Profiling lymphocyte interactions at the single-cell level by microfluidic cell pairing

The T Cell Receptor's  -Chain Connecting Peptide Motif Promotes Close Approximation of the CD8 Coreceptor Allowing Efficient Signal Initiation

(2014) M. Mallaun et al.   JOURNAL OF IMMUNOLOGY

Th17 Cells Exhibit a Distinct Calcium Profile from Th1 and Th2 Cells and Have Th1-Like Motility and NF-AT Nuclear Localization

(2014) K. S. Weber et al.   JOURNAL OF IMMUNOLOGY

Single cell behavior in T cell differentiation

(2014) Jan C. Rohr et al.   TRENDS IN IMMUNOLOGY

T cells translate individual, quantal activation into collective, analog cytokine responses via time-integrated feedbacks

(2014) Karen E Tkach et al.   eLife

CD40-activated B cells as antigen-presenting cells: the final sprint toward clinical application

(2013) Kerstin Wennhold et al.   Expert Review of Vaccines

Annular PIP 3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse

(2013) Audrey Le Floc’h et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Phenotypic CD8+ T Cell Diversification Occurs before, during, and after the First T Cell Division

(2013) F. Lemaitre et al.   JOURNAL OF IMMUNOLOGY

T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy

(2013) S. Zhong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phenotypic model for early T-cell activation displaying sensitivity, specificity, and antagonism

(2013) P. Francois et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disparate Individual Fates Compose Robust CD8+ T Cell Immunity

(2013) V. R. Buchholz et al.   SCIENCE

Heterogeneous Differentiation Patterns of Individual CD8+ T Cells

(2013) C. Gerlach et al.   SCIENCE

Cell-to-Cell Variability Analysis Dissects the Plasticity of Signaling of Common   Chain Cytokines in T Cells

(2013) J. W. Cotari et al.   Science Signaling

Transnuclear TRP1-Specific CD8 T Cells with High or Low Affinity TCRs Show Equivalent Antitumor Activity

(2013) S. K. Dougan et al.   Cancer Immunology Research

T cell responses to antigen: hasty proposals resolved through long engagements

(2012) Karen Tkach et al.   CURRENT OPINION IN IMMUNOLOGY

Interplay between T Cell Receptor Binding Kinetics and the Level of Cognate Peptide Presented by Major Histocompatibility Complexes Governs CD8+T Cell Responsiveness

(2012) Melita Irving et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Asymmetric Memory T Cell Division in Response to Rechallenge

(2012) M. L. Ciocca et al.   JOURNAL OF IMMUNOLOGY

Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses

(2012) R. A. Gottschalk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Strength of TCR-Peptide/MHC Interactions and In Vivo T Cell Responses

(2011) E. Corse et al.   JOURNAL OF IMMUNOLOGY

Ca 2+ Release from the Endoplasmic Reticulum of NY-ESO-1–Specific T Cells Is Modulated by the Affinity of TCR and by the Use of the CD8 Coreceptor

(2010) Ji-Li Chen et al.   JOURNAL OF IMMUNOLOGY

Structural Biology of the T-cell Receptor: Insights into Receptor Assembly, Ligand Recognition, and Initiation of Signaling

(2010) K. W. Wucherpfennig et al.   Cold Spring Harbor Perspectives in Biology

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

Organization of proximal signal initiation at the TCR:CD3 complex

(2009) Clifford S. Guy et al.   IMMUNOLOGICAL REVIEWS

Plastic masters—rigid templates for soft lithography

(2009) Salil P. Desai et al.   LAB ON A CHIP

Microfluidic control of cell pairing and fusion

(2009) Alison M Skelley et al.   NATURE METHODS

Secondary Replicative Function of CD8+ T Cells That Had Developed an Effector Phenotype

(2009) O. Bannard et al.   SCIENCE

Efficient generation of human alloantigen-specific CD4+ regulatory T cells from naive precursors by CD40-activated B cells

(2008) W. Tu et al.   BLOOD

BCR-mediated apoptosis associated with negative selection of immature B cells is selectively dependent on Pten

(2008) Shuhua Cheng et al.   CELL RESEARCH

Memory CD4 T cells emerge from effector T-cell progenitors

(2008) Laurie E. Harrington et al.   NATURE

T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation

(2008) Sarah E Henrickson et al.   NATURE IMMUNOLOGY

Variability and Robustness in T Cell Activation from Regulated Heterogeneity in Protein Levels

(2008) O. Feinerman et al.   SCIENCE