Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90

An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors – potential therapeutics in cancer and neurodegeneration

(2013) Russell R. A. Kitson et al.   CHEMICAL COMMUNICATIONS

Learning from Nature: Advances in Geldanamycin- and Radicicol-Based Inhibitors of Hsp90

(2013) Russell R. A. Kitson et al.   JOURNAL OF ORGANIC CHEMISTRY

Targeting heat-shock-protein 90 (Hsp90) by natural products: geldanamycin, a show case in cancer therapy

(2013) Jana Franke et al.   NATURAL PRODUCT REPORTS

Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90

(2013) Russell R. A. Kitson et al.   Nature Chemistry

Molecular Chaperones as Rational Drug Targets for Parkinsons Disease Therapeutics

(2012) S. K. Kalia et al.   CNS & Neurological Disorders-Drug Targets

Targeting the Hsp90 Molecular Chaperone with Novel Macrolactams. Synthesis, Structural, Binding, and Cellular Studies

(2011) James E. H. Day et al.   ACS Chemical Biology

Protective Role of Heat Shock Proteins in Parkinson’s Disease

(2011) Paolo Aridon et al.   Neurodegenerative Diseases

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Targeting the Hsp90 Chaperone: Synthesis of Novel Resorcylic Acid Macrolactone Inhibitors of Hsp90

(2010) James E. H. Day et al.   CHEMISTRY-A EUROPEAN JOURNAL

Inhibition of Hsp90 with Resorcylic Acid Macrolactones: Synthesis and Binding Studies

(2010) James E. H. Day et al.   CHEMISTRY-A EUROPEAN JOURNAL

Discovery and development of Hsp90 inhibitors: a promising pathway for cancer therapy

(2010) James R Porter et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Heat Shock Proteins: Therapeutic Drug Targets for Chronic Neurodegeneration?

(2010) M. Sajjad et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Macrocyclic Inhibitors of Hsp90

(2010) Victoria A. Johnson et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

ATPase inhibitors of heat-shock protein 90, second season

(2010) Yves L. Janin   DRUG DISCOVERY TODAY

Total synthesis of graphislactone G

(2010) Judith Cudaj et al.   TETRAHEDRON LETTERS

Synthesis and structure–activity relationships of radicicol derivatives and WNT-5A expression inhibitory activity

(2009) Hideki Shinonaga et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibition of HSP90 with Pochoximes: SAR and Structure-Based Insights

(2009) Sofia Barluenga et al.   CHEMBIOCHEM

Ansamycin Inhibitors of Hsp90: Natures Prototype for Anti-Chaperone Therapy

(2009) James Porter et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Heat shock proteins in neurodegenerative diseases: Pathogenic roles and therapeutic implications

(2009) Hiroaki Adachi et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

xia2: an expert system for macromolecular crystallography data reduction

(2009) G. Winter   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Heat Shock Protein 90: Inhibitors in Clinical Trials

(2009) Marco A. Biamonte et al.   JOURNAL OF MEDICINAL CHEMISTRY

The complementation of yeast with human or Plasmodium falciparum Hsp90 confers differential inhibitor sensitivities

(2009) Diana Wider et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Efficient Synthesis of a Novel Resorcyclide as Anticancer Agent Based on Hsp90 Inhibition

(2008) Xiaoguang Lei et al.   ADVANCED SYNTHESIS & CATALYSIS

Discovery and development of heat shock protein 90 inhibitors

(2008) Tony Taldone et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Medicinal Chemistry of Hsp90 Inhibitors

(2008) Martin Drysdale et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Heat Shock Protein 90

(2008) Ariamala Gopalsamy et al.   JOURNAL OF MEDICINAL CHEMISTRY