Review
Biochemistry & Molecular Biology
Sahib Zada, Jin Seok Hwang, Mahmoud Ahmed, Trang Huyen Lai, Trang Minh Pham, Omar Elashkar, Deok Ryong Kim
Summary: Autophagy is a crucial metabolic process involved in cancer development. It can either suppress or promote cancer progression, and is functionally correlated with oncogenic signaling pathways. Possible cancer therapeutic strategies may involve the regulation of autophagy to influence cancer progression.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Review
Oncology
Aaron C. Tan, Daniel S. W. Tan
Summary: The therapeutic landscape of non-small-cell lung cancer is undergoing significant changes with the shift from histology-based classification to molecularly defined subsets. Targeted therapies for specific driver mutations such as EGFR, ALK, and ROS1 have shown promising results, and there is a growing list of approved therapies for other mutations. The importance of diagnostic molecular testing, optimal sequencing of therapies, application of targeted therapies in early-stage disease, and the impact of genomic mutations on targeted therapy efficacy are important areas of research.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Adlina Roslan, Nurshahira Sulaiman, Khairul Asri Mohd Ghani, Armania Nurdin
Summary: This review discusses the studies on membrane proteins as potential biomarkers for personalized medicine, describing their types and significant functions as potential biomarkers for future medicine.
Review
Biochemistry & Molecular Biology
Munishwar Nath Gupta, Vladimir N. Uversky
Summary: This article discusses the importance of protein multi-specificity, with a focus on the concept of enzyme specificity and the phenomenon of moonlighting. It provides examples of protein moonlighting and outlines the role of protein plasticity and intrinsic disorder in blurring the distinction between enzymes and other biologically active proteins. Additionally, it updates information on the significant roles of moonlighting in human diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Kristian M. Hargadon
Summary: Since the turn of the century, advances in targeted therapy and immunotherapy have revolutionized the treatment of cancer by overcoming mechanisms of innate and acquired resistance. This review focuses on the knowledge of genetic dysregulation in cancer cells that enable immune escape, highlighting the impact of genomic, epigenomic, transcriptomic, and proteomic aberrations on pathways related to immune resistance. Furthermore, the review discusses the role of interferon signaling, antigen processing and presentation, and immunologic cell death, as well as dysregulated RAS-MAPK, WNT, PI3K-AKT-mTOR, and cell cycle pathways in tumor immune resistance.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ilona Turek, Helen Irving
Summary: Plants have developed highly nuanced signaling systems to deal with daily environmental challenges, with moonlighting kinases contributing to cellular signaling cascades by generating cGMP and adding complexity to the system. These moonlighting proteins play roles in the regulation of signaling cascades through the development of localized cGMP-enriched nanodomains, modulating kinase activity and other molecules in protein complexes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Annalisa Adamo, Cristina Frusteri, Maria Teresa Pallotta, Tracey Pirali, Silvia Sartoris, Stefano Ugel
Summary: Plasticity and adaptation to environmental stress are main characteristics shared by tumors and the immune system. Moonlighting proteins, capable of diverse and unpredictable functions, play crucial roles in shaping immune responses during cancer progression.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Zhen Zeng, Minyang Fu, Yuan Hu, Yuquan Wei, Xiawei Wei, Min Luo
Summary: This article reviews the origin, biological characteristics, and regulatory networks of cancer stem cells (CSCs), discusses the factors influencing therapy resistance in CSCs, and introduces some treatment strategies specifically targeting CSCs.
