Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties

The complex contribution of chemokines to neuroinflammation: switching from beneficial to detrimental effects

(2015) Ophélia Le Thuc et al.   Annals of the New York Academy of Sciences

The role and modulation of CCR6+ Th17 cell populations in rheumatoid arthritis

(2015) Sandra M.J. Paulissen et al.   CYTOKINE

Astrocyte response to IFN-γ limits IL-6-mediated microglia activation and progressive autoimmune encephalomyelitis

(2015) Carine Savarin et al.   Journal of Neuroinflammation

Control of autoimmune CNS inflammation by astrocytes

(2015) Veit Rothhammer et al.   Seminars in Immunopathology

Effector molecules released by Th1 but not Th17 cells drive an M1 response in microglia

(2014) Chittappen K. Prajeeth et al.   BRAIN BEHAVIOR AND IMMUNITY

Tumour necrosis factor alpha-induced neuronal loss is mediated by microglial phagocytosis

(2014) Urte Neniskyte et al.   FEBS LETTERS

Phenotype Switching by Inflammation-Inducing Polarized Th17 Cells, but Not by Th1 Cells

(2014) G. Shi et al.   JOURNAL OF IMMUNOLOGY

IL-17A Induces MIP-1α Expression in Primary Astrocytes via Src/MAPK/PI3K/NF-kB Pathways: Implications for Multiple Sclerosis

(2014) Hongwei Yi et al.   Journal of Neuroimmune Pharmacology

Role of Microglia in CNS Autoimmunity

(2013) Tobias Goldmann et al.   Clinical & Developmental Immunology

Astrocytes play a key role in EAE pathophysiology by orchestrating in the CNS the inflammatory response of resident and peripheral immune cells and by suppressing remyelination

(2013) Roberta Brambilla et al.   GLIA

IL-17 and TNF Synergistically Modulate Cytokine Expression while Suppressing Melanogenesis: Potential Relevance to Psoriasis

(2013) Claire Q.F. Wang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Regulation of Immune Cell Infiltration into the CNS by Regional Neural Inputs Explained by the Gate Theory

(2013) Yasunobu Arima et al.   MEDIATORS OF INFLAMMATION

Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis

(2013) Amanda Sierra et al.   Frontiers in Cellular Neuroscience

Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination

(2012) Thomas Skripuletz et al.   BRAIN

Characterization of the interaction between astrocytes and encephalitogenic lymphocytes during the development of experimental autoimmune encephalitomyelitis (EAE) in mice

(2012) J. F. Yang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Mechanisms regulating regional localization of inflammation during CNS autoimmunity

(2012) Emily Pierson et al.   IMMUNOLOGICAL REVIEWS

Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease

(2012) Azeb Tadesse Argaw et al.   JOURNAL OF CLINICAL INVESTIGATION

IFN-γ-induced increase in the mobility of MHC class II compartments in astrocytes depends on intermediate filaments

(2012) Nina Vardjan et al.   Journal of Neuroinflammation

CNS-specific Therapy for Ongoing EAE by Silencing IL-17 Pathway in Astrocytes

(2012) Yaping Yan et al.   MOLECULAR THERAPY

Induction and molecular signature of pathogenic TH17 cells

(2012) Youjin Lee et al.   NATURE IMMUNOLOGY

Th17 lymphocytes traffic to the central nervous system independently of α4 integrin expression during EAE

(2011) Veit Rothhammer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T cells in multiple sclerosis and experimental autoimmune encephalomyelitis

(2010) J. M. Fletcher et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Inhibition of reactive astrocytosis in established experimental autoimmune encephalomyelitis favors infiltration by myeloid cells over T cells and enhances severity of disease

(2010) Henrik Toft-Hansen et al.   GLIA

Astrocyte-Restricted Ablation of Interleukin-17-Induced Act1-Mediated Signaling Ameliorates Autoimmune Encephalomyelitis

(2010) Zizhen Kang et al.   IMMUNITY

Trafficking of immune cells in the central nervous system

(2010) Emma H. Wilson et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-17 Enhancement of the IL-6 Signaling Cascade in Astrocytes

(2010) X. Ma et al.   JOURNAL OF IMMUNOLOGY

Functional and Pathogenic Differences of Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis

(2010) Helena S. Domingues et al.   PLoS One

A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia

(2010) Stephan J. Guyenet et al.   Jove-Journal of Visualized Experiments

Late Developmental Plasticity in the T Helper 17 Lineage

(2009) Yun Kyung Lee et al.   IMMUNITY

Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice

(2009) David Bending et al.   JOURNAL OF CLINICAL INVESTIGATION

T-bet is essential for encephalitogenicity of both Th1 and Th17 cells

(2009) Yuhong Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reactive Astrocytes Form Scar-Like Perivascular Barriers to Leukocytes during Adaptive Immune Inflammation of the CNS

(2009) R. R. Voskuhl et al.   JOURNAL OF NEUROSCIENCE

C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

(2009) Andrea Reboldi et al.   NATURE IMMUNOLOGY

Gaining entry to an uninflamed brain

(2009) Robert C Axtell et al.   NATURE IMMUNOLOGY

Microglia: gatekeepers of central nervous system immunology

(2008) Bart R. Tambuyzer et al.   JOURNAL OF LEUKOCYTE BIOLOGY