Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes

The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARα-tr, autonomously regulates proliferative and pro-inflammatory genes

(2015) Maria Thomas et al.   BMC CANCER

Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo

(2015) Cara Lunn Shirai et al.   CANCER CELL

In Silico Prescription of Anticancer Drugs to Cohorts of 28 Tumor Types Reveals Targeting Opportunities

(2015) Carlota Rubio-Perez et al.   CANCER CELL

CEACAM1-3S Drives Melanoma Cells into NK Cell-Mediated Cytolysis and Enhances Patient Survival

(2015) N. Ullrich et al.   CANCER RESEARCH

CD44 Isoform Status Predicts Response to Treatment with Anti-CD44 Antibody in Cancer Patients

(2015) F. Birzele et al.   CLINICAL CANCER RESEARCH

CD22ΔE12 as a molecular target for corrective repair using RNA trans-splicing: anti-leukemic activity of a rationally designed RNA trans-splicing molecule

(2015) Fatih M. Uckun et al.   Integrative Biology

Comprehensive transcriptome analysis using synthetic long-read sequencing reveals molecular co-association of distant splicing events

(2015) Hagen Tilgner et al.   NATURE BIOTECHNOLOGY

The role of regulatory variation in complex traits and disease

(2015) Frank W. Albert et al.   NATURE REVIEWS GENETICS

Are androgen receptor variants a substitute for the full-length receptor?

(2015) Ji Lu et al.   Nature Reviews Urology

Detection of recurrent alternative splicing switches in tumor samples reveals novel signatures of cancer

(2015) Endre Sebestyén et al.   NUCLEIC ACIDS RESEARCH

The human transcriptome across tissues and individuals

(2015) M. Mele et al.   SCIENCE

Activation of MET via Diverse Exon 14 Splicing Alterations Occurs in Multiple Tumor Types and Confers Clinical Sensitivity to MET Inhibitors

(2015) G. M. Frampton et al.   Cancer Discovery

A germline mutation in SRRM2, a splicing factor gene, is implicated in papillary thyroid carcinoma predisposition

(2015) Jerneja Tomsic et al.   Scientific Reports

Widespread intron retention diversifies most cancer transcriptomes

(2015) Heidi Dvinge et al.   Genome Medicine

Higher gene expression variability in the more aggressive subtype of chronic lymphocytic leukemia

(2015) Simone Ecker et al.   Genome Medicine

Transcriptome Sequencing Reveals Potential Mechanism of Cryptic 3’ Splice Site Selection in SF3B1-mutated Cancers

(2015) Christopher DeBoever et al.   PLoS Computational Biology

Therapeutic vaccination against fibronectin ED-A attenuates progression of metastatic breast cancer

(2015) Julia Femel et al.   Oncotarget

Prognostic impact of alternative splicing-derived hMENA isoforms in resected, node-negative, non-small-cell lung cancer

(2015) Emilio Bria et al.   Oncotarget

Identification of an Exon 4-Deletion Variant of Epidermal Growth Factor Receptor with Increased Metastasis-Promoting Capacity

(2015) Hai Wang et al.   NEOPLASIA

Gene Fusions Associated with Recurrent Amplicons Represent a Class of Passenger Aberrations in Breast Cancer

(2015) Shanker Kalyana-Sundaram et al.   NEOPLASIA

Transcriptome instability as a molecular pan-cancer characteristic of carcinomas

(2014) Anita Sveen et al.   BMC GENOMICS

The Splicing Factor RBM4 Controls Apoptosis, Proliferation, and Migration to Suppress Tumor Progression

(2014) Yang Wang et al.   CANCER CELL

PRMT7 Induces Epithelial-to-Mesenchymal Transition and Promotes Metastasis in Breast Cancer

(2014) R. Yao et al.   CANCER RESEARCH

Expression of Variant Isoforms of the Tyrosine Kinase SYK Determines the Prognosis of Hepatocellular Carcinoma

