Rapid clearance of cellular debris by microglia limits secondary neuronal cell death after brain injury in vivo

Tumor initiating cells induce Cxcr4-mediated infiltration of pro-tumoral macrophages into the brain

(2018) Kelda Chia et al.   eLife

Glutamate Neurotransmission in Rodent Models of Traumatic Brain Injury

(2017) Christopher R. Dorsett et al.   JOURNAL OF NEUROTRAUMA

A Tol2 Gateway-Compatible Toolbox for the Study of the Nervous System and Neurodegenerative Disease

(2017) Emily K. Don et al.   Zebrafish

Neuroprotection Trials in Traumatic Brain Injury

(2016) Shamik Chakraborty et al.   Current Neurology and Neuroscience Reports

Spinal motor neurons are regenerated after mechanical lesion and genetic ablation in larval zebrafish

(2016) Jochen Ohnmacht et al.   DEVELOPMENT

Clearing the corpses: regulatory mechanisms, novel tools, and therapeutic potential of harnessing microglial phagocytosis in the diseased brain

(2016) Amanda Sierra et al.   Neural Regeneration Research

Past, Present, and Future of Traumatic Brain Injury Research

(2016) Gregory W.J. Hawryluk et al.   NEUROSURGERY CLINICS OF NORTH AMERICA

A Model of Excitotoxic Brain Injury in Larval Zebrafish: Potential Application for High-Throughput Drug Evaluation to Treat Traumatic Brain Injury

(2016) Victoria McCutcheon et al.   Zebrafish

Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling

(2016) Oihane Abiega et al.   PLOS BIOLOGY

Defining the gene repertoire and spatiotemporal expression profiles of adhesion G protein-coupled receptors in zebrafish

(2015) Breanne L Harty et al.   BMC GENOMICS

A tale of two domains - a structural perspective of the pseudokinase, MLKL

(2015) Peter E. Czabotar et al.   FEBS Journal

Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Deficiency Attenuates Phagocytic Activities of Microglia and Exacerbates Ischemic Damage in Experimental Stroke

(2015) M. Kawabori et al.   JOURNAL OF NEUROSCIENCE

Wild-type microglia do not reverse pathology in mouse models of Rett syndrome

(2015) Jieqi Wang et al.   NATURE

In vivo characterization of microglial engulfment of dying neurons in the zebrafish spinal cord

(2015) Marco Morsch et al.   Frontiers in Cellular Neuroscience

The Macrophage-Specific Promoter mfap4 Allows Live, Long-Term Analysis of Macrophage Behavior during Mycobacterial Infection in Zebrafish

(2015) Eric M. Walton et al.   PLoS One

Oxidative Stress in Traumatic Brain Injury

(2014) Ana Rodriguez-Rodriguez et al.   CURRENT MEDICINAL CHEMISTRY

Calcium-Dependent Neuroepithelial Contractions Expel Damaged Cells from the Developing Brain

(2014) Leah Herrgen et al.   DEVELOPMENTAL CELL

Redox and Src family kinase signaling control leukocyte wound attraction and neutrophil reverse migration

(2014) Sebastien Tauzin et al.   JOURNAL OF CELL BIOLOGY

Phagocytosis of Microglia in the Central Nervous System Diseases

(2014) Ruying Fu et al.   MOLECULAR NEUROBIOLOGY

Microglial phagocytosis of live neurons

(2014) Guy C. Brown et al.   NATURE REVIEWS NEUROSCIENCE

Distinct roles for BAI1 and TIM-4 in the engulfment of dying neurons by microglia

(2014) Fargol Mazaheri et al.   Nature Communications

Microglial CD33-Related Siglec-E Inhibits Neurotoxicity by Preventing the Phagocytosis-Associated Oxidative Burst

(2013) J. Claude et al.   JOURNAL OF NEUROSCIENCE

Ultrasensitive fluorescent proteins for imaging neuronal activity

(2013) Tsai-Wen Chen et al.   NATURE

Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system

(2013) Li-En Jao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis

(2013) Amanda Sierra et al.   Frontiers in Cellular Neuroscience

Apoptotic Cells Are Cleared by Directional Migration and elmo1- Dependent Macrophage Engulfment

(2012) Tjakko J. van Ham et al.   CURRENT BIOLOGY

Long-Range Ca2+ Waves Transmit Brain-Damage Signals to Microglia

(2012) Dirk Sieger et al.   DEVELOPMENTAL CELL

Early redox, Src family kinase, and calcium signaling integrate wound responses and tissue regeneration in zebrafish

(2012) Sa Kan Yoo et al.   JOURNAL OF CELL BIOLOGY

Lesion-induced generation of interneuron cell types in specific dorsoventral domains in the spinal cord of adult zebrafish

(2012) Veronika Kuscha et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Wild-type microglia arrest pathology in a mouse model of Rett syndrome

(2012) Noël C. Derecki et al.   NATURE

Temporal Changes in Cell Marker Expression and Cellular Infiltration in a Controlled Cortical Impact Model in Adult Male C57BL/6 Mice

(2012) Xuemei Jin et al.   PLoS One

Host-Pathogen Interactions Made Transparent with the Zebrafish Model

(2011) Annemarie H. Meijer et al.   CURRENT DRUG TARGETS

Individual axons regulate the myelinating potential of single oligodendrocytes in vivo

(2011) R. G. Almeida et al.   DEVELOPMENT

Regeneration of the adult zebrafish brain from neurogenic radial glia-type progenitors

(2011) V. Kroehne et al.   DEVELOPMENT

Inhibition of Microglial Phagocytosis Is Sufficient To Prevent Inflammatory Neuronal Death

(2011) J. J. Neher et al.   JOURNAL OF IMMUNOLOGY

Phagocytic activity of neuronal progenitors regulates adult neurogenesis

(2011) Zhenjie Lu et al.   NATURE CELL BIOLOGY

mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafish

(2010) F. Ellett et al.   BLOOD

The inhibitor of phagocytosis, O-phospho-l-serine, suppresses Müller glia proliferation and cone cell regeneration in the light-damaged zebrafish retina

(2010) Travis J. Bailey et al.   EXPERIMENTAL EYE RESEARCH

Live imaging of apoptotic cells in zebrafish

(2010) Tjakko J. van Ham et al.   FASEB JOURNAL

Fractalkine Attenuates Excito-neurotoxicity via Microglial Clearance of Damaged Neurons and Antioxidant Enzyme Heme Oxygenase-1 Expression

(2010) Mariko Noda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-throughput in vivo vertebrate screening

(2010) Carlos Pardo-Martin et al.   NATURE METHODS

Cell death mechanisms and modulation in traumatic brain injury

(2010) Bogdan A. Stoica et al.   Neurotherapeutics

Dually inducible TetON systems for tissue-specific conditional gene expression in zebrafish

(2010) F. Knopf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Traumatic brain injury: Can the consequences be stopped?

(2008) E. Park et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Live Imaging of Neuronal Degradation by Microglia Reveals a Role for v0-ATPase a1 in Phagosomal Fusion In Vivo

(2008) Francesca Peri et al.   CELL

Microglia Cells Protect Neurons by Direct Engulfment of Invading Neutrophil Granulocytes: A New Mechanism of CNS Immune Privilege

(2008) J. Neumann et al.   JOURNAL OF NEUROSCIENCE

Moderate and severe traumatic brain injury in adults

(2008) Andrew IR Maas et al.   LANCET NEUROLOGY