Beyond Stem Cells: Self-Renewal of Differentiated Macrophages

Nr4a1-Dependent Ly6Clow Monocytes Monitor Endothelial Cells and Orchestrate Their Disposal

(2013) Leo M. Carlin et al.   CELL

Recruitment of Beneficial M2 Macrophages to Injured Spinal Cord Is Orchestrated by Remote Brain Choroid Plexus

(2013) Ravid Shechter et al.   IMMUNITY

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

Multicolor fate mapping of Langerhans cell homeostasis

(2013) Clément Ghigo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1

(2013) Stephen J. Jenkins et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Local proliferation dominates lesional macrophage accumulation in atherosclerosis

(2013) Clinton S Robbins et al.   NATURE MEDICINE

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

Nontransformed, GM-CSF-dependent macrophage lines are a unique model to study tissue macrophage functions

(2013) G. Fejer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation

(2013) Luke C. Davies et al.   Nature Communications

Induction of IL-4R -dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4-driven murine macrophage proliferation in vivo

(2012) D. Ruckerl et al.   BLOOD

Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans

(2012) Charalambos Gustav Antoniades et al.   HEPATOLOGY

Stroma-Derived Interleukin-34 Controls the Development and Maintenance of Langerhans Cells and the Maintenance of Microglia

(2012) Melanie Greter et al.   IMMUNITY

Ly6Chi Monocytes in the Inflamed Colon Give Rise to Proinflammatory Effector Cells and Migratory Antigen-Presenting Cells

(2012) Ehud Zigmond et al.   IMMUNITY

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

Non-canonical alternatives: What a macrophage is 4

(2012) Christopher L. Karp et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages

(2012) Guillaume Hoeffel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

(2012) Yaming Wang et al.   NATURE IMMUNOLOGY

Re(de)fining the dendritic cell lineage

(2012) Ansuman T Satpathy et al.   NATURE IMMUNOLOGY

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling

(2011) D. A. Hume et al.   BLOOD

A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation

(2011) Luke C. Davies et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency

(2011) Venetia Bigley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1

(2011) Elisa Tagliani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

(2011) Bahareh Ajami et al.   NATURE NEUROSCIENCE

IRF8Mutations and Human Dendritic-Cell Immunodeficiency

(2011) Sophie Hambleton et al.   NEW ENGLAND JOURNAL OF MEDICINE

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

Sustained IL-4 exposure leads to a novel pathway for hemophagocytosis, inflammation, and tissue macrophage accumulation

(2010) J. D. Milner et al.   BLOOD

Monocytes: Protagonists of Infarct Inflammation and Repair After Myocardial Infarction

(2010) Matthias Nahrendorf et al.   CIRCULATION

Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors

(2010) Jérôme Cros et al.   IMMUNITY

Essential role of c-myb in definitive hematopoiesis is evolutionarily conserved

(2010) C. Soza-Ried et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Mechanisms of Stem Cell Self-Renewal

(2009) He Shenghui et al.   Annual Review of Cell and Developmental Biology

Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells

(2009) Cedric Auffray et al.   Annual Review of Immunology

IL-4 blocks M-CSF-dependent macrophage proliferation by inducing p21Waf1 in a STAT6-dependent way

(2009) Luis Arpa et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network

(2009) Laurent Chorro et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MafB/c-Maf Deficiency Enables Self-Renewal of Differentiated Functional Macrophages

(2009) A. Aziz et al.   SCIENCE

The Prolonged Life-Span of Alveolar Macrophages

(2008) Jaime Murphy et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A core Klf circuitry regulates self-renewal of embryonic stem cells

(2008) Jianming Jiang et al.   NATURE CELL BIOLOGY