Halogenases for biosynthetic pathway engineering: Toward new routes to naturals and non-naturals

An Engineered E. coli Strain for Direct in Vivo Fluorination

(2020) Konstantinos Markakis et al.   CHEMBIOCHEM

Exploring the biocatalytic potential of Fe/α‐ketoglutarate dependent halogenases

(2020) Moritz Voss et al.   CHEMISTRY-A EUROPEAN JOURNAL

Exploring Chloride Selectivity and Halogenase Regioselectivity of the SalL Enzyme through Quantum Mechanical/Molecular Mechanical Modeling

(2020) Paulo R. M. Pereira et al.   Journal of Chemical Information and Modeling

An iron(II)‐ and α‐ketoglutarate‐dependent halogenase acts on nucleotide substrates

(2020) Yonghui Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorine biocatalysis

(2020) Linrui Wu et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The chloroalkaloid (−)-acutumine is biosynthesized via a Fe(II)- and 2-oxoglutarate-dependent halogenase in Menispermaceae plants

(2020) Colin Y. Kim et al.   Nature Communications

Embracing the Diversity of Halogen Bonding Motifs in Fragment-Based Drug Discovery—Construction of a Diversity-Optimized Halogen-Enriched Fragment Library

(2019) Johannes Heidrich et al.   Frontiers in Chemistry

Chlorinated Natural Products and Related Halogenases

(2019) Jia Zeng et al.   ISRAEL JOURNAL OF CHEMISTRY

Heck diversification of indole based substrates under aqueous conditions: from indoles to unprotected halo‐tryptophans and halo‐tryptophans in a natural and a new to nature natural product

(2019) Rebecca Jane Miriam Goss et al.   CHEMISTRY-A EUROPEAN JOURNAL

Designing Metabolic Division of Labor in Microbial Communities

(2019) Meghan Thommes et al.   mSystems

Assembling a plug-and-play production line for combinatorial biosynthesis of aromatic polyketides in Escherichia coli

(2019) Matthew Cummings et al.   PLOS BIOLOGY

A family of radical halogenases for the engineering of amino-acid-based products

(2019) Monica E. Neugebauer et al.   Nature Chemical Biology

Total Synthesis of Naphterpin and Marinone Natural Products

(2019) Lauren A. M. Murray et al.   ORGANIC LETTERS

Bromination of L-tryptophan in a Fermentative Process With Corynebacterium glutamicum

(2019) Kareen H. Veldmann et al.   Frontiers in Bioengineering and Biotechnology

A marine viral halogenase that iodinates diverse substrates

(2019) Danai S. Gkotsi et al.   Nature Chemistry

Site-Selective C–H Halogenation Using Flavin-Dependent Halogenases Identified via Family-Wide Activity Profiling

(2019) Brian F. Fisher et al.   ACS Central Science

Structure and Activity of the Thermophilic Tryptophan‐6 Halogenase BorH

(2019) Kazi Lingkon et al.   CHEMBIOCHEM

Targeted Enzyme Engineering Unveiled Unexpected Patterns of Halogenase Stabilization

(2019) Hannah Minges et al.   ChemCatChem

Computational Study on the Catalytic Reaction Mechanism of Heme Haloperoxidase Enzymes

(2019) M. Qadri E. Mubarak et al.   ISRAEL JOURNAL OF CHEMISTRY

Synthesis of Chiral Alkenyl Cyclopropane Amino Acids for Incorporation into Stapled Peptides

(2019) Tsz Ying Yuen et al.   JOURNAL OF ORGANIC CHEMISTRY

Identification and characterisation of a fluorinase from Actinopolyspora mzabensis

(2019) Selisha Ann Sooklal et al.   PROTEIN EXPRESSION AND PURIFICATION

Directed Evolution of an FeII-Dependent Halogenase for Asymmetric C(sp3)–H Chlorination

(2019) Sabine Duewel et al.   ACS Catalysis

Total Synthesis Establishes the Biosynthetic Pathway to the Naphterpin and Marinone Natural Products

(2018) Lauren Murray et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Understanding and Improving the Activity of Flavin-Dependent Halogenases via Random and Targeted Mutagenesis

