The Role of RNA Splicing Factors in Cancer: Regulation of Viral and Human Gene Expression in Human Papillomavirus-Related Cervical Cancer

Long non‐coding RNA ARAP1‐AS1 promotes tumorigenesis and metastasis through facilitating proto‐oncogene c‐Myc translation via dissociating PSF/PTB dimer in cervical cancer

(2020) Yao Zhang et al.   Cancer Medicine

The Role of microRNAs, Long Non-coding RNAs, and Circular RNAs in Cervical Cancer

(2020) Maria Lina Tornesello et al.   Frontiers in Oncology

Human papillomavirus type 16 infection activates the host serine arginine protein kinase 1 (SRPK1) – splicing factor axis

(2020) Sarah Mole et al.   JOURNAL OF GENERAL VIROLOGY

Roles and mechanisms of alternative splicing in cancer — implications for care

(2020) Sophie C. Bonnal et al.   Nature Reviews Clinical Oncology

Transcription of human papillomavirus oncogenes in head and neck squamous cell carcinomas

(2020) Zurab Bzhalava et al.   VACCINE

Role of human papillomavirus infection in the etiology of vulvar cancer in Italian women

(2020) Mario Preti et al.   Infectious Agents and Cancer

Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes

(2019) Berthold Kastner et al.   Cold Spring Harbor Perspectives in Biology

Oncogenic splicing factor SRSF3 regulates ILF3 alternative splicing to promote cancer cell proliferation and transformation

(2019) Rong Jia et al.   RNA

Sirtuin-mediated deacetylation of hnRNP A1 suppresses glycolysis and growth in hepatocellular carcinoma

(2019) Hao Yang et al.   ONCOGENE

Correction: Control of PD-L1 expression by miR-140/142/340/383 and oncogenic activation of the OCT4–miR-18a pathway in cervical cancer

(2019) Peixin Dong et al.   ONCOGENE

Comparative RNA sequencing reveals that HPV16 E6 abrogates the effect of E6*I on ROS metabolism

(2019) Philippe Paget-Bailly et al.   Scientific Reports

Inhibition of SF3b1 by pladienolide B evokes cycle arrest, apoptosis induction and p73 splicing in human cervical carcinoma cells

(2019) Qianjing Zhang et al.   Artificial Cells Nanomedicine and Biotechnology

Myelodysplastic Syndrome-Associated SRSF2 Mutations Cause Splicing Changes by Altering Binding Motif Sequences

(2019) So Masaki et al.   Frontiers in Genetics

The RNA-binding protein SRSF1 is a key cell cycle regulator via stabilizing NEAT1 in glioma

(2019) Xuexia Zhou et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Pan-cancer analysis of clinical relevance of alternative splicing events in 31 human cancers

(2019) Yangjun Zhang et al.   ONCOGENE

Alternative Splicing Regulatory Networks: Functions, Mechanisms, and Evolution

(2019) Jernej Ule et al.   MOLECULAR CELL

Long non-coding RNA MIR205HG regulates KRT17 and tumor processes in cervical cancer via interaction with SRSF1

(2019) Mingli Dong et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Mobilization of a splicing factor through a nuclear kinase–kinase complex

(2018) Brandon E. Aubol et al.   BIOCHEMICAL JOURNAL

SRSF5 functions as a novel oncogenic splicing factor and is upregulated by oncogene SRSF3 in oral squamous cell carcinoma

(2018) Sisi Yang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

LncRNA XIST accelerates cervical cancer progression via upregulating Fus through competitively binding with miR-200a

(2018) Hong Zhu et al.   BIOMEDICINE & PHARMACOTHERAPY

Long non-coding RNA linc00460 promotes epithelial-mesenchymal transition and cell migration in lung cancer cells

(2018) Ke Li et al.   CANCER LETTERS

microRNA-mediated regulation of splicing factors SRSF1, SRSF2 and hnRNP A1 in context of their alternatively spliced 3′UTRs

(2018) Elżbieta Sokół et al.   EXPERIMENTAL CELL RESEARCH

Regulation of alternative mRNA splicing: old players and new perspectives

(2018) Heidi Dvinge   FEBS LETTERS

A comprehensive characterization ofcis-acting splicing-associated variants in human cancer

(2018) Yuichi Shiraishi et al.   GENOME RESEARCH

Prognostic significance of SRSF2 mutations in myelodysplastic syndromes and chronic myelomonocytic leukemia: a meta-analysis

(2018) Pourya Arbab Jafari et al.   Hematology

Understanding the HPV integration and its progression to cervical cancer

(2018) Mariel Araceli Oyervides-Muñoz et al.   INFECTION GENETICS AND EVOLUTION

High-Risk Human Papillomaviral Oncogenes E6 and E7 Target Key Cellular Pathways to Achieve Oncogenesis

(2018) Nicole Yeo-Teh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

hnRNP G prevents inclusion on the HPV16 L1 mRNAs of the central exon between splice sites SA3358 and SD3632

(2018) Haoran Yu et al.   JOURNAL OF GENERAL VIROLOGY

SRSF2 mutations drive oncogenesis by activating a global program of aberrant alternative splicing in hematopoietic cells

(2018) Yang Liang et al.   LEUKEMIA

The DNA damage response activates HPV16 late gene expression at the level of RNA processing

(2018) Kersti Nilsson et al.   NUCLEIC ACIDS RESEARCH

SRSF10-mediated IL1RAP alternative splicing regulates cervical cancer oncogenesis via mIL1RAP-NF-κB-CD47 axis

(2018) Fei Liu et al.   ONCOGENE

Splicing factors as regulators of miRNA biogenesis – links to human disease

(2018) Madara Ratnadiwakara et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Role of E6 Spliced Isoforms (E6*) in Human Papillomavirus-Induced Carcinogenesis

(2018) Leslie Olmedo-Nieva et al.   Viruses-Basel

Structural basis for terminal loop recognition and stimulation of pri-miRNA-18a processing by hnRNP A1

(2018) Hamed Kooshapur et al.   Nature Communications

Regulatory role of resveratrol, a microRNA-controlling compound, in HNRNPA1 expression, which is associated with poor prognosis in breast cancer

(2018) Kurataka Otsuka et al.   Oncotarget

RNA-binding protein AUF1 suppresses miR-122 biogenesis by down-regulating Dicer1 in hepatocellular carcinoma

(2018) Xia Wu et al.   Oncotarget

Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types

(2018) Michael Seiler et al.   Cell Reports

Alternative-splicing defects in cancer: Splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics

(2018) Laura M. Urbanski et al.   Wiley Interdisciplinary Reviews-RNA

Poly(rC) binding protein 2 (PCBP2) promotes the viability of human gastric cancer cells by regulating CDK2

(2018) Changyu Chen et al.   FEBS Open Bio

Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers

(2018) Maria Lina Tornesello et al.   Cancers

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

(2018) André Kahles et al.   CANCER CELL

Upregulated microRNA-193a-3p is responsible for cisplatin resistance in CD44(+) gastric cancer cells

(2018) So D. Lee et al.   CANCER SCIENCE

Function, clinical application, and strategies of Pre-mRNA splicing in cancer

(2018) Cuixia Di et al.   CELL DEATH AND DIFFERENTIATION

Characterization of HPV integration, viral gene expression and E6E7 alternative transcripts by RNA-Seq: A descriptive study in invasive cervical cancer

(2018) Ayslan C. Brant et al.   GENOMICS

Distinct mechanisms govern the phosphorylation of different SR protein splicing factors

(2018) Yunxin Long et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

microRNA-802 inhibits cell proliferation and induces apoptosis in human cervical cancer by targeting serine/arginine-rich splicing factor 9

(2018) Qianwen Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Serine arginine protein kinase 1 (SRPK1): a moonlighting protein with theranostic ability in cancer prevention

(2018) Mitesh Patel et al.   MOLECULAR BIOLOGY REPORTS

O-GlcNAc-induced nuclear translocation of hnRNP-K is associated with progression and metastasis of cholangiocarcinoma

(2018) Chatchai Phoomak et al.   Molecular Oncology

Modulation of MKNK2 alternative splicing by splice-switching oligonucleotides as a novel approach for glioblastoma treatment

