The Role of Monocytes and Macrophages in Acute and Acute-on-Chronic Liver Failure

Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage

(2018) Maria J Perugorria et al.   GUT

A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis

(2018) Scott L. Friedman et al.   HEPATOLOGY

Hepatocyte-specific deletion of IL1-RI attenuates liver injury by blocking IL-1 driven autoinflammation

(2018) Nadine Gehrke et al.   JOURNAL OF HEPATOLOGY

Infections complicating cirrhosis

(2018) Salvatore Piano et al.   LIVER INTERNATIONAL

Increased Expression of Cytotoxic T-Lymphocyte−Associated Protein 4 by T Cells, Induced by B7 in Sera, Reduces Adaptive Immunity in Patients With Acute Liver Failure

(2017) Wafa Khamri et al.   GASTROENTEROLOGY

CD14+CD15−HLA-DR−myeloid-derived suppressor cells impair antimicrobial responses in patients with acute-on-chronic liver failure

(2017) Christine Bernsmeier et al.   GUT

Bacterial and fungal infections in acute-on-chronic liver failure: prevalence, characteristics and impact on prognosis

(2017) Javier Fernández et al.   GUT

MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure

(2017) Evangelos Triantafyllou et al.   GUT

Acute-on-chronic liver failure: an update

(2017) Ruben Hernaez et al.   GUT

A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment

(2017) Frederic Sierro et al.   IMMUNITY

Targeting hepatic macrophages to treat liver diseases

(2017) Frank Tacke   JOURNAL OF HEPATOLOGY

Ly6Chi Monocytes and Their Macrophage Descendants Regulate Neutrophil Function and Clearance in Acetaminophen-Induced Liver Injury

(2017) Nadine Graubardt et al.   Frontiers in Immunology

Spatiotemporal Characterization of the Cellular and Molecular Contributors to Liver Fibrosis in a Murine Hepatotoxic-Injury Model

(2016) Michelle Melino et al.   AMERICAN JOURNAL OF PATHOLOGY

A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade Visceral Organs to Affect Tissue Repair

(2016) Jing Wang et al.   CELL

Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies

(2016) Cynthia Ju et al.   Cellular & Molecular Immunology

Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice

(2016) Bruna Araujo David et al.   GASTROENTEROLOGY

Chemokine (C-C motif) receptor 2-positive monocytes aggravate the early phase of acetaminophen-induced acute liver injury

(2016) Jana C. Mossanen et al.   HEPATOLOGY

A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice

(2016) Peter Lundbäck et al.   HEPATOLOGY

Systemic inflammation in decompensated cirrhosis: Characterization and role in acute-on-chronic liver failure

(2016) Joan Clària et al.   HEPATOLOGY

Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species

(2016) Martin Guilliams et al.   IMMUNITY

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

(2016) Irma Garcia-Martinez et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification and treatment of the Staphylococcus aureus reservoir in vivo

(2016) Bas G.J. Surewaard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions

(2016) Lynette Beattie et al.   JOURNAL OF HEPATOLOGY

Macrophage activation markers predict mortality in patients with liver cirrhosis without or with acute-on-chronic liver failure (ACLF)

(2016) Henning Grønbæk et al.   JOURNAL OF HEPATOLOGY

The Acute-on-Chronic Liver Failure Syndrome, or When the Innate Immune System Goes Astray

(2016) Joan Clària et al.   JOURNAL OF IMMUNOLOGY

Patients with HBV-related acute-on-chronic liver failure have increased concentrations of extracellular histones aggravating cellular damage and systemic inflammation

(2016) X. Li et al.   JOURNAL OF VIRAL HEPATITIS

New insights into the multidimensional concept of macrophage ontogeny, activation and function

(2016) Florent Ginhoux et al.   NATURE IMMUNOLOGY

Liver — guardian, modifier and target of sepsis

(2016) Pavel Strnad et al.   Nature Reviews Gastroenterology & Hepatology

Immunology in the liver — from homeostasis to disease

(2016) Felix Heymann et al.   Nature Reviews Gastroenterology & Hepatology

Circulating histones are major mediators of systemic inflammation and cellular injury in patients with acute liver failure

(2016) Zongmei Wen et al.   Cell Death & Disease

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

(2016) Charlotte L. Scott et al.   Nature Communications

Antifibrotic Effects of the Dual CCR2/CCR5 Antagonist Cenicriviroc in Animal Models of Liver and Kidney Fibrosis

(2016) Eric Lefebvre et al.   PLoS One

Macrophages: Development and Tissue Specialization

(2015) Chen Varol et al.   Annual Review of Immunology

Fluorescent cell-traceable dexamethasone-loaded liposomes for the treatment of inflammatory liver diseases

(2015) Matthias Bartneck et al.   BIOMATERIALS

CSF1 Restores Innate Immunity After Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure

(2015) Benjamin M. Stutchfield et al.   GASTROENTEROLOGY

Patients With Acute-on-Chronic Liver Failure Have Increased Numbers of Regulatory Immune Cells Expressing the Receptor Tyrosine Kinase MERTK