(2018) Mary C. Andorfer et al.   Annual Review of Biochemistry

Halogenase engineering and its utility in medicinal chemistry

(2018) Amy E. Fraley et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Recent examples of α-ketoglutarate-dependent mononuclear non-haem iron enzymes in natural product biosyntheses

(2018) Shu-Shan Gao et al.   NATURAL PRODUCT REPORTS

A flavin-dependent halogenase from metagenomic analysis prefers bromination over chlorination

(2018) Pia R. Neubauer et al.   PLoS One

Entropy drives selective fluorine recognition in the fluoroacetyl–CoA thioesterase fromStreptomyces cattleya

(2018) Amy M. Weeks et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amazing Diversity in Biochemical Roles of Fe(II)/2-Oxoglutarate Oxygenases

(2018) Caitlyn Q Herr et al.   TRENDS IN BIOCHEMICAL SCIENCES

Metal-free selective mono-halodecarboxylation of heteroarenes under mild conditions

(2018) Scott H. Henderson et al.   Royal Society Open Science

A coupled chlorinase–fluorinase system with a high efficiency of trans-halogenation and a shared substrate tolerance

(2018) H. Sun et al.   CHEMICAL COMMUNICATIONS

A Comparative Review on the Catalytic Mechanism of Nonheme Iron Hydroxylases and Halogenases

(2018) Amy Timmins et al.   Catalysts

Structure-based switch of regioselectivity in the flavin-dependent tryptophan 6-halogenase Thal

(2018) Ann-Christin Moritzer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Total Enzyme Syntheses of Napyradiomycins A1 and B1

(2018) Shaun M. K. McKinnie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Does Substrate Positioning Affect the Selectivity and Reactivity in the Hectochlorin Biosynthesis Halogenase?

(2018) Amy Timmins et al.   Frontiers in Chemistry

Design and synthesis of emodin derivatives as novel inhibitors of ATP-citrate lyase

(2017) Steffi K. Koerner et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Function and Structure of MalA/MalA′, Iterative Halogenases for Late-Stage C–H Functionalization of Indole Alkaloids

(2017) Amy E. Fraley et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A new strategy for aromatic ring alkylation in cylindrocyclophane biosynthesis

(2017) Hitomi Nakamura et al.   Nature Chemical Biology

A unifying paradigm for naphthoquinone-based meroterpenoid (bio)synthesis

(2017) Zachary D. Miles et al.   Nature Chemistry

Fluorothreonyl-tRNA deacylase prevents mistranslation in the organofluorine producerStreptomyces cattleya

(2017) Jonathan L. McMurry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Asymmetric Alkene and Arene Halofunctionalization Reactions in Meroterpenoid Biosynthesis

(2017) Bradley Moore   SYNLETT

Sonogashira diversification of unprotected halotryptophans, halotryptophan containing tripeptides; and generation of a new to nature bromo-natural product and its diversification in water

(2017) M. J. Corr et al.   Chemical Science

Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo

(2017) Sunil V. Sharma et al.   Nature Communications

Fluoroacetate in plants - a review of its distribution, toxicity to livestock and microbial detoxification

(2017) Lex Ee Xiang Leong et al.   Journal of Animal Science and Biotechnology

Halogenation of organic compounds using continuous flow and microreactor technology

(2017) David Cantillo et al.   Reaction Chemistry & Engineering

Mechanistic Insights into the Reaction of Chlorination of Tryptophan Catalyzed by Tryptophan 7-Halogenase

(2017) Tatyana G. Karabencheva-Christova et al.   Scientific Reports

Discovery of a Promiscuous Non-Heme Iron Halogenase in Ambiguine Alkaloid Biogenesis: Implication for an Evolvable Enzyme Family for Late-Stage Halogenation of Aliphatic Carbons in Small Molecules

(2016) Matthew L. Hillwig et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Directed Evolution of a Fluorinase for Improved Fluorination Efficiency with a Non-native Substrate

(2016) Huihua Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Halogenase-Inspired Oxidative Chlorination Using Flavin Photocatalysis

(2016) Thea Hering et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regioselective Dichlorination of a Non-Activated Aliphatic Carbon Atom and Phenolic Bismethylation by a Multifunctional Fungal Flavoenzyme

