Role of Microglia TLRs in Neurodegeneration

Changes in the Messenger RNA Expression of Toll-Like Receptors 2 and 4 in Healthy Infants According to Age

(2018) Ilaria Galliano et al.   AMERICAN JOURNAL OF PERINATOLOGY

Microbiome-Gut-Brain Axis and Toll-Like Receptors in Parkinson’s Disease

(2018) Valentina Caputi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nurr1: A vital participant in the TLR4-NF-κB signal pathway stimulated by α-synuclein in BV-2 cells

(2018) Qian-Hang Shao et al.   NEUROPHARMACOLOGY

Increased expression of toll-like receptor 3, an anti-viral signaling molecule, and related genes in Alzheimer's disease brains

(2018) Douglas G. Walker et al.   EXPERIMENTAL NEUROLOGY

Innate immune memory in the brain shapes neurological disease hallmarks

(2018) Ann-Christin Wendeln et al.   NATURE

Author Correction: TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons

(2018) Layal Maatouk et al.   Nature Communications

Activation of EP2 receptor suppresses poly(I: C) and LPS-mediated inflammation in primary microglia and organotypic hippocampal slice cultures: Contributing role for MAPKs

(2017) Nizar M. Yousif et al.   GLIA

The effects of physical exercise on nonmotor symptoms and on neuroimmune RAGE network in experimental parkinsonism

(2017) Sofia D. Viana et al.   JOURNAL OF APPLIED PHYSIOLOGY

Microglia in Alzheimer’s disease

(2017) Heela Sarlus et al.   JOURNAL OF CLINICAL INVESTIGATION

Let’s make microglia great again in neurodegenerative disorders

(2017) Marie-Victoire Guillot-Sestier et al.   JOURNAL OF NEURAL TRANSMISSION

Aging and amyloid β oligomers enhance TLR4 expression, LPS-induced Ca2+ responses, and neuron cell death in cultured rat hippocampal neurons

(2017) María Calvo-Rodríguez et al.   Journal of Neuroinflammation

Mild endoplasmic reticulum stress ameliorates lipopolysaccharide-induced neuroinflammation and cognitive impairment via regulation of microglial polarization

(2017) Yi-wei Wang et al.   Journal of Neuroinflammation

Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal α-synucleinopathy

(2017) Serena Venezia et al.   Molecular Neurodegeneration

Endoplasmic reticulum stress and inflammation in the central nervous system

(2017) Neil T. Sprenkle et al.   Molecular Neurodegeneration

Treadmill exercise produces neuroprotective effects in a murine model of Parkinson’s disease by regulating the TLR2/MyD88/NF-κB signaling pathway

(2017) Jung-Hoon Koo et al.   NEUROSCIENCE

Key Aging-Associated Alterations in Primary Microglia Response to Beta-Amyloid Stimulation

(2017) Cláudia Caldeira et al.   Frontiers in Aging Neuroscience

Tlr7 Deletion Selectively Ameliorates Spatial Learning but does not Influence beta Deposition and Inflammatory Response in an Alzheimers Disease Mouse Model

(2017) Hsin Yu Liu et al.   Neuropsychiatry

Microglial response to LPS increases in wild-type mice during aging but diminishes in an Alzheimer's mouse model: Implication of TLR4 signaling in disease progression

(2016) Michelle Go et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Histone deacetylase inhibitor SAHA attenuates post-seizure hippocampal microglia TLR4/MYD88 signaling and inhibits TLR4 gene expression via histone acetylation

(2016) Qing-Peng Hu et al.   BMC NEUROSCIENCE

Inhibiting TLR2 activation attenuates amyloid accumulation and glial activation in a mouse model of Alzheimer’s disease

(2016) Claire L. McDonald et al.   BRAIN BEHAVIOR AND IMMUNITY

Stimulation of TLR4 Attenuates Alzheimer’s Disease–Related Symptoms and Pathology in Tau-Transgenic Mice

(2016) Yiren Qin et al.   JOURNAL OF IMMUNOLOGY

Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary microglia

(2016) Antonio Carlos Pinheiro de Oliveira et al.   Journal of Neuroinflammation

Synthetic and natural small molecule TLR4 antagonists inhibit motoneuron death in cultures from ALS mouse model

(2016) Massimiliano De Paola et al.   PHARMACOLOGICAL RESEARCH

TLR4 Signaling in MPP+-Induced Activation of BV-2 Cells

(2016) Peng Zhou et al.   NEURAL PLASTICITY

Non-cell-autonomous Neurotoxicity of α-synuclein Through Microglial Toll-like Receptor 2

(2016) Changyoun Kim et al.   Experimental Neurobiology

Prostaglandin E2 Receptor Subtype 2 Regulation of Scavenger Receptor CD36 Modulates Microglial Aβ42 Phagocytosis

(2015) Xianwu Li et al.   AMERICAN JOURNAL OF PATHOLOGY

TLR1 expression in mouse brain was increased in a KA-induced seizure model

(2015) Fa-Xiang Wang et al.   INFLAMMATION RESEARCH

Does HIV Infection Alter Parkinson Disease?

(2015) Antoine Moulignier et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Neural stem cell transplantation decreases neuroinflammation in a transgenic mouse model of Alzheimer's disease

(2015) Qi Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Absence of toll-like receptor 4 (TLR4) extends survival in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

(2015) Jia Y Lee et al.   Journal of Neuroinflammation

Hepatitis C virus infection: a risk factor for Parkinson's disease

(2015) W. Y.-Y. Wu et al.   JOURNAL OF VIRAL HEPATITIS

Genetic Factors Affecting Late-Onset Alzheimer’s Disease Susceptibility

(2015) Maryam Rezazadeh et al.   NEUROMOLECULAR MEDICINE

Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders

(2015) Stefano G. Daniele et al.   Science Signaling

TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus

(2015) Taito Matsuda et al.   Nature Communications

Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders

(2015) Stefano G. Daniele et al.   Science Signaling

Toll-Like Receptor Expression in the Blood and Brain of Patients and a Mouse Model of Parkinson's Disease

(2015) J. Drouin-Ouellet et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Peripheral administration of poly I:C leads to increased hippocampal amyloid-beta and cognitive deficits in a non-transgenic mouse

(2014) Marielle K. Weintraub et al.   BEHAVIOURAL BRAIN RESEARCH

Toll-Like Receptors in Alzheimer’s Disease: A Therapeutic Perspective

(2014) Maria Gambuzza et al.   CNS & Neurological Disorders-Drug Targets

Fibrillar Amyloid-  Peptides Activate Microglia via TLR2: Implications for Alzheimer's Disease

(2014) M. Jana et al.   JOURNAL OF IMMUNOLOGY

The impact of single and pairwise Toll-like receptor activation on neuroinflammation and neurodegeneration

(2014) Karen Rosenberger et al.   Journal of Neuroinflammation

Hypothesis: A role for EBV-induced molecular mimicry in Parkinson's disease

(2014) John M. Woulfe et al.   PARKINSONISM & RELATED DISORDERS

Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson’s disease patients

(2014) Karlijn J Doorn et al.   Acta Neuropathologica Communications

The role of TLR2/JNK/NF-κB pathway in amyloid β peptide-induced inflammatory response in mouse NG108-15 neural cells

(2013) Wei Lin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Toll-like receptor 4 mediates microglial activation and production of inflammatory mediators in neonatal rat brain following hypoxia: role of TLR4 in hypoxic microglia

(2013) Linli Yao et al.   Journal of Neuroinflammation

Different TLR4 expression and microglia/macrophage activation induced by hemorrhage in the rat spinal cord after compressive injury

(2013) Yu-Kai Zhang et al.   Journal of Neuroinflammation

Screening of Toll-Like Receptors Expression in Multiple System Atrophy Brains

(2013) Tomasz Brudek et al.   NEUROCHEMICAL RESEARCH

Toll-like receptors as therapeutic targets for autoimmune connective tissue diseases

(2013) Jing Li et al.   PHARMACOLOGY & THERAPEUTICS

Chronic Intermittent Hypoxia Exerts CNS Region-Specific Effects on Rat Microglial Inflammatory and TLR4 Gene Expression

(2013) Stephanie M. C. Smith et al.   PLoS One

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

(2013) Changyoun Kim et al.   Nature Communications

Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease

(2013) Carmen Noelker et al.   Scientific Reports

Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia

(2012) Lisa Fellner et al.   GLIA

Chaperone Insufficiency Links TLR4 Protein Signaling to Endoplasmic Reticulum Stress

(2012) Andressa Coope et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellularly Delivered Single-Stranded Viral RNA Causes Neurodegeneration Dependent on TLR7

(2012) S. M. Lehmann et al.   JOURNAL OF IMMUNOLOGY

(2012) Massimiliano DePaola et al.   MOLECULAR MEDICINE

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration

(2012) Sabrina M Lehmann et al.   NATURE NEUROSCIENCE

TLR9 −1237 T/C and TLR2 −194 to −174 del polymorphisms and the risk of Parkinson’s disease in the Greek population: a pilot study

(2012) Kallirhoe Kalinderi et al.   NEUROLOGICAL SCIENCES

Review: Activation patterns of microglia and their identification in the human brain

(2012) D. Boche et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Inflammation and neurodegeneration: the story ‘retolled’