(2014) Jian Hong et al.   CANCER RESEARCH

Modulation of p53β and p53γ expression by regulating the alternative splicing of TP53 gene modifies cellular response

(2014) V Marcel et al.   CELL DEATH AND DIFFERENTIATION

CD44v6 Is a Marker of Constitutive and Reprogrammed Cancer Stem Cells Driving Colon Cancer Metastasis

(2014) Matilde Todaro et al.   Cell Stem Cell

An integrative analysis of colon cancer identifies an essential function for PRPF6 in tumor growth

(2014) A. S. Adler et al.   GENES & DEVELOPMENT

Splice factor mutations and alternative splicing as drivers of hematopoietic malignancy

(2014) Christopher N. Hahn et al.   IMMUNOLOGICAL REVIEWS

CD20 alternative splicing isoform generates immunogenic CD4 helper T epitopes

(2014) Charline Vauchy et al.   INTERNATIONAL JOURNAL OF CANCER

A novel transcript,VNN1-AB, as a biomarker for colorectal cancer

(2014) Marthe Løvf et al.   INTERNATIONAL JOURNAL OF CANCER

Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression

(2014) Roberto Ferrarese et al.   JOURNAL OF CLINICAL INVESTIGATION

Comprehensive molecular profiling of lung adenocarcinoma

(2014) Eric A. Collisson et al.   NATURE

Context-dependent control of alternative splicing by RNA-binding proteins

(2014) Xiang-Dong Fu et al.   NATURE REVIEWS GENETICS

A day in the life of the spliceosome

(2014) A. Gregory Matera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms for U2AF to define 3′ splice sites and regulate alternative splicing in the human genome

(2014) Changwei Shao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

AR-V7 and Resistance to Enzalutamide and Abiraterone in Prostate Cancer

(2014) Emmanuel S. Antonarakis et al.   NEW ENGLAND JOURNAL OF MEDICINE

A comprehensive survey of non-canonical splice sites in the human transcriptome

(2014) Guillermo E. Parada et al.   NUCLEIC ACIDS RESEARCH

Alternative splicing in cancer: implications for biology and therapy

(2014) J Chen et al.   ONCOGENE

A Pan-Cancer Analysis of Transcriptome Changes Associated with Somatic Mutations in U2AF1 Reveals Commonly Altered Splicing Events

(2014) Angela N. Brooks et al.   PLoS One

Overexpression of Mcl-1L Splice Variant Is Associated with Poor Prognosis and Chemoresistance in Oral Cancers

(2014) Vinayak Palve et al.   PLoS One

A Comprehensive Analysis of CXCL12 Isoforms in Breast Cancer1,2

(2014) Shuang Zhao et al.   Translational Oncology

Alternative splicing regulation of telomerase: a new paradigm?

(2014) Mandy S. Wong et al.   TRENDS IN GENETICS

Splicing mutation analysis reveals previously unrecognized pathways in lymph node-invasive breast cancer

(2014) Stephanie N. Dorman et al.   Scientific Reports

Exon identity crisis: disease-causing mutations that disrupt the splicing code

(2014) Timothy Sterne-Weiler et al.   GENOME BIOLOGY

OncodriveCLUST: exploiting the positional clustering of somatic mutations to identify cancer genes

(2013) David Tamborero et al.   BIOINFORMATICS

Patterns of missplicing due to somatic U2AF1 mutations in myeloid neoplasms

(2013) B. Przychodzen et al.   BLOOD

mRNA Splicing Variants: Exploiting Modularity to Outwit Cancer Therapy

(2013) S. M. Dehm   CANCER RESEARCH

The Major Reverse Transcriptase-Incompetent Splice Variant of the Human Telomerase Protein Inhibits Telomerase Activity but Protects from Apoptosis

(2013) I. Listerman et al.   CANCER RESEARCH

Lessons from the Cancer Genome

(2013) Levi A. Garraway et al.   CELL

EGFR Mutation-Induced Alternative Splicing of Max Contributes to Growth of Glycolytic Tumors in Brain Cancer