(2015) Christine Bernsmeier et al.   GASTROENTEROLOGY

Combination of Granulocyte Colony-Stimulating Factor and Erythropoietin Improves Outcomes of Patients With Decompensated Cirrhosis

(2015) Chandan Kumar Kedarisetty et al.   GASTROENTEROLOGY

Plasma cholesteryl ester transfer protein is predominantly derived from Kupffer cells

(2015) Yanan Wang et al.   HEPATOLOGY

Liver inflammation abrogates immunological tolerance induced by Kupffer cells

(2015) Felix Heymann et al.   HEPATOLOGY

Liver-Resident Macrophage Necroptosis Orchestrates Type 1 Microbicidal Inflammation and Type-2-Mediated Tissue Repair during Bacterial Infection

(2015) Camille Blériot et al.   IMMUNITY

Immunotherapy in the treatment and prevention of infection in acute-on-chronic liver failure

(2015) Christine Bernsmeier et al.   Immunotherapy

A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+monocytes at a site of sterile injury

(2015) Daniela Dal-Secco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Acute-on-chronic liver failure: A new syndrome that will re-classify cirrhosis

(2015) Vicente Arroyo et al.   JOURNAL OF HEPATOLOGY

Circulating levels of soluble receptor for advanced glycation end products and ligands of the receptor for advanced glycation end products in patients with acute liver failure

(2015) Giuseppina Basta et al.   LIVER TRANSPLANTATION

Inflammasome activation and function in liver disease

(2015) Gyongyi Szabo et al.   Nature Reviews Gastroenterology & Hepatology

Circulating cell death biomarker: good candidates of prognostic indicator for patients with hepatitis B virus related acute-on-chronic liver failure

(2015) Zhujun Cao et al.   Scientific Reports

CCR5 knockout mice with C57BL6 background are resistant to acetaminophen-mediated hepatotoxicity due to decreased macrophages migration into the liver

(2014) Dong-Young Choi et al.   ARCHIVES OF TOXICOLOGY

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Lack of interleukin-1α in Kupffer cells attenuates liver inflammation and expression of inflammatory cytokines in hypercholesterolaemic mice

(2014) Sarita Olteanu et al.   DIGESTIVE AND LIVER DISEASE

Toward an Improved Definition of Acute-on-Chronic Liver Failure

(2014) Rajiv Jalan et al.   GASTROENTEROLOGY

Roles for Chemokines in Liver Disease

(2014) Fabio Marra et al.   GASTROENTEROLOGY

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

Origin and Functions of Tissue Macrophages

(2014) Slava Epelman et al.   IMMUNITY

Could targeting secretory leukocyte protease inhibitor be an effective therapeutic option to prevent infections in acute liver failure?

(2014) Lucia A Possamai et al.   Immunotherapy

What’s new in acute liver failure?

(2014) Christine Bernsmeier et al.   INTENSIVE CARE MEDICINE

Understanding infection susceptibility in patients with acute-on-chronic liver failure

(2014) Nowlan Selvapatt et al.   INTENSIVE CARE MEDICINE

Cirrhosis-associated immune dysfunction: Distinctive features and clinical relevance

(2014) Agustín Albillos et al.   JOURNAL OF HEPATOLOGY

Modulation of monocyte/macrophage function: A therapeutic strategy in the treatment of acute liver failure

(2014) Lucia A. Possamai et al.   JOURNAL OF HEPATOLOGY

Macrophage heterogeneity in liver injury and fibrosis

(2014) Frank Tacke et al.   JOURNAL OF HEPATOLOGY

Infiltrating Monocyte-Derived Macrophages and Resident Kupffer Cells Display Different Ontogeny and Functions in Acute Liver Injury

(2014) E. Zigmond et al.   JOURNAL OF IMMUNOLOGY

Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2

(2014) Alastair J O'Brien et al.   NATURE MEDICINE

Role of hepatic resident and infiltrating macrophages in liver repair after acute injury

(2013) Qiang You et al.   BIOCHEMICAL PHARMACOLOGY

Character and Temporal Evolution of Apoptosis in Acetaminophen-Induced Acute Liver Failure*

(2013) Lucia A. Possamai et al.   CRITICAL CARE MEDICINE

Acute-on-Chronic Liver Failure Is a Distinct Syndrome That Develops in Patients With Acute Decompensation of Cirrhosis

(2013) Richard Moreau et al.   GASTROENTEROLOGY

Steroid use in acute liver failure

(2013) Jamuna Karkhanis et al.   HEPATOLOGY

Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital

(2013) Daniel J. Antoine et al.   HEPATOLOGY

Secretory leukocyte protease inhibitor: A pivotal mediator of anti-inflammatory responses in acetaminophen-induced acute liver failure

(2013) Charalambos Gustav Antoniades et al.   HEPATOLOGY

Blockade of high-mobility group box-1 ameliorates acute on chronic liver failure in rats

(2013) Xun Li et al.   INFLAMMATION RESEARCH

Circulating histones exacerbate inflammation in mice with acute liver failure

(2013) Zongmei Wen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse

(2013) Anna Moles et al.   JOURNAL OF HEPATOLOGY

The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis

(2013) Huan Yang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Immune surveillance by the liver

