Innate immune cells in the adipose tissue

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

(2018) Anette Christ et al.   CELL

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

(2018) Ioannis Mitroulis et al.   CELL

Elevating adipose eosinophils in obese mice to physiologically normal levels does not rescue metabolic impairments

(2018) W. Reid Bolus et al.   Molecular Metabolism

Neutrophil Elastase Regulates Emergency Myelopoiesis Preceding Systemic Inflammation in Diet-induced Obesity

(2017) Jun-Yuan Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of innate and adaptive immunity in obesity-associated metabolic disease

(2017) Tracey McLaughlin et al.   JOURNAL OF CLINICAL INVESTIGATION

Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis

(2017) Katrin Fischer et al.   NATURE MEDICINE

Advances in the understanding of adipose tissue biology

(2017) Shingo Kajimura   Nature Reviews Endocrinology

Adipokines as atherothrombotic risk factors in obese subjects: Associations with haemostatic markers and common carotid wall thickness

(2017) É. Csongrádi et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Eosinophils are key regulators of perivascular adipose tissue and vascular functionality

(2017) Sarah B. Withers et al.   Scientific Reports

Adipose Natural Killer Cells Regulate Adipose Tissue Macrophages to Promote Insulin Resistance in Obesity

(2016) Byung-Cheol Lee et al.   Cell Metabolism

Caloric Restriction Leads to Browning of White Adipose Tissue through Type 2 Immune Signaling

(2016) Salvatore Fabbiano et al.   Cell Metabolism

Glucocorticoids Acutely Increase Brown Adipose Tissue Activity in Humans, Revealing Species-Specific Differences in UCP-1 Regulation

(2016) Lynne E. Ramage et al.   Cell Metabolism

Adipose Recruitment and Activation of Plasmacytoid Dendritic Cells Fuel Metaflammation

(2016) Amrit Raj Ghosh et al.   DIABETES

Biomarkers in Obesity: Serum Myeloperoxidase and Traditional Cardiac Risk Parameters

(2016) D. Borato et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Adipose-Resident Group 1 Innate Lymphoid Cells Promote Obesity-Associated Insulin Resistance

(2016) Timothy E. O’Sullivan et al.   IMMUNITY

Adipose Tissue Dendritic Cells Are Independent Contributors to Obesity-Induced Inflammation and Insulin Resistance

(2016) Kae Won Cho et al.   JOURNAL OF IMMUNOLOGY

Perivascular adipose tissue: An unique fat compartment relevant for the cardiometabolic syndrome

(2016) D. I. Siegel-Axel et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

The role of innate immunity in the regulation of brown and beige adipogenesis

(2016) Vasileia Ismini Alexaki et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

The effects of indoor and outdoor temperature on metabolic rate and adipose tissue – the Mississippi perspective on the obesity epidemic

(2016) J. B. Turner et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Obesity and Atherosclerosis: Mechanistic Insights

(2015) Fina Lovren et al.   CANADIAN JOURNAL OF CARDIOLOGY

Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis

(2015) Min-Woo Lee et al.   CELL

Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation

(2015) Xiaoyan Hui et al.   Cell Metabolism

Type 2 responses at the interface between immunity and fat metabolism

(2015) Justin I Odegaard et al.   CURRENT OPINION IN IMMUNOLOGY

IL-33 activates eosinophils of visceral adipose tissue both directly and via innate lymphoid cells

(2015) Masaaki Hashiguchi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Perforin-Positive Dendritic Cells Exhibit an Immuno-regulatory Role in Metabolic Syndrome and Autoimmunity

(2015) Yael Zlotnikov-Klionsky et al.   IMMUNITY

Natural Killer Cell Memory

(2015) Timothy E. O’Sullivan et al.   IMMUNITY

Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation

(2015) Ari B. Molofsky et al.   IMMUNITY

NK cells link obesity-induced adipose stress to inflammation and insulin resistance

(2015) Felix M Wensveen et al.   NATURE IMMUNOLOGY

Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets

(2015) Michelle L Robinette et al.   NATURE IMMUNOLOGY

Innate lymphoid cells: A new paradigm in immunology

(2015) G. Eberl et al.   SCIENCE

Leptin applications in 2015

(2015) Olivia M. Farr et al.   Current Opinion in Endocrinology Diabetes and Obesity

The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis

(2015) Chiara Saponaro et al.   Nutrients

Associations of Different Adipose Tissue Depots with Insulin Resistance: A Systematic Review and Meta-analysis of Observational Studies

(2015) Mingzhi Zhang et al.   Scientific Reports

Homeostatic Control of Memory Cell Progenitors in the Natural Killer Cell Lineage

(2015) Yosuke Kamimura et al.   Cell Reports

High Fat Diet Causes Depletion of Intestinal Eosinophils Associated with Intestinal Permeability

(2015) Andrew M. F. Johnson et al.   PLoS One

Visceral adipose tissue as a source of inflammation and promoter of atherosclerosis

(2014) Nikolaos Alexopoulos et al.   ATHEROSCLEROSIS

Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat

(2014) Yifu Qiu et al.   CELL

Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis

(2014) Rajesh R. Rao et al.   CELL

Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation

(2014) Shinya U. Amano et al.   Cell Metabolism

Myeloperoxidase Deletion Prevents High-Fat Diet-Induced Obesity and Insulin Resistance

(2014) Q. Wang et al.   DIABETES

Immune Cell Crosstalk in Obesity: A Key Role for Costimulation?

(2014) T. Seijkens et al.   DIABETES

Inflammatory Status is Different in Relationship to Insulin Resistance in Severely Obese People and Changes after Bariatric Surgery or Diet-induced Weight Loss

(2014) M. Ballesteros-Pomar et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

DNA methylation is altered in B and NK lymphocytes in obese and type 2 diabetic human

(2014) David Simar et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity

(2014) Jonathan R. Brestoff et al.   NATURE

Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity

(2014) Bhama Ramkhelawon et al.   NATURE MEDICINE

Adipocytes arise from multiple lineages that are heterogeneously and dynamically distributed

(2014) Joan Sanchez-Gurmaches et al.   Nature Communications

Imbalance between Neutrophil Elastase and its Inhibitor α1-Antitrypsin in Obesity Alters Insulin Sensitivity, Inflammation, and Energy Expenditure

(2013) Virginie Mansuy-Aubert et al.   Cell Metabolism

Induction of Cytosolic Phospholipase A 2 α Is Required for Adipose Neutrophil Infiltration and Hepatic Insulin Resistance Early in the Course of High-Fat Feeding

(2013) Nurit Hadad et al.   DIABETES

Interferon Regulatory Factor 4 Regulates Obesity-Induced Inflammation Through Regulation of Adipose Tissue Macrophage Polarization

(2013) J. Eguchi et al.   DIABETES

Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages

(2013) Ari B. Molofsky et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: IL-25 Elicits Innate Lymphoid Type 2 and Type II NKT Cells That Regulate Obesity in Mice

(2013) E. Hams et al.   JOURNAL OF IMMUNOLOGY

Human white adipocytes express the cold receptor TRPM8 which activation induces UCP1 expression, mitochondrial activation and heat production

(2013) Marco Rossato et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages

(2013) Takashi Satoh et al.   NATURE

Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch

(2013) Jiqiu Wang et al.   NATURE CELL BIOLOGY

Bi-directional interconversion of brite and white adipocytes

(2013) Matthias Rosenwald et al.   NATURE CELL BIOLOGY

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Evidence for two types of brown adipose tissue in humans

(2013) Martin E Lidell et al.   NATURE MEDICINE

The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance

(2013) Triantafyllos Chavakis et al.   THROMBOSIS AND HAEMOSTASIS

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

In Vivo Identification of Bipotential Adipocyte Progenitors Recruited by β3-Adrenoceptor Activation and High-Fat Feeding

