEIMERS DISEASE

Regulation of sub-compartmental targeting and folding properties of the Prion-like protein Shadoo

(2017) Anna Pepe et al.   Scientific Reports

Characterization of Soft Amyloid Cores in Human Prion-Like Proteins

(2017) Cristina Batlle et al.   Scientific Reports

Limited ER quality control for GPI-anchored proteins

(2016) Natalia Sikorska et al.   JOURNAL OF CELL BIOLOGY

The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6

(2016) Alexander Küffer et al.   NATURE

Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo

(2016) Sarah K. Kaufman et al.   NEURON

The neuronal extracellular matrix restricts distribution and internalization of aggregated Tau-protein

(2016) A. Suttkus et al.   NEUROSCIENCE

Tunneling nanotubes: A possible highway in the spreading of tau and other prion-like proteins in neurodegenerative diseases

(2016) Saida Abounit et al.   Prion

A functional role for intrinsic disorder in the tau-tubulin complex

(2016) Ana M. Melo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-β pathology and cerebral amyloid angiopathy are frequent in iatrogenic Creutzfeldt-Jakob disease after dural grafting

(2016) K Frontzek et al.   SWISS MEDICAL WEEKLY

Chronic Pharmacological mGluR5 Inhibition Prevents Cognitive Impairment and Reduces Pathogenesis in an Alzheimer Disease Mouse Model

(2016) Alison Hamilton et al.   Cell Reports

The Prion-Like Properties of Amyloid-β Assemblies: Implications for Alzheimer's Disease

(2016) Lary C. Walker et al.   Cold Spring Harbor Perspectives in Medicine

Secretory pathway retention of mutant prion protein induces p38-MAPK activation and lethal disease in mice

(2016) Berta Puig et al.   Scientific Reports

The 37/67kDa laminin receptor (LR) inhibitor, NSC47924, affects 37/67kDa LR cell surface localization and interaction with the cellular prion protein

(2016) Daniela Sarnataro et al.   Scientific Reports

Prion-mediated neurodegeneration is associated with early impairment of the ubiquitin–proteasome system

(2015) Chris McKinnon et al.   ACTA NEUROPATHOLOGICA

Iatrogenic CJD due to pituitary-derived growth hormone with genetically determined incubation times of up to 40 years

(2015) Peter Rudge et al.   BRAIN

Spatially Organized Aggregation of Misfolded Proteins as Cellular Stress Defense Strategy

(2015) Stephanie B.M. Miller et al.   JOURNAL OF MOLECULAR BIOLOGY

Interaction between Shadoo and PrP Affects the PrP-Folding Pathway

(2015) Danica Ciric et al.   JOURNAL OF VIROLOGY

Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy

(2015) Zane Jaunmuktane et al.   NATURE

Tau and neurodegenerative disease: the story so far

(2015) Khalid Iqbal et al.   Nature Reviews Neurology

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Trafficking and degradation pathways in pathogenic conversion of prions and prion-like proteins in neurodegenerative diseases

(2015) Guiliana Soraya Victoria et al.   VIRUS RESEARCH

Acute ER stress regulates amyloid precursor protein processing through ubiquitin-dependent degradation

(2015) Eun Sun Jung et al.   Scientific Reports

Role of Different Alpha-Synuclein Strains in Synucleinopathies, Similarities with other Neurodegenerative Diseases

(2015) Ronald Melki   Journal of Parkinsons Disease

The cell biology of prion-like spread of protein aggregates: mechanisms and implication in neurodegeneration

(2015) Maddalena Costanzo et al.   BIOCHEMICAL JOURNAL

Hyperphosphorylation of Intrinsically Disordered Tau Protein Induces an Amyloidogenic Shift in Its Conformational Ensemble

(2015) Shaolong Zhu et al.   PLoS One

Toxicity of Protein Oligomers Is Rationalized by a Function Combining Size and Surface Hydrophobicity

(2014) Benedetta Mannini et al.   ACS Chemical Biology

Interaction of Alzheimer’s β-Amyloid Peptides with Cholesterol: Mechanistic Insights into Amyloid Pore Formation

(2014) Coralie Di Scala et al.   BIOCHEMISTRY

ER Stress-Induced Clearance of Misfolded GPI-Anchored Proteins via the Secretory Pathway

(2014) Prasanna Satpute-Krishnan et al.   CELL

Multiple Factors Contribute to the Peripheral Induction of Cerebral  -Amyloidosis

(2014) Y. S. Eisele et al.   JOURNAL OF NEUROSCIENCE

Altered lipid composition in cortical lipid rafts occurs at early stages of sporadic Alzheimer's disease and facilitates APP/BACE1 interactions