(2013) Craig N Jenne et al.   NATURE IMMUNOLOGY

Tissue-resident macrophages

(2013) Luke C Davies et al.   NATURE IMMUNOLOGY

Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance

(2013) Connie H Y Wong et al.   NATURE IMMUNOLOGY

Acute Liver Failure

(2013) William Bernal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Toll Like Receptor 3 Plays a Critical Role in the Progression and Severity of Acetaminophen-Induced Hepatotoxicity

(2013) Karen A. Cavassani et al.   PLoS One

P2X7 receptor-mediated purinergic signaling promotes liver injury in acetaminophen hepatotoxicity in mice

(2012) Rafaz Hoque et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Sterile Inflammation in the Liver

(2012) Paul Kubes et al.   GASTROENTEROLOGY

Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans

(2012) Charalambos Gustav Antoniades et al.   HEPATOLOGY

Circulating neutrophil dysfunction in acute liver failure

(2012) Nicholas J. Taylor et al.   HEPATOLOGY

Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics

(2012) Evaggelia Liaskou et al.   HEPATOLOGY

High-mobility group box 1 (HMGB1)-toll-like receptor (TLR)4-interleukin (IL)-23-IL-17A axis in drug-induced damage-associated lethal hepatitis: Interaction of γδ T cells with macrophages

(2012) Xuefu Wang et al.   HEPATOLOGY

Natural killer cells in liver disease

(2012) Zhigang Tian et al.   HEPATOLOGY

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity

(2012) Daniel J. Antoine et al.   JOURNAL OF HEPATOLOGY

IL-33 and HMGB1 alarmins: sensors of cellular death and their involvement in liver pathology

(2012) Muhammad I. Arshad et al.   LIVER INTERNATIONAL

Pathological bacterial translocation in cirrhosis: pathophysiology, diagnosis and clinical implications

(2012) Pablo Bellot et al.   LIVER INTERNATIONAL

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

(2012) P. Ramachandran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Granulocyte Colony–Stimulating Factor Mobilizes CD34+ Cells and Improves Survival of Patients With Acute-on-Chronic Liver Failure

(2011) Vishal Garg et al.   GASTROENTEROLOGY

Cyclophilin A Is a Damage-Associated Molecular Pattern Molecule That Mediates Acetaminophen-Induced Liver Injury

(2011) J. W. Dear et al.   JOURNAL OF IMMUNOLOGY

Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity

(2011) Hartmut Jaeschke et al.   LIVER INTERNATIONAL

Severity of the compensatory anti-inflammatory response determined by monocyte HLA-DR expression may assist outcome prediction in cirrhosis

(2010) Philip A. Berry et al.   INTENSIVE CARE MEDICINE

Admission levels and early changes in serum interleukin-10 are predictive of poor outcome in acute liver failure and decompensated cirrhosis

(2010) P. A. Berry et al.   LIVER INTERNATIONAL

Dual Role of CCR2 in the Constitution and the Resolution of Liver Fibrosis in Mice

(2009) Claudia Mitchell et al.   AMERICAN JOURNAL OF PATHOLOGY

Bacteremia, Acute Physiology and Chronic Health Evaluation II and Modified End Stage Liver Disease are independent predictors of mortality in critically ill nontransplanted patients with acute on chronic liver failure

(2009) Constantine J. Karvellas et al.   CRITICAL CARE MEDICINE

Hepatic recruitment of the inflammatory Gr1+monocyte subset upon liver injury promotes hepatic fibrosis

(2009) Karlin Raja Karlmark et al.   HEPATOLOGY

Predictors of bacteraemia and mortality in patients with acute liver failure

(2009) Constantine J. Karvellas et al.   INTENSIVE CARE MEDICINE

Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome

(2009) Avlin B. Imaeda et al.   JOURNAL OF CLINICAL INVESTIGATION

Bacterial Endotoxin Induces the Release of High Mobility Group Box 1 via the IFN-  Signaling Pathway

(2009) J.-H. Kim et al.   JOURNAL OF IMMUNOLOGY

Longitudinal monocyte Human leukocyte antigen-DR expression is a prognostic marker in critically ill patients with decompensated liver cirrhosis

(2009) Marie-Luise Berres et al.   LIVER INTERNATIONAL

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

High-Mobility Group Box-1 Protein and Keratin-18, Circulating Serum Proteins Informative of Acetaminophen-Induced Necrosis and Apoptosis In Vivo

(2009) Daniel J. Antoine et al.   TOXICOLOGICAL SCIENCES

Endotoxin tolerance: new mechanisms, molecules and clinical significance

(2009) Subhra K. Biswas et al.   TRENDS IN IMMUNOLOGY

Origins and tissue-context-dependent fates of blood monocytes

(2008) Chen Varol et al.   IMMUNOLOGY AND CELL BIOLOGY

The importance of immune dysfunction in determining outcome in acute liver failure

(2008) Charalambos Gustav Antoniades et al.   JOURNAL OF HEPATOLOGY

Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury

(2008) Michael P. Holt et al.   JOURNAL OF LEUKOCYTE BIOLOGY