Recent examples of α-ketoglutarate-dependent mononuclear non-haem iron enzymes in natural product biosyntheses

Insights into the Desaturation of Cyclopeptin and its C3 Epimer Catalyzed by a non-Heme Iron Enzyme: Structural Characterization and Mechanism Elucidation

(2018) Hsuan-Jen Liao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mini-Review: Ergothioneine and Ovothiol Biosyntheses, an Unprecedented Trans-Sulfur Strategy in Natural Product Biosynthesis

(2018) Nathchar Naowarojna et al.   BIOCHEMISTRY

Unique chemistry of non-heme iron enzymes in fungal biosynthetic pathways

(2018) Hitomi Nakamura et al.   NATURAL PRODUCT REPORTS

Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis

(2018) Yu Nakashima et al.   Nature Communications

Evidence that oxidative dephosphorylation by the nonheme Fe(II), α-ketoglutarate:UMP oxygenase occurs by stereospecific hydroxylation

(2017) Anwesha Goswami et al.   FEBS LETTERS

Dioxygen activation by nonheme iron enzymes with the 2-His-1-carboxylate facial triad that generate high-valent oxoiron oxidants

(2017) Subhasree Kal et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Visualizing the Reaction Cycle in an Iron(II)- and 2-(Oxo)-glutarate-Dependent Hydroxylase

(2017) Andrew J. Mitchell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structures and Mechanisms of the Non-Heme Fe(II)- and 2-Oxoglutarate-Dependent Ethylene-Forming Enzyme: Substrate Binding Creates a Twist

(2017) Salette Martinez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Okaramine insecticidal alkaloids show similar activity on both exon 3c and exon 3b variants of glutamate-gated chloride channels of the larval silkworm, Bombyx mori

(2017) Shogo Furutani et al.   NEUROTOXICOLOGY

Evidence That Trimethyllysine Hydroxylase Catalyzes the Formation of (2S,3S)-3-Hydroxy-Nε-trimethyllysine

(2017) Y. Vijayendar Reddy et al.   ORGANIC LETTERS

A 2-Oxoglutarate-Dependent Dioxygenase Mediates the Biosynthesis of Glucoraphasatin in Radish

(2017) Tomohiro Kakizaki et al.   PLANT PHYSIOLOGY

Structural and stereoelectronic insights into oxygenase-catalyzed formation of ethylene from 2-oxoglutarate

(2017) Zhihong Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ArabidopsisJASMONATE-INDUCED OXYGENASES down-regulate plant immunity by hydroxylation and inactivation of the hormone jasmonic acid

(2017) Lotte Caarls et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanistic Insights into the Decoupled Desaturation and Epoxidation Catalyzed by Dioxygenase AsqJ Involved in the Biosynthesis of Quinolone Alkaloids

(2017) Hao Su et al.   ACS Catalysis

Jmjd6, a JmjC Dioxygenase with Many Interaction Partners and Pleiotropic Functions

(2017) Janice Kwok et al.   Frontiers in Genetics

Discovery of a Promiscuous Non-Heme Iron Halogenase in Ambiguine Alkaloid Biogenesis: Implication for an Evolvable Enzyme Family for Late-Stage Halogenation of Aliphatic Carbons in Small Molecules

(2016) Matthew L. Hillwig et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Heterologous Production of Fungal Maleidrides Reveals the Cryptic Cyclization Involved in their Biosynthesis

(2016) Katherine Williams et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Specific Enzymatic Halogenation-From the Discovery of Halogenated Enzymes to Their Applications In Vitro and In Vivo

(2016) Veit Weichold et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

RadicalS-Adenosylmethionine Enzymes in Human Health and Disease

(2016) Bradley J. Landgraf et al.   Annual Review of Biochemistry

Enduracididine, a rare amino acid component of peptide antibiotics: Natural products and synthesis

(2016) Darcy J Atkinson et al.   Beilstein Journal of Organic Chemistry

Biochemical and Spectroscopic Characterization of the Non-Heme Fe(II)- and 2-Oxoglutarate-Dependent Ethylene-Forming Enzyme from Pseudomonas syringae pv. phaseolicola PK2