(2014) Noemí Fabelo et al.   NEUROBIOLOGY OF AGING

Soluble Aβ Oligomers Are Rapidly Sequestered from Brain ISF In Vivo and Bind GM1 Ganglioside on Cellular Membranes

(2014) Soyon Hong et al.   NEURON

Sequence Complexity of Amyloidogenic Regions in Intrinsically Disordered Human Proteins

(2014) Swagata Das et al.   PLoS One

The GPI-anchoring of PrP

(2014) Berta Puig et al.   Prion

Distinct synthetic A  prion strains producing different amyloid deposits in bigenic mice

(2014) J. Stohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau mutants bind tubulin heterodimers with enhanced affinity

(2014) S. Elbaum-Garfinkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer’s disease

(2014) Lluís Pujadas et al.   Nature Communications

mGlu5 receptors and cellular prion protein mediate amyloid-β-facilitated synaptic long-term depression in vivo

(2014) Neng-Wei Hu et al.   Nature Communications

Structural features within the nascent chain regulate alternative targeting of secretory proteins to mitochondria

(2013) Natalie V Pfeiffer et al.   EMBO JOURNAL

Tau Accumulation Activates the Unfolded Protein Response by Impairing Endoplasmic Reticulum-Associated Degradation

(2013) J. F. Abisambra et al.   JOURNAL OF NEUROSCIENCE

Turnover of C99 is Controlled by a Crosstalk between ERAD and Ubiquitin-Independent Lysosomal Degradation in Human Neuroglioma Cells

(2013) Hianara A. Bustamante et al.   PLoS One

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogenic prions deviate PrPC signaling in neuronal cells and impair A-beta clearance

(2013) E Pradines et al.   Cell Death & Disease

Prions disturb post-Golgi trafficking of membrane proteins

(2013) Keiji Uchiyama et al.   Nature Communications

Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration

(2013) E.-M. Mandelkow et al.   Cold Spring Harbor Perspectives in Medicine

GPI-anchor remodeling: Potential functions of GPI-anchors in intracellular trafficking and membrane dynamics

(2012) Morihisa Fujita et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Avoiding the oligomeric state: αB-crystallin inhibits fragmentation and induces dissociation of apolipoprotein C-II amyloid fibrils

(2012) Katrina J. Binger et al.   FASEB JOURNAL

Tau Oligomers Impair Artificial Membrane Integrity and Cellular Viability

(2012) Katharina Flach et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Molecular Approaches to the Treatment, Prophylaxis, and Diagnosis of Alzheimer’s Disease: Possible Involvement of HRD1, a Novel Molecule Related to Endoplasmic Reticulum Stress, in Alzheimer’s Disease

(2012) Masayuki Kaneko et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Prion propagation, toxicity and degradation

(2012) Adriano Aguzzi et al.   NATURE NEUROSCIENCE

Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-  Uptake

(2011) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's Disease: The Challenge of the Second Century

(2011) D. M. Holtzman et al.   Science Translational Medicine

The Golgi apparatus: an organelle with multiple complex functions

(2010) Cathal Wilson et al.   BIOCHEMICAL JOURNAL

Loss of HRD1-Mediated Protein Degradation Causes Amyloid Precursor Protein Accumulation and Amyloid-  Generation

(2010) M. Kaneko et al.   JOURNAL OF NEUROSCIENCE

Neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer's disease

(2010) M. Morawski et al.   NEUROSCIENCE

The propagation of prion-like protein inclusions in neurodegenerative diseases

(2010) Michel Goedert et al.   TRENDS IN NEUROSCIENCES

Classification and basic pathology of Alzheimer disease

(2009) Charles Duyckaerts et al.   ACTA NEUROPATHOLOGICA

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

A Recessive Mutation in the APP Gene with Dominant-Negative Effect on Amyloidogenesis

(2009) G. Di Fede et al.   SCIENCE

Selective Processing and Metabolism of Disease-Causing Mutant Prion Proteins

(2009) Aarthi Ashok et al.   PLoS Pathogens

Intrinsically Disordered Proteins in Human Diseases: Introducing the D2 Concept

(2008) Vladimir N. Uversky et al.   Annual Review of Biophysics

Function and structure of inherently disordered proteins

(2008) A Keith Dunker et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Protein quality control in the early secretory pathway

(2008) Tiziana Anelli et al.   EMBO JOURNAL

Conformational Diversity of Wild-type Tau Fibrils Specified by Templated Conformation Change

(2008) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Retrotranslocation of Prion Proteins from the Endoplasmic Reticulum by Preventing GPI Signal Transamidation

(2008) Aarthi Ashok et al.   MOLECULAR BIOLOGY OF THE CELL

One step at a time: endoplasmic reticulum-associated degradation

(2008) Shruthi S. Vembar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY