Discovery of a Promiscuous Non-Heme Iron Halogenase in Ambiguine Alkaloid Biogenesis: Implication for an Evolvable Enzyme Family for Late-Stage Halogenation of Aliphatic Carbons in Small Molecules

Stereoselective Halogenation in Natural Product Synthesis

(2016) Won-jin Chung et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Unified biogenesis of ambiguine, fischerindole, hapalindole and welwitindolinone: identification of a monogeranylated indolenine as a cryptic common biosynthetic intermediate by an unusual magnesium-dependent aromatic prenyltransferase

(2016) Xinyu Liu et al.   CHEMICAL COMMUNICATIONS

Site-Selective Aliphatic C–H Chlorination Using N-Chloroamides Enables a Synthesis of Chlorolissoclimide

(2016) Ryan K. Quinn et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Halogenase Engineering for the Generation of New Natural Product Analogues

(2015) Stephanie Brown et al.   CHEMBIOCHEM

More than just a Halogenase: Modification of Fatty Acyl Moieties by a Trifunctional Metal Enzyme

(2014) Sarah M. Pratter et al.   CHEMBIOCHEM

Identification and Characterization of a Welwitindolinone Alkaloid Biosynthetic Gene Cluster in the Stigonematalean CyanobacteriumHapalosiphon welwitschii

(2014) Matthew L. Hillwig et al.   CHEMBIOCHEM

Site-Selective Aliphatic C–H Bromination Using N-Bromoamides and Visible Light

(2014) Valerie A. Schmidt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A new family of iron-dependent halogenases acts on freestanding substrates

(2014) Matthew L Hillwig et al.   Nature Chemical Biology

Biosynthesis of Ambiguine Indole Alkaloids in Cyanobacterium Fischerella ambigua

(2013) Matthew L. Hillwig et al.   ACS Chemical Biology

Biosynthetic Chlorination of the Piperazate Residue in Kutzneride Biosynthesis by KthP

(2011) Wei Jiang et al.   BIOCHEMISTRY

Manganese Porphyrins Catalyze Selective C−H Bond Halogenations

(2010) Wei Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Substrate-Triggered Formation and Remarkable Stability of the C−H Bond-Cleaving Chloroferryl Intermediate in the Aliphatic Halogenase, SyrB2

(2009) Megan L. Matthews et al.   BIOCHEMISTRY

Metamorphic enzyme assembly in polyketide diversification

(2009) Liangcai Gu et al.   NATURE

Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2

(2009) M. L. Matthews et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biosynthesis of (−)-(1S,2R)-Allocoronamic Acyl Thioester by an FeII-Dependent Halogenase and a Cyclopropane-Forming Flavoprotein

(2008) Christopher S. Neumann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY