Platelets: No longer bystanders in liver disease

Immunosurveillance of the Liver by Intravascular Effector CD8 + T Cells

(2015) Luca G. Guidotti et al.   CELL

Chronic hepatitis B: role of anti-platelet therapy in inflammation control

(2015) Roberto Aiolfi et al.   Cellular & Molecular Immunology

Imaging the dynamic platelet-neutrophil response in sterile liver injury and repair in mice

(2015) Ingrid Slaba et al.   HEPATOLOGY

Could abnormal neutrophil-platelet interactions and complex formation contribute to oxidative stress and organ failure in cirrhosis?

(2015) Jonathan P. Sturgeon et al.   HEPATOLOGY

A focus on the role of platelets in liver regeneration: Do platelet-endothelial cell interactions initiate the regenerative process?

(2015) Jeremy Meyer et al.   JOURNAL OF HEPATOLOGY

Serotonin Deficiency Exacerbates Acetaminophen-Induced Liver Toxicity In Mice

(2015) Jingyao Zhang et al.   Scientific Reports

Association between aspirin use and the prevalence of nonalcoholic fatty liver disease: a cross-sectional study from the Third National Health and Nutrition Examination Survey

(2014) H. Shen et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Emerging roles for platelets as immune and inflammatory cells

(2014) C. N. Morrell et al.   BLOOD

Extrahepatic Platelet-Derived Growth Factor-β, Delivered by Platelets, Promotes Activation of Hepatic Stellate Cells and Biliary Fibrosis in Mice

(2014) Shuhei Yoshida et al.   GASTROENTEROLOGY

Sphingosine 1-phosphate has anti-apoptotic effect on liver sinusoidal endothelial cells and proliferative effect on hepatocytes in a paracrine manner in human

(2014) Takeshi Nowatari et al.   HEPATOLOGY RESEARCH

Macrophage heterogeneity in liver injury and fibrosis

(2014) Frank Tacke et al.   JOURNAL OF HEPATOLOGY

Coagulation-driven platelet activation reduces cholestatic liver injury and fibrosis in mice

(2014) N. Joshi et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Interaction of Kupffer Cells and Platelets Determines the Severity of Ischemia-Reperfusion Injury in Steatosis

(2014) Koichi Ogawa et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Aspirin may reduce liver fibrosis progression: Evidence from a multicenter retrospective study of recurrent hepatitis C after liver transplantation

(2014) Armelle Poujol-Robert et al.   Clinics and Research in Hepatology and Gastroenterology

Platelets Mediate Oxidized Low-Density Lipoprotein–Induced Monocyte Extravasation and Foam Cell Formation

(2013) Sigrun Badrnya et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role of platelets in chronic liver disease and acute liver injury

(2013) Takeshi Nowatari et al.   HEPATOLOGY RESEARCH

Liver sinusoidal endothelial cells and liver regeneration

(2013) Laurie D. DeLeve   JOURNAL OF CLINICAL INVESTIGATION

Anti-platelet therapy in the prevention of hepatitis B virus-associated hepatocellular carcinoma

(2013) Giovanni Sitia et al.   JOURNAL OF HEPATOLOGY

Damage-Associated Molecular Patterns Control Neutrophil Recruitment

(2013) Keir Pittman et al.   Journal of Innate Immunity

Platelet-macrophage partnership in innate immunity and inflammation

(2013) Alberto Mantovani et al.   NATURE IMMUNOLOGY

Serotonin 5-HT2A Receptor Activation Blocks TNF-α Mediated Inflammation In Vivo

(2013) Felix Nau et al.   PLoS One

Human platelets inhibit liver fibrosis in severe combined immunodeficiency mice

(2013) Kazuhiro Takahashi   WORLD JOURNAL OF GASTROENTEROLOGY

Hepatic sinusoidal endothelium avidly binds platelets in an integrin-dependent manner, leading to platelet and endothelial activation and leukocyte recruitment

(2012) Patricia F. Lalor et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Accumulation of platelets in the liver may be an important contributory factor to thrombocytopenia and liver fibrosis in chronic hepatitis C

(2012) Reiichiro Kondo et al.   JOURNAL OF GASTROENTEROLOGY

Interaction between Kupffer cells and platelets in the early period of hepatic ischemia–reperfusion injury—An in vivo study

(2012) Takafumi Tamura et al.   JOURNAL OF SURGICAL RESEARCH

Effector CD8 T cell trafficking within the liver

(2012) Luca G. Guidotti et al.   MOLECULAR IMMUNOLOGY

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

(2012) P. Ramachandran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel therapy for liver regeneration by increasing the number of platelets

(2012) Kazuhiro Takahashi et al.   SURGERY TODAY

Podoplanin: emerging functions in development, the immune system, and cancer

(2012) Jillian L. Astarita et al.   Frontiers in Immunology

TGF-β in progression of liver disease

(2011) Steven Dooley et al.   CELL AND TISSUE RESEARCH

Mean platelet volume as a marker of increased cardiovascular risk in patients with nonalcoholic steatohepatitis

(2011) Naim Alkhouri et al.   HEPATOLOGY

How platelets safeguard vascular integrity

(2011) B. HO-TIN-NOÉ et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Podoplanin-expressing inflammatory macrophages activate murine platelets via CLEC-2

(2011) A. M. KERRIGAN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The neutrophil in vascular inflammation

(2011) Mia Phillipson et al.   NATURE MEDICINE

Stimulating healthy tissue regeneration by targeting the 5-HT2B receptor in chronic liver disease

(2011) Mohammad R Ebrahimkhani et al.   NATURE MEDICINE

The Coagulopathy of Chronic Liver Disease

(2011) Armando Tripodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Serotonin reverts age-related capillarization and failure of regeneration in the liver through a VEGF-dependent pathway

(2011) K. Furrer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serotonin: A double-edged sword for the liver?