(2012) Janelle Drouin-Ouellet et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Toll-Like Receptor 4 Promotes α-Synuclein Clearance and Survival of Nigral Dopaminergic Neurons

(2011) Nadia Stefanova et al.   AMERICAN JOURNAL OF PATHOLOGY

Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential

(2011) Mark L. Hanke et al.   CLINICAL SCIENCE

TLR2 Is a Primary Receptor for Alzheimer's Amyloid   Peptide To Trigger Neuroinflammatory Activation

(2011) S. Liu et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptor 2 -196 to -174 del polymorphism influences the susceptibility of Han Chinese people to Alzheimer's disease

(2011) Jin-Tai Yu et al.   Journal of Neuroinflammation

TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease

(2011) Min Song et al.   Journal of Neuroinflammation

No association of toll-like receptor 2 polymorphisms with Alzheimer's disease in Han Chinese

(2011) Jin-Tai Yu et al.   NEUROBIOLOGY OF AGING

Toll-like receptor signaling in amyotrophic lateral sclerosis spinal cord tissue

(2011) M. Casula et al.   NEUROSCIENCE

Misfolded α-synuclein and toll-like receptors: therapeutic targets for Parkinson's disease

(2011) Dawn Béraud et al.   PARKINSONISM & RELATED DISORDERS

Microglial glucocorticoid receptors play a pivotal role in regulating dopaminergic neurodegeneration in parkinsonism

(2011) F. Ros-Bernal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like receptor signaling in neural plasticity and disease

(2011) Eitan Okun et al.   TRENDS IN NEUROSCIENCES

Systemic challenge with the TLR3 agonist poly I:C induces amplified IFNα/β and IL-1β responses in the diseased brain and exacerbates chronic neurodegeneration

(2010) Robert Field et al.   BRAIN BEHAVIOR AND IMMUNITY

Linking oxidative stress to inflammation: Toll-like receptors

(2010) Roop Gill et al.   FREE RADICAL BIOLOGY AND MEDICINE

Active Immunization with Amyloid-  1-42 Impairs Memory Performance through TLR2/4-Dependent Activation of the Innate Immune System

(2010) P. Vollmar et al.   JOURNAL OF IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

Association between late-onset Alzheimer's disease and microsatellite polymorphisms in intron II of the human toll-like receptor 2 gene

(2010) Li-Zhu Wang et al.   NEUROSCIENCE LETTERS

UPR to TLR Connection

(2010) N. R. Gough   Science Signaling

Microglia Activated with the Toll-Like Receptor 9 Ligand CpG Attenuate Oligomeric Amyloid β Neurotoxicity in in Vitro and in Vivo Models of Alzheimer’s Disease

(2009) Yukiko Doi et al.   AMERICAN JOURNAL OF PATHOLOGY

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

Extracellular mutant SOD1 induces microglial-mediated motoneuron injury

(2009) Weihua Zhao et al.   GLIA

Stimulation of Toll-Like Receptor 9 by Chronic Intraventricular Unmethylated Cytosine-Guanine DNA Infusion Causes Neuroinflammation and Impaired Spatial Memory

(2009) Simone C. Tauber et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar A -Stimulated Microglial Activation

(2009) E. G. Reed-Geaghan et al.   JOURNAL OF NEUROSCIENCE

Induction of Toll-Like Receptor 9 Signaling as a Method for Ameliorating Alzheimer's Disease-Related Pathology

(2009) H. Scholtzova et al.   JOURNAL OF NEUROSCIENCE

Differential regulation of toll-like receptor mRNAs in amyloid plaque-associated brain tissue of aged APP23 transgenic mice

(2009) Stefanie Frank et al.   NEUROSCIENCE LETTERS

Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration

(2009) H. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like receptors in neurodegeneration

(2008) Eitan Okun et al.   BRAIN RESEARCH REVIEWS

Toll-like receptors control autophagy

(2008) Mónica A Delgado et al.   EMBO JOURNAL

Expression of Amyotrophic Lateral Sclerosis-linked SOD1 Mutant Increases the Neurotoxic Potential of Microglia via TLR2

(2008) Yang Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll-Like Receptor 2 Acts as a Natural Innate Immune Receptor to Clear Amyloid  1-42 and Delay the Cognitive Decline in a Mouse Model of Alzheimer's Disease

(2008) K. L. Richard et al.   JOURNAL OF NEUROSCIENCE

Screening of innate immune receptors in neurodegenerative diseases: A similar pattern

(2007) Maryse Letiembre et al.   NEUROBIOLOGY OF AGING

Circulating cell wall components derived from gram-negative, not gram-positive, bacteria cause a profound induction of the gene-encoding Toll-like receptor 2 in the CNS

(2003) Nathalie Laflamme et al.   JOURNAL OF NEUROCHEMISTRY