Glia Crosstalk in Neuroinflammatory Diseases

Systemic activation of NLRP3 inflammasome and plasma α-synuclein levels are correlated with motor severity and progression in Parkinson’s disease

(2020) Zheng Fan et al.   Journal of Neuroinflammation

G-Protein-Coupled Receptors in Astrocyte–Neuron Communication

(2020) Paulo Kofuji et al.   NEUROSCIENCE

A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease

(2020) Harald Hampel et al.   Frontiers in Immunology

Metabolic Plasticity of Astrocytes and Aging of the Brain

(2019) Mitsuhiro Morita et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Systemic inflammation impairs microglial Aβ clearance through NLRP 3 inflammasome

(2019) Dario Tejera et al.   EMBO JOURNAL

DJ-1 in Parkinson’s Disease: Clinical Insights and Therapeutic Perspectives

(2019) Mariaelena Repici et al.   Journal of Clinical Medicine

The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins

(2019) Vandana Deora et al.   GLIA

Microglial regional heterogeneity and its role in the brain

(2019) Yun-Long Tan et al.   MOLECULAR PSYCHIATRY

Pharmacological Targeting of Microglial Activation: New Therapeutic Approach

(2019) Cai-Yun Liu et al.   Frontiers in Cellular Neuroscience

Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia

(2019) Oliver H. Tam et al.   Cell Reports

Mouse models of ALS: Past, present and future

(2018) Cathleen Lutz   BRAIN RESEARCH

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

(2018) Aleksandra Deczkowska et al.   CELL

Potential Role of Humoral IL-6 Cytokine in Mediating Pro-Inflammatory Endothelial Cell Response in Amyotrophic Lateral Sclerosis

(2018) Svitlana Garbuzova-Davis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extravascular CD3+ T Cells in Brains of Alzheimer Disease Patients Correlate with Tau but Not with Amyloid Pathology: An Immunohistochemical Study

(2018) Mario Merlini et al.   Neurodegenerative Diseases

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis

(2018) Craig D. Hughes et al.   ACTA NEUROPATHOLOGICA

CB2 Cannabinoid Receptor Agonist Ameliorates Alzheimer-Like Phenotype in AβPP/PS1 Mice

(2018) Ester Aso et al.   JOURNAL OF ALZHEIMERS DISEASE

Inflammasome signalling in brain function and neurodegenerative disease

(2018) Michael T. Heneka et al.   NATURE REVIEWS NEUROSCIENCE

Cyclo(His-Pro) inhibits NLRP3 inflammasome cascade in ALS microglial cells

(2018) Silvia Grottelli et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development

(2018) Emily K. Lehrman et al.   NEURON

Role of Microglia TLRs in Neurodegeneration

(2018) Bernd L. Fiebich et al.   Frontiers in Cellular Neuroscience

ALS-Associated E478G Mutation in Human OPTN (Optineurin) Promotes Inflammation and Induces Neuronal Cell Death

(2018) Zhengzhao Liu et al.   Frontiers in Immunology

Induction of Adaptive Immunity Leads to Nigrostriatal Disease Progression in MPTP Mouse Model of Parkinson’s Disease

(2017) Goutam Chandra et al.   JOURNAL OF IMMUNOLOGY

Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties

(2017) Chittappen K. Prajeeth et al.   Journal of Neuroinflammation

Astrocyte Transforming Growth Factor Beta 1 Protects Synapses against Aβ Oligomers in Alzheimer's Disease Model

(2017) Luan Pereira Diniz et al.   JOURNAL OF NEUROSCIENCE

Drug therapy: On the treatment trail for ALS

(2017) Andrew Scott   NATURE

Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain

(2017) Kassandra Kisler et al.   NATURE NEUROSCIENCE

Review: Astrocytes in Alzheimer's disease and other age-associated dementias: a supporting player with a central role

(2017) C. J. Garwood et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

NF-κB-mediated astrocyte dysfunction initiates neurodegeneration

(2017) Michael Lattke et al.   Oncotarget

Hypomethylation of intron1 of α-synuclein gene does not correlate with Parkinson’s disease

(2017) Subhrangshu Guhathakurta et al.   Molecular Brain

Aerobic glycolysis during brain activation: adrenergic regulation and influence of norepinephrine on astrocytic metabolism

(2016) Gerald A. Dienel et al.   JOURNAL OF NEUROCHEMISTRY

A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system

(2016) Takuya Iizumi et al.   Journal of Neuroinflammation

Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease

(2016) Julien Couturier et al.   Journal of Neuroinflammation

Microglia across the lifespan: from origin to function in brain development, plasticity and cognition

(2016) Tuan Leng Tay et al.   JOURNAL OF PHYSIOLOGY-LONDON

The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease

(2016) Marina Saresella et al.   Molecular Neurodegeneration

Adult mouse cortical cell taxonomy revealed by single cell transcriptomics

(2016) Bosiljka Tasic et al.   NATURE NEUROSCIENCE

Insensitivity of astrocytes to interleukin 10 signaling following peripheral immune challenge results in prolonged microglial activation in the aged brain

(2016) Diana M. Norden et al.   NEUROBIOLOGY OF AGING

The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function

(2016) Samuel E. Marsh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models

(2016) Michael J. D. Daniels et al.   Nature Communications

Mechanisms of Aβ Clearance and Degradation by Glial Cells

(2016) Miriam Ries et al.   Frontiers in Aging Neuroscience

Involvement of nitric oxide in the induction of interleukin-1 beta in microglia

(2015) Kenji Sudo et al.   BRAIN RESEARCH

TDP-43 activates microglia through NF-κB and NLRP3 inflammasome

(2015) Weihua Zhao et al.   EXPERIMENTAL NEUROLOGY

Anti-inflammatory effects of glaucocalyxin B in microglia cells

(2015) Ping Gan et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Epigenetic mechanisms in Parkinson's disease

(2015) Ya Feng et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Microglial cell dysregulation in brain aging and neurodegeneration

(2015) Rommy von Bernhardi et al.   Frontiers in Aging Neuroscience

Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: Assessed with [11C]-PBR28

(2015) Nicole R. Zürcher et al.   NeuroImage-Clinical

Reduced β-amyloid pathology in an APP transgenic mouse model of Alzheimer’s disease lacking functional B and T cells

(2015) Claudia Späni et al.   Acta Neuropathologica Communications

CD200R1 and CD200 expression are regulated by PPAR-γ in activated glial cells

(2014) Guido Dentesano et al.   GLIA

Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis

(2014) Ashley E. Frakes et al.   NEURON

Fractalkine regulation of microglial physiology and consequences on the brain and behavior

(2014) Rosa Chiara Paolicelli et al.   Frontiers in Cellular Neuroscience

TREM2Variant p.R47H as a Risk Factor for Sporadic Amyotrophic Lateral Sclerosis

(2014) Janet Cady et al.   JAMA Neurology

Sirtuin modulators control reactive gliosis in an in vitro model of Alzheimer’s disease

(2014) Caterina Scuderi et al.   Frontiers in Pharmacology

Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson’s disease

(2013) Y Tang et al.   CELL DEATH AND DIFFERENTIATION

The multifaceted role of glial cells in amyotrophic lateral sclerosis

(2013) Chiara F. Valori et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Neuroglial Roots of Neurodegenerative Diseases: Therapeutic Potential of Palmitoylethanolamide in Models of Alzheimer’s Disease

(2013) Caterina Scuderi et al.   CNS & Neurological Disorders-Drug Targets

Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection

(2013) Youssef Aachoui et al.   CURRENT OPINION IN MICROBIOLOGY

Recruitment of Beneficial M2 Macrophages to Injured Spinal Cord Is Orchestrated by Remote Brain Choroid Plexus

(2013) Ravid Shechter et al.   IMMUNITY

Fingolimod phosphate promotes the neuroprotective effects of microglia

(2013) Hiromi Noda et al.   JOURNAL OF NEUROIMMUNOLOGY

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

Epigenetic targeting of histone deacetylase: Therapeutic potential in Parkinson's disease?

