Expanding the Fluorine Chemistry of Living Systems Using Engineered Polyketide Synthase Pathways

Promiscuity of a modular polyketide synthase towards natural and non-natural extender units

(2013) Irina Koryakina et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Temporal and Fluoride Control of Secondary Metabolism Regulates Cellular Organofluorine Biosynthesis

(2012) Mark C. Walker et al.   ACS Chemical Biology

Enzyme-Directed Mutasynthesis: A Combined Experimental and Theoretical Approach to Substrate Recognition of a Polyketide Synthase

(2012) Uschi Sundermann et al.   ACS Chemical Biology

Constructing de Novo Biosynthetic Pathways for Chemical Synthesis inside Living Cells

(2011) Amy M. Weeks et al.   BIOCHEMISTRY

Structure and Mechanism of thetrans-Acting Acyltransferase from the Disorazole Synthase

(2011) Fong T. Wong et al.   BIOCHEMISTRY

Acyl-CoA Subunit Selectivity in the Pikromycin Polyketide Synthase PikAIV: Steady-State Kinetics and Active-Site Occupancy Analysis by FTICR-MS

(2011) Shilah A. Bonnett et al.   CHEMISTRY & BIOLOGY

Enzymatic Extender Unit Generation for In Vitro Polyketide Synthase Reactions: Structural and Func-tional Showcasing of Streptomyces coelicolor MatB

(2011) Amanda J. Hughes et al.   CHEMISTRY & BIOLOGY

Catalysis for fluorination and trifluoromethylation

(2011) Takeru Furuya et al.   NATURE

Enzyme mechanism as a kinetic control element for designing synthetic biofuel pathways

(2011) Brooks B Bond-Watts et al.   Nature Chemical Biology

A Fluoride-Derived Electrophilic Late-Stage Fluorination Reagent for PET Imaging

(2011) E. Lee et al.   SCIENCE

Asymmetric Electrophilic Fluorination Using an Anionic Chiral Phase-Transfer Catalyst

(2011) V. Rauniyar et al.   SCIENCE

Binding and Action of CEM-101, a New Fluoroketolide Antibiotic That Inhibits Protein Synthesis

(2010) B. Llano-Sotelo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

An Expeditious Route to Fluorinated Rapamycin Analogues by Utilising Mutasynthesis

(2010) Rebecca J. M. Goss et al.   CHEMBIOCHEM

Engineering Fluorometabolite Production: Fluorinase Expression inSalinispora tropicaYields Fluorosalinosporamide†

(2010) Alessandra S. Eustáquio et al.   JOURNAL OF NATURAL PRODUCTS

Biosynthesis of the Allylmalonyl-CoA Extender Unit for the FK506 Polyketide Synthase Proceeds through a Dedicated Polyketide Synthase and Facilitates the Mutasynthesis of Analogues

(2010) SangJoon Mo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway

(2010) E. Okamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein−Protein Recognition between Acyltransferases and Acyl Carrier Proteins in Multimodular Polyketide Synthases

(2009) Fong T. Wong et al.   BIOCHEMISTRY

Synthesis and Reactivity of a Mono-σ-Aryl Palladium(IV) Fluoride Complex

(2009) Nicholas D. Ball et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli

(2009) Bryson D Bennett et al.   Nature Chemical Biology

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

Protein structure prediction on the Web: a case study using the Phyre server

(2009) Lawrence A Kelley et al.   Nature Protocols

Silencing of tryptamine biosynthesis for production of nonnatural alkaloids in plant culture

(2009) W. Runguphan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Formation of ArF from LPdAr(F): Catalytic Conversion of Aryl Triflates to Aryl Fluorides

(2009) D. A. Watson et al.   SCIENCE

Biosynthesis of polyketide synthase extender units

(2008) Yolande A. Chan et al.   NATURAL PRODUCT REPORTS

Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels

(2008) Shota Atsumi et al.   NATURE

Understanding organofluorine chemistry. An introduction to the C–F bond

(2007) David O'Hagan   CHEMICAL SOCIETY REVIEWS