The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins

Misfolded SOD1 inclusions in patients with mutations in C9orf72 and other ALS/FTD-associated genes

(2019) Karin Forsberg et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Complement components are upregulated and correlate with disease progression in the TDP-43Q331K mouse model of amyotrophic lateral sclerosis

(2018) John D. Lee et al.   Journal of Neuroinflammation

Misfolded SOD1 pathology in sporadic Amyotrophic Lateral Sclerosis

(2018) Bastien Paré et al.   Scientific Reports

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

(2018) Richard Gordon et al.   Science Translational Medicine

NLRP3 Inflammasome Activation in a Transgenic Amyotrophic Lateral Sclerosis Model

(2017) Agnese Gugliandolo et al.   INFLAMMATION

The Ketone Body β-Hydroxybutyrate Does Not Inhibit Synuclein Mediated Inflammasome Activation in Microglia

(2017) Vandana Deora et al.   Journal of Neuroimmune Pharmacology

Peroxynitrite Activates the NLRP3 Inflammasome Cascade in SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis

(2017) Ilaria Bellezza et al.   MOLECULAR NEUROBIOLOGY

Inflammasome Priming in Sterile Inflammatory Disease

(2017) Meghana N. Patel et al.   TRENDS IN MOLECULAR MEDICINE

NLRP3 Inflammasome in Neurological Diseases, from Functions to Therapies

(2017) Limin Song et al.   Frontiers in Cellular Neuroscience

Prion Properties of SOD1 in Amyotrophic Lateral Sclerosis and Potential Therapy

(2017) Caroline Sibilla et al.   Cold Spring Harbor Perspectives in Biology

Inflammasome-dependent IL-1β release depends upon membrane permeabilisation

(2016) F Martín-Sánchez et al.   CELL DEATH AND DIFFERENTIATION

K + Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria

(2016) Christina J. Groß et al.   IMMUNITY

Human Monocytes Engage an Alternative Inflammasome Pathway

(2016) Moritz M. Gaidt et al.   IMMUNITY

A clinical tool for predicting survival in ALS

(2016) Jonathan A Knibb et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Riluzole exerts transient modulating effects on cortical and axonal hyperexcitability in ALS

(2016) Nimeshan Geevasinga et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Susceptibility of Mutant SOD1 to Form a Destabilized Monomer Predicts Cellular Aggregation and Toxicity but Not In vitro Aggregation Propensity

(2016) Luke McAlary et al.   Frontiers in Neuroscience

TDP-43 activates microglia through NF-κB and NLRP3 inflammasome

(2015) Weihua Zhao et al.   EXPERIMENTAL NEUROLOGY

NLRP3 inflammasome is expressed by astrocytes in the SOD1 mouse model of ALS and in human sporadic ALS patients

(2015) Sonja Johann et al.   GLIA

Inflammasome-Induced IL-1  Secretion in Microglia Is Characterized by Delayed Kinetics and Is Only Partially Dependent on Inflammatory Caspases

(2015) S. M. Burm et al.   JOURNAL OF NEUROSCIENCE

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era

(2015) Ximena Paez-Colasante et al.   Nature Reviews Neurology

NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes

(2015) Audrey Gustin et al.   PLoS One

Microglia centered pathogenesis in ALS: insights in cell interconnectivity

(2014) Dora Brites et al.   Frontiers in Cellular Neuroscience

The role of oxidative stress in degeneration of the neuromuscular junction in amyotrophic lateral sclerosis

(2014) Eveliina Pollari et al.   Frontiers in Cellular Neuroscience

Reactive oxygen species at the crossroads of inflammasome and inflammation

(2014) Anantha Harijith et al.   Frontiers in Physiology

The NADPH Oxidase Pathway Is Dysregulated by the P2X7 Receptor in the SOD1-G93A Microglia Model of Amyotrophic Lateral Sclerosis

(2013) S. Apolloni et al.   JOURNAL OF IMMUNOLOGY

Dysregulation of the complement cascade in the hSOD1G93A transgenic mouse model of amyotrophic lateral sclerosis

(2013) John D Lee et al.   Journal of Neuroinflammation

Triggering of Inflammasome by Aggregated α–Synuclein, an Inflammatory Response in Synucleinopathies

(2013) Gaia Codolo et al.   PLoS One

ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43

(2013) E. S. Arnold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An emerging role for misfolded wild-type SOD1 in sporadic ALS pathogenesis

(2013) Melissa S. Rotunno et al.   Frontiers in Cellular Neuroscience

Oligomeric amyloid β induces IL-1β processing via production of ROS: implication in Alzheimer’s disease

(2013) B Parajuli et al.   Cell Death & Disease

Extracellular aggregated Cu/Zn superoxide dismutase activates microglia to give a cytotoxic phenotype

(2012) Kate Roberts et al.   GLIA

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Transmission electron microscopy characterization of fluorescently labelled amyloid β 1-40 and α-synuclein aggregates

(2011) Valerie L Anderson et al.   BMC BIOTECHNOLOGY

Differential Expression of NLRP3 among Hematopoietic Cells

(2011) G. Guarda et al.   JOURNAL OF IMMUNOLOGY

Cytoplasmic Mislocalization of TDP-43 Is Toxic to Neurons and Enhanced by a Mutation Associated with Familial Amyotrophic Lateral Sclerosis

(2010) S. J. Barmada et al.   JOURNAL OF NEUROSCIENCE

A simple magnetic separation method for high-yield isolation of pure primary microglia

(2010) Richard Gordon et al.   JOURNAL OF NEUROSCIENCE METHODS

Mutant superoxide dismutase 1-induced IL-1  accelerates ALS pathogenesis

(2010) F. Meissner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immature Copper-Zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis

(2009) Sai V. Seetharaman et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Extracellular mutant SOD1 induces microglial-mediated motoneuron injury

(2009) Weihua Zhao et al.   GLIA

Variation in aggregation propensities among ALS-associated variants of SOD1: Correlation to human disease

(2009) Mercedes Prudencio et al.   HUMAN MOLECULAR GENETICS

Activation of Microglia by Amyloid   Requires P2X7 Receptor Expression

(2009) J. M. Sanz et al.   JOURNAL OF IMMUNOLOGY

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2008) J. Sreedharan et al.   SCIENCE