The generation of “unNatural” products: Synthetic biology meets synthetic chemistry

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Site-Selective Bromination of Vancomycin

(2012) Tejas P. Pathak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineered Thiomarinol Antibiotics Active against MRSA Are Generated by Mutagenesis and Mutasynthesis of Pseudoalteromonas SANK73390

(2011) Annabel C. Murphy et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Diversity in natural product families is governed by more than enzyme promiscuity alone: establishing control of the pacidamycin portfolio

(2011) Sabine Grüschow et al.   Chemical Science

Salinosporamide Natural Products: Potent 20 S Proteasome Inhibitors as Promising Cancer Chemotherapeutics

(2010) Tobias A. M. Gulder et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

DNA Binding Characteristics of Mithramycin and Chromomycin Analogues Obtained by Combinatorial Biosynthesis

(2010) Francisca Barceló et al.   BIOCHEMISTRY

An Expeditious Route to Fluorinated Rapamycin Analogues by Utilising Mutasynthesis

(2010) Rebecca J. M. Goss et al.   CHEMBIOCHEM

Engineering Fluorometabolite Production: Fluorinase Expression inSalinispora tropicaYields Fluorosalinosporamide†

(2010) Alessandra S. Eustáquio et al.   JOURNAL OF NATURAL PRODUCTS

Exploiting Enzymatic Promiscuity to Engineer a Focused Library of Highly Selective Antifungal and Antiproliferative Aureothin Analogues

(2010) Martina Werneburg et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

On the potential of natural products in the discovery of pharma leads: A case for reassessment

(2010) Samuel Danishefsky   NATURAL PRODUCT REPORTS

Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis

(2010) Carlos Olano et al.   NATURAL PRODUCT REPORTS

Integrating carbon–halogen bond formation into medicinal plant metabolism

(2010) Weerawat Runguphan et al.   NATURE

Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome

(2010) Heinz Neumann et al.   NATURE

New pacidamycins biosynthetically: probing N- and C-terminal substrate specificity

(2010) Amany E. Ragab et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Diverse DNA-Cleaving Capacities of the Jadomycins through Precursor-Directed Biosynthesis

(2010) Krista M. Cottreau et al.   ORGANIC LETTERS

The chromomycin CmmA acetyltransferase: a membrane-bound enzyme as a tool for increasing structural diversity of the antitumour mithramycin

(2010) Beatriz García et al.   Microbial Biotechnology

New, Highly Active Nonbenzoquinone Geldanamycin Derivatives by Using Mutasynthesis

(2009) Simone Eichner et al.   CHEMBIOCHEM

Potent Non-Benzoquinone Ansamycin Heat Shock Protein 90 Inhibitors from Genetic Engineering ofStreptomyces hygroscopicus

(2009) Hugo G. Menzella et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evaluating Indole-Related Derivatives as Precursors in the Directed Biosynthesis of Diazepinomicin Analogues§

(2009) Anokha S. Ratnayake et al.   JOURNAL OF NATURAL PRODUCTS

An Approach to the Site-Selective Diversification of Apoptolidin A with Peptide-Based Catalysts

(2009) Chad A. Lewis et al.   JOURNAL OF NATURAL PRODUCTS

Biosynthesis of Salinosporamides from α,β-Unsaturated Fatty Acids: Implications for Extending Polyketide Synthase Diversity

(2009) Yuan Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genomic basis for natural product biosynthetic diversity in the actinomycetes

(2009) Markus Nett et al.   NATURAL PRODUCT REPORTS

The impact of genomics on the exploitation of the myxobacterial secondary metabolome

(2009) Silke C. Wenzel et al.   NATURAL PRODUCT REPORTS

Antimicrobial nucleoside antibiotics targeting cell wall assembly: Recent advances in structure–function studies and nucleoside biosynthesis

(2009) Michael Winn et al.   NATURAL PRODUCT REPORTS

Precursor-directed biosynthesis of fluorinated iturin A in Bacillus spp.

(2009) Stephen Moran et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Silencing of tryptamine biosynthesis for production of nonnatural alkaloids in plant culture

(2009) W. Runguphan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutasynthesis of Fluorosalinosporamide, a Potent and Reversible Inhibitor of the Proteasome

(2008) Alessandra S. Eustáquio et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic site-selective synthesis and evaluation of a series of erythromycin analogs

(2008) Chad A. Lewis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Generation of Novel Pikromycin Antibiotic Products Through Mutasynthesis

(2008) Shuchi Gupta et al.   CHEMBIOCHEM

Highly Active Ansamitocin Derivatives: Mutasynthesis Using an AHBA-Blocked Mutant

(2008) Florian Taft et al.   CHEMBIOCHEM

Use of a Halogenase of Hormaomycin Biosynthesis for Formation of New Clorobiocin Analogues with 5-Chloropyrrole Moieties

(2008) Lutz Heide et al.   CHEMBIOCHEM

Protein–Protein Interactions in Multienzyme Megasynthetases

(2008) Kira J. Weissman et al.   CHEMBIOCHEM

New Pacidamycin Antibiotics Through Precursor-Directed Biosynthesis

(2008) Sabine Grüschow et al.   CHEMBIOCHEM

Auxotrophic-precursor directed biosynthesis of nonribosomal lipopeptides with modified tryptophan residues

(2008) Bagher Amir-Heidari et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Mutasynthesis, chemobiosynthesis, and back to semi-synthesis: combining synthetic chemistry and biosynthetic engineering for diversifying natural products

(2007) Jonathan Kennedy   NATURAL PRODUCT REPORTS