(2016) Pranatchareeya Chankhamjon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Specific Enzymatic Halogenation-From the Discovery of Halogenated Enzymes to Their Applications In Vitro and In Vivo

(2016) Veit Weichold et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A High-Throughput Fluorescence Assay to Determine the Activity of Tryptophan Halogenases

(2016) Christian Schnepel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Exploration of a potential difluoromethyl-nucleoside substrate with the fluorinase enzyme

(2016) Stephen Thompson et al.   BIOORGANIC CHEMISTRY

Recombinant flavin-dependent halogenases are functional in tobacco chloroplasts without co-expression of flavin reductase genes

(2016) Sabine Fräbel et al.   Biotechnology Journal

Characterization of a Cyanobacterial Haloperoxidase and Evaluation of its Biocatalytic Halogenation Potential

(2016) Annika Frank et al.   CHEMBIOCHEM

A Structure-Guided Switch in the Regioselectivity of a Tryptophan Halogenase

(2016) Sarah A. Shepherd et al.   CHEMBIOCHEM

Saccharomyces cerevisiae as a tool for mining, studying and engineering fungal polyketide synthases

(2016) Carly Bond et al.   FUNGAL GENETICS AND BIOLOGY

Electronic Structure of the Ferryl Intermediate in the α-Ketoglutarate Dependent Non-Heme Iron Halogenase SyrB2: Contributions to H Atom Abstraction Reactivity

(2016) Martin Srnec et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Halogenases: A Biotechnological Alternative for the Synthesis of Halogenated Pharmaceuticals

(2016) Marcela Ayala et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Structural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5

(2016) Andrew J Mitchell et al.   Nature Chemical Biology

Structure and biocatalytic scope of thermophilic flavin-dependent halogenase and flavin reductase enzymes

(2016) Binuraj R. K. Menon et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Biosynthesis of coral settlement cue tetrabromopyrrole in marine bacteria by a uniquely adapted brominase–thioesterase enzyme pair

(2016) Abrahim El Gamal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Directed evolution of RebH for catalyst-controlled halogenation of indole C–H bonds

(2016) Mary C. Andorfer et al.   Chemical Science

Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C–H activation

(2016) Jonathan Latham et al.   Nature Communications

Recombinant flavin-dependent halogenases are functional in tobacco chloroplasts without co-expression of flavin reductase genes

(2016) Sabine Fräbel et al.   Biotechnology Journal

The Important Role of Halogen Bond in Substrate Selectivity of Enzymatic Catalysis

(2016) Shuiqin Jiang et al.   Scientific Reports

Directed Evolution of RebH for Site-Selective Halogenation of Large Biologically Active Molecules

(2015) James T. Payne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Investigation of halogenation during the biosynthesis of ramoplanin in Actinoplanes sp. ATCC33076

(2015) Jun-Sheng Chen et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Vanadium haloperoxidases: From the discovery 30 years ago to X-ray crystallographic and V K-edge absorption spectroscopic studies

(2015) C. Leblanc et al.   COORDINATION CHEMISTRY REVIEWS

Crystal structure of halogenase PltA from the pyoluteorin biosynthetic pathway

(2015) Allan H. Pang et al.   JOURNAL OF STRUCTURAL BIOLOGY

Biological Activity of Recently Discovered Halogenated Marine Natural Products

(2015) Gordon Gribble   Marine Drugs

Metabolic engineering of Escherichia coli for the biosynthesis of various phenylpropanoid derivatives

(2015) Siyuan Wang et al.   METABOLIC ENGINEERING

Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation

(2015) Andrew R. Buller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a fluorometabolite from Streptomyces sp. MA37: (2R3S4S)-5-fluoro-2,3,4-trihydroxypentanoic acid

(2015) Long Ma et al.   Chemical Science

Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes

(2015) Sarah A. Shepherd et al.   Chemical Science

One-Pot Enzymatic Synthesis of Merochlorin A and B

(2014) Robin Teufel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Multitasking Vanadium-Dependent Chloroperoxidase as an Inspiration for the Chemical Synthesis of the Merochlorins

(2014) Stefan Diethelm et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Vanadium Iodoperoxidase from the Marine Flavobacteriaceae Species Zobellia galactanivorans Reveals Novel Molecular and Evolutionary Features of Halide Specificity in the Vanadium Haloperoxidase Enzyme Family

(2014) Jean-Baptiste Fournier et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Molecular Recognition of Fluorine Impacts Substrate Selectivity in the Fluoroacetyl-CoA Thioesterase FlK

(2014) Amy M. Weeks et al.   BIOCHEMISTRY

Identification of Fluorinases fromStreptomycessp MA37,Norcardia brasiliensis, andActinoplanessp N902-109 by Genome Mining

(2014) Hai Deng et al.   CHEMBIOCHEM

Improving the Stability and Catalyst Lifetime of the Halogenase RebH By Directed Evolution

(2014) Catherine B. Poor et al.   CHEMBIOCHEM

Enzymatic Fluorination and Biotechnological Developments of the Fluorinase

(2014) David O’Hagan et al.   CHEMICAL REVIEWS

Natural and engineered biosynthesis of fluorinated natural products

(2014) Mark C. Walker et al.   CHEMICAL SOCIETY REVIEWS

The Role of Chloride in the Mechanism of O2 Activation at the Mononuclear Nonheme Fe(II) Center of the Halogenase HctB

(2014) Sarah M. Pratter et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis of polybrominated aromatic organic compounds by marine bacteria

(2014) Vinayak Agarwal et al.   Nature Chemical Biology

Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase

(2014) Megan L Matthews et al.   Nature Chemical Biology

Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90

(2014) Bridie L. Dutton et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Fluoroacetate biosynthesis from the marine-derived bacterium Streptomyces xinghaiensis NRRL B-24674

(2014) Sheng Huang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Insights into enzymatic halogenation from computational studies

(2014) Hans M. Senn   Frontiers in Chemistry

Scope and potential of halogenases in biosynthetic applications

(2013) Duncan RM Smith et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The role of vanadium haloperoxidases in the formation of volatile brominated compounds and their impact on the environment

(2013) Ron Wever et al.   DALTON TRANSACTIONS

Substrate Placement Influences Reactivity in Non-heme Fe(II) Halogenases and Hydroxylases

(2013) Heather J. Kulik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Halogen Bond: Its Role beyond Drug–Target Binding Affinity for Drug Discovery and Development

(2013) Zhijian Xu et al.   Journal of Chemical Information and Modeling

Stereospecific Suzuki, Sonogashira, and Negishi Coupling Reactions of N-Alkoxyimidoyl Iodides and Bromides

(2013) Debra D. Dolliver et al.   JOURNAL OF ORGANIC CHEMISTRY

ATP Citrate Lyase Mediates Resistance of Colorectal Cancer Cells to SN38

(2013) Y. Zhou et al.   MOLECULAR CANCER THERAPEUTICS

Diversification of Monoterpene Indole Alkaloid Analogs through Cross-Coupling

(2013) Weerawat Runguphan et al.   ORGANIC LETTERS

Expanding the Fluorine Chemistry of Living Systems Using Engineered Polyketide Synthase Pathways

(2013) M. C. Walker et al.   SCIENCE

Specific chlorination of isoquinolines by a fungal flavin-dependent halogenase

(2012) Jia Zeng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Oxidative purification of halogenated ferrocenes

(2012) Michael S. Inkpen et al.   DALTON TRANSACTIONS

Hypohalous acid-mediated halogenation of resveratrol and its role in antioxidant and antimicrobial activities

(2012) Xiu-Zhuang Li et al.   FOOD CHEMISTRY

Principles and Applications of Halogen Bonding in Medicinal Chemistry and Chemical Biology

(2012) Rainer Wilcken et al.   JOURNAL OF MEDICINAL CHEMISTRY

Merochlorins A–D, Cyclic Meroterpenoid Antibiotics Biosynthesized in Divergent Pathways with Vanadium-Dependent Chloroperoxidases

(2012) Leonard Kaysser et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A novel Fe(II)/α-ketoglutarate-dependent dioxygenase fromBurkholderia ambifariahas β-hydroxylating activity ofN-succinyl l-leucine

(2012) M. Hibi et al.   LETTERS IN APPLIED MICROBIOLOGY

The generation of “unNatural” products: Synthetic biology meets synthetic chemistry

