Modulating splicing with small molecular inhibitors of the spliceosome
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Modulating splicing with small molecular inhibitors of the spliceosome
Authors
Keywords
-
Journal
Wiley Interdisciplinary Reviews-RNA
Volume 8, Issue 2, Pages e1381
Publisher
Wiley
Online
2016-07-21
DOI
10.1002/wrna.1381
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Defective control of pre–messenger RNA splicing in human disease
- (2016) Benoit Chabot et al. JOURNAL OF CELL BIOLOGY
- Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins
- (2016) Stanley Chun-Wei Lee et al. NATURE MEDICINE
- Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stages
- (2016) Kerstin A. Effenberger et al. RNA
- Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage
- (2016) Samar Alsafadi et al. Nature Communications
- Antiangiogenic activity of herboxidiene via downregulation of vascular endothelial growth factor receptor-2 and hypoxia-inducible factor-1α
- (2015) Hye Jin Jung et al. ARCHIVES OF PHARMACAL RESEARCH
- Inhibitory activities of biflavonoids against amyloid-β peptide 42 cytotoxicity in PC-12 cells
- (2015) Hiroaki Sasaki et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B
- (2015) M. K. Kashyap et al. HAEMATOLOGICA
- RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component and inhibits angiogenesis
- (2015) Hideaki Kakeya et al. JOURNAL OF ANTIBIOTICS
- The Natural ProductN-Palmitoyl-l-leucine Selectively Inhibits Late Assembly of Human Spliceosomes
- (2015) Kerstin A. Effenberger et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The SF3B1 inhibitor spliceostatin A (SSA) elicits apoptosis in chronic lymphocytic leukaemia cells through downregulation of Mcl-1
- (2015) M Larrayoz et al. LEUKEMIA
- Functional Splicing Network Reveals Extensive Regulatory Potential of the Core Spliceosomal Machinery
- (2015) Panagiotis Papasaikas et al. MOLECULAR CELL
- The spliceosome is a therapeutic vulnerability in MYC-driven cancer
- (2015) Tiffany Y.-T. Hsu et al. NATURE
- SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice
- (2015) James Palacino et al. Nature Chemical Biology
- The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia
- (2015) Sílvia Xargay-Torrent et al. Oncotarget
- Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3′ Splice Site Selection through Use of a Different Branch Point
- (2015) Rachel B. Darman et al. Cell Reports
- Transcriptome Sequencing Reveals Potential Mechanism of Cryptic 3’ Splice Site Selection in SF3B1-mutated Cancers
- (2015) Christopher DeBoever et al. PLoS Computational Biology
- Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B
- (2015) M. K. Kashyap et al. HAEMATOLOGICA
- Identification of Small Molecule Inhibitors of Pre-mRNA Splicing
- (2014) Andrea Pawellek et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cytotoxic Spliceostatins from Burkholderia sp. and Their Semisynthetic Analogues
- (2014) Haiyin He et al. JOURNAL OF NATURAL PRODUCTS
- Enantioselective Total Syntheses of FR901464 and Spliceostatin A and Evaluation of Splicing Activity of Key Derivatives
- (2014) Arun K. Ghosh et al. JOURNAL OF ORGANIC CHEMISTRY
- Sudemycin E influences alternative splicing and changes chromatin modifications
- (2014) Paolo Convertini et al. NUCLEIC ACIDS RESEARCH
- Enantioselective Synthesis of Spliceostatin E and Evaluation of Biological Activity
- (2014) Arun K. Ghosh et al. ORGANIC LETTERS
- Total Synthesis of GEX1Q1, Assignment of C-5 Stereoconfiguration and Evaluation of Spliceosome Inhibitory Activity
- (2014) Arun K. Ghosh et al. ORGANIC LETTERS
- Total Synthesis of 6-Deoxypladienolide D and Assessment of Splicing Inhibitory Activity in a Mutant SF3B1 Cancer Cell Line
- (2014) Kenzo Arai et al. ORGANIC LETTERS
- Multiple components of the spliceosome regulate Mcl1 activity in neuroblastoma
- (2014) T W Laetsch et al. Cell Death & Disease
- Pre-mRNA Splicing-Modulatory Pharmacophores: The Total Synthesis of Herboxidiene, a Pladienolide–Herboxidiene Hybrid Analog and Related Derivatives
- (2013) Chandraiah Lagisetti et al. ACS Chemical Biology
- Chemical Perturbation of Mcl-1 Pre-mRNA Splicing to Induce Apoptosis in Cancer Cells
- (2013) Yang Gao et al. ACS Chemical Biology
- Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia
- (2013) Dan A. Landau et al. CELL
- Regulation of splicing by SR proteins and SR protein-specific kinases
- (2013) Zhihong Zhou et al. CHROMOSOMA
- Phase I Pharmacokinetic and Pharmacodynamic Study of the First-in-Class Spliceosome Inhibitor E7107 in Patients with Advanced Solid Tumors
- (2013) F. A. L. M. Eskens et al. CLINICAL CANCER RESEARCH
- Coherence between Cellular Responses andin VitroSplicing Inhibition for the Anti-tumor Drug Pladienolide B and Its Analogs
- (2013) Kerstin A. Effenberger et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Optimization of Antitumor Modulators of Pre-mRNA Splicing
- (2013) Chandraiah Lagisetti et al. JOURNAL OF MEDICINAL CHEMISTRY
- Stabilized Cyclopropane Analogs of the Splicing Inhibitor FD-895
- (2013) Reymundo Villa et al. JOURNAL OF MEDICINAL CHEMISTRY