(2018) Maxim Mogilevsky et al.   NUCLEIC ACIDS RESEARCH

Aberrant RNA Splicing in Cancer and Drug Resistance

(2018) Bi-Dar Wang et al.   Cancers

HnRNPM and CD44s expression affects tumor aggressiveness and predicts poor prognosis in breast cancer with axillary lymph node metastases

(2017) Huizhi Sun et al.   GENES CHROMOSOMES & CANCER

SRSF6-regulated alternative splicing that promotes tumour progression offers a therapy target for colorectal cancer

(2017) Ledong Wan et al.   GUT

Protein kinases that phosphorylate splicing factors: Roles in cancer development, progression and possible therapeutic options

(2017) Alicja Czubaty et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

HNRNPA1, a Splicing Regulator, Is an Effective Target Protein for Cervical Cancer Detection

(2017) Young-Jon Kim et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Therapeutic Applications of Targeted Alternative Splicing to Cancer Treatment

(2017) Jung-Chun Lin   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Splicing and Polyadenylation of Human Papillomavirus Type 16 mRNAs

(2017) Chengjun Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fyn/heterogeneous nuclear ribonucleoprotein E1 signaling regulates pancreatic cancer metastasis by affecting the alternative splicing of integrin β1

(2017) Peng Jiang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Protein Sam68 regulates the alternative splicing of survivin DEx3

(2017) Javier Gaytan-Cervantes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SR Proteins: Binders, Regulators, and Connectors of RNA

(2017) Sunjoo Jeong   MOLECULES AND CELLS

Mechanistic insights into precursor messenger RNA splicing by the spliceosome

(2017) Yigong Shi   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Alternative splicing as a regulator of development and tissue identity

(2017) Francisco E. Baralle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

hnRNP L controls HPV16 RNA polyadenylation and splicing in an Akt kinase-dependent manner

(2017) Naoko Kajitani et al.   NUCLEIC ACIDS RESEARCH

Proteomic identification of potential biomarkers for cervical squamous cell carcinoma and human papillomavirus infection

(2017) Song Qing et al.   TUMOR BIOLOGY

Control of human papillomavirus gene expression by alternative splicing

(2017) Sheila V. Graham et al.   VIRUS RESEARCH

Theophylline exhibits anti-cancer activity via suppressing SRSF3 in cervical and breast cancer cell lines

(2017) Yung-Lung Chang et al.   Oncotarget

Gene expression profiling reveals U1 snRNA regulates cancer gene expression

(2017) Zhi Cheng et al.   Oncotarget

HnRNP-L mediates bladder cancer progression by inhibiting apoptotic signaling and enhancing MAPK signaling pathways

(2017) Daojun Lv et al.   Oncotarget

Comparative analysis of HPV16 gene expression profiles in cervical and in oropharyngeal squamous cell carcinoma

(2017) Andrea Cerasuolo et al.   Oncotarget

The Functional Impact of Alternative Splicing in Cancer

(2017) Héctor Climente-González et al.   Cell Reports

Regulation of hnRNPA1 by microRNAs controls the miR-18a–K-RAS axis in chemotherapy-resistant ovarian cancer

(2017) Cristian Rodriguez-Aguayo et al.   Cell Discovery

Knockdown of HNRNPA1 inhibits lung adenocarcinoma cell proliferation through cell cycle arrest at G0/G1 phase

(2016) Xianxun Liu et al.   GENE

The hnRNP family: insights into their role in health and disease

(2016) Thomas Geuens et al.   HUMAN GENETICS

Upregulation of AUF1 is involved in the proliferation of esophageal squamous cell carcinoma through GCH1

(2016) Yi Gao et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Serine/Arginine-Rich Splicing Factor 3 and Heterogeneous Nuclear Ribonucleoprotein A1 Regulate Alternative RNA Splicing and Gene Expression of Human Papillomavirus 18 through Two Functionally DistinguishablecisElements

(2016) Masahiko Ajiro et al.   JOURNAL OF VIROLOGY

Human Papillomavirus E2 Regulates SRSF3 (SRp20) To Promote Capsid Protein Expression in Infected Differentiated Keratinocytes

(2016) T. Klymenko et al.   JOURNAL OF VIROLOGY

Human Papillomavirus E2 Protein: Linking Replication, Transcription, and RNA Processing

(2016) Sheila V. Graham   JOURNAL OF VIROLOGY

SRSF5: a novel marker for small-cell lung cancer and pleural metastatic cancer

(2016) Hak-Ryul Kim et al.   LUNG CANCER

Therapeutic targeting of splicing in cancer

(2016) Stanley Chun-Wei Lee et al.   NATURE MEDICINE

The Papillomavirus Episteme: a major update to the papillomavirus sequence database

(2016) Koenraad Van Doorslaer et al.   NUCLEIC ACIDS RESEARCH

Splice-switching antisense oligonucleotides as therapeutic drugs

(2016) Mallory A. Havens et al.   NUCLEIC ACIDS RESEARCH

Pharmacology of Modulators of Alternative Splicing

(2016) David O. Bates et al.   PHARMACOLOGICAL REVIEWS

Splicing-factor alterations in cancers

(2016) Olga Anczuków et al.   RNA

The Spliceosome: The Ultimate RNA Chaperone and Sculptor

(2016) Panagiotis Papasaikas et al.   TRENDS IN BIOCHEMICAL SCIENCES

HnRNP-L promotes prostate cancer progression by enhancing cell cycling and inhibiting apoptosis

(2016) Xumin Zhou et al.   Oncotarget

Upregulation of p27 cyclin-dependent kinase inhibitor and a C-terminus truncated form of p27 contributes to G1 phase arrest

(2016) Takayuki Satoh et al.   Scientific Reports

Modulating splicing with small molecular inhibitors of the spliceosome

(2016) Kerstin A. Effenberger et al.   Wiley Interdisciplinary Reviews-RNA

Carcinogenic human papillomavirus infection

(2016) Mark Schiffman et al.   Nature Reviews Disease Primers

Alternative splicing as a biomarker and potential target for drug discovery

(2015) Kai-qin Le et al.   ACTA PHARMACOLOGICA SINICA

Mechanisms and Regulation of Alternative Pre-mRNA Splicing

(2015) Yeon Lee et al.   Annual Review of Biochemistry

hnRNP K Is a Haploinsufficient Tumor Suppressor that Regulates Proliferation and Differentiation Programs in Hematologic Malignancies

(2015) Miguel Gallardo et al.   CANCER CELL

CLK2 Is an Oncogenic Kinase and Splicing Regulator in Breast Cancer

(2015) T. Yoshida et al.   CANCER RESEARCH

Combinatorial control ofDrosophilacircular RNA expression by intronic repeats, hnRNPs, and SR proteins

(2015) Marianne C. Kramer et al.   GENES & DEVELOPMENT

Heterogeneous Nuclear Ribonucleoprotein C Proteins Interact with the Human Papillomavirus Type 16 (HPV16) Early 3′-Untranslated Region and Alleviate Suppression of HPV16 Late L1 mRNA Splicing

(2015) Soniya Dhanjal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circulating U2 small nuclear RNA fragments as a diagnostic and prognostic biomarker in lung cancer patients

(2015) Jens Köhler et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Oral squamous cancer cell exploits hnRNP A1 to regulate cell cycle and proliferation

(2015) Cheng Yu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The RNA-binding protein Sam68 regulates tumor cell viability and hepatic carcinogenesis by inhibiting the transcriptional activity of FOXOs

(2015) Tingting Zhang et al.   JOURNAL OF MOLECULAR HISTOLOGY

Characterization of the Human Papillomavirus 16 E8 Promoter

(2015) Elke Straub et al.   JOURNAL OF VIROLOGY

Human Papillomavirus 16 Oncoprotein Expression Is Controlled by the Cellular Splicing Factor SRSF2 (SC35)

(2015) Melanie McFarlane et al.   JOURNAL OF VIROLOGY

SRSF2 Is Essential for Hematopoiesis, and Its Myelodysplastic Syndrome-Related Mutations Dysregulate Alternative Pre-mRNA Splicing

(2015) Yukiko Komeno et al.   MOLECULAR AND CELLULAR BIOLOGY

Involvement of SRSF11 in cell cycle-specific recruitment of telomerase to telomeres at nuclear speckles

(2015) Ji Hoon Lee et al.   NUCLEIC ACIDS RESEARCH

A genome landscape of SRSF3-regulated splicing events and gene expression in human osteosarcoma U2OS cells

(2015) Masahiko Ajiro et al.   NUCLEIC ACIDS RESEARCH

Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes

(2015) A Sveen et al.   ONCOGENE

Inhibitors of CLK Protein Kinases Suppress Cell Growth and Induce Apoptosis by Modulating Pre-mRNA Splicing

(2015) Shinsuke Araki et al.   PLoS One

A proteomic approach to discover and compare interacting partners of papillomavirus E2 proteins from diverse phylogenetic groups

(2015) Moon Kyoo Jang et al.   PROTEOMICS

Human papillomavirus molecular biology and disease association

(2015) John Doorbar et al.   REVIEWS IN MEDICAL VIROLOGY

E6^E7, a Novel Splice Isoform Protein of Human Papillomavirus 16, Stabilizes Viral E6 and E7 Oncoproteins via HSP90 and GRP78

(2015) Masahiko Ajiro et al.   mBio

Activation of MET via Diverse Exon 14 Splicing Alterations Occurs in Multiple Tumor Types and Confers Clinical Sensitivity to MET Inhibitors

(2015) G. M. Frampton et al.   Cancer Discovery

Bortezomib inhibits Burkitt’s lymphoma cell proliferation by downregulating sumoylated hnRNP K and c-Myc expression

(2015) Fat-Moon Suk et al.   Oncotarget

The RNA-binding protein Sam68 regulates expression and transcription function of the androgen receptor splice variant AR-V7

(2015) Jacqueline Stockley et al.   Scientific Reports

SWI/SNF complexes are required for full activation of the DNA-damage response

(2015) Stephanie L. Smith-Roe et al.   Oncotarget

High Sam68 expression predicts poor prognosis in non-small cell lung cancer

(2014) Z. Zhang et al.   Clinical & Translational Oncology

Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43

(2014) Diane Moujalled et al.   HUMAN MOLECULAR GENETICS

Human Papillomavirus Type 16 E6* Induces Oxidative Stress and DNA Damage

(2014) V. M. Williams et al.   JOURNAL OF VIROLOGY

Serine–arginine protein kinase 1 (SRPK1) inhibition as a potential novel targeted therapeutic strategy in prostate cancer

(2014) A Mavrou et al.   ONCOGENE

Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells

(2014) V. Goncalves et al.   RNA

SR proteins control a complex network of RNA-processing events

(2014) Todd Bradley et al.   RNA

Mapping of HPV transcripts in four human cervical lesions using RNAseq suggests quantitative rearrangements during carcinogenic progression

(2014) Jinmiao Chen et al.   VIROLOGY

The small splice variant of HPV16 E6, E6⁎, reduces tumor formation in cervical carcinoma xenografts

(2014) Maria Filippova et al.   VIROLOGY

BCLAF1 and its splicing regulator SRSF10 regulate the tumorigenic potential of colon cancer cells

(2014) Xuexia Zhou et al.   Nature Communications

The RNAissance family: SR proteins as multifaceted regulators of gene expression

(2014) Jonathan M. Howard et al.   Wiley Interdisciplinary Reviews-RNA

Exon identity crisis: disease-causing mutations that disrupt the splicing code

(2014) Timothy Sterne-Weiler et al.   GENOME BIOLOGY

Lobaplatin arrests cell cycle progression, induces apoptosis and alters the proteome in human cervical cancer cell Line CaSki

(2013) Xiaoqin Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Beyond Secondary Structure: Primary-Sequence Determinants License Pri-miRNA Hairpins for Processing

(2013) Vincent C. Auyeung et al.   CELL

Splicing factor SRSF3 represses the translation of programmed cell death 4 mRNA by associating with the 5′-UTR region