(2013) Ivan Babic et al.   Cell Metabolism

Tumor-Specific Isoform Switch of the Fibroblast Growth Factor Receptor 2 Underlies the Mesenchymal and Malignant Phenotypes of Clear Cell Renal Cell Carcinomas

(2013) Q. Zhao et al.   CLINICAL CANCER RESEARCH

Integrative analysis revealed the molecular mechanism underlying RBM10-mediated splicing regulation

(2013) Yongbo Wang et al.   EMBO Molecular Medicine

Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia

(2013) P. G. Ferreira et al.   GENOME RESEARCH

From human genome to cancer genome: The first decade

(2013) D. A. Wheeler et al.   GENOME RESEARCH

The transcription-splicing protein NonO/p54nrb and three NonO-interacting proteins bind to distal enhancer region and augment rhodopsin expression

(2013) Sharda P. Yadav et al.   HUMAN MOLECULAR GENETICS

Alternative splicing ofBRAFtranscripts and characterization of C-terminally truncated B-Raf isoforms in colorectal cancer

(2013) Benjamin Hirschi et al.   INTERNATIONAL JOURNAL OF CANCER

HE4 Transcription- and Splice Variants-Specific Expression in Endometrial Cancer and Correlation with Patient Survival

(2013) Shi-Wen Jiang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Acquired Mutations That Affect Pre-mRNA Splicing in Hematologic Malignancies and Solid Tumors

(2013) L. M. Scott et al.   JNCI-Journal of the National Cancer Institute

Epithelial-mesenchymal transition: focus on metastatic cascade, alternative splicing, non-coding RNAs and modulating compounds

(2013) Timur R Samatov et al.   Molecular Cancer

Systematic analysis of somatic mutations in phosphorylation signaling predicts novel cancer drivers

(2013) J. Reimand et al.   Molecular Systems Biology

Widespread splicing changes in human brain development and aging

(2013) P. Mazin et al.   Molecular Systems Biology

Mutational heterogeneity in cancer and the search for new cancer-associated genes

(2013) Michael S. Lawrence et al.   NATURE

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Transcriptome and genome sequencing uncovers functional variation in humans

(2013) Tuuli Lappalainen et al.   NATURE

Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma

(2013) J William Harbour et al.   NATURE GENETICS

The Cancer Genome Atlas Pan-Cancer analysis project

(2013) John N Weinstein et al.   NATURE GENETICS

Systematic evaluation of spliced alignment programs for RNA-seq data

(2013) Pär G Engström et al.   NATURE METHODS

Emerging patterns of somatic mutations in cancer

(2013) Ian R. Watson et al.   NATURE REVIEWS GENETICS

Identification of latent biomarkers in hepatocellular carcinoma by ultra-deep whole-transcriptome sequencing

(2013) K-T Lin et al.   ONCOGENE

The RNA-binding protein Rbfox2: an essential regulator of EMT-driven alternative splicing and a mediator of cellular invasion

(2013) C Braeutigam et al.   ONCOGENE

Hallmarks of alternative splicing in cancer

(2013) S Oltean et al.   ONCOGENE

Redox regulation in stem-like cancer cells by CD44 variant isoforms

(2013) O Nagano et al.   ONCOGENE

HnRNP A1/A2 and SF2/ASF Regulate Alternative Splicing of Interferon Regulatory Factor-3 and Affect Immunomodulatory Functions in Human Non-Small Cell Lung Cancer Cells

(2013) Rong Guo et al.   PLoS One

Overexpression of RNA-binding protein CELF1 prevents apoptosis and destabilizes pro-apoptotic mRNAs in oral cancer cells

(2013) Sudha Talwar et al.   RNA Biology

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Targeting the Intracellular WT1 Oncogene Product with a Therapeutic Human Antibody

(2013) T. Dao et al.   Science Translational Medicine

KLF6-SV1 Drives Breast Cancer Metastasis and Is Associated with Poor Survival

(2013) R. Hatami et al.   Science Translational Medicine

SF3B1 Mutations Are Associated with Alternative Splicing in Uveal Melanoma

(2013) S. J. Furney et al.   Cancer Discovery

Misregulation of Pre-mRNA Alternative Splicing in Cancer

(2013) J. Zhang et al.   Cancer Discovery

RNA sequencing of cancer reveals novel splicing alterations

(2013) Jeyanthy Eswaran et al.   Scientific Reports

Comprehensive identification of mutational cancer driver genes across 12 tumor types

(2013) David Tamborero et al.   Scientific Reports

Regulation of Telomerase Alternative Splicing: A Target for Chemotherapy

(2013) Mandy S. Wong et al.   Cell Reports

Global Properties and Functional Complexity of Human Gene Regulatory Variation

(2013) Daniel J. Gaffney   PLoS Genetics

Transcriptome analysis of human tissues and cell lines reveals one dominant transcript per gene

(2013) Mar Gonzàlez-Porta et al.   GENOME BIOLOGY

IL-7 splicing variant IL-7δ5 induces human breast cancer cell proliferation via activation of PI3K/Akt pathway

(2012) Deshun Pan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SpliceSeq: a resource for analysis and visualization of RNA-Seq data on alternative splicing and its functional impacts

(2012) Michael C. Ryan et al.   BIOINFORMATICS

The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial

(2012) D. G. Oscier et al.   BLOOD

Analysis of glutamine dependency in non-small cell lung cancer

(2012) A. Pieter J. van den Heuvel et al.   CANCER BIOLOGY & THERAPY

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

A non-secretory form of FAM3B promotes invasion and metastasis of human colon cancer cells by upregulating Slug expression

(2012) Zongmeng Li et al.   CANCER LETTERS

Alternate Splicing of the p53 Inhibitor HDMX Offers a Superior Prognostic Biomarker than p53 Mutation in Human Cancer

(2012) Kristiaan Lenos et al.   CANCER RESEARCH

DDX39 acts as a suppressor of invasion for bladder cancer

(2012) Minoru Kato et al.   CANCER SCIENCE

Splice isoforms as therapeutic targets for colorectal cancer

(2012) K. Miura et al.   CARCINOGENESIS

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing

(2012) Marcin Imielinski et al.   CELL

Association between VEGF Splice Isoforms and Progression-Free Survival in Metastatic Colorectal Cancer Patients Treated with Bevacizumab

(2012) D. O. Bates et al.   CLINICAL CANCER RESEARCH

Function of alternative splicing

(2012) Olga Kelemen et al.   GENE

Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events

(2012) J. Liu et al.   GENOME RESEARCH

MuSiC: Identifying mutational significance in cancer genomes

(2012) N. D. Dees et al.   GENOME RESEARCH

GENCODE: The reference human genome annotation for The ENCODE Project

(2012) J. Harrow et al.   GENOME RESEARCH

The splicing factor SRSF6 is amplified and is an oncoprotein in lung and colon cancers

(2012) Michal Cohen-Eliav et al.   JOURNAL OF PATHOLOGY

RBFOX2 Is an Important Regulator of Mesenchymal Tissue-Specific Splicing in both Normal and Cancer Tissues

(2012) J. P. Venables et al.   MOLECULAR AND CELLULAR BIOLOGY

Fibroblast Growth Factor Receptor 2 IIIc as a Therapeutic Target for Colorectal Cancer Cells

(2012) Y. Matsuda et al.   MOLECULAR CANCER THERAPEUTICS

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

(2012) Andrew V. Biankin et al.   NATURE

Landscape of transcription in human cells

(2012) Sarah Djebali et al.   NATURE

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Comprehensive genomic characterization of squamous cell lung cancers

(2012)   NATURE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer

(2012) King Pan Ng et al.   NATURE MEDICINE

Splicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness

(2012) Etienne Dardenne et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Functional impact bias reveals cancer drivers

(2012) Abel Gonzalez-Perez et al.   NUCLEIC ACIDS RESEARCH

Gemcitabine triggers a pro-survival response in pancreatic cancer cells through activation of the MNK2/eIF4E pathway

(2012) L Adesso et al.   ONCOGENE

The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis

(2012) C Zhou et al.   ONCOGENE

Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types

(2012) Julia Salzman et al.   PLoS One

Identification of Novel Deregulated RNA Metabolism-Related Genes in Non-Small Cell Lung Cancer

(2012) Iñaki Valles et al.   PLoS One

U2AF1 Mutations in Chinese Patients with Acute Myeloid Leukemia and Myelodysplastic Syndrome

(2012) Jun Qian et al.   PLoS One

Pre-mRNA splicing in disease and therapeutics

(2012) Ravi K. Singh et al.   TRENDS IN MOLECULAR MEDICINE

Integrative Genome-wide Analysis Reveals Cooperative Regulation of Alternative Splicing by hnRNP Proteins

(2012) Stephanie C. Huelga et al.   Cell Reports

Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns

(2012) Joachim Weischenfeldt et al.   GENOME BIOLOGY

Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness

(2011) D. Rossi et al.   BLOOD

Deep RNA sequencing analysis of readthrough gene fusions in human prostate adenocarcinoma and reference samples

(2011) Serban Nacu et al.   BMC Medical Genomics

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Caspases and cancer

(2011) M Olsson et al.   CELL DEATH AND DIFFERENTIATION

Silencing Survivin Splice Variant 2B Leads to Antitumor Activity in Taxane-Resistant Ovarian Cancer

(2011) P. E. Vivas-Mejia et al.   CLINICAL CANCER RESEARCH

Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas

(2011) Clare V LeFave et al.   EMBO JOURNAL

Regulation of alternative splicing by the core spliceosomal machinery

(2011) A. L. Saltzman et al.   GENES & DEVELOPMENT

Fusion gene microarray reveals cancer type-specificity among fusion genes

(2011) Marthe Løvf et al.   GENES CHROMOSOMES & CANCER

Increased levels of noisy splicing in cancers, but not for oncogene-derived transcripts

(2011) Lu Chen et al.   HUMAN MOLECULAR GENETICS

The exon-level biomarker SLC39A14 has organ-confined cancer-specificity in colorectal cancer

(2011) Anita Sveen et al.   INTERNATIONAL JOURNAL OF CANCER

An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers

(2011) Terence K. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical proteomics identified ATP-dependent RNA helicase DDX39 as a novel biomarker to predict poor prognosis of patients with gastrointestinal stromal tumor

(2011) Kazutaka Kikuta et al.   Journal of Proteomics

Cell-to-cell variability of alternative RNA splicing

(2011) Z. Waks et al.   Molecular Systems Biology

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

(2011) Poulikos I. Poulikakos et al.   NATURE

Frequent pathway mutations of splicing machinery in myelodysplasia

(2011) Kenichi Yoshida et al.   NATURE

Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes

(2011) Timothy A Graubert et al.   NATURE GENETICS

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

(2011) Víctor Quesada et al.   NATURE GENETICS

SF3B1and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia

(2011) Lili Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antitumorigenic potential of STAT3 alternative splicing modulation

(2011) F. Zammarchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human transcriptome array for high-throughput clinical studies

(2011) Weihong Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptome instability in colorectal cancer identified by exon microarray analyses: Associations with splicing factor expression levels and patient survival

(2011) Anita Sveen et al.   Genome Medicine

An EMT–Driven Alternative Splicing Program Occurs in Human Breast Cancer and Modulates Cellular Phenotype

(2011) Irina M. Shapiro et al.   PLoS Genetics

Cancer-Associated Splicing Variant of Tumor Suppressor AIMP2/p38: Pathological Implication in Tumorigenesis

(2011) Jin Woo Choi et al.   PLoS Genetics

Targeting the Anti-Apoptotic Protein c-FLIP for Cancer Therapy

(2011) Ahmad R. Safa et al.   Cancers

Massively Parallel Sequencing of Exons on the X Chromosome Identifies RBM10 as the Gene that Causes a Syndromic Form of Cleft Palate

(2010) Jennifer J. Johnston et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Hypoxia inducible factor 1α gene (HIF-1α) splice variants: potential prognostic biomarkers in breast cancer

(2010) Jean-Philippe Dales et al.   BMC Medicine

GP369, an FGFR2-IIIb-Specific Antibody, Exhibits Potent Antitumor Activity against Human Cancers Driven by Activated FGFR2 Signaling

(2010) A. Bai et al.   CANCER RESEARCH

Alternative Splicing Variant of Kallikrein-Related Peptidase 8 as an Independent Predictor of Unfavorable Prognosis in Lung Cancer

(2010) C. Planque et al.   CLINICAL CHEMISTRY

Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged

(2010) C. J. David et al.   GENES & DEVELOPMENT

Analysis of next-generation genomic data in cancer: accomplishments and challenges

(2010) L. Ding et al.   HUMAN MOLECULAR GENETICS

Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant

(2010) Shihua Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Alternative Splicing of SLC39A14 in Colorectal Cancer is Regulated by the Wnt Pathway

(2010) Kasper Thorsen et al.   MOLECULAR & CELLULAR PROTEOMICS

Exon-Level Microarray Analyses Identify Alternative Splicing Programs in Breast Cancer

(2010) A. Lapuk et al.   MOLECULAR CANCER RESEARCH

Deciphering the splicing code

(2010) Yoseph Barash et al.   NATURE

International network of cancer genome projects

(2010) Thomas J. Hudson (Chairperson) et al.   NATURE

Expansion of the eukaryotic proteome by alternative splicing

(2010) Timothy W. Nilsen et al.   NATURE

Anti-tumor activity of splice-switching oligonucleotides

(2010) John A. Bauman et al.   NUCLEIC ACIDS RESEARCH

Global regulation of alternative splicing during myogenic differentiation

(2010) Christopher S. Bland et al.   NUCLEIC ACIDS RESEARCH

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

(2010) S. A. Forbes et al.   NUCLEIC ACIDS RESEARCH

SRRM2, a Potential Blood Biomarker Revealing High Alternative Splicing in Parkinson's Disease

(2010) Lina A. Shehadeh et al.   PLoS One

Spliceosome Structure and Function

(2010) C. L. Will et al.   Cold Spring Harbor Perspectives in Biology

Noisy Splicing Drives mRNA Isoform Diversity in Human Cells

(2010) Joseph K. Pickrell et al.   PLoS Genetics

Fibronectins in vascular morphogenesis

(2009) Sophie Astrof et al.   ANGIOGENESIS

Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia

(2009) M. Stark et al.   BLOOD

EGFRvIII and DNA Double-Strand Break Repair: A Molecular Mechanism for Radioresistance in Glioblastoma

(2009) B. Mukherjee et al.   CANCER RESEARCH

Cancer-Specific High-Throughput Annotation of Somatic Mutations: Computational Prediction of Driver Missense Mutations

(2009) H. Carter et al.   CANCER RESEARCH

The Spliceosome: Design Principles of a Dynamic RNP Machine

(2009) Markus C. Wahl et al.   CELL

The consensus coding sequence (CCDS) project: Identifying a common protein-coding gene set for the human and mouse genomes

(2009) K. D. Pruitt et al.   GENOME RESEARCH

Modification of Alternative Splicing of Mcl-1 Pre-mRNA Using Antisense Morpholino Oligonucleotides Induces Apoptosis in Basal Cell Carcinoma Cells

(2009) Jeng-Jer Shieh et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Non-genetic heterogeneity — a mutation-independent driving force for the somatic evolution of tumours

(2009) Amy Brock et al.   NATURE REVIEWS GENETICS

Cancer-associated regulation of alternative splicing

(2009) Julian P Venables et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Stochastic noise in splicing machinery