(2012) Rebecca J. M. Goss et al.   NATURAL PRODUCT REPORTS

A fungal ketoreductase domain that displays substrate-dependent stereospecificity

(2012) Hui Zhou et al.   Nature Chemical Biology

One-step 18F-labeling of peptides for positron emission tomography imaging using the SiFA methodology

(2012) Carmen Wängler et al.   Nature Protocols

 -Frontier molecular orbitals in S = 2 ferryl species and elucidation of their contributions to reactivity

(2012) M. Srnec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The biology and chemistry of high-valent iron–oxo and iron–nitrido complexes

(2012) Johannes Hohenberger et al.   Nature Communications

Fungal and Plant Phenylalanine Ammonia-lyase

(2012) Min Woo Hyun et al.   MYCOBIOLOGY

Biosynthetic Chlorination of the Piperazate Residue in Kutzneride Biosynthesis by KthP

(2011) Wei Jiang et al.   BIOCHEMISTRY

The Moderately Efficient Enzyme: Evolutionary and Physicochemical Trends Shaping Enzyme Parameters

(2011) Arren Bar-Even et al.   BIOCHEMISTRY

Mutational Biosynthesis of Ansamitocin Antibiotics: A Diversity-Oriented Approach to Exploit Biosynthetic Flexibility

(2011) Tobias Knobloch et al.   CHEMBIOCHEM

Supramolecular Templating in Kirromycin Biosynthesis: The Acyltransferase KirCII Loads Ethylmalonyl-CoA Extender onto a Specific ACP of the trans-AT PKS

(2011) Ewa M. Musiol et al.   CHEMISTRY & BIOLOGY

CHARACTERIZATION OF A FUNCTIONAL VANADIUM-DEPENDENT BROMOPEROXIDASE IN THE MARINE CYANOBACTERIUM SYNECHOCOCCUS SP. CC93111

(2011) Todd L. Johnson et al.   JOURNAL OF PHYCOLOGY

A Stereoselective Vanadium-Dependent Chloroperoxidase in Bacterial Antibiotic Biosynthesis

(2011) Peter Bernhardt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reengineering a Tryptophan Halogenase To Preferentially Chlorinate a Direct Alkaloid Precursor

(2011) Weslee S. Glenn et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cloning and functional analysis of the naphthomycin biosynthetic gene cluster in Streptomyces sp. CS

(2011) Yingying Wu et al.   Molecular BioSystems

Nonheme oxo-iron(IV) intermediates form an oxyl radical upon approaching the C-H bond activation transition state

(2011) S. Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineered polyketide biosynthesis and biocatalysis in Escherichia coli

(2010) Xue Gao et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Fluorinase mediated chemoenzymatic synthesis of [18F]-fluoroacetate

(2010) Xiang-Guo Li et al.   CHEMICAL COMMUNICATIONS

Contribution of Synthetic and Naturally Occurring Organobromine Compounds to Bromine Mass in Marine Organisms

(2010) Yi Wan et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Insights into Radicicol Biosynthesis via Heterologous Synthesis of Intermediates and Analogs

(2010) Hui Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chloramphenicol Biosynthesis: The Structure of CmlS, a Flavin-Dependent Halogenase Showing a Covalent Flavin–Aspartate Bond

(2010) Kateryna Podzelinska et al.   JOURNAL OF MOLECULAR BIOLOGY

Engineering Fluorometabolite Production: Fluorinase Expression inSalinispora tropicaYields Fluorosalinosporamide†

(2010) Alessandra S. Eustáquio et al.   JOURNAL OF NATURAL PRODUCTS

Enduracidin Analogues with Altered Halogenation Patterns Produced by Genetically Engineered Strains ofStreptomyces fungicidicus

(2010) Xihou Yin et al.   JOURNAL OF NATURAL PRODUCTS

Gene Expression Enabling Synthetic Diversification of Natural Products: Chemogenetic Generation of Pacidamycin Analogs

(2010) Abhijeet Deb Roy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chlorosulfolipids: Structure, synthesis, and biological relevance

