Regulation of antitumour CD8 T-cell immunity and checkpoint blockade immunotherapy by Neuropilin-1

Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells

(2018) Bertram Bengsch et al.   IMMUNITY

A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

(2018) Daniela S. Thommen et al.   NATURE MEDICINE

Transcription Factor IRF4 Promotes CD8 + T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection

(2017) Kevin Man et al.   IMMUNITY

The EGR2 targets LAG-3 and 4-1BB describe and regulate dysfunctional antigen-specific CD8 + T cells in the tumor microenvironment

(2017) Jason B. Williams et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

(2016) N. McGranahan et al.   SCIENCE

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

(2015) Suzanne L. Topalian et al.   CANCER CELL

The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells

(2015) Gustavo J. Martinez et al.   IMMUNITY

Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

(2015) N. A. Rizvi et al.   SCIENCE

Novel expression of Neuropilin 1 on human tumor-infiltrating lymphocytes in colorectal cancer liver metastases

(2014) Belal Chaudhary et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Protein kinase LKB1 promotes RAB7-mediated neuropilin-1 degradation to inhibit angiogenesis

(2014) Imoh S. Okon et al.   JOURNAL OF CLINICAL INVESTIGATION

Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1–dependent ABL1 activation in endothelial cells

(2014) Claudio Raimondi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

(2014) Roy S. Herbst et al.   NATURE

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

Neuropilin-1 Expression Is Induced on Tolerant Self-Reactive CD8+ T Cells but Is Dispensable for the Tolerant Phenotype

(2014) Stephanie R. Jackson et al.   PLoS One

T-Cell and NK-Cell Infiltration into Solid Tumors: A Key Limiting Factor for Efficacious Cancer Immunotherapy

(2014) I. Melero et al.   Cancer Discovery

Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis

(2013) Greg M. Delgoffe et al.   NATURE

Semaphorins and neuropilins: new players in the neuroendocrine control of the intrathymic T-cell migration in humans

(2012) Daniella Arêas Mendes-da-Cruz et al.   EXPERIMENTAL PHYSIOLOGY

Developing T-cell migration: role of semaphorins and ephrins

(2012) Daniella Arêas Mendes-da-Cruz et al.   FASEB JOURNAL

Neuropilin 1 deficiency on CD4+Foxp3+regulatory T cells impairs mouse melanoma growth

(2012) Wiebke Hansen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo

(2012) Mahesh Yadav et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Minimal Engagement of CD103 on Cytotoxic T Lymphocytes with an E-Cadherin-Fc Molecule Triggers Lytic Granule Polarization via a Phospholipase Cγ–Dependent Pathway

(2011) Audrey Le Floc'h et al.   CANCER RESEARCH

Inhibitory effect of semaphorin-3A, a known axon guidance molecule, in the human thymocyte migration induced by CXCL12

(2011) Flavia Garcia et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+T cell dysfunction in melanoma patients

(2010) Julien Fourcade et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neuropilins in Tumor Biology

(2009) A. Bagri et al.   CLINICAL CANCER RESEARCH

Neuropilin‐1 is not a marker of human Foxp3+Treg

(2009) Pierre Milpied et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Role for the Transcriptional Repressor Blimp-1 in CD8+ T Cell Exhaustion during Chronic Viral Infection

(2009) Haina Shin et al.   IMMUNITY

Neuropilins: structure, function and role in disease

(2008) Caroline Pellet-Many et al.   BIOCHEMICAL JOURNAL

Neuropilins: a versatile partner of extracellular molecules that regulate development and disease

(2008) Katarzyna Adela Uniewicz   Frontiers in Bioscience-Landmark

Selective expansion of a subset of exhausted CD8 T cells by  PD-L1 blockade

(2008) S. D. Blackburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropilin-1 expression identifies a subset of regulatory T cells in human lymph nodes that is modulated by preoperative chemoradiation therapy in cervical cancer

(2007) Alessandra Battaglia et al.   IMMUNOLOGY