Inhibition of SF3b1 by pladienolide B evokes cycle arrest, apoptosis induction and p73 splicing in human cervical carcinoma cells

SF3B1 deficiency impairs human erythropoiesis via activation of p53 pathway: implications for understanding of ineffective erythropoiesis in MDS

(2018) Yumin Huang et al.   Journal of Hematology & Oncology

Inhibition of SF3B1 by molecules targeting the spliceosome results in massive aberrant exon skipping

(2018) Gang Wu et al.   RNA

Alternative-splicing defects in cancer: Splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics

(2018) Laura M. Urbanski et al.   Wiley Interdisciplinary Reviews-RNA

Carvacrol nanoemulsion evokes cell cycle arrest, apoptosis induction and autophagy inhibition in doxorubicin resistant-A549 cell line

(2018) Imran Khan et al.   Artificial Cells Nanomedicine and Biotechnology

The combinational effect of E6/E7 siRNA and anti-miR-182 on apoptosis induction in HPV16-positive cervical cells

(2018) Hamidreza Javadi et al.   Artificial Cells Nanomedicine and Biotechnology

MicroRNA-1297 contributes to the progression of human cervical carcinoma through PTEN

(2018) Zhihua Chen et al.   Artificial Cells Nanomedicine and Biotechnology

Alternative splicing in prostate cancer

(2018) Alec Paschalis et al.   Nature Reviews Clinical Oncology

Mutational landscape of RNA-binding proteins in human cancers

(2017) Yaseswini Neelamraju et al.   RNA Biology

The Relationship between Alternative Splicing and Proteomic Complexity

(2017) Benjamin J. Blencowe   TRENDS IN BIOCHEMICAL SCIENCES

Exploring the interplay between autoimmunity and cancer to find the target therapeutic hotspots

(2017) Neeraj Kumar et al.   Artificial Cells Nanomedicine and Biotechnology

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015

(2017) et al.   JAMA Oncology

SF3B1 is a stress-sensitive splicing factor that regulates both HSF1 concentration and activity

(2017) Karen S. Kim Guisbert et al.   PLoS One

Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stages

(2016) Kerstin A. Effenberger et al.   RNA

Novel imatinib-loaded silver nanoparticles for enhanced apoptosis of human breast cancer MCF-7 cells

(2016) Seyed Ataollah Sadat Shandiz et al.   Artificial Cells Nanomedicine and Biotechnology

High  Np73/TAp73 ratio is associated with poor prognosis in acute promyelocytic leukemia

(2015) A. R. Lucena-Araujo et al.   BLOOD

Diallyl disulfide enhances carbon ion beams–induced apoptotic cell death in cervical cancer cells through regulating Tap73 /ΔNp73

(2015) Cuixia Di et al.   CELL CYCLE

RNA mis-splicing in disease

(2015) Marina M. Scotti et al.   NATURE REVIEWS GENETICS

The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia

(2015) Sílvia Xargay-Torrent et al.   Oncotarget

Diallyl disulfide attenuated carbon ion irradiation-induced apoptosis in mouse testis through changing the ratio of Tap73/ΔNp73 via mitochondrial pathway

(2015) Cui-xia Di et al.   Scientific Reports

MiR-634 decreases cell proliferation and induces apoptosis by targeting mTOR signaling pathway in cervical cancer cells

(2015) Jianglin Cong et al.   Artificial Cells Nanomedicine and Biotechnology

A day in the life of the spliceosome

(2014) A. Gregory Matera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

High antitumor activity of pladienolide B and its derivative in gastric cancer

(2013) Momoko Sato et al.   CANCER SCIENCE

Mechanisms, function and clinical applications of DNp73

(2013) Cuixia Di et al.   CELL CYCLE

Coherence between Cellular Responses andin VitroSplicing Inhibition for the Anti-tumor Drug Pladienolide B and Its Analogs

(2013) Kerstin A. Effenberger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defects in spliceosomal machinery: a new pathway of leukaemogenesis

(2012) Jaroslaw P. Maciejewski et al.   BRITISH JOURNAL OF HAEMATOLOGY

The spliceosome as a target of novel antitumour drugs

(2012) Sophie Bonnal et al.   NATURE REVIEWS DRUG DISCOVERY

Exon and intron definition in pre-mRNA splicing

(2012) Laura De Conti et al.   Wiley Interdisciplinary Reviews-RNA

Biological validation that SF3b is a target of the antitumor macrolide pladienolide

(2011) Akira Yokoi et al.   FEBS Journal

Functional consequences of developmentally regulated alternative splicing

(2011) Auinash Kalsotra et al.   NATURE REVIEWS GENETICS

Alternative splicing and breast cancer

(2010) Martin Dutertre et al.   RNA Biology

The spliceosome as target for anticancer treatment

(2008) R J van Alphen et al.   BRITISH JOURNAL OF CANCER

Alternative isoform regulation in human tissue transcriptomes

(2008) Eric T. Wang et al.   NATURE