Reduced β-amyloid pathology in an APP transgenic mouse model of Alzheimer’s disease lacking functional B and T cells

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Innate immunity in Alzheimer's disease

(2015) Michael T Heneka et al.   NATURE IMMUNOLOGY

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Clinical relevance of specific T-cell activation in the blood and cerebrospinal fluid of patients with mild Alzheimer's disease

(2015) Gero Lueg et al.   NEUROBIOLOGY OF AGING

IL-10 Alters Immunoproteostasis in APP Mice, Increasing Plaque Burden and Worsening Cognitive Behavior

(2015) Paramita Chakrabarty et al.   NEURON

Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer’s disease pathology

(2015) Kuti Baruch et al.   Nature Communications

Beta-amyloid auto-antibodies are reduced in Alzheimer's disease

(2014) Bao-Xi Qu et al.   JOURNAL OF NEUROIMMUNOLOGY

Transition from an M1 to a mixed neuroinflammatory phenotype increases amyloid deposition in APP/PS1 transgenic mice

(2014) Erica M Weekman et al.   Journal of Neuroinflammation

Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders

(2014) Kristi M Anderson et al.   Translational Neurodegeneration

Inflammation in neurodegenerative diseases - an update

(2013) Sandra Amor et al.   IMMUNOLOGY

IFN-  Production by Amyloid  -Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer's Disease

(2013) T. C. Browne et al.   JOURNAL OF IMMUNOLOGY

Th1 Polarization of T Cells Injected into the Cerebrospinal Fluid Induces Brain Immunosurveillance

(2013) Y. Fisher et al.   JOURNAL OF IMMUNOLOGY

Mechanisms of action of naturally occurring antibodies against β-amyloid on microglia

(2013) Maike Gold et al.   Journal of Neuroinflammation

Increased Levels of Antigen-Bound β-Amyloid Autoantibodies in Serum and Cerebrospinal Fluid of Alzheimer’s Disease Patients

(2013) Madalina Maftei et al.   PLoS One

Th17 Cell-Mediated Neuroinflammation Is Involved in Neurodegeneration of Aβ1-42-Induced Alzheimer’s Disease Model Rats

(2013) Jun Zhang et al.   PLoS One

Naturally occurring autoantibodies interfere with β-amyloid metabolism and improve cognition in a transgenic mouse model of Alzheimer’s disease 24 h after single treatment

(2013) D Mengel et al.   Translational Psychiatry

Beta-Amyloid Peptides Enhance the Proliferative Response of Activated CD4+CD28+ Lymphocytes from Alzheimer Disease Patients and from Healthy Elderly

(2012) Agnieszka Jóźwik et al.   PLoS One

Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation

(2012) L Kulic et al.   Translational Psychiatry

Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis

(2011) David R. Beers et al.   BRAIN

Immune profiling of Alzheimer patients

(2011) Mariavaleria Pellicanò et al.   JOURNAL OF NEUROIMMUNOLOGY

Naturally Occurring Autoantibodies against  -Amyloid: Investigating Their Role in Transgenic Animal and In Vitro Models of Alzheimer's Disease

(2011) R. Dodel et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's Disease

(2011) D. J. Selkoe   Cold Spring Harbor Perspectives in Biology

Regulatory T Cells Attenuate Th17 Cell-Mediated Nigrostriatal Dopaminergic Neurodegeneration in a Model of Parkinson’s Disease

(2010) Ashley D. Reynolds et al.   JOURNAL OF IMMUNOLOGY

Vorzeitige Immunalterung: ein pathogenetischer Faktor bei Alzheimer-Demenz?

(2010) E. Richartz-Salzburger et al.   NERVENARZT

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

T Cells Specifically Targeted to Amyloid Plaques Enhance Plaque Clearance in a Mouse Model of Alzheimer's Disease

(2010) Yair Fisher et al.   PLoS One

Autoantibodies against β-amyloid are common in Alzheimer's disease and help control plaque burden

(2009) Alexander Kellner et al.   ANNALS OF NEUROLOGY

Mutant presenilin-1 deregulated peripheral immunity exacerbates Alzheimer-like pathology

(2009) Yuyan Zhu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

CD4-Positive T Lymphocytes Provide a Neuroimmunological Link in the Control of Adult Hippocampal Neurogenesis

(2009) S. A. Wolf et al.   JOURNAL OF IMMUNOLOGY

Immune Activation in Brain Aging and Neurodegeneration: Too Much or Too Little?

(2009) Kurt M. Lucin et al.   NEURON

Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease

(2009) M. Britschgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunotherapy and naturally occurring autoantibodies in neurodegenerative disorders

(2008) Frauke Neff et al.   AUTOIMMUNITY REVIEWS

Natural human antibodies to amyloid beta peptide

(2008) Paul Szabo et al.   AUTOIMMUNITY REVIEWS

Adaptive immunity affects learning behavior in mice

(2008) Anna Brynskikh et al.   BRAIN BEHAVIOR AND IMMUNITY

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS

(2008) D. R. Beers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA