Structural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5

Discovery of a Promiscuous Non-Heme Iron Halogenase in Ambiguine Alkaloid Biogenesis: Implication for an Evolvable Enzyme Family for Late-Stage Halogenation of Aliphatic Carbons in Small Molecules

(2016) Matthew L. Hillwig et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aliphatic Halogenase Enables Late-Stage C−H Functionalization: Selective Synthesis of a Brominated Fischerindole Alkaloid with Enhanced Antibacterial Activity

(2016) Qin Zhu et al.   CHEMBIOCHEM

Experimental Correlation of Substrate Position with Reaction Outcome in the Aliphatic Halogenase, SyrB2

(2015) Ryan J. Martinie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

More than just a Halogenase: Modification of Fatty Acyl Moieties by a Trifunctional Metal Enzyme

(2014) Sarah M. Pratter et al.   CHEMBIOCHEM

Identification and Characterization of a Welwitindolinone Alkaloid Biosynthetic Gene Cluster in the Stigonematalean CyanobacteriumHapalosiphon welwitschii

(2014) Matthew L. Hillwig et al.   CHEMBIOCHEM

A new family of iron-dependent halogenases acts on freestanding substrates

(2014) Matthew L Hillwig et al.   Nature Chemical Biology

Mechanism of the C5 Stereoinversion Reaction in the Biosynthesis of Carbapenem Antibiotics

(2014) W.-c. Chang et al.   SCIENCE

Biosynthesis of Ambiguine Indole Alkaloids in Cyanobacterium Fischerella ambigua

(2013) Matthew L. Hillwig et al.   ACS Chemical Biology

Substrate Placement Influences Reactivity in Non-heme Fe(II) Halogenases and Hydroxylases

(2013) Heather J. Kulik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elucidation of the Fe(iv)=O intermediate in the catalytic cycle of the halogenase SyrB2

(2013) Shaun D. Wong et al.   NATURE

Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases

(2012) WeiShen Aik et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Biosynthetic Chlorination of the Piperazate Residue in Kutzneride Biosynthesis by KthP

(2011) Wei Jiang et al.   BIOCHEMISTRY

Mechanism of Selective Halogenation by SyrB2: A Computational Study

(2010) Tomasz Borowski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Conformational switch triggered by  -ketoglutarate in a halogenase of curacin A biosynthesis

(2010) D. Khare et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Oxidative Halogenation with “Green” Oxidants: Oxygen and Hydrogen Peroxide

(2009) Ajda Podgoršek et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Substrate-Triggered Formation and Remarkable Stability of the C−H Bond-Cleaving Chloroferryl Intermediate in the Aliphatic Halogenase, SyrB2

(2009) Megan L. Matthews et al.   BIOCHEMISTRY

Why does the enzyme SyrB2 chlorinate, but does not hydroxylate, saturated hydrocarbons? A density functional theory (DFT) study

(2009) Shanthi Pandian et al.   DALTON TRANSACTIONS

Structural Analysis of an Open Active Site Conformation of Nonheme Iron Halogenase CytC3

(2009) Cintyu Wong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metamorphic enzyme assembly in polyketide diversification

(2009) Liangcai Gu et al.   NATURE

Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2

(2009) M. L. Matthews et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biosynthesis of (−)-(1S,2R)-Allocoronamic Acyl Thioester by an FeII-Dependent Halogenase and a Cyclopropane-Forming Flavoprotein

(2008) Christopher S. Neumann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7

(2008) Gerrit Langer et al.   Nature Protocols