(2016) Salette Martinez et al.   BIOCHEMISTRY

Ferrous iron and α-ketoglutarate-dependent dioxygenases in the biosynthesis of microbial natural products

(2016) Long-Fei Wu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Overcoming substrate limitations for improved production of ethylene in E. coli

(2016) Sean Lynch et al.   Biotechnology for Biofuels

Aliphatic Halogenase Enables Late-Stage C−H Functionalization: Selective Synthesis of a Brominated Fischerindole Alkaloid with Enhanced Antibacterial Activity

(2016) Qin Zhu et al.   CHEMBIOCHEM

Substrate scope for trimethyllysine hydroxylase catalysis

(2016) Abbas H. K. Al Temimi et al.   CHEMICAL COMMUNICATIONS

Phosphonate Biochemistry

(2016) Geoff P. Horsman et al.   CHEMICAL REVIEWS

Structure–function relationships of human JmjC oxygenases—demethylases versus hydroxylases

(2016) Suzana Markolovic et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Beyond ferryl-mediated hydroxylation: 40 years of the rebound mechanism and C–H activation

(2016) Xiongyi Huang et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Discovery of Key Dioxygenases that Diverged the Paraherquonin and Acetoxydehydroaustin Pathways in Penicillium brasilianum

(2016) Yudai Matsuda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanistic Investigation of a Non-Heme Iron Enzyme Catalyzed Epoxidation in (−)-4′-Methoxycyclopenin Biosynthesis

(2016) Wei-chen Chang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5

(2016) Andrew J Mitchell et al.   Nature Chemical Biology

Nonclassical Biological Activities of Quinolone Derivatives

(2016) Mohsen Daneshtalab et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Structure of the Dioxygenase AsqJ: Mechanistic Insights into a One-Pot Multistep Quinolone Antibiotic Biosynthesis

(2015) Alois Bräuer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Streptomyces wadayamensis MppP Is a Pyridoxal 5′-Phosphate-Dependent l-Arginine α-Deaminase, γ-Hydroxylase in the Enduracididine Biosynthetic Pathway

(2015) Lanlan Han et al.   BIOCHEMISTRY

Inhibition of L-carnitine biosynthesis and transport by methyl-γ-butyrobetaine decreases fatty acid oxidation and protects against myocardial infarction

(2015) E Liepinsh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cation-π Interactions Contribute to Substrate Recognition in γ-Butyrobetaine Hydroxylase Catalysis

(2015) Jos J. A. G. Kamps et al.   CHEMISTRY-A EUROPEAN JOURNAL

Fosmidomycin as an antimalarial drug: a meta-analysis of clinical trials

(2015) Jose Francisco Fernandes et al.   Future Microbiology

The Biosynthesis of Capuramycin-type Antibiotics

(2015) Wenlong Cai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular cloning of melatonin 2-hydroxylase responsible for 2-hydroxymelatonin production in rice (Oryza sativa)

(2015) Yeong Byeon et al.   JOURNAL OF PINEAL RESEARCH

Endoperoxide formation by an α-ketoglutarate-dependent mononuclear non-haem iron enzyme

(2015) Wupeng Yan et al.   NATURE

Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes

(2015) Kou-San Ju et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biosynthesis of fosfazinomycin is a convergent process

(2015) Zedu Huang et al.   Chemical Science

The plasticity of cyanobacterial metabolism supports direct CO2 conversion to ethylene

(2015) Wei Xiong et al.   Nature Plants

Highly Selective but Multifunctional Oxygenases in Secondary Metabolism

(2014) Rachel V. K. Cochrane et al.   ACCOUNTS OF CHEMICAL RESEARCH

Multi-Enzymatic Synthesis of Optically Pure β-Hydroxy α-Amino Acids

(2014) Makoto Hibi et al.   ADVANCED SYNTHESIS & CATALYSIS

Non-Heme Dioxygenase Catalyzes Atypical Oxidations of 6,7-Bicyclic Systems To Form the 6,6-Quinolone Core of Viridicatin-Type Fungal Alkaloids

(2014) Noriyasu Ishikawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Engineering of Glarea lozoyensis for Exclusive Production of the Pneumocandin B0Precursor of the Antifungal Drug Caspofungin Acetate

(2014) Li Chen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Spectroscopic characterization and mechanistic investigation of P-methyl transfer by a radical SAM enzyme from the marine bacterium Shewanella denitrificans OS217

(2014) Kylie D. Allen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Ethylene-forming enzyme and bioethylene production

(2014) Carrie Eckert et al.   Biotechnology for Biofuels

More than just a Halogenase: Modification of Fatty Acyl Moieties by a Trifunctional Metal Enzyme

(2014) Sarah M. Pratter et al.   CHEMBIOCHEM

Pneumocandin Biosynthesis: Involvement of atrans-Selective Proline Hydroxylase

(2014) Stefanie Houwaart et al.   CHEMBIOCHEM

Radical S-Adenosylmethionine Enzymes

(2014) Joan B. Broderick et al.   CHEMICAL REVIEWS

Alkaloids: An overview of their antibacterial, antibiotic-enhancing and antivirulence activities

(2014) T.P. Tim Cushnie et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Crystal Structure of the Ectoine Hydroxylase, a Snapshot of the Active Site

(2014) Astrid Höppner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and characterization of 2-oxoglutarate-dependent dioxygenases catalyzing selective cis-hydroxylation of proline and pipecolinic acid from actinomycetes

(2014) Ryotaro Hara et al.   JOURNAL OF BIOTECHNOLOGY

Jasmonate-Triggered Plant Immunity

(2014) Marcelo L. Campos et al.   JOURNAL OF CHEMICAL ECOLOGY

Targeting Carnitine Biosynthesis: Discovery of New Inhibitors against γ-Butyrobetaine Hydroxylase

(2014) Kaspars Tars et al.   JOURNAL OF MEDICINAL CHEMISTRY

Optimal Translational Termination Requires C4 Lysyl Hydroxylation of eRF1

(2014) Tianshu Feng et al.   MOLECULAR CELL

A new family of iron-dependent halogenases acts on freestanding substrates

(2014) Matthew L Hillwig et al.   Nature Chemical Biology

Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase

(2014) Megan L Matthews et al.   Nature Chemical Biology

Evolution and diversity of the 2-oxoglutarate-dependent dioxygenase superfamily in plants

(2014) Yosuke Kawai et al.   PLANT JOURNAL

Crystal structure of PhnZ in complex with substrate reveals a di-iron oxygenase mechanism for catabolism of organophosphonates

(2014) L. M. van Staalduinen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of the C5 Stereoinversion Reaction in the Biosynthesis of Carbapenem Antibiotics

(2014) W.-c. Chang et al.   SCIENCE

Refined Regio- and Stereoselective Hydroxylation of l-Pipecolic Acid by Protein Engineering of l-Proline cis-4-Hydroxylase Based on the X-ray Crystal Structure

(2014) Kento Koketsu et al.   ACS Synthetic Biology

2-Oxoglutarate-dependent dioxygenases in the biosynthesis of simple coumarins

(2014) Bun-Ichi Shimizu   Frontiers in Plant Science

Discovery of the Antibiotic Phosacetamycin via a New Mass Spectrometry-Based Method for Phosphonic Acid Detection

(2013) Bradley S. Evans et al.   ACS Chemical Biology

Nonproteinogenic Amino Acid Building Blocks for Nonribosomal Peptide and Hybrid Polyketide Scaffolds

(2013) Christopher T. Walsh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Methylerythritol Phosphate Pathway of Isoprenoid Biosynthesis

(2013) Lishan Zhao et al.   Annual Review of Biochemistry

Structural and Functional Characterization of MppR, an Enduracididine Biosynthetic Enzyme from Streptomyces hygroscopicus: Functional Diversity in the Acetoacetate Decarboxylase-like Superfamily

(2013) A. Maxwell Burroughs et al.   BIOCHEMISTRY

Scope and potential of halogenases in biosynthetic applications

(2013) Duncan RM Smith et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

A Role for a Dioxygenase in Auxin Metabolism and Reproductive Development in Rice

(2013) Zhigang Zhao et al.   DEVELOPMENTAL CELL

Fosfomycin Trometamol: A Review of Its Use as a Single-Dose Oral Treatment for Patients with Acute Lower Urinary Tract Infections and Pregnant Women with Asymptomatic Bacteriuria

(2013) Gillian M. Keating   DRUGS

Genomics-enabled discovery of phosphonate natural products and their biosynthetic pathways

(2013) Kou-San Ju et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Spiro-Ring Formation is Catalyzed by a Multifunctional Dioxygenase in Austinol Biosynthesis

(2013) Yudai Matsuda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Imposing function down a (cupin)-barrel: secondary structure and metal stereochemistry in the αKG-dependent oxygenases

(2013) John A. Hangasky et al.   Metallomics

Discovery and development of first in class antifungal caspofungin (CANCIDAS®)—A case study

(2013) James M. Balkovec et al.   NATURAL PRODUCT REPORTS

Distinct mechanisms for spiro-carbon formation reveal biosynthetic pathway crosstalk

(2013) Yuta Tsunematsu et al.   Nature Chemical Biology

Chemical structure, biosynthesis and synthesis of free and glycosylated pyridinolines formed by cross-link of bone and synovium collagen

(2013) Luigi Anastasia et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Crystal Structure of a Novel N-Substituted L-Amino Acid Dioxygenase from Burkholderia ambifaria AMMD

(2013) Hui-Min Qin et al.   PLoS One

Chiral Hydroxylation at the Mononuclear Nonheme Fe(II) Center of 4-(S) Hydroxymandelate Synthase – A Structure-Activity Relationship Analysis

(2013) Cristiana M. L. Di Giuro et al.   PLoS One

Revisiting the biosynthesis of dehydrophos reveals a tRNA-dependent pathway

(2013) D. J. Bougioukou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

γ-Butyrobetaine hydroxylase catalyses a Stevens type rearrangement

(2012) Luc Henry et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Oxoferryl species in mononuclear non-heme iron enzymes: Biosynthesis, properties and reactivity from a theoretical perspective

(2012) Marcus Lundberg et al.   COORDINATION CHEMISTRY REVIEWS

Structure and function of atypically coordinated enzymatic mononuclear non-heme-Fe(II) centers

(2012) Daniela Buongiorno et al.   COORDINATION CHEMISTRY REVIEWS

Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases

(2012) WeiShen Aik et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

PhnY and PhnZ Comprise a New Oxidative Pathway for Enzymatic Cleavage of a Carbon–Phosphorus Bond

(2012) Fern R. McSorley et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A novel Fe(II)/α-ketoglutarate-dependent dioxygenase fromBurkholderia ambifariahas β-hydroxylating activity ofN-succinyl l-leucine

(2012) M. Hibi et al.   LETTERS IN APPLIED MICROBIOLOGY

The enzymes of β-lactam biosynthesis

(2012) Refaat B. Hamed et al.   NATURAL PRODUCT REPORTS

Time course production of indole alkaloids by an endophytic strain ofPenicillium brasilianumcultivated in rice

(2012) Taicia Pacheco Fill et al.   NATURAL PRODUCT RESEARCH

Ethylene Synthesis and Regulated Expression of Recombinant Protein in Synechocystis sp. PCC 6803

(2012) Fernando Guerrero et al.   PLoS One

Characterization of Bacillus thuringiensis l-Isoleucine Dioxygenase for Production of Useful Amino Acids

(2011) Makoto Hibi et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The crystal structure of isopenicillin N synthase with δ-(l-α-aminoadipoyl)-l-cysteinyl-d-methionine reveals thioether coordination to iron

(2011) Ian J. Clifton et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Biosynthetic Chlorination of the Piperazate Residue in Kutzneride Biosynthesis by KthP

(2011) Wei Jiang et al.   BIOCHEMISTRY

Genome Mining inStreptomyces. Elucidation of the Role of Baeyer−Villiger Monooxygenases and Non-Heme Iron-Dependent Dehydrogenase/Oxygenases in the Final Steps of the Biosynthesis of Pentalenolactone and Neopentalenolactone

(2011) Myung-Ji Seo et al.   BIOCHEMISTRY

In Vitro Phosphinate Methylation by PhpK fromKitasatospora phosalacinea

(2011) Williard J. Werner et al.   BIOCHEMISTRY

Gene Disruption and Biochemical Characterization of Verruculogen Synthase of Aspergillus fumigatus

(2011) Naoki Kato et al.   CHEMBIOCHEM

Drug Discovery Targeting Amino Acid Racemases

(2011) Paola Conti et al.   CHEMICAL REVIEWS

Inhibition of 2-oxoglutarate dependent oxygenases

(2011) Nathan R. Rose et al.   CHEMICAL SOCIETY REVIEWS

Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A

(2011) T. Sengoku et al.   GENES & DEVELOPMENT

Characterization of LipL as a Non-heme, Fe(II)-dependent α-Ketoglutarate:UMP Dioxygenase That Generates Uridine-5′-aldehyde during A-90289 Biosynthesis

(2011) Zhaoyong Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure and RNA Binding Properties of the RNA Recognition Motif (RRM) and AlkB Domains in Human AlkB Homolog 8 (ABH8), an Enzyme Catalyzing tRNA Hypermodification

(2011) Chiara Pastore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nine Post-translational Modifications during the Biosynthesis of Cinnamycin

(2011) Ayşe Ökesli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biochemistry and occurrence of O-demethylation in plant metabolism

(2011) Jillian M. Hagel   Frontiers in Physiology

Metabolic engineering of Escherichia coli to produce (2S, 3R, 4S)-4-hydroxyisoleucine

(2010) Sergey V. Smirnov et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Crystal structure of human gamma-butyrobetaine hydroxylase

(2010) Kaspars Tars et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Crystal structure of the catalytic core ofSaccharomyces cerevesiaehistone demethylase Rph1: insights into the substrate specificity and catalytic mechanism

(2010) Yuanyuan Chang et al.   BIOCHEMICAL JOURNAL

Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans

(2010) Ying Yang et al.   CELL RESEARCH

Functions of Genes and Enzymes Involved in Phenalinolactone Biosynthesis

(2010) Martina Daum  et al.   CHEMBIOCHEM

Structure–activity relationships of the phosphonate antibiotic dehydrophos

(2010) Michael Kuemin et al.   CHEMICAL COMMUNICATIONS

Biosynthesis of Rhizocticins, Antifungal Phosphonate Oligopeptides Produced by Bacillus subtilis ATCC6633

(2010) Svetlana A. Borisova et al.   CHEMISTRY & BIOLOGY

Structural and Mechanistic Studies on γ-Butyrobetaine Hydroxylase

(2010) Ivanhoe K.H. Leung et al.   CHEMISTRY & BIOLOGY

Molecular Cloning and Heterologous Expression of the Dehydrophos Biosynthetic Gene Cluster

(2010) Benjamin T. Circello et al.   CHEMISTRY & BIOLOGY

Structural studies on human 2-oxoglutarate dependent oxygenases

(2010) Michael A McDonough et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6

(2010) Monica Mantri et al.   JOURNAL OF MOLECULAR BIOLOGY

The unique mechanistic transformations involved in the biosynthesis of modular natural products from marine cyanobacteria

(2010) Adam C. Jones et al.   NATURAL PRODUCT REPORTS

Synthesis of 5-Hydroxyectoine from Ectoine: Crystal Structure of the Non-Heme Iron(II) and 2-Oxoglutarate-Dependent Dioxygenase EctD

(2010) Klaus Reuter et al.   PLoS One

Insight into the mechanism of an iron dioxygenase by resolution of steps following the FeIVboxHO species

(2010) P. K. Grzyska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational switch triggered by  -ketoglutarate in a halogenase of curacin A biosynthesis

(2010) D. Khare et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dioxygenases in Burkholderia ambifaria and Yersinia pestis that hydroxylate the outer Kdo unit of lipopolysaccharide

(2010) H. S. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction of JMJD6 with single-stranded RNA

(2010) X. Hong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases

(2010) Christoph Loenarz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues

(2010) Mark D. Rosen et al.   ACS Medicinal Chemistry Letters

Biosynthesis of Phosphonic and Phosphinic Acid Natural Products

(2009) William W. Metcalf et al.   Annual Review of Biochemistry

Characterization of novel 2-oxoglutarate dependent dioxygenases converting l-proline to cis-4-hydroxy-l-proline

