PHD Inhibition Mitigates and Protects Against Radiation-Induced Gastrointestinal Toxicity via HIF2

Structure-based drug design for hypoxia-inducible factor prolyl-hydroxylase inhibitors and its therapeutic potential for the treatment of erythropoiesis-stimulating agent-resistant anemia: raising expectations for exploratory clinical trials

(2013) Yoshiki Higashijima et al.   Expert Opinion on Drug Discovery

The HIF Signaling Pathway in Osteoblasts Directly Modulates Erythropoiesis through the Production of EPO

(2012) Erinn B. Rankin et al.   CELL

Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in mice

(2012) Jimmy Rotolo et al.   JOURNAL OF CLINICAL INVESTIGATION

1,3,8-Triazaspiro[4.5]decane-2,4-diones as Efficacious Pan-Inhibitors of Hypoxia-Inducible Factor Prolyl Hydroxylase 1–3 (HIF PHD1–3) for the Treatment of Anemia

(2012) Petr Vachal et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacological targeting of the thrombomodulin–activated protein C pathway mitigates radiation toxicity

(2012) Hartmut Geiger et al.   NATURE MEDICINE

Acute radiation syndrome caused by accidental radiation exposure - therapeutic principles

(2011) Harald Dörr et al.   BMC Medicine

A review of radiation countermeasure work ongoing at the Armed Forces Radiobiology Research Institute

(2011) Vijay K. Singh et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

(2011) Hua Tian et al.   NATURE

Activation of Hif1α by the Prolylhydroxylase Inhibitor Dimethyoxalyglycine Decreases Radiosensitivity

(2011) Marina K. Ayrapetov et al.   PLoS One

The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations

(2011) K. S. Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bactericidal/Permeability-Increasing Protein (rBPI21) and Fluoroquinolone Mitigate Radiation-Induced Bone Marrow Aplasia and Death

(2011) E. C. Guinan et al.   Science Translational Medicine

Histone  H2AX and Poly(ADP-Ribose) as Clinical Pharmacodynamic Biomarkers

(2010) C. E. Redon et al.   CLINICAL CANCER RESEARCH

Reduced mucin sulfonation and impaired intestinal barrier function in the hyposulfataemic NaS1 null mouse

(2009) P A Dawson et al.   GUT

History and development of radiation-protective agents

(2009) Joseph F. Weiss et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Protective Role of R-spondin1, an Intestinal Stem Cell Growth Factor, against Radiation-Induced Gastrointestinal Syndrome in Mice

(2009) Payel Bhanja et al.   PLoS One

Bmi1 lineage tracing identifies a self-renewing pancreatic acinar cell subpopulation capable of maintaining pancreatic organ homeostasis

(2009) E. Sangiorgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 Controls Radiation-Induced Gastrointestinal Syndrome in Mice Independent of Apoptosis

(2009) D. G. Kirsch et al.   SCIENCE

Bmi1 is expressed in vivo in intestinal stem cells

(2008) Eugenio Sangiorgi et al.   NATURE GENETICS

An Agonist of Toll-Like Receptor 5 Has Radioprotective Activity in Mouse and Primate Models

(2008) L. G. Burdelya et al.   SCIENCE

Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

(2007) K. Takeda et al.   BLOOD

The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis

(2007) Eoin P. Cummins et al.   GASTROENTEROLOGY