Directed Evolution of RebH for Site-Selective Halogenation of Large Biologically Active Molecules

Enzymatic Halogenation of Tryptophan on a Gram Scale

(2014) Marcel Frese et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Improving the Stability and Catalyst Lifetime of the Halogenase RebH By Directed Evolution

(2014) Catherine B. Poor et al.   CHEMBIOCHEM

Synthesis and Antiviral and Fungicidal Activity Evaluation of β-Carboline, Dihydro-β-carboline, Tetrahydro-β-carboline Alkaloids, and Their Derivatives

(2014) Hongjian Song et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Regioselective Arene Halogenation using the FAD-Dependent Halogenase RebH

(2013) James T. Payne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Changing the Regioselectivity of the Tryptophan 7-Halogenase PrnA by Site-Directed Mutagenesis

(2011) Alexander Lang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Intercepting Bacterial Indole Signaling with Flustramine Derivatives

(2011) Cynthia A. Bunders et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reengineering a Tryptophan Halogenase To Preferentially Chlorinate a Direct Alkaloid Precursor

(2011) Weslee S. Glenn et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Combinatorial Alanine Substitution Enables Rapid Optimization of Cytochrome P450BM3 for Selective Hydroxylation of Large Substrates

(2010) Jared C. Lewis et al.   CHEMBIOCHEM

Halogen Atoms in the Modern Medicinal Chemistry: Hints for the Drug Design

(2010) Marcelo Hernandes et al.   CURRENT DRUG TARGETS

Gene Expression Enabling Synthetic Diversification of Natural Products: Chemogenetic Generation of Pacidamycin Analogs

(2010) Abhijeet Deb Roy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Integrating carbon–halogen bond formation into medicinal plant metabolism

(2010) Weerawat Runguphan et al.   NATURE

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

(2010) C. K. Savile et al.   SCIENCE

Exploring protein fitness landscapes by directed evolution

(2009) Philip A. Romero et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The unique role of halogen substituents in the design of modern agrochemicals

(2009) Peter Jeschke   PEST MANAGEMENT SCIENCE

Evolutionary History of a Specialized P450 Propane Monooxygenase

(2008) Rudi Fasan et al.   JOURNAL OF MOLECULAR BIOLOGY

Discovery and Structure−Activity Relationship of (1R)-8-Chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a Selective Serotonin 5-HT2CReceptor Agonist for the Treatment of Obesity

(2007) Brian M. Smith et al.   JOURNAL OF MEDICINAL CHEMISTRY