(2009) Eugene Melamud et al.   NUCLEIC ACIDS RESEARCH

Therapeutic Potential of Splice-Switching Oligonucleotides

(2009) John Bauman et al.   OLIGONUCLEOTIDES

A Global View of Cancer-Specific Transcript Variants by Subtractive Transcriptome-Wide Analysis

(2009) Chunjiang He et al.   PLoS One

Candidate metastasis suppressor genes uncovered by array comparative genomic hybridization in a mouse allograft model of prostate cancer

(2009) Yajun Yi et al.   Molecular Cytogenetics

AmiGO: online access to ontology and annotation data

(2008) Seth Carbon et al.   BIOINFORMATICS

Expression of spliced oncogenic Ikaros isoforms in Philadelphia-positive acute lymphoblastic leukemia patients treated with tyrosine kinase inhibitors: implications for a new mechanism of resistance

(2008) I. Iacobucci et al.   BLOOD

Gene Expression and Isoform Variation Analysis using Affymetrix Exon Arrays

(2008) Amandine Bemmo et al.   BMC GENOMICS

Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo

(2008) Sumanta Goswami et al.   CLINICAL & EXPERIMENTAL METASTASIS

Claudin-18 Splice Variant 2 Is a Pan-Cancer Target Suitable for Therapeutic Antibody Development

(2008) U. Sahin et al.   CLINICAL CANCER RESEARCH

Aberrant RNA splicing and its functional consequences in cancer cells

(2008) J. D. Fackenthal et al.   Disease Models & Mechanisms

The emerging role of splicing factors in cancer

(2008) Ana Rita Grosso et al.   EMBO REPORTS

Increased alternative splicing of the KLF6 tumour suppressor gene correlates with prognosis and tumour grade in patients with pancreatic cancer

(2008) Mark Hartel et al.   EUROPEAN JOURNAL OF CANCER

Expression analysis and functional activity of interleukin-7 splice variants

(2008) N K Vudattu et al.   GENES AND IMMUNITY

ASTD: The Alternative Splicing and Transcript Diversity database

(2008) Gautier Koscielny et al.   GENOMICS

Cornelia de Lange syndrome mutations in SMC1A or SMC3 affect binding to DNA

(2008) Ekaterina Revenkova et al.   HUMAN MOLECULAR GENETICS

Alternative Splicing in Colon, Bladder, and Prostate Cancer Identified by Exon Array Analysis

(2008) Kasper Thorsen et al.   MOLECULAR & CELLULAR PROTEOMICS

Increased Rac1b Expression Sustains Colorectal Tumor Cell Survival

(2008) P. Matos et al.   MOLECULAR CANCER RESEARCH

Alternative isoform regulation in human tissue transcriptomes

(2008) Eric T. Wang et al.   NATURE

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

(2008) Qun Pan et al.   NATURE GENETICS

Whole genome exon arrays identify differential expression of alternatively spliced, cancer-related genes in lung cancer

(2008) Liqiang Xi et al.   NUCLEIC ACIDS RESEARCH

Tissue-specific splicing factor gene expression signatures

(2008) Ana Rita Grosso et al.   NUCLEIC ACIDS RESEARCH

The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-κB target genes by interaction with NFKBIZ

(2008) M Göransson et al.   ONCOGENE

Up-regulation of the proapoptotic caspase 2 splicing isoform by a candidate tumor suppressor, RBM5

(2008) K. Fushimi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Splicing regulation: From a parts list of regulatory elements to an integrated splicing code

(2008) Z. Wang et al.   RNA

A Neoplastic Gene Fusion Mimics Trans-Splicing of RNAs in Normal Human Cells

(2008) H. Li et al.   SCIENCE

Alternative splicing resulting in nonsense-mediated mRNA decay: what is the meaning of nonsense?

(2008) Nicholas J. McGlincy et al.   TRENDS IN BIOCHEMICAL SCIENCES

Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues

(2008) Sami Kilpinen et al.   GENOME BIOLOGY