- Genomics-Guided Discovery of Thailanstatins A, B, and C As Pre-mRNA Splicing Inhibitors and Antiproliferative Agents from Burkholderia thailandensis MSMB43
- (2013) Xiangyang Liu et al. JOURNAL OF NATURAL PRODUCTS
- Competition between Pre-mRNAs for the Splicing Machinery Drives Global Regulation of Splicing
- (2013) Elizabeth M. Munding et al. MOLECULAR CELL
- Enantioselective Syntheses of FR901464 and Spliceostatin A: Potent Inhibitors of Spliceosome
- (2013) Arun K. Ghosh et al. ORGANIC LETTERS
- Rearrangements within human spliceosomes captured after exon ligation
- (2013) J. O. Ilagan et al. RNA
- Transcriptional Amplification in Tumor Cells with Elevated c-Myc
- (2012) Charles Y. Lin et al. CELL
- Psoromic Acid Derivatives: A New Family of Small-Molecule Pre-mRNA Splicing Inhibitors Discovered by a Stage-Specific High-Throughput in Vitro Splicing Assay
- (2012) Timur R. Samatov et al. CHEMBIOCHEM
- Comparison of Splicing Factor 3b Inhibitors in Human Cells
- (2012) Yang Gao et al. CHEMBIOCHEM
- Psoromic Acid is a Selective and Covalent Rab-Prenylation Inhibitor Targeting Autoinhibited RabGGTase
- (2012) Céline Deraeve et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- A Quantitative High-Throughput In Vitro Splicing Assay Identifies Inhibitors of Spliceosome Catalysis
- (2012) M. G. Berg et al. MOLECULAR AND CELLULAR BIOLOGY
- Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
- (2012) Andrew V. Biankin et al. NATURE
- Structural bioinformatics of the human spliceosomal proteome
- (2012) Iga Korneta et al. NUCLEIC ACIDS RESEARCH
- Structure of FD-895 Revealed through Total Synthesis
- (2012) Reymundo Villa et al. ORGANIC LETTERS
- Enantioselective Total Synthesis of Pladienolide B: A Potent Spliceosome Inhibitor
- (2012) Arun K. Ghosh et al. ORGANIC LETTERS
- Pre-mRNA splicing in disease and therapeutics
- (2012) Ravi K. Singh et al. TRENDS IN MOLECULAR MEDICINE
- Sudemycins, Novel Small Molecule Analogues of FR901464, Induce Alternative Gene Splicing
- (2011) Liying Fan et al. ACS Chemical Biology
- Radiosynthesis of antitumor spliceosome modulators
- (2011) Tinopiwa Goronga et al. APPLIED RADIATION AND ISOTOPES
- Biological validation that SF3b is a target of the antitumor macrolide pladienolide
- (2011) Akira Yokoi et al. FEBS Journal
- Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A
- (2011) A. Corrionero et al. GENES & DEVELOPMENT
- The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region
- (2011) E. G. Folco et al. GENES & DEVELOPMENT
- Frequent pathway mutations of splicing machinery in myelodysplasia
- (2011) Kenichi Yoshida et al. NATURE
- Breaking Up the C Complex Spliceosome Shows Stable Association of Proteins with the Lariat Intron Intermediate
- (2011) Patricia Coltri et al. PLoS One
- Design, synthesis and initial biological evaluation of a novel pladienolide analog scaffold
- (2011) Mahesh Kumar Gundluru et al. MedChemComm
- Identification of SAP155 as the Target of GEX1A (Herboxidiene), an Antitumor Natural Product
- (2010) Makoto Hasegawa et al. ACS Chemical Biology
- Spliceostatin A blocks angiogenesis by inhibiting global gene expression including VEGF
- (2010) Ryohei Furumai et al. CANCER SCIENCE
- An Alternative Splicing Network Links Cell-Cycle Control to Apoptosis
- (2010) Michael J. Moore et al. CELL
- Structural Requirements for the Antiproliferative Activity of Pre-mRNA Splicing Inhibitor FR901464
- (2010) Sami Osman et al. CHEMISTRY-A EUROPEAN JOURNAL
- Rapid-Response Splicing Reporter Screens Identify Differential Regulators of Constitutive and Alternative Splicing
- (2010) I. Younis et al. MOLECULAR AND CELLULAR BIOLOGY
- Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation
- (2010) Marc Schneider et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation
- (2010) Gabriel A. Roybal et al. NUCLEIC ACIDS RESEARCH
- A Stereoselective Synthesis of (+)-Herboxidiene/GEX1A
- (2010) Arun K. Ghosh et al. ORGANIC LETTERS
- Release of SF3 from the intron branchpoint activates the first step of pre-mRNA splicing
- (2010) R. M. Lardelli et al. RNA
- Small Molecule Inhibitors of Yeast Pre-mRNA Splicing
- (2009) Kelly G. Aukema et al. ACS Chemical Biology
- The A–Z of bacterial translation inhibitors
- (2009) Daniel N. Wilson CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Synthetic mRNA Splicing Modulator Compounds with in Vivo Antitumor Activity
- (2009) Chandraiah Lagisetti et al. JOURNAL OF MEDICINAL CHEMISTRY
- Meayamycin inhibits pre-messenger RNA splicing and exhibits picomolar activity against multidrug-resistant cells
- (2009) B. J. Albert et al. MOLECULAR CANCER THERAPEUTICS
- The Biflavonoid Isoginkgetin Is a General Inhibitor of Pre-mRNA Splicing
- (2008) Kristine O'Brien et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Antitumor Compounds Based on a Natural Product Consensus Pharmacophore
- (2008) Chandraiah Lagisetti et al. JOURNAL OF MEDICINAL CHEMISTRY
- Isolation of an active step I spliceosome and composition of its RNP core
- (2008) Sergey Bessonov et al. NATURE
- A role for ubiquitin in the spliceosome assembly pathway
- (2008) Priya Bellare et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome
- (2008) Rebecca Mathew et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started