(2013) J Kim et al.   CELL DEATH AND DIFFERENTIATION

Regulation of splicing by SR proteins and SR protein-specific kinases

(2013) Zhihong Zhou et al.   CHROMOSOMA

SRSF1 and SRSF9 RNA binding proteins promote Wnt signalling-mediated tumorigenesis by enhancing β-catenin biosynthesis

(2013) Yu Fu et al.   EMBO Molecular Medicine

Caffeine induces tumor cytotoxicity via the regulation of alternative splicing in subsets of cancer-associated genes

(2013) Guan-Yu Lu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Heterogeneous Nuclear Ribonucleoprotein K (hnRNP-K) Promotes Tumor Metastasis by Induction of Genes Involved in Extracellular Matrix, Cell Movement, and Angiogenesis

(2013) Ran Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Emerging patterns of somatic mutations in cancer

(2013) Ian R. Watson et al.   NATURE REVIEWS GENETICS

Regulation of human papillomavirus gene expression by splicing and polyadenylation

(2013) Cecilia Johansson et al.   NATURE REVIEWS MICROBIOLOGY

Suppression of HPV-16 late L1 5′-splice site SD3632 by binding of hnRNP D proteins and hnRNP A2/B1 to upstream AUAGUA RNA motifs

(2013) Xiaoze Li et al.   NUCLEIC ACIDS RESEARCH

The centrosomal kinase NEK2 is a novel splicing factor kinase involved in cell survival

(2013) C. Naro et al.   NUCLEIC ACIDS RESEARCH

Hallmarks of alternative splicing in cancer

(2013) S Oltean et al.   ONCOGENE

Arginine Methylation of hnRNP A2 Does Not Directly Govern Its Subcellular Localization

(2013) Lexie R. Friend et al.   PLoS One

Eight Nucleotide Substitutions Inhibit Splicing to HPV-16 3′-Splice Site SA3358 and Reduce the Efficiency by which HPV-16 Increases the Life Span of Primary Human Keratinocytes

(2013) Xiaoze Li et al.   PLoS One

Estrogen Alters the Splicing of Type 1 Corticotropin-Releasing Hormone Receptor in Breast Cancer Cells

(2013) S. Lal et al.   Science Signaling

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Specific interaction between hnRNP H and HPV16 L1 proteins: Implications for late gene auto-regulation enabling rapid viral capsid protein production

(2012) Zi-Zheng Zheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

How does Tra2β protein regulate tissue-specific RNA splicing?

(2012) David J. Elliott et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage

(2012) Seong Won Lee et al.   EMBO JOURNAL

SRp20 is a proto-oncogene critical for cell proliferation and tumor induction and maintenance

(2012) Rong Jia et al.   International Journal of Biological Sciences

Overexpression of HnRNP A1 promotes tumor invasion through regulating CD44v6 and indicates poor prognosis for hepatocellular carcinoma

(2012) Zheng-Jun Zhou et al.   INTERNATIONAL JOURNAL OF CANCER

Heterogeneous Nuclear Ribonucleoprotein C1/C2 Controls the Metastatic Potential of Glioblastoma by Regulating PDCD4

(2012) Y. M. Park et al.   MOLECULAR AND CELLULAR BIOLOGY

Tissue-Specific Splicing of Disordered Segments that Embed Binding Motifs Rewires Protein Interaction Networks

(2012) Marija Buljan et al.   MOLECULAR CELL

mRNA Decay Factor AUF1 Maintains Normal Aging, Telomere Maintenance, and Suppression of Senescence by Activation of Telomerase Transcription

(2012) Adam R. Pont et al.   MOLECULAR CELL

Intron Definition and a Branch Site Adenosine at nt 385 Control RNA Splicing of HPV16 E6*I and E7 Expression

(2012) Masahiko Ajiro et al.   PLoS One

The Biology and Life-Cycle of Human Papillomaviruses

(2012) John Doorbar et al.   VACCINE

Oncogenic Splicing Factor SRSF1 Is a Critical Transcriptional Target of MYC

(2012) Shipra Das et al.   Cell Reports

The significant other: splicing by the minor spliceosome

(2012) Janne J. Turunen et al.   Wiley Interdisciplinary Reviews-RNA

Sam68 expression and cytoplasmic localization is correlated with lymph node metastasis as well as prognosis in patients with early-stage cervical cancer

(2011) Z. Li et al.   ANNALS OF ONCOLOGY

Splicing Factor hnRNP A2/B1 Regulates Tumor Suppressor Gene Splicing and Is an Oncogenic Driver in Glioblastoma

(2011) R. Golan-Gerstl et al.   CANCER RESEARCH

The RNA-binding protein Sam68 is a multifunctional player in human cancer

(2011) P. Bielli et al.   ENDOCRINE-RELATED CANCER

Transcriptional analysis of human papillomavirus type 16 in histological sections of cervical dysplasia by in situ hybridisation

(2011) V M Coupe et al.   JOURNAL OF CLINICAL PATHOLOGY

Serine/arginine-rich protein 30c activates human papillomavirus type 16 L1 mRNA expression via a bimodal mechanism

(2011) M. Somberg et al.   JOURNAL OF GENERAL VIROLOGY

Human Papillomavirus in Men

(2011) Anna-Barbara Moscicki et al.   Journal of Lower Genital Tract Disease

hnRNP F directs formation of an exon 4 minus variant of tumor-associated NADH oxidase (ENOX2)

(2011) Xiaoyu Tang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The HPV transcriptome in HPV16 positive cell lines

(2011) Markus Schmitt et al.   MOLECULAR AND CELLULAR PROBES

SRSF1 Regulates the Alternative Splicing of Caspase 9 Via A Novel Intronic Splicing Enhancer Affecting the Chemotherapeutic Sensitivity of Non-Small Cell Lung Cancer Cells

(2011) J. C. Shultz et al.   MOLECULAR CANCER RESEARCH

Activation and repression functions of an SR splicing regulator depend on exonic versus intronic-binding position

(2011) Manli Shen et al.   NUCLEIC ACIDS RESEARCH

hnRNP A1 and hnRNP F Modulate the Alternative Splicing of Exon 11 of the Insulin Receptor Gene

(2011) Indrani Talukdar et al.   PLoS One

Depletion of the histone chaperone tNASP inhibits proliferation and induces apoptosis in prostate cancer PC-3 cells

(2011) Oleg M Alekseev et al.   Reproductive Biology and Endocrinology

Identification of Evolutionarily Conserved Exons as Regulated Targets for the Splicing Activator Tra2β in Development

(2011) Sushma Grellscheid et al.   PLoS Genetics

Evolution of SR protein and hnRNP splicing regulatory factors

(2011) Anke Busch et al.   Wiley Interdisciplinary Reviews-RNA

Functional diversity of the hnRNPs: past, present and perspectives

(2010) Siew Ping Han et al.   BIOCHEMICAL JOURNAL

Deregulated expression of hnRNP A/B proteins in human non-small cell lung cancer: parallel assessment of protein and mRNA levels in paired tumour/non-tumour tissues

(2010) Georgios Boukakis et al.   BMC CANCER

Identification of ASF/SF2 as a Critical, Allele-Specific Effector of the Cyclin D1b Oncogene

(2010) N. A. Olshavsky et al.   CANCER RESEARCH

hnRNP A2/B1 Modulates Epithelial-Mesenchymal Transition in Lung Cancer Cell Lines

(2010) J. Tauler et al.   CANCER RESEARCH

Alternative Splicing of Caspase 9 Is Modulated by the Phosphoinositide 3-Kinase/Akt Pathway via Phosphorylation of SRp30a

(2010) J. C. Shultz et al.   CANCER RESEARCH

HPV16 E2 Is an Immediate Early Marker of Viral Infection, Preceding E7 Expression in Precursor Structures of Cervical Carcinoma

(2010) Y. Xue et al.   CANCER RESEARCH

Serine-arginine protein kinases: a small protein kinase family with a large cellular presence

(2010) Thomas Giannakouros et al.   FEBS Journal

Human papillomavirus: gene expression, regulation and prospects for novel diagnostic methods and antiviral therapies

(2010) Sheila V Graham   Future Microbiology

A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins)

(2010) J. L. Manley et al.   GENES & DEVELOPMENT

Sam68 up-regulation correlates with, and its down-regulation inhibits, proliferation and tumourigenicity of breast cancer cells

(2010) Libing Song et al.   JOURNAL OF PATHOLOGY

Multiple ASF/SF2 Sites in the Human Papillomavirus Type 16 (HPV-16) E4-Coding Region Promote Splicing to the Most Commonly Used 3'-Splice Site on the HPV-16 Genome

(2010) M. Somberg et al.   JOURNAL OF VIROLOGY

A Splicing-Independent Function of SF2/ASF in MicroRNA Processing

(2010) Han Wu et al.   MOLECULAR CELL

Anti-tumor activity of splice-switching oligonucleotides

(2010) John A. Bauman et al.   NUCLEIC ACIDS RESEARCH

Alternative splicing of human papillomavirus type-16 E6/E6* early mRNA is coupled to EGF signaling via Erk1/2 activation

(2010) S. Rosenberger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterogeneous nuclear ribonucleoproteins (hnRNPs) in cellular processes: Focus on hnRNP E1's multifunctional regulatory roles

(2010) A. Chaudhury et al.   RNA

Spliceosome Structure and Function

(2010) C. L. Will et al.   Cold Spring Harbor Perspectives in Biology

Expression and Cytoplasmic Localization of SAM68 Is a Significant and Independent Prognostic Marker for Renal Cell Carcinoma

(2009) Z. Zhang et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Diagnosing Cervical Cancer and High-Grade Precursors by HPV16 Transcription Patterns

(2009) M. Schmitt et al.   CANCER RESEARCH

Disruption of the E2 Gene Is a Common and Early Event in the Natural History of Cervical Human Papillomavirus Infection: A Longitudinal Cohort Study

(2009) S. I. Collins et al.   CANCER RESEARCH

Alternative Splicing of the Cyclin D1 Proto-Oncogene Is Regulated by the RNA-Binding Protein Sam68

(2009) M. P. Paronetto et al.   CANCER RESEARCH

The Spliceosome: Design Principles of a Dynamic RNP Machine

(2009) Markus C. Wahl et al.   CELL

Increased expression of cellular RNA-binding proteins in HPV-induced neoplasia and cervical cancer

(2009) Joanna Fay et al.   JOURNAL OF MEDICAL VIROLOGY

RNA splicing factors regulated by HPV16 during cervical tumour progression

(2009) Sarah Mole et al.   JOURNAL OF PATHOLOGY

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

(2009) Charles J. David et al.   NATURE

Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches

(2009) Mo Chen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human papillomavirus type 16 E2 and E6 are RNA-binding proteins and inhibit in vitro splicing of pre-mRNAs with suboptimal splice sites

(2009) Sohrab Bodaghi et al.   VIROLOGY

Significance of nuclear hTra2-beta1 expression in cervical cancer

(2008) Boris Gabriel et al.   ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA

Polypyrimidine Tract-binding Protein (PTB) Differentially Affects Malignancy in a Cell Line-dependent Manner

(2008) Chen Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Papillomavirus Type 16 E2 Protein Transcriptionally Activates the Promoter of a Key Cellular Splicing Factor, SF2/ASF

(2008) S. Mole et al.   JOURNAL OF VIROLOGY

Control of the Papillomavirus Early-to-Late Switch by Differentially Expressed SRp20

(2008) R. Jia et al.   JOURNAL OF VIROLOGY

Polypyrimidine Tract Binding Protein Induces Human Papillomavirus Type 16 Late Gene Expression by Interfering with Splicing Inhibitory Elements at the Major Late 5' Splice Site, SD3632

(2008) M. Somberg et al.   JOURNAL OF VIROLOGY

Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: a retrospective cohort study

(2008) Margaret RE McCredie et al.   LANCET ONCOLOGY

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Phosphorylation switches the general splicing repressor SRp38 to a sequence-specific activator

(2008) Ying Feng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Splicing regulation: From a parts list of regulatory elements to an integrated splicing code

(2008) Z. Wang et al.   RNA

The alternative splicing factor hnRNP A1 is up-regulated during virus-infected epithelial cell differentiation and binds the human papillomavirus type 16 late regulatory element

(2007) Thanaporn Cheunim et al.   VIRUS RESEARCH