Article
Plant Sciences
Yunhua Liu, Pengfei Zheng, Tingting Jiao, Mengmeng Zhang, Yingjie Wu, Xinjiang Zhang, Shuyue Wang, Zongjiang Zhao
Summary: This study investigated the pharmacological mechanism of paiteling in regulating cervical cancer cell apoptosis. The results showed that paiteling can induce cervical cancer cell apoptosis by inhibiting the E6/E7-Pi3k/Akt signaling pathway, providing an effective alternative strategy of traditional Chinese medicine for the treatment of epithelial neoplasia caused by HPV infection.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Oncology
Mei-Zhen Dai, Yi Qiu, Xing-Hong Di, Wei-Wu Shi, Hui-Hui Xu
Summary: This study investigated the genetic variability of HPV16 E6 and E7 oncogenes in isolates from cervical exfoliated cells in women from Taizhou, China. The majority of HPV16 variants belonged to lineage A, with the A4 (Asian) sublineage being dominant. The A4 sublineage had a higher risk of CIN2+ compared to the A1-3 (European) sublineages, and nucleotide variation in HPV16 E6 T178G was associated with cervical cancer development.
Review
Oncology
Laura Downham, Iman Jaafar, Mary Luz Rol, Victoria Nyawira Nyaga, Joan Valls, Armando Baena, Li Zhang, Marc J. Gunter, Marc Arbyn, Maribel Almonte
Summary: This study evaluated the accuracy of HPV-E6/E7 oncoprotein tests in detecting cervical precancer and cancer through a systematic review and meta-analysis. The results showed that oncoprotein tests have high specificity and can be used for triaging HPV-positive women. However, further follow-up is needed for oncoprotein-negative women.
BRITISH JOURNAL OF CANCER
(2023)
Article
Engineering, Biomedical
Liming Zhang, Kun Wang, Yuheng Huang, Hui Zhang, Long Zhou, Ang Li, Yunyan Sun
Summary: A novel HPV nanovaccine combining nanotechnology and photodynamic therapy was constructed, which could effectively inhibit the progression of cervical cancer and was experimentally demonstrated in a mouse model.
Article
Immunology
Ayazhan Akhatova, Chee Kai Chan, Azliyati Azizan, Gulzhanat Aimagambetova
Summary: Cervical cancer is a serious public health concern, and despite existing preventative and screening methods, it remains a common and deadly cancer. DNA therapeutic vaccines show promise in treating cervical cancer, with their safety and effectiveness being well-documented.
Article
Multidisciplinary Sciences
Jinichi Sakamoto, Mayumi Saito, Shitai Zhang, Masahiro Takakura, Hiroaki Takagi, Toshiyuki Sasagawa
Summary: This study conducted molecular mapping and HPV genotyping on cervical cancer tissue specimens to confirm previous observations of multiple HPV types or no HPV DNA in invasive cervical cancers (ICC). The findings suggest that different HPV types induce different histological cancers.
Article
Oncology
Paolo Giorgi Rossi, Guglielmo Ronco, Pamela Mancuso, Francesca Carozzi, Elena Allia, Simonetta Bisanzi, Anna Gillio-Tos, Laura De Marco, Raffaella Rizzolo, Daniela Gustinucci, Annarosa Del Mistro, Helena Frayle, Massimo Confortini, Anna Iossa, Elena Cesarini, Simonetta Bulletti, Basilio Passamonti, Silvia Gori, Laura Toniolo, Alessandra Barca, Laura Bonvicini, Francesco Venturelli, Maria Benevolo
Summary: As a primary screening test, E6/E7 mRNA has shown high sensitivity but a high positivity rate, requiring triage strategies. In this study, using mRNA as a primary test would miss about 3% of CIN3+ cases.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Sabrina Nicolo, Alberto Antonelli, Michele Tanturli, Ilaria Baccani, Chiara Bonaiuto, Giuseppe Castronovo, Gian Maria Rossolini, G. Mattiuz, M. G. Torcia
Summary: Vaginal dysbiosis, characterized by decreased Lactobacillus abundance, facilitates the infection of sexually transmitted pathogens, including high-risk human papilloma viruses (HPVs) associated with cervical cancer development. In this study, SiHa cells, an HPV-16-transformed epithelial cell line, were exposed to representative vaginal microbial communities to investigate their impact on the expression of HPV oncogenes. The results showed that Lactobacillus crispatus and Lactobacillus gasseri modulated the expression of HPV oncogenes, while other dysbiotic bacteria had contrasting effects. These findings highlight the protective role of L. crispatus against neoplastic progression of HR-HPV infected cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Yuji Ikeda, Katsuyuki Adachi, Kensuke Tomio, Satoko Eguchi-Kojima, Tetsushi Tsuruga, Mayuyo Uchino-Mori, Ayumi Taguchi, Atsushi Komatsu, Takeshi Nagamatsu, Katsutoshi Oda, Ai Kawana-Tachikawa, Yukari Uemura, Shizunobu Igimi, Yutaka Osuga, Tomoyuki Fujii, Kei Kawana
Summary: The clinical trial of GLBL101c treatment for CIN2 patients showed no significant differences between the GLBL101c and placebo groups in patient background, adverse events, and the primary endpoint of pathological regression. Only two cases of complete regression were observed in the GLBL101c group. IFN gamma production was significantly correlated with Th1 immune responses.