(2009) Ryotaro Hara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genome Mining inStreptomyces avermitilis: A Biochemical Baeyer−Villiger Reaction and Discovery of a New Branch of the Pentalenolactone Family Tree

(2009) Jiaoyang Jiang et al.   BIOCHEMISTRY

Substrate-Triggered Formation and Remarkable Stability of the C−H Bond-Cleaving Chloroferryl Intermediate in the Aliphatic Halogenase, SyrB2

(2009) Megan L. Matthews et al.   BIOCHEMISTRY

Rubratoxin A specifically and potently inhibits protein phosphatase 2A and suppresses cancer metastasis

(2009) Shun-ichi Wada et al.   CANCER SCIENCE

Characterization of the Polyoxin Biosynthetic Gene Cluster fromStreptomyces cacaoiand Engineered Production of Polyoxin H

(2009) Wenqing Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stereospecific Synthesis ofthreo- anderythro-β-Hydroxyglutamic Acid During Kutzneride Biosynthesis

(2009) Matthias Strieker et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural Analysis of an Open Active Site Conformation of Nonheme Iron Halogenase CytC3

(2009) Cintyu Wong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metamorphic enzyme assembly in polyketide diversification

(2009) Liangcai Gu et al.   NATURE

Phytoplankton in the ocean use non-phosphorus lipids in response to phosphorus scarcity

(2009) Benjamin A. S. Van Mooy et al.   NATURE

Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases

(2009) John R Horton et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

FtmOx1, a non-heme Fe(ii) and α-ketoglutarate-dependent dioxygenase, catalyses the endoperoxide formation of verruculogen in Aspergillus fumigatus

(2009) Nicola Steffan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Enzymological and structural studies of the mechanism of promiscuous substrate recognition by the oxidative DNA repair enzyme AlkB

(2009) B. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2

(2009) M. L. Matthews et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Jmjd6 Catalyses Lysyl-Hydroxylation of U2AF65, a Protein Associated with RNA Splicing

(2009) Celia J. Webby et al.   SCIENCE

Structural Perspective on Enzymatic Halogenation

(2008) Leah C. Blasiak et al.   ACCOUNTS OF CHEMICAL RESEARCH

Synthesis and Uptake of the Compatible Solutes Ectoine and 5-Hydroxyectoine by Streptomyces coelicolor A3(2) in Response to Salt and Heat Stresses

(2008) J. Bursy et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

An Inner Membrane Dioxygenase that Generates the 2-Hydroxymyristate Moiety ofSalmonellaLipid A†

(2008) Henry S. Gibbons et al.   BIOCHEMISTRY

Discovery and development of the anticancer agent salinosporamide A (NPI-0052)

(2008) William Fenical et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Halogenation Strategies In Natural Product Biosynthesis

(2008) Christopher S. Neumann et al.   CHEMISTRY & BIOLOGY

Fosfomycin: Use Beyond Urinary Tract and Gastrointestinal Infections

(2008) Matthew E. Falagas et al.   CLINICAL INFECTIOUS DISEASES

The multifunctional role of ectoine as a natural cell protectant

(2008) Ruediger Graf et al.   CLINICS IN DERMATOLOGY

FeII/α-ketoglutarate hydroxylases involved in nucleobase, nucleoside, nucleotide, and chromatin metabolism

(2008) Jana M. Simmons et al.   DALTON TRANSACTIONS

Biosynthesis of (−)-(1S,2R)-Allocoronamic Acyl Thioester by an FeII-Dependent Halogenase and a Cyclopropane-Forming Flavoprotein

(2008) Christopher S. Neumann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ethylene production by metabolic engineering of the yeast Saccharomyces cerevisiae

(2008) I. Pirkov et al.   METABOLIC ENGINEERING

Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA

(2008) Cai-Guang Yang et al.   NATURE

Versatility of biological non-heme Fe(II) centers in oxygen activation reactions

(2008) Elena G Kovaleva et al.   Nature Chemical Biology

Expanding chemical biology of 2-oxoglutarate oxygenases

(2008) Christoph Loenarz et al.   Nature Chemical Biology