Intestine-specific Disruption of Hypoxia-inducible Factor (HIF)-2α Improves Anemia in Sickle Cell Disease

Sickle cell disease: a neglected chronic disease of increasing global health importance

(2014) Subarna Chakravorty et al.   ARCHIVES OF DISEASE IN CHILDHOOD

A competitive enzyme-linked immunosorbent assay specific for murine hepcidin-1: correlation with hepatic mRNA expression in established and novel models of dysregulated iron homeostasis

(2014) P. Gutschow et al.   HAEMATOLOGICA

The gut in iron homeostasis: role of HIF-2 under normal and pathological conditions

(2013) M. Mastrogiannaki et al.   BLOOD

Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies

(2013) D. Manwani et al.   BLOOD

Endothelial PAS Domain Protein 1 Activates the Inflammatory Response in the Intestinal Epithelium to Promote Colitis in Mice

(2013) Xiang Xue et al.   GASTROENTEROLOGY

Allosteric inhibition of hypoxia inducible factor-2 with small molecules

(2013) Thomas H Scheuermann et al.   Nature Chemical Biology

Intestinal HIF2  promotes tissue-iron accumulation in disorders of iron overload with anemia

(2013) E. R. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

World Distribution, Population Genetics, and Health Burden of the Hemoglobinopathies

(2013) T. N. Williams et al.   Cold Spring Harbor Perspectives in Medicine

Serum ferritin and total units transfused for assessing iron overload in adults with sickle cell disease

(2012) Emma Drasar et al.   BRITISH JOURNAL OF HAEMATOLOGY

Hypoxia-Inducible Factor-2  Activation Promotes Colorectal Cancer Progression by Dysregulating Iron Homeostasis

(2012) X. Xue et al.   CANCER RESEARCH

Hypoxia-Inducible Factor-2α Mediates the Adaptive Increase of Intestinal Ferroportin During Iron Deficiency in Mice

(2011) Matthew Taylor et al.   GASTROENTEROLOGY

Intestinal Hypoxia-inducible Factor-2α (HIF-2α) Is Critical for Efficient Erythropoiesis

(2011) Erik R. Anderson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes

(2011) A. D. Campbell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice

(2010) Sara Gardenghi et al.   JOURNAL OF CLINICAL INVESTIGATION

Sickle-cell disease

(2010) David C Rees et al.   LANCET

Vasculopathy in sickle cell disease: Biology, pathophysiology, genetics, translational medicine, and new research directions

(2009) Gregory J. Kato et al.   AMERICAN JOURNAL OF HEMATOLOGY

Recent advances in improving the management of sickle cell disease

(2009) Adlette Inati   BLOOD REVIEWS

Intestinal Hypoxia-Inducible Transcription Factors Are Essential for Iron Absorption following Iron Deficiency

(2009) Yatrik M. Shah et al.   Cell Metabolism

Hemoglobinopathies Worldwide: Present and Future

(2008) David Weatherall   CURRENT MOLECULAR MEDICINE