(2012) Yun-Hee Lee et al.   Cell Metabolism

CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status

(2012) H. Kitade et al.   DIABETES

Dendritic Cells Promote Macrophage Infiltration and Comprise a Substantial Proportion of Obesity-Associated Increases in CD11c+ Cells in Adipose Tissue and Liver

(2012) M. Stefanovic-Racic et al.   DIABETES

High frequency of activated natural killer and natural killer T-cells in patients with new onset of type 2 diabetes mellitus

(2012) Hui Guo et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Advances in adipokines

(2012) A. Sahin-Efe et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Adipose tissue heterogeneity: Implication of depot differences in adipose tissue for obesity complications

(2012) Mi-Jeong Lee et al.   MOLECULAR ASPECTS OF MEDICINE

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

(2012) Saswata Talukdar et al.   NATURE MEDICINE

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

(2012) Durba Pal et al.   NATURE MEDICINE

The cellular and signaling networks linking the immune system and metabolism in disease

(2012) Olivia Osborn et al.   NATURE MEDICINE

NASH and atherosclerosis are two aspects of a shared disease: Central role for macrophages

(2011) Veerle Bieghs et al.   ATHEROSCLEROSIS

Increased Macrophage Migration Into Adipose Tissue in Obese Mice

(2011) D. Y. Oh et al.   DIABETES

Eosinophils: multifaceted biological properties and roles in health and disease

(2011) Hirohito Kita   IMMUNOLOGICAL REVIEWS

Krüppel-like factor 4 regulates macrophage polarization

(2011) Xudong Liao et al.   JOURNAL OF CLINICAL INVESTIGATION

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

(2011) D. Wu et al.   SCIENCE

Uncoupling protein 1 expression and high-fat diets

(2010) Tobias Fromme et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity

(2010) R. R. Ricardo-Gonzalez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP-Binding Cassette Transporters and HDL Suppress Hematopoietic Stem Cell Proliferation

(2010) L. Yvan-Charvet et al.   SCIENCE

Chemerin: at the crossroads of inflammation and obesity

(2010) Matthew C. Ernst et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

CCL5 Promotes Macrophage Recruitment and Survival in Human Adipose Tissue

(2009) Mayoura Keophiphath et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Protein Kinase IKKɛ Regulates Energy Balance in Obese Mice

(2009) Shian-Huey Chiang et al.   CELL

CXC Ligand 5 Is an Adipose-Tissue Derived Factor that Links Obesity to Insulin Resistance

(2009) Carine Chavey et al.   Cell Metabolism

Regulatory Mechanisms for Adipose Tissue M1 and M2 Macrophages in Diet-Induced Obese Mice

(2009) S. Fujisaka et al.   DIABETES

Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-γ in inflammation in human adipose tissue

(2009) R W O'Rourke et al.   INTERNATIONAL JOURNAL OF OBESITY

Adipose tissue as an endocrine organ

(2009) Sandra Galic et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells

(2009) Kazuyo Moro et al.   NATURE

Adipokines as novel modulators of lipid metabolism

(2009) Francisca Lago et al.   TRENDS IN BIOCHEMICAL SCIENCES

Adipocyte-Derived Th2 Cytokines and Myeloid PPARδ Regulate Macrophage Polarization and Insulin Sensitivity

(2008) Kihwa Kang et al.   Cell Metabolism

Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals

(2008) David Patsouris et al.   Cell Metabolism

Impact of visceral adipose tissue on liver metabolism and insulin resistance. Part II: Visceral adipose tissue production and liver metabolism

(2008) J. Girard et al.   DIABETES & METABOLISM

Visceral fat: A key mediator of steatohepatitis in metabolic liver disease

(2008) David van der Poorten et al.   HEPATOLOGY

Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice

(2008) I. Murano et al.   JOURNAL OF LIPID RESEARCH

A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance

(2008) G. Sabio et al.   SCIENCE