(2010) D. Karl Bedke et al.   NATURAL PRODUCT REPORTS

Integrating carbon–halogen bond formation into medicinal plant metabolism

(2010) Weerawat Runguphan et al.   NATURE

Conformational switch triggered by  -ketoglutarate in a halogenase of curacin A biosynthesis

(2010) D. Khare et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Determination of the extent of phosphopantetheinylation of polyketide synthases expressed in Escherichia coli and Saccharomyces cerevisiae

(2009) Ka Kit Michael Lee et al.   ANALYTICAL BIOCHEMISTRY

Substrate-Triggered Formation and Remarkable Stability of the C−H Bond-Cleaving Chloroferryl Intermediate in the Aliphatic Halogenase, SyrB2

(2009) Megan L. Matthews et al.   BIOCHEMISTRY

An enzymatic route to 5-deoxy-5-[18F]fluoro-d-ribose, a [18F]-fluorinated sugar for PET imaging

(2009) Mayca Onega et al.   CHEMICAL COMMUNICATIONS

Why does the enzyme SyrB2 chlorinate, but does not hydroxylate, saturated hydrocarbons? A density functional theory (DFT) study

(2009) Shanthi Pandian et al.   DALTON TRANSACTIONS

Exploring the Chemistry and Biology of Vanadium-dependent Haloperoxidases

(2009) Jaclyn M. Winter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Insights into Regioselectivity in the Enzymatic Chlorination of Tryptophan

(2009) Xiaofeng Zhu et al.   JOURNAL OF MOLECULAR BIOLOGY

Biohalogenation: Nature’s Way to Synthesize Halogenated Metabolites†

(2009) Claudia Wagner et al.   JOURNAL OF NATURAL PRODUCTS

Enantioselective Total Synthesis of (−)-Napyradiomycin A1 via Asymmetric Chlorination of an Isolated Olefin

(2009) Scott A. Snyder et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural Analysis of an Open Active Site Conformation of Nonheme Iron Halogenase CytC3

(2009) Cintyu Wong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metamorphic enzyme assembly in polyketide diversification

(2009) Liangcai Gu et al.   NATURE

Stringency of the 2-His–1-Asp Active-Site Motif in Prolyl 4-Hydroxylase

(2009) Kelly L. Gorres et al.   PLoS One

Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2

(2009) M. L. Matthews et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Palladium-Catalyzed Suzuki−Miyaura Cross-Coupling Reactions Employing Dialkylbiaryl Phosphine Ligands

(2008) Ruben Martin et al.   ACCOUNTS OF CHEMICAL RESEARCH

Structural Perspective on Enzymatic Halogenation

(2008) Leah C. Blasiak et al.   ACCOUNTS OF CHEMICAL RESEARCH

Fluorinase-Coupled Base Swaps: Synthesis of [18F]-5′-Deoxy-5′-fluorouridines

(2008) Margit Winkler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Incorporation of Fluoroacetate into an Aromatic Polyketide and Its Influence on the Mode of Cyclization

(2008) Hui Hong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Use of a Halogenase of Hormaomycin Biosynthesis for Formation of New Clorobiocin Analogues with 5-Chloropyrrole Moieties

(2008) Lutz Heide et al.   CHEMBIOCHEM

Halogenation Strategies In Natural Product Biosynthesis

(2008) Christopher S. Neumann et al.   CHEMISTRY & BIOLOGY

In Vitro Reconstituted Biotransformation of 4-Fluorothreonine from Fluoride Ion: Application of the Fluorinase

(2008) Hai Deng et al.   CHEMISTRY & BIOLOGY

The fluorinase, the chlorinase and the duf-62 enzymes

(2008) Hai Deng et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

QM/MM investigation of structure and spectroscopic properties of a vanadium-containing peroxidase

(2008) Yuan Zhang et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Structure and Action of the Myxobacterial Chondrochloren Halogenase CndH: A New Variant of FAD-dependent Halogenases

(2008) Stefan Buedenbender et al.   JOURNAL OF MOLECULAR BIOLOGY

Biosynthesis of (−)-(1S,2R)-Allocoronamic Acyl Thioester by an FeII-Dependent Halogenase and a Cyclopropane-Forming Flavoprotein

(2008) Christopher S. Neumann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli

(2008) W. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA