Article
Biochemistry & Molecular Biology
Xiangyun Li, Jianbo Yu, Lirong Gong, Yuan Zhang, Shuan Dong, Jia Shi, Cui Li, Yuting Li, Yanfang Zhang, Haibo Li
Summary: Sepsis-induced acute lung injury leads to oxidative stress, inflammation, apoptosis, and changes in Golgi morphology. Activating the HO-1 pathway can alleviate Golgi stress and oxidative stress, providing a therapeutic target for treating acute lung injury.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Jose Angel Alonso-Pineiro, Almudena Gonzalez-Rovira, Ismael Sanchez-Gomar, Juan Antonio Moreno, Ma Carmen Duran-Ruiz
Summary: Atherosclerosis, the underlying cause of cardiovascular diseases and high mortality rates, progresses with the formation of atherosclerotic plaques due to oxidative stress. Strategies aimed at reducing oxidative damage, including the use of antioxidant molecules such as Nrf2 and HO-1, have been studied to inhibit the progression of atherosclerosis.
Review
Biochemistry & Molecular Biology
Jia-Jing Lu, Ayitila Abudukeyoumu, Xing Zhang, Li-Bing Liu, Ming-Qing Li, Feng Xie
Summary: This review summarizes the different effects of HO-1 under normal and diseased conditions, with implications on the diagnosis and treatment of gynecological cancers, suggesting its potential role in cell proliferation, metastasis, immune regulation, and angiogenesis as an oncogene.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Psychiatry
Thomas Bertrand, Ayda Tavitian, Julia M. Galindez, Vimal Kothari, Shrisha Mohit, Carmela Galindez, Adrienne Liberman, Judy Glass, Ana M. Velly, Mervyn Gornitsky, Karl Looper, Soham Rej, Hyman M. Schipper
Summary: This study found that higher levels of salivary HO-1 expression were detected in patients experiencing an acute psychotic episode compared to control participants, and this overexpression was positively associated with psychiatric symptom severity and disability. The results suggest that overexpression of HO-1 in saliva may serve as a potential biomarker for psychosis and should be explored further in larger clinical trials.
PSYCHIATRY RESEARCH
(2021)
Review
Immunology
Sen Yang, Jing Ouyang, Yanqiu Lu, Vijay Harypursat, Yaokai Chen
Summary: Iron metabolism is essential for the survival of humans and microorganisms, and heme oxygenase-1 (HO-1) plays a significant role in this process. Recent studies have shown that HO-1 has a dual role in tuberculosis, acting as both a cytoprotective molecule and potentially facilitating the survival and dissemination of Mycobacterium tuberculosis. This understanding of the interplay between HO-1, tuberculosis, and the host is crucial for the development of potential strategies to modulate HO-1 and iron metabolism.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Akihiro Yachie
Summary: HO-1 is crucial in protecting tissues and organs from oxidative stress and excessive inflammatory reactions. Deficiency in HO-1 leads to dysfunction in monocytes, macrophages, and endothelial cells, resulting in systemic inflammatory response syndrome. Therapeutic induction of HO-1 production through pharmacological intervention shows promise in controlling inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Zihao Yan, Jiwu Wan, Jia Liu, Baolan Yao, Yuqian Lu, Zhengyao Guo, Yuehong Li
Summary: Alpha-lipoic acid exhibits protective effects against chronic ammonia stress in crucian carp by alleviating oxidative stress and endoplasmic reticulum stress.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Zihao Yan, Jiwu Wan, Jia Liu, Baolan Yao, Yuqian Lu, Zhengyao Guo, Yuehong Li
Summary: This study investigated the protective effects of alpha-lipoic acid against chronic ammonia stress in crucian carp. The results showed that alpha-lipoic acid effectively induced humoral immunity, alleviated oxidative stress and endoplasmic reticulum stress, and ultimately reduced liver injury caused by ammonia poisoning.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Valeria Sorrenti, Agata Grazia D'Amico, Ignazio Barbagallo, Valeria Consoli, Salvo Grosso, Luca Vanella
Summary: The overexpression of HO-1 in NSCLC cells and the inhibitory effect of SnMP on cell proliferation and migration, as well as the increase in oxidative stress, suggest that HO activity inhibition may be a potential target for selective chemotherapy in lung cancer subtypes.
Review
Pharmacology & Pharmacy
Yumin Wang, Luyan Gao, Jichao Chen, Qiang Li, Liang Huo, Yanchao Wang, Hongquan Wang, Jichen Du
Summary: Parkinson's disease is a complex neurodegenerative disorder characterized by the loss of dopaminergic neurons in the brain. Oxidative stress has been implicated in its pathogenesis, with the transcription factor Nrf2 playing a key role in activating protective genes against oxidative stress. Recent studies have shown that bioactive compounds can activate Nrf2 and ameliorate neurotoxins associated with PD, suggesting a potential therapeutic target for the treatment of the disease.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yang Huang, Zi Ye, Yujing Yin, Tianju Ma, Qi Zhang, Kun Shang, Wenqian Chen, Zhaohui Li
Summary: The loss of HO-1 enzymatic activity induces early-onset nuclear cataracts by activating oxidative stress and ER stress.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Physiology
Marta Martinez-Casales, Raquel Hernanz, Maria J. Alonso
Summary: Hypertension is considered an inflammatory disease with elevated cytokine levels and oxidative stress. In hypertension, the polarization of macrophages to the M1 phenotype plays a key role in producing inflammatory cytokines and oxidative stress.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chiara Caselli, Raffaele De Caterina, Rosetta Ragusa, Riccardo Liga, Alessia Gimelli, Arthur J. H. A. Scholte, Aldo Clerico, Juhani Knuuti, Danilo Neglia
Summary: The study aimed to evaluate the relationship between plasma HO-1 levels, clinical/molecular profiles, and coronary disease patterns in patients with chronic coronary syndromes (CCS). Results showed that patients with higher HO-1 levels were more often male, had higher BMI, and presented with a more diffuse but mainly non-obstructive coronary atherosclerosis, suggesting a potential protective role for the Nrf2/HO-1 pathway.
Review
Biochemistry & Molecular Biology
Somayyeh Ghareghomi, Faezeh Moosavi-Movahedi, Luciano Saso, Mehran Habibi-Rezaei, Ali Khatibi, Jun Hong, Ali A. Moosavi-Movahedi
Summary: Oxidative stresses play a pivotal role in various pathophysiological conditions. The Keap1/Nrf2 pathway is a dual-edged sword with beneficial effects on both normal and cancer cells by regulating endogenous antioxidant enzymes. Targeting the Nrf2/HO-1 axis is considered a novel strategy for cancer treatment, especially in lung cancer.
Review
Biochemistry & Molecular Biology
Marilina Mascaro, Eliana N. Alonso, Exequiel G. Alonso, Ezequiel Lacunza, Alejandro C. Curino, Maria Marta Facchinetti
Summary: Heme Oxygenase-1 (HO-1) is a detoxifying enzyme that catalyzes heme degradation, and its nuclear translocation may play a role in cancer progression. This enzyme leaves the smooth endoplasmic reticulum membrane and migrates to the nucleus, potentially contributing to therapy resistance and metastasis.
Article
Cell Biology
Larissa Daniele Bobermin, Fernanda Becker Weber, Tiago Marcon dos Santos, Adriane Bello-Klein, Angela T. S. Wyse, Carlos-Alberto Goncalves, Andre Quincozes-Santos
Summary: Sulforaphane, a natural compound, has anti-inflammatory and antioxidant properties. This study found that sulforaphane protects astroglial cells by inhibiting inflammation and oxidative stress, through modulation of multiple molecular mechanisms.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Review
Neurosciences
Angela T. S. Wyse, Larissa Daniele Bobermin, Tiago Marcon dos Santos, Andre Quincozes-Santos
Summary: Hyperhomocysteinemia can result from dietary intake, lifestyle factors, or enzyme deficiency, leading to tissue accumulation of the amino acid and potential neurological symptoms. The link between homocysteine and neurodegenerative/neuropsychiatric disorders has been suggested, with astrocyte dysfunction possibly playing a role in the neurotoxicity.Understanding the impact of homocysteine on gliotoxicity may lead to novel preventive/therapeutic strategies for these diseases.
NEUROTOXICITY RESEARCH
(2021)
Article
Cell Biology
Tiago Marcon dos Santos, Cassiana Siebert, Larissa Daniele Bobermin, Andre Quincozes-Santos, Angela T. S. Wyse
Summary: The study revealed that mild hyperhomocysteinemia may lead to anxiety-like behavior and alterations in locomotion/exploration in rats. Glutamate uptake remained unchanged, but the activities of glutamine synthetase and ATPases were increased. Cell viability was not affected.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Review
Neurosciences
Vanessa Sovrani, Larissa Daniele Bobermin, Izaviany Schmitz, Guilhian Leipnitz, Andre Quincozes-Santos
Summary: Astrocytes play a crucial role in maintaining brain homeostasis by supporting neurons through metabolic coupling and glucose utilization. Diabetes mellitus-induced glucose metabolism disorders can damage astrocytes, affecting CNS functionality. Glioprotective molecules and natural products are being studied as potential strategies to protect against such harmful effects.
NEUROTOXICITY RESEARCH
(2021)
Article
Environmental Sciences
Melissa Rosa de Souza, Ana Leticia Hilario Garcia, Daiana Dalberto, Gabriela Martins, Juliana Picinini, Guilherme Mauricio Soares de Souza, Paola Chytry, Johnny Ferraz Dias, Larissa Daniele Bobermin, Andre Quincozes-Santos, Juliana da Silva
Summary: Although no genotoxic or mutagenic effects were evident from exposure to coal in the environment, levels of inflammatory cytokines were increased in cities around power plants. Micronucleus levels were associated with body mass index and cardiovascular risk, while inorganic elements showed correlations with DNA damage and inflammatory responses. Furthermore, reductions in inorganic elements were linked to aging and health status.
ENVIRONMENTAL POLLUTION
(2021)
Article
Neurosciences
Larissa Daniele Bobermin, Romulo Rodrigo de Souza Almeida, Fernanda Becker Weber, Lara Scopel Medeiros, Livia Medeiros, Angela T. S. Wyse, Carlos-Alberto Goncalves, Andre Quincozes-Santos
Summary: The study showed that resveratrol can protect aged astrocytes from LPS-induced toxicity, reduce inflammatory response, and improve astroglial functions. The glioprotective effects of resveratrol on aged astrocytes may be associated with molecular mechanisms such as SIRT1, Nrf2, and HO-1.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Juliana Cavalli, Pollyana Mendonca de Assis, Elaine Cristina Dalazen Goncalves, Larissa Daniele Bobermin, Andre Quincozes-Santos, Nadia Rezende Barbosa Raposo, Marcus Vinicius Gomez, Rafael Cypriano Dutra
Summary: CTK 01512-2 was found to be effective in reducing mechanical hypersensitivity and thermal allodynia in chronic pain conditions. It also increased glial cell viability