Structure and biocatalytic scope of thermophilic flavin-dependent halogenase and flavin reductase enzymes

Specific Enzymatic Halogenation-From the Discovery of Halogenated Enzymes to Their Applications In Vitro and In Vivo

(2016) Veit Weichold et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Structure-Guided Switch in the Regioselectivity of a Tryptophan Halogenase

(2016) Sarah A. Shepherd et al.   CHEMBIOCHEM

Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C–H activation

(2016) Jonathan Latham et al.   Nature Communications

Late-Stage Diversification of Biologically Active Molecules via Chemoenzymatic C–H Functionalization

(2016) Landon J. Durak et al.   ACS Catalysis

Directed Evolution of RebH for Site-Selective Halogenation of Large Biologically Active Molecules

(2015) James T. Payne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Halogenase Engineering for the Generation of New Natural Product Analogues

(2015) Stephanie Brown et al.   CHEMBIOCHEM

Computational Tools To Model Halogen Bonds in Medicinal Chemistry

(2015) Melissa Coates Ford et al.   JOURNAL OF MEDICINAL CHEMISTRY

Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes

(2015) Sarah A. Shepherd et al.   Chemical Science

Enzymatic Halogenation of Tryptophan on a Gram Scale

(2014) Marcel Frese et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Improving the Stability and Catalyst Lifetime of the Halogenase RebH By Directed Evolution

(2014) Catherine B. Poor et al.   CHEMBIOCHEM

The two common polymorphic forms of human NRH-quinone oxidoreductase 2 (NQO2) have different biochemical properties

(2014) Clare F. Megarity et al.   FEBS LETTERS

Recent advances in homogeneous nickel catalysis

(2014) Sarah Z. Tasker et al.   NATURE

Merging photoredox with nickel catalysis: Coupling of  -carboxyl sp3-carbons with aryl halides

(2014) Z. Zuo et al.   SCIENCE

Recently publishedStreptomycesgenome sequences

(2014) James Harrison et al.   Microbial Biotechnology

Engineered thermostable fungal Cel6A and Cel7A cellobiohydrolases hydrolyze cellulose efficiently at elevated temperatures

(2013) Indira Wu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Transition-metal-catalyzed Suzuki–Miyaura cross-coupling reactions: a remarkable advance from palladium to nickel catalysts

(2013) Fu-She Han   CHEMICAL SOCIETY REVIEWS

Chloroquine Binding Reveals Flavin Redox Switch Function of Quinone Reductase 2

(2013) Kevin K. K. Leung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Development of Bulky Palladium NHC Complexes for the Most-Challenging Cross-Coupling Reactions

(2012) Cory Valente et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Electrostatic Contribution of Surface Charge Residues to the Stability of a Thermophilic Protein: Benchmarking Experimental and Predicted pKa Values

(2012) Chi-Ho Chan et al.   PLoS One

Changing the Regioselectivity of the Tryptophan 7-Halogenase PrnA by Site-Directed Mutagenesis

(2011) Alexander Lang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Moderately Efficient Enzyme: Evolutionary and Physicochemical Trends Shaping Enzyme Parameters

(2011) Arren Bar-Even et al.   BIOCHEMISTRY

Characterization of a tryptophan 6-halogenase from Streptomyces toxytricini

(2011) Jia Zeng et al.   BIOTECHNOLOGY LETTERS

Metabolic Engineering for the Production of Natural Products

(2011) Lauren B. Pickens et al.   Annual Review of Chemical and Biomolecular Engineering

Halogen Atoms in the Modern Medicinal Chemistry: Hints for the Drug Design

(2010) Marcelo Hernandes et al.   CURRENT DRUG TARGETS

Gene Expression Enabling Synthetic Diversification of Natural Products: Chemogenetic Generation of Pacidamycin Analogs

(2010) Abhijeet Deb Roy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fre Is the Major Flavin Reductase Supporting Bioluminescence fromVibrio harveyiLuciferase inEscherichia coli

(2009) Zachary T. Campbell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of a flavin reductase from a thermophilic dibenzothiophene-desulfurizing bacterium, Bacillus subtilis WU-S2B

(2009) Shusuke Takahashi et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Structural Insights into Regioselectivity in the Enzymatic Chlorination of Tryptophan

(2009) Xiaofeng Zhu et al.   JOURNAL OF MOLECULAR BIOLOGY

Mechanistic considerations of halogenating enzymes

(2009) Alison Butler et al.   NATURE

The unique role of halogen substituents in the design of modern agrochemicals

(2009) Peter Jeschke   PEST MANAGEMENT SCIENCE

Halogenation Strategies In Natural Product Biosynthesis

(2008) Christopher S. Neumann et al.   CHEMISTRY & BIOLOGY

Tandem Action of the O2- and FADH2-Dependent Halogenases KtzQ and KtzR Produce 6,7-Dichlorotryptophan for Kutzneride Assembly

(2008) John R. Heemstra et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY