Peyer's patches: organizing B-cell responses at the intestinal frontier

Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes

(2015) Leng-Siew Yeap et al.   CELL

BALB/c and C57BL/6 Mice Differ in Polyreactive IgA Abundance, which Impacts the Generation of Antigen-Specific IgA and Microbiota Diversity

(2015) Floris Fransen et al.   IMMUNITY

Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A

(2015) Jeffrey J. Bunker et al.   IMMUNITY

Strategically Localized Dendritic Cells Promote Rapid T Cell Responses to Lymph-Borne Particulate Antigens

(2015) Michael Y. Gerner et al.   IMMUNITY

Sampling of Candida albicans and Candida tropicalis by Langerin-positive dendritic cells in mouse Peyer’s patches

(2015) Magdia De Jesus et al.   IMMUNOLOGY LETTERS

Cutting Edge: Retinoic Acid Signaling in B Cells Is Essential for Oral Immunization and Microflora Composition

(2015) Eirini Pantazi et al.   JOURNAL OF IMMUNOLOGY

Phenotypic and Morphological Properties of Germinal Center Dark ZoneCxcl12-Expressing Reticular Cells

(2015) Lauren B. Rodda et al.   JOURNAL OF IMMUNOLOGY

Increased serum IgA in Fcα/μR-deficient mice on the (129 x C57BL/6) F1 genetic background

(2015) Naoki Kurita et al.   MOLECULAR IMMUNOLOGY

Interleukin (IL)-21 promotes intestinal IgA response to microbiota

(2015) A T Cao et al.   Mucosal Immunology

Long-lived plasma cells are generated in mucosal immune responses and contribute to the bone marrow plasma cell pool in mice

(2015) A Lemke et al.   Mucosal Immunology

IL-1β in eosinophil-mediated small intestinal homeostasis and IgA production

(2015) Y Jung et al.   Mucosal Immunology

Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota

(2015) Cornelia Lindner et al.   NATURE IMMUNOLOGY

Complexity of the human memory B-cell compartment is determined by the versatility of clonal diversification in germinal centers

(2015) Bettina Budeus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The bilateral responsiveness between intestinal microbes and IgA

(2015) Andrew J. Macpherson et al.   TRENDS IN IMMUNOLOGY

Emerging and Novel Functions of Complement Protein C1q

(2015) Lubna Kouser et al.   Frontiers in Immunology

Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease

(2014) Noah W. Palm et al.   CELL

Eosinophils Promote Generation and Maintenance of Immunoglobulin-A-Expressing Plasma Cells and Contribute to Gut Immune Homeostasis

(2014) Van Trung Chu et al.   IMMUNITY

Segmented Filamentous Bacterium Uses Secondary and Tertiary Lymphoid Tissues to Induce Gut IgA and Specific T Helper 17 Cell Responses

(2014) Emelyne Lécuyer et al.   IMMUNITY

Intestinal IgA production and its role in host-microbe interaction

(2014) Cindy Gutzeit et al.   IMMUNOLOGICAL REVIEWS

Cutting Edge: Instructive Role of Peripheral Tissue Cells in the Imprinting of T Cell Homing Receptor Patterns

(2014) F. Edele et al.   JOURNAL OF IMMUNOLOGY

Cell Intrinsic TGF- 1 Regulation of B Cells

(2014) M. J. Gros et al.   JOURNAL OF IMMUNOLOGY

Sphingosine 1-Phosphate Regulates the Egress of IgA Plasmablasts from Peyer's Patches for Intestinal IgA Responses

(2014) M. Gohda et al.   JOURNAL OF IMMUNOLOGY

Integrin-Mediated Interactions between B Cells and Follicular Dendritic Cells Influence Germinal Center B Cell Fitness

(2014) X. Wang et al.   JOURNAL OF IMMUNOLOGY

Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity

(2014) Serge A. van de Pavert et al.   NATURE

Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma

(2014) Jagan R. Muppidi et al.   NATURE

Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens

(2014) Krzysztof Kiryluk et al.   NATURE GENETICS

Identification and distribution of developing innate lymphoid cells in the fetal mouse intestine

(2014) Jennifer K Bando et al.   NATURE IMMUNOLOGY

Generation of colonic IgA-secreting cells in the caecal patch

(2014) Kazunori Masahata et al.   Nature Communications

Germinal Center Centroblasts Transition to a Centrocyte Phenotype According to a Timed Program and Depend on the Dark Zone for Effective Selection

(2013) Oliver Bannard et al.   IMMUNITY

Neutrophils control the magnitude and spread of the immune response in a thromboxane A2-mediated process

(2013) Chiao-Wen Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CXCR4 promotes B cell egress from Peyer’s patches

(2013) Timothy H. Schmidt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Peyer's Patch Inducer Cells Play a Leading Role in the Formation of B and T Cell Zone Architecture

(2013) R. Nakagawa et al.   JOURNAL OF IMMUNOLOGY

Retinoic acid, acting as a highly specific IgA isotype switch factor, cooperates with TGF-β1 to enhance the overall IgA response

(2013) Goo-Young Seo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Microbial colonization influences early B-lineage development in the gut lamina propria

(2013) Duane R. Wesemann et al.   NATURE

Dectin-1 Is Essential for Reverse Transcytosis of Glycosylated SIgA-Antigen Complexes by Intestinal M Cells

(2013) Nicolas Rochereau et al.   PLOS BIOLOGY

The Gastrointestinal Frontier: IgA and Viruses

(2013) Sarah E. Blutt et al.   Frontiers in Immunology

Induction of gut IgA production through T cell-dependent and T cell-independent pathways

(2012) Mats Bemark et al.   Annals of the New York Academy of Sciences

Germinal Centers

(2012) Gabriel D. Victora et al.   Annual Review of Immunology

Sphingosine-1-Phosphate and Lymphocyte Egress from Lymphoid Organs

(2012) Jason G. Cyster et al.   Annual Review of Immunology

S1PR2 links germinal center confinement and growth regulation

(2012) Jesse A. Green et al.   IMMUNOLOGICAL REVIEWS

Germinal center selection and the development of memory B and plasma cells

(2012) Mark J. Shlomchik et al.   IMMUNOLOGICAL REVIEWS

Expression pattern changes and function of RANKL during mouse lymph node microarchitecture development

(2012) Machiko Sugiyama et al.   INTERNATIONAL IMMUNOLOGY

Serum from patients with SLE instructs monocytes to promote IgG and IgA plasmablast differentiation

(2012) HyeMee Joo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Age, microbiota, and T cells shape diverse individual IgA repertoires in the intestine

(2012) Cornelia Lindner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IgA Response in Preterm Neonates Shows Little Evidence of Antigen-Driven Selection

(2012) T. Rogosch et al.   JOURNAL OF IMMUNOLOGY

Diversification of the primary antibody repertoire begins during early follicle development in the rabbit appendix

(2012) Shi-Kang Zhai et al.   MOLECULAR IMMUNOLOGY

Re-utilization of germinal centers in multiple Peyer's patches results in highly synchronized, oligoclonal and affinity-matured gut IgA responses

(2012) P Bergqvist et al.   Mucosal Immunology

Divergent transcriptional programming of class-specific B cell memory by T-bet and RORα

(2012) Nathaniel S Wang et al.   NATURE IMMUNOLOGY

The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells

(2012) Takashi Kanaya et al.   NATURE IMMUNOLOGY

The Inhibitory Receptor PD-1 Regulates IgA Selection and Bacterial Composition in the Gut

(2012) S. Kawamoto et al.   SCIENCE

Differential RET Signaling Pathways Drive Development of the Enteric Lymphoid and Nervous Systems

(2012) A. Patel et al.   Science Signaling

The role of Peyer’s patches in synchronizing gut IgA responses

(2012) Nils Y. Lycke et al.   Frontiers in Immunology

Lymph node B lymphocyte trafficking is constrained by anatomy and highly dependent upon chemoattractant desensitization

(2011) C. Park et al.   BLOOD

MyD88 and Retinoic Acid Signaling Pathways Interact to Modulate Gastrointestinal Activities of Dendritic Cells

(2011) Eduardo J. Villablanca et al.   GASTROENTEROLOGY

Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion

(2011) Rimpei Morita et al.   IMMUNITY

The habitat, double life, citizenship, and forgetfulness of IgA

(2011) Andrew J. Macpherson et al.   IMMUNOLOGICAL REVIEWS

CCR6hiCD11cint B cells promote M-cell differentiation in Peyer's patch

(2011) Masashi Ebisawa et al.   INTERNATIONAL IMMUNOLOGY

The majority of intestinal IgA+ and IgG+ plasmablasts in the human gut are antigen-specific

(2011) Julia Benckert et al.   JOURNAL OF CLINICAL INVESTIGATION

Mice overexpressing BAFF develop a commensal flora–dependent, IgA-associated nephropathy

(2011) Douglas D. McCarthy et al.   JOURNAL OF CLINICAL INVESTIGATION

Convergent and Divergent Development among M Cell Lineages in Mouse Mucosal Epithelium

(2011) Jing Wang et al.   JOURNAL OF IMMUNOLOGY

EBI2 Guides Serial Movements of Activated B Cells and Ligand Activity Is Detectable in Lymphoid and Nonlymphoid Tissues

(2011) L. M. Kelly et al.   JOURNAL OF IMMUNOLOGY

Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense

(2011) Min Wei et al.   NATURE IMMUNOLOGY

Critical roles of chemokine receptor CCR10 in regulating memory IgA responses in intestines

(2011) S. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prion Uptake in the Gut: Identification of the First Uptake and Replication Sites

(2011) Pekka Kujala et al.   PLoS Pathogens

Adaptive Immune Regulation in the Gut: T Cell–Dependent and T Cell–Independent IgA Synthesis

(2010) Sidonia Fagarasan et al.   Annual Review of Immunology

IgA-Producing Plasma Cells Originate From Germinal Centers That Are Induced by B-Cell Receptor Engagement in Humans

(2010) Francesca Barone et al.   GASTROENTEROLOGY

The Sensing of Environmental Stimuli by Follicular Dendritic Cells Promotes Immunoglobulin A Generation in the Gut

(2010) Keiichiro Suzuki et al.   IMMUNITY

Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses

(2010) J. P. Pereira et al.   INTERNATIONAL IMMUNOLOGY

A Protease-Dependent Mechanism for Initiating T-Dependent B Cell Responses to Large Particulate Antigens

(2010) D. M. Catron et al.   JOURNAL OF IMMUNOLOGY

T Cell-Independent IgA Class Switch Recombination Is Restricted to the GALT and Occurs Prior to Manifest Germinal Center Formation

(2010) P. Bergqvist et al.   JOURNAL OF IMMUNOLOGY

Naive CD4+ T Lymphocytes Circulate through Lymphoid Organs To Interact with Endogenous Antigens and Upregulate Their Function

(2010) M. Tomura et al.   JOURNAL OF IMMUNOLOGY

Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes

(2010) Santiago F Gonzalez et al.   NATURE IMMUNOLOGY

Lymph node cortical sinus organization and relationship to lymphocyte egress dynamics and antigen exposure

(2010) I. L. Grigorova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversible Microbial Colonization of Germ-Free Mice Reveals the Dynamics of IgA Immune Responses

(2010) S. Hapfelmeier et al.   SCIENCE

The microanatomy of B cell activation

(2009) Tri Giang Phan et al.   CURRENT OPINION IN IMMUNOLOGY

A T Cell-Dependent Mechanism for the Induction of Human Mucosal Homing Immunoglobulin A-Secreting Plasmablasts

(2009) Melissa Dullaers et al.   IMMUNITY

Guidance of B Cells by the Orphan G Protein-Coupled Receptor EBI2 Shapes Humoral Immune Responses

(2009) Dominique Gatto et al.   IMMUNITY

Visualizing B cell capture of cognate antigen from follicular dendritic cells

(2009) Kazuhiro Suzuki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Germinal center reutilization by newly activated B cells

(2009) Tanja A. Schwickert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning

(2009) Trung H.M. Pham et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymph Node Stromal Cells Support Dendritic Cell-Induced Gut-Homing of T Cells

(2009) R. Molenaar et al.   JOURNAL OF IMMUNOLOGY

RANKL Is Necessary and Sufficient to Initiate Development of Antigen-Sampling M Cells in the Intestinal Epithelium

(2009) K. A. Knoop et al.   JOURNAL OF IMMUNOLOGY

IL-21 ensures TGF-β1-induced IgA isotype expression in mouse Peyer's patches

(2009) Goo-Young Seo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Uptake through glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune response

(2009) Koji Hase et al.   NATURE

Enhanced humoral immune responses against T-independent antigens in Fc / R-deficient mice

(2009) S.-i. Honda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

B-cell activating factor receptor deficiency is associated with an adult-onset antibody deficiency syndrome in humans

(2009) K. Warnatz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Requirement for Lymphoid Tissue-Inducer Cells in Isolated Follicle Formation and T Cell-Independent Immunoglobulin A Generation in the Gut

(2008) Masayuki Tsuji et al.   IMMUNITY

Sheepish B cells: evidence for antigen-independent antibody diversification in humans and mice: Figure 1.

(2008) David Tarlinton   JOURNAL OF EXPERIMENTAL MEDICINE

Somatic diversification in the absence of antigen-driven responses is the hallmark of the IgM+IgD+CD27+B cell repertoire in infants

(2008) Sandra Weller et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Stromal mesenteric lymph node cells are essential for the generation of gut-homing T cells in vivo

(2008) Swantje I. Hammerschmidt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differentiation and homing of IgA-secreting cells

(2008) J R Mora et al.   Mucosal Immunology

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

(2008) Djahida Bouskra et al.   NATURE

Intestinal Bacteria Condition Dendritic Cells to Promote IgA Production

(2008) Joanna C. Massacand et al.   PLoS One

Follicular dendritic cell networks of primary follicles and germinal centers: Phenotype and function

(2008) Christopher D.C. Allen et al.   SEMINARS IN IMMUNOLOGY