Article
Oncology
Xinmei Wang, Guangnan Shuai, Junhui Xu, Meihua Liu, Jianguo Zhao, Na Zhang, Wenwen Zhang, Pengpeng Qu
Summary: This study investigated the application of quantitative HPV16 E7 oncoprotein detection in cervical cancer screening. The results showed a positive correlation between the level of HPV16 E7 oncoprotein and the degree of cervical lesions, with a cut-off value of 8.68 ng/ml for identifying HSIL+. This method demonstrated good diagnostic value and predictive ability for disease progression.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Natasa Nikolic, Branka Basica, Aljosa Mandic, Nela Surla, Vera Gusman, Deana Medic, Tamas Petrovic, Mirjana Strbac, Vladimir Petrovic
Summary: Cervical cancer caused by persistent infection with HR HPV genotypes is a significant cause of death among women aged 15 to 44 in Serbia. The expression of E6 and E7 HPV oncogenes can be used as a biomarker for diagnosing high-grade squamous intraepithelial lesions (HSIL). This study aimed to evaluate the diagnostic potential of HPV mRNA and DNA tests for HSIL.
Article
Immunology
Lina Zhang, Xinyi Shi, Qing Zhang, Zhilei Mao, Xiaoyu Shi, Jun Zhou, Aili Jian, Renying Zhu, Shisong Jiang, Wenshu Lu
Summary: High-risk human papillomavirus (HPV) infection is the main cause of cervical cancer, and the specific T cell response to HPV16 E7 in peripheral blood mononuclear cells is related to HPV16 clearance and protection against malignant development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Mamiko Onuki, Kasumi Yamamoto, Hideaki Yahata, Hiroyuki Kanao, Koji Horie, Katsuyuki Konnai, Ai Nio, Kazuhiro Takehara, Shoji Kamiura, Naotake Tsuda, Yuji Takei, Shogo Shigeta, Hidekatsu Nakai, Hiroyuki Yoshida, Takeshi Motohara, Tatsuya Kato, Keiichiro Nakamura, Junzo Hamanishi, Nobutaka Tasaka, Mitsuya Ishikawa, Nobuhiro Kado, Yusuke Taira, Mayuyo Mori, Takashi Iwata, Fumiaki Takahashi, Iwao Kukimoto, Hiroyuki Yoshikawa, Nobuo Yaegashi, Koji Matsumoto
Summary: Since the introduction of the HPV vaccination program in Japan in 2010, there has been a significant difference in vaccination uptake among different age groups. This study found a significant reduction in HPV16/18 prevalence among young unvaccinated women with CIN1 and CIN2-3/AIS, suggesting the herd effects of HPV vaccination.
Article
Biochemistry & Molecular Biology
Katsuyoshi Kumagai, Masakatsu Takanashi, Shin-ichiro Ohno, Yuichirou Harada, Koji Fujita, Keiki Oikawa, Katsuko Sudo, Shun-ichi Ikeda, Hirotaka Nishi, Kosuke Oikawa, Masahiko Kuroda
Summary: Cervical cancer development involves HPV infection and estrogen receptor signaling. WAPL plays a crucial role in CIN development by activating MACROD1 to increase ESR1 sensitivity, thereby promoting the expression of MYC and Cyclin D1.
Article
Microbiology
Shiwen Peng, Deyin Xing, Louise Ferrall, Ya-Chea Tsai, Richard B. S. Roden, Chien-Fu Hung, T. -C. Wu
Summary: Our research focused on eliminating the confounding effects of dominant HPV antigen presentation through murine MHC-I via epitope mutagenesis, while ensuring oncogenicity. Mutated DNA constructs of HPV16 E6 and E7 were able to abolish murine MHC-I presentation and instead use human HLA-A2 molecules for presentation. These mutated constructs still maintained their oncogenic properties.
Article
Dentistry, Oral Surgery & Medicine
Agostino Guida, Franco Ionna, Camile S. Farah
Summary: This study analyzed the intrapapillary capillary loop (IPCL) patterns of oral lichenoid lesions using narrow-band imaging (NBI) and correlated them with histopathological outcomes. The results showed that NBI cannot differentiate among oral lichen planus (OLP), oral lichenoid lesion (OLL), and oral lichenoid reaction (OLR) lesions. However, IPCL pattern IV may serve as a clinical marker for malignant transformation in chronic inflammatory lesions during long-term follow-up.
Article
Oncology
Noemy Starita, Francesca Pezzuto, Sabrina Sarno, Nunzia Simona Losito, Sisto Perdona, Luigi Buonaguro, Franco M. Buonaguro, Maria Lina Tornesello
Summary: Penile carcinoma can develop through either HPV-related or unrelated carcinogenic pathways. Genetic alterations in coding regions, such as TP53, CDKN2A, PIK3CA, and NOTCH1, play a key role in both HPV positive and negative tumors. Researchers investigated hotspot mutations in the TERT promoter and PIK3CA exon 9 in 69 penile cancer cases and found that TERT promoter mutations were highly prevalent and significantly more frequent in HPV negative cases. PIK3CA mutations were distributed similarly in virus-related and unrelated cases and often coexisted with TERT promoter changes. The frequency of these mutations was higher in Italian cases compared to Ugandan cases and inversely correlated with HPV status.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Medicine, Research & Experimental
Concetta Ragone, Carmen Manolio, Angela Mauriello, Beatrice Cavalluzzo, Franco M. Buonaguro, Maria Lina Tornesello, Maria Tagliamonte, Luigi Buonaguro
Summary: This study demonstrates for the first time a high degree of homology in linear sequence, structure, and conformation between microbiota and tumor-associated antigens, suggesting that the anti-microbiota T cell memory in cancer patients may play a role in controlling cancer growth. This finding may have implications for the development of a novel preventive anti-cancer vaccine strategy.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Maria Antonietta Isgro, Giusy Trillo, Luigi Russo, Anna Lucia Tornesello, Luigi Buonaguro, Maria Lina Tornesello, Leonardo Miscio, Nicola Normanno, Attilio Antonio Montano Bianchi, Franco Maria Buonaguro, Ernesta Cavalcanti
INFECTIOUS AGENTS AND CANCER
(2022)
Review
Oncology
Valli De Re, Anna Rossetto, Alessandro Rosignoli, Elena Muraro, Vito Racanelli, Maria Lina Tornesello, Aron Zompicchiatti, Alessandro Uzzau
Summary: Ablative and locoregional treatment options are effective therapies for early-stage HCC, enhancing immunogenicity and survival rates. Surgical approaches combined with immune-modulating drugs show promise in maximizing therapeutic outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Carmen Manolio, Concetta Ragone, Beatrice Cavalluzzo, Angela Mauriello, Maria Lina Tornesello, Franco M. Buonaguro, Angelo Salomone Megna, Giovanna D'Alessio, Roberta Penta, Maria Tagliamonte, Luigi Buonaguro
Summary: This study demonstrates molecular mimicry between HIV antigens and TAAs in breast, prostate, and colon cancers, and identifies cross-reacting CD8(+) T cells. It suggests that memory CD8(+) T cells elicited during HIV infection may play a key role in controlling the development and progression of these cancers.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Oncology
Maria Lina Tornesello, Andrea Cerasuolo, Noemy Starita, Anna Lucia Tornesello, Patrizia Bonelli, Franca Maria Tuccillo, Luigi Buonaguro, Maria G. Isaguliants, Franco M. Buonaguro
Summary: Human oncoviruses disrupt the function of telomerase reverse transcriptase (TERT) through multiple strategies, promoting cancer development.