Article
Biochemistry & Molecular Biology
Jingwen Jiang, Liyuan Peng, Kui Wang, Canhua Huang
Summary: Metabolic reprogramming in cancer cells leads to altered functions of metabolic enzymes, including the regulation of epigenetic modifications, gene transcription, post-translational modifications, and cellular antioxidant capacity. Understanding the noncanonical functions of metabolic enzymes, especially in response to redox manipulation, is crucial for clarifying the connection between metabolism and redox processes, and exploring novel therapeutic strategies for cancer treatment.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Cell Biology
Heng-Hsiung Wu, Lung-Hung Tsai, Chun-Kai Huang, Pang-Hung Hsu, Mei-Yu Chen, Yi-Ing Chen, Chun-Mei Hu, Chia-Ning Shen, Chen-Chen Lee, Ming-Chu Chang, Yu-Ting Chang, Yu-Wen Tien, Yung-Ming Jeng, Eva Y-H P. Lee, Wen-Hwa Lee
Summary: Members of the IL-17 cytokine family and their receptors have been identified for decades, with IL-17RB playing a role in tumor growth and metastasis upon stimulation with IL-17B. Research shows that IL-17RB forms a homodimer and recruits MLK4 to phosphorylate it, leading to downstream oncogenic signaling in pancreatic cancer. Inhibiting IL-17RB signaling pathway could offer a therapeutic target for pancreatic cancer treatment.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Henna Pehkonen, Ivan de Curtis, Outi Monni
Summary: Liprins are a multifunctional family of scaffold proteins involved in important neuronal functions as well as processes relevant to cancer progression. They may serve as potential biomarkers for cancer progression and have therapeutic implications.
Article
Multidisciplinary Sciences
Chi-Ling Chiang, Yifan Ma, Ya-Chin Hou, Junjie Pan, Sin-Yu Chen, Ming-Hsien Chien, Zhi-Xuan Zhang, Wei-Hsiang Hsu, Xinyu Wang, Jingjing Zhang, Hong Li, Lili Sun, Shannon Fallen, Inyoul Lee, Xing-Yu Chen, Yeh-Shiu Chu, Chi Zhang, Tai-Shan Cheng, Wen Jiang, Betty Y. S. Kim, Eduardo Reategui, Robert Lee, Yuan Yuan, Hsiao-Chun Liu, Kai Wang, Michael Hsiao, Chi-Ying F. Huang, Yan-Shen Shan, Andrew S. Lee, L. James Lee
Summary: This study reports a dual targeted extracellular vesicle (dtEV) that can effectively suppress large PDAC tumors. The dtEV carries high loads of therapeutic RNA and is delivered to target cells through electroporation. When used in combination with the chemotherapy drug Gemcitabine, the dtEVs can inhibit tumor growth and prolong animal survival.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Tin Lok Wong, Kayla R. Strandberg, Courtney R. Croley, Sarah E. Fraser, Kalyan C. Nagulapalli Venkata, Carmela Fimognari, Gautam Sethi, Anupam Bishayee
Summary: Pomegranate has shown enormous potential in cancer prevention and intervention due to its rich source of polyphenols and other phytochemicals with powerful anticancer effects. Research has demonstrated the effectiveness of pomegranate extracts in inhibiting proliferation, reducing inflammation, and enhancing antioxidative capacity, making it an attractive strategy in the fight against cancer.
SEMINARS IN CANCER BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Carolina Rodriguez-Saavedra, Luis Enrique Morgado-Martinez, Andres Burgos-Palacios, Beatriz King-Diaz, Montserrat Lopez-Coria, Sobeida Sanchez-Nieto
Summary: Moonlighting proteins, like Hexokinase, have multiple unrelated functions in different organisms, with the most common function being a glucose sensor across multiple kingdoms. These proteins play diverse roles, impacting responses to nutritional challenges and disease. Regulation mechanisms can influence their subcellular localization, oligomeric state, and interactions with other molecules, affecting their moonlighting functions.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biology
Wentong Fang, Chengheng Liao, Rachel Shi, Jeremy M. Simon, Travis S. Ptacek, Giada Zurlo, Youqiong Ye, Leng Han, Cheng Fan, Lei Bao, Christopher Llynard Ortiz, Hong-Rui Lin, Ujjawal Manocha, Weibo Luo, Yan Peng, William Y. Kim, Lee-Wei Yang, Qing Zhang
Summary: The study demonstrates that ZHX2 plays a critical role in TNBC by activating oncogenic HIF1α signaling pathway, promoting tumor growth and metastasis. ZHX2 overexpression affects the expression of multiple genes, contributing to the growth and invasion of TNBC cells.