(2011) M. Lesurtel et al.   SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND

Platelets, inflammation and tissue regeneration

(2011) Alan Nurden   THROMBOSIS AND HAEMOSTASIS

Erratum: Microparticles from apoptotic platelets promote resident macrophage differentiation

(2011) E M Vasina et al.   Cell Death & Disease

Blood platelets and inflammation: Their relationship with liver and digestive diseases

(2011) J. Ripoche   Clinics and Research in Hepatology and Gastroenterology

Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis

(2010) D. Lievens et al.   BLOOD

Thrombocytopenia Exacerbates Cholestasis-Induced Liver Fibrosis in Mice

(2010) Takahiro Kodama et al.   GASTROENTEROLOGY

Activation of serotonin receptor-2B rescues small-for-size liver graft failure in mice

(2010) Yinghua Tian et al.   HEPATOLOGY

Activation of human liver sinusoidal endothelial cell by human platelets induces hepatocyte proliferation

(2010) Takuya Kawasaki et al.   JOURNAL OF HEPATOLOGY

Platelets arrive at the scene of fibrosis……studies

(2010) Virginia Hernandez-Gea et al.   JOURNAL OF HEPATOLOGY

CXC Chemokine Ligand 4 Induces a Unique Transcriptome in Monocyte-Derived Macrophages

(2010) C. A. Gleissner et al.   JOURNAL OF IMMUNOLOGY

Macrophage pro-inflammatory cytokine secretion is enhanced following interaction with autologous platelets

(2010) Christopher M Scull et al.   Journal of Inflammation-London

Molecular Mechanisms of SERT in Platelets: Regulation of Plasma Serotonin Levels

(2010) C. P. Mercado et al.   MOLECULAR INTERVENTIONS

Platelet adhesion in the sinusoid caused hepatic injury by neutrophils after hepatic ischemia reperfusion

(2010) Sugiru Pak et al.   PLATELETS

Protective and Damaging Effects of Platelets in Acute Cholestatic Liver Injury Revealed by Depletion and Inhibition Strategies

(2010) Bradley P. Sullivan et al.   TOXICOLOGICAL SCIENCES

CXC chemokine ligand 4 (Cxcl4) is a platelet-derived mediator of experimental liver fibrosis

(2009) Mirko Moreno Zaldivar et al.   HEPATOLOGY

On the role of platelets in the pathogenesis of viral hepatitis

(2009) Matteo Iannacone et al.   JOURNAL OF HEPATOLOGY

The Rho-kinase inhibitor Y-27632 inhibits cholestasis-induced platelet interactions in the hepatic microcirculation

(2009) Matthias W. Laschke et al.   MICROVASCULAR RESEARCH

Mean platelet volume in patients with non-alcoholic fatty liver disease

(2009) Hakan Ozhan et al.   PLATELETS

Risk of Venous Thromboembolism in Patients With Liver Disease: A Nationwide Population-Based Case–Control Study

(2008) Kirstine Kobberøe Søgaard et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Single Administration of Thrombopoietin Prevents Progression of Liver Fibrosis and Promotes Liver Regeneration After Partial Hepatectomy in Cirrhotic Rats

(2008) Soichiro Murata et al.   ANNALS OF SURGERY

Immune Interactions in Hepatic Fibrosis

(2008) Andrew P. Holt et al.   Clinics in Liver Disease

Effectiveness of antiplatelet drugs against experimental non-alcoholic fatty liver disease

(2008) K Fujita et al.   GUT

Platelets contribute to the reduction of liver fibrosis in mice

(2008) Motonobu Watanabe et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

The function of serotonin within the liver

(2008) Richard G. Ruddell et al.   JOURNAL OF HEPATOLOGY

Role of platelets on liver regeneration after 90% hepatectomy in mice

(2008) Andriy Myronovych et al.   JOURNAL OF HEPATOLOGY

Platelets, neutrophils, and neutrophil extracellular traps (NETs) in sepsis

(2008) A. C. MA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Aggravation of viral hepatitis by platelet-derived serotonin

(2008) Philipp A Lang et al.   NATURE MEDICINE

Platelets Promote Liver Regeneration under Conditions of Kupffer Cell Depletion after Hepatectomy in Mice

(2008) Soichiro Murata et al.   WORLD JOURNAL OF SURGERY

Platelet-dependent accumulation of leukocytes in sinusoids mediates hepatocellular damage in bile duct ligation-induced cholestasis

(2007) M W Laschke et al.   BRITISH JOURNAL OF PHARMACOLOGY

Platelet Dynamics in the Early Phase of Postischemic Liver In Vivo

(2007) Yoritaka Nakano et al.   JOURNAL OF SURGICAL RESEARCH