Article
Medicine, Research & Experimental
Anna Lucia Tornesello, Chiara Botti, Alberto Micillo, Francesco Labonia, Sergio Arpino, Maria Antonietta Isgro, Serena Meola, Luigi Russo, Ernesta Cavalcanti, Silvia Sale, Carmine Nicastro, Luigi Atripaldi, Noemy Starita, Andrea Cerasuolo, Ulf Reimer, Pavlo Holenya, Luigi Buonaguro, Franco M. M. Buonaguro, Maria Lina Tornesello
Summary: This study evaluated the IgG response to linear peptides in SARS-CoV-2 infected patients, aiming to identify immunological indicators of COVID-19 clinical outcome. The results showed that antibody production in SARS-CoV-2 infected patients is age-dependent and related to the severity of the disease. Additionally, antibodies against other coronaviruses were detected in all patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Maria Tagliamonte, Beatrice Cavalluzzo, Angela Mauriello, Concetta Ragone, Franco M. Buonaguro, Maria Lina Tornesello, Luigi Buonaguro
Summary: The development of cancer immunotherapeutic strategies relies on the identification and validation of optimal target tumor antigens, which should be tumor-specific as well as able to elicit a swift and potent anti-tumor immune response. Most strategies are based on tumor associated antigens (TAAs), but these may be affected by immunological tolerance or elicit autoimmune responses. Therefore, non-self-antigens derived from microorganisms (MoAs) may be beneficial in overcoming these limitations.
Review
Biochemistry & Molecular Biology
Valli De Re, Maria Lina Tornesello, Vito Racanelli, Marcella Prete, Agostino Steffan
Summary: Several studies are being conducted to investigate the role of immunity in the development of hepatocellular carcinoma and to identify individuals who would benefit most from systemic therapy based on the etiology of their tumor. Human leukocyte antigens (HLAs) are crucial for antigen presentation to T cells and play a crucial role in the defense against pathogens and tumor cells. Interactions between HLA and innate lymphoid cell receptors, such as natural killer cells and innate lymphoid cell type 2, have been found to activate immune function in liver diseases. Recent studies have highlighted the importance of non-classical HLA-Ib molecules and FAT10, a transcript adjacent to the HLA-F locus, in hepatocarcinoma.
Review
Biochemistry & Molecular Biology
Luigi Buonaguro, Beatrice Cavalluzzo, Angela Mauriello, Concetta Ragone, Anna Lucia Tornesello, Franco M. Buonaguro, Maria Lina Tornesello, Maria Tagliamonte
Summary: Cancer prevention is a top priority to reduce the burden of cancer diagnosis and treatment. Vaccines are the most efficient strategy for preventing cancer, as they can elicit an anti-cancer immune response that can prevent tumor progression.
MOLECULAR ASPECTS OF MEDICINE
(2023)
Editorial Material
Cell Biology
Dino Bekric, Maria Lina Tornesello, Matthias Ocker, Christian Mayr, Tobias Kiesslich, Daniel Neureiter
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell Biology
Maria Lina Tornesello, Andrea Cerasuolo, Noemy Starita, Sara Amiranda, Patrizia Bonelli, Franca Maria Tuccillo, Franco M. Buonaguro, Luigi Buonaguro, Anna Lucia Tornesello
Summary: This review summarizes recent advancements in understanding the role of TERT promoter mutations, telomerase expression, and telomere elongation in cancer development, as well as their clinical significance and therapeutic opportunities.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Maria Lina Tornesello, Anna Lucia Tornesello, Noemy Starita, Andrea Cerasuolo, Francesco Izzo, Luigi Buonaguro, Franco Maria Buonaguro
Summary: The expression and activity of TERT in the liver are closely associated with liver damage and the development of hepatocellular carcinoma (HCC). In addition to its role in telomere regulation, TERT has other oncogenic activities, making it a potential target for liver cancer therapy.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2022)