Article
Medicine, Research & Experimental
Manzar Alam, Gulam Mustafa Hasan, Sayed M. Eldin, Mohd Adnan, Muhammad Bilal Riaz, Asimul Islam, Ilyas Khan, Md. Imtaiyaz Hassan
Summary: Non-small cell lung carcinoma (NSCLC) is the most common malignancy worldwide. Genetic modifications in upstream signaling molecules stimulate signaling cascades, leading to cancer cell proliferation, cancer development, and drug resistance. Efforts have been made to understand the mechanisms of cancer development and develop effective therapeutic approaches for NSCLC by modifying transcription factors and targeting specific cellular signaling pathways in tumor progression. This comprehensive review provides deeper mechanistic insights into the molecular mechanism of action of various signaling molecules and their targeting in the clinical management of NSCLC.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biology
Arif Jamal Siddiqui, Vikash Kumar, Sadaf Jahan, Mohammed Merae Alshahrani, Ahmed Abdullah Al Awadh, Maqsood Ahmed Siddiqui, Walid Sabri Hamadou, Abdelmushin Abdelgadir, Juhi Saxena, Riadh Badraoui, Mejdi Snoussi, Mohd Adnan
Summary: Two drugs, C22 and C27, have been found to selectively inhibit human ELOVL1 enzyme, blocking the binding of long-chain fatty acids. This study provides important insights for the discovery and design of novel, selective, and potent ELOVL1 inhibitors.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Arif Jamal Siddiqui, Riadh Badraoui, Sadaf Jahan, Mohammed Merae Alshahrani, Maqsood Ahmed Siddiqui, Andleeb Khan, Mohd Adnan
Summary: NMDARs are important for brain function and NMDAR over activation is involved in many diseases. In this study, potential Gly/NMDA receptor antagonists were discovered using computational methods. Six molecules with high binding affinity were identified as potential new perspectives for therapeutic strategies.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Abdul Haque, Saghir Ahmad, Z. R. A. A. Azad, Mohd Adnan, Syed Amir Ashraf
Summary: Every year, the food industry generates a significant amount of waste, including inedible portions of fruits and vegetables and those that are no longer suitable for human consumption. By-products from these sources, such as natural antioxidants and dietary fiber, can be incorporated into meat products to improve their quality and enhance their health benefits. This approach can help reduce waste disposal and improve the sustainability of the food industry.
Editorial Material
Immunology
Arif Jamal Siddiqui, Mohd Adnan, Fevzi Bardakci, Adebayo James Molehin
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Reyaz Hassan Mir, Prince Ahad Mir, Jasreen Uppal, Apporva Chawla, Mitesh Patel, Fevzi Bardakci, Mohd Adnan, Roohi Mohi-ud-din
Summary: Homeostasis between protein synthesis and degradation is critical in biological functions. The ubiquitin-proteasome pathway (UPP) plays a major role in cellular protein degradation. UPP inhibition has been used as an anticancer therapy to shift the balance towards cell death. Natural products have been found to be involved in UPP engagement. The discovery of natural compounds targeting UPP pathway could lead to new anticancer medications.
Article
Infectious Diseases
Valiappan Ranjutha, Yeng Chen, Lamya Ahmed Al-Keridis, Mitesh Patel, Nawaf Alshammari, Mohd Adnan, Sumaira Sahreen, Subash C. B. Gopinath, Sreenivasan Sasidharan
Summary: Polyalthia longifolia is a medicinal plant used in traditional medicine for skin diseases. This study confirms the synergistic antimicrobial activity of Polyalthia longifolia methanol leaf extract (MEPL) and ceftriaxone against methicillin-resistant Staphylococcus aureus (MRSA) bacteria. The combination of MEPL and ceftriaxone significantly reduces the minimum inhibitory concentration of ceftriaxone and inhibits the expression of the resistant mecA gene in MRSA.
Review
Food Science & Technology
Syed Amir Ashraf, Danish Mahmood, Abd Elmoneim O. Elkhalifa, Arif Jamal Siddiqui, Mohammad Idreesh Khan, Fauzia Ashfaq, Mitesh Patel, Mejdi Snoussi, Marek Kieliszek, Mohd Adnan
Summary: This review discusses the issue of pesticide contamination in honey and its impact on human health. It highlights the consequences of uncontrolled pesticide use in agriculture and apiculture and calls for stricter regulation and monitoring.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Review
Nanoscience & Nanotechnology
Harjeet Singh, Martin F. Desimone, Shivani Pandya, Srushti Jasani, Noble George, Mohd Adnan, Abdu Aldarhami, Abdulrahman S. Bazaid, Suliman A. Alderhami
Summary: This study explores the scientific intricacies of plant-mediated synthesis of nanoparticles and highlights the advantages of this approach over traditional chemical synthesis methods. Utilizing renewable biological resources and controlling nanoparticle characteristics through biomolecule interactions, plant-mediated green synthesis offers immense potential for cost-effective nanoparticle production with significant pharmacological properties, promising for medical and other applications.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Pharmacology & Pharmacy
Mohd Adnan, Debarati Dasgupta, Saleha Anwar, Anas Shamsi, Arif Jamal Siddiqui, Mejdi Snoussi, Fevzi Bardakci, Mitesh Patel, Md Imtaiyaz Hassan
Summary: This study showed that galantamine, an acetylcholinesterase inhibitor, binds to MARK4 with strong affinity and significantly inhibits its kinase activity. These results suggest that galantamine could be a potential inhibitor of MARK4 and a promising therapeutic target for AD.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Abdulrahman S. Bazaid, Ahmed Alsolami, Mitesh Patel, Aiah Mustafa Khateb, Abdu Aldarhami, Mejdi Snoussi, Shekah M. Almusheet, Husam Qanash
Summary: The present study assessed the antimicrobial, antioxidant, and anti-quorum sensing properties of Saudi Sidr honey. The results showed promising antibacterial activity, important antioxidant activities, and the ability to inhibit biofilm formation. The honey also exhibited drug-likeness properties. This highlights the potential of Saudi Sidr honey as a rich source of bioactive compounds.
Article
Biology
Abd Elmoneim O. Elkhalifa, Eyad Al-Shammari, Mohammed Kuddus, Mohd Adnan, Manojkumar Sachidanandan, Amir Mahgoub Awadelkareem, Malak Yahia Qattan, Mohammad Idreesh Khan, Sanaa Ismael Abduljabbar, Mirza Sarwar Baig, Syed Amir Ashraf
Summary: Based on multi-targeted molecular docking and simulation studies, genistin, a soybean-derived isoflavone, is identified as a potential drug for the management and treatment of breast cancer. It exhibits high binding affinity with breast cancer signaling proteins and shows stability in molecular dynamics simulations. ADMET studies also support its potential in the development of nutraceuticals. These findings highlight the importance of genistin in breast cancer research and new drug discovery.
Article
Biology
Fevzi Bardakci, Sarah Hilan Mohammed Al-Subaie, Riadh Badraoui, Mohd Adnan, Arif Jamal Siddiqui
Summary: The present study used the mitochondrial barcoding gene COI to identify and characterize hard ticks infesting camels in Ha'il province, Saudi Arabia. Nine haplotypes were found, with six being newly described. Phylogenetic analysis revealed two distinct clades corresponding to H. dromedarii and H. impeltatum. The presence of H. scupense together with H. impeltatum suggests possible asymmetrical hybridization and mitochondrial introgression between these species.
Article
Multidisciplinary Sciences
Hassan H. Alhassan, Lamya Ahmed Al-Keridis, Huma Ayub, Fawaz O. Alenazy, Yasir Alruwaili, Muhammad Rashid Khan, Mehreen Fatima, Mitesh Patel, Nawaf Alshammari, Mohd Adnan, Sumaira Sahreen
Summary: The study evaluated the metabolic profile and antioxidant potential of Carissa opaca fruit against carbon tetrachloride-induced cardiotoxicity and testicular toxicity. Gas Chromatography-Mass Spectrometry (GC-MS) analysis revealed the presence of bioactive metabolites in the fruit, and the derived fractions of the fruit showed antioxidant activity. The study supports the use of Carissa opaca fruit as an alternative medicine for cardiac dysfunction and highlights its antioxidant role in testicular tissues.
Article
Chemistry, Medicinal
Walid Sabri Hamadou, Nouha Bouali, Elham Bader Alhejaili, Zohra Soua, Mitesh Patel, Mohd Adnan, Arif Jamal Siddiqui, Abdel-Muhsin Abdel-Gadir, Abdel Moneim Elhadi Sulieman, Mejdi Snoussi, Riadh Badraoui
Summary: This study assessed the interaction between bioactive compounds derived from honey and the apoptotic protein p53, which could trigger apoptosis. The results showed that certain compounds in honey have a strong binding ability to p53 and may possess anti-cancer activity, potentially serving as alternative therapy for breast cancer.
PHARMACOGNOSY MAGAZINE
(2023)