(2013) Ian F. Harrison et al.   PHARMACOLOGY & THERAPEUTICS

Intricate interplay between astrocytes and motor neurons in ALS

(2013) H. P. Phatnani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell type-specific genes show striking and distinct patterns of spatial expression in the mouse brain

(2013) Y. Ko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuron-glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stage

(2013) G. K. Sheridan et al.   Open Biology

TGF-β signaling through SMAD2/3 induces the quiescent microglial phenotype within the CNS environment

(2012) Shai Abutbul et al.   GLIA

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

Age-dependent neuroinflammatory responses and deficits in long-term potentiation in the hippocampus during systemic inflammation

(2012) X. Liu et al.   NEUROSCIENCE

Glatiramer Acetate Increases Phagocytic Activity of Human Monocytes In Vitro and in Multiple Sclerosis Patients

(2012) Refik Pul et al.   PLoS One

The remarkable, yet not extraordinary, human brain as a scaled-up primate brain and its associated cost

(2012) S. Herculano-Houzel   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reactive Glia not only Associates with Plaques but also Parallels Tangles in Alzheimer's Disease

(2011) Alberto Serrano-Pozo et al.   AMERICAN JOURNAL OF PATHOLOGY

Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease

(2011) Chia-Hsiung Chen et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Blocking IL-1 Signaling Rescues Cognition, Attenuates Tau Pathology, and Restores Neuronal  -Catenin Pathway Function in an Alzheimer's Disease Model

(2011) M. Kitazawa et al.   JOURNAL OF IMMUNOLOGY

A novel glycogen synthase kinase-3 inhibitor 2-methyl-5-(3-{4-[(S )-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer’s disease

(2011) Tomohiro Onishi et al.   JOURNAL OF NEUROCHEMISTRY

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo

(2011) S. T. Papadeas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

D-Amino acid oxidase controls motoneuron degeneration through D-serine

(2011) J. Sasabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease

(2011) C Barcia et al.   Cell Death & Disease

A Two-Stage Meta-Analysis Identifies Several New Loci for Parkinson's Disease

(2011) et al.   PLoS Genetics

CX3CR1 Deficiency Alters Microglial Activation and Reduces Beta-Amyloid Deposition in Two Alzheimer's Disease Mouse Models

(2010) Sungho Lee et al.   AMERICAN JOURNAL OF PATHOLOGY

Anti-TNF-α reduces amyloid plaques and tau phosphorylation and induces CD11c-positive dendritic-like cell in the APP/PS1 transgenic mouse brains

(2010) Jian-Quan Shi et al.   BRAIN RESEARCH

Astrocytes: Glutamate transport and alternate splicing of transporters

(2010) Aven Lee et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Role of Excitatory Amino Acid Transporter-2 (EAAT2) and glutamate in neurodegeneration: Opportunities for developing novel therapeutics

(2010) Keetae Kim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Distribution of the Immune Inhibitory Molecules CD200 and CD200R in the Normal Central Nervous System and Multiple Sclerosis Lesions Suggests Neuron-Glia and Glia-Glia Interactions

(2009) Nathalie Koning et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Tripartite synapses: astrocytes process and control synaptic information

(2009) Gertrudis Perea et al.   TRENDS IN NEUROSCIENCES

Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease

(2008) Vanessa Brochard et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuroinflammation and Oxidation/Nitration of  -Synuclein Linked to Dopaminergic Neurodegeneration

(2008) H.-M. Gao et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial Dysfunction in SOD1G93A-Bearing Astrocytes Promotes Motor Neuron Degeneration: Prevention by Mitochondrial-Targeted Antioxidants

(2008) P. Cassina et al.   JOURNAL OF NEUROSCIENCE

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS

(2008) D. R. Beers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS

(2008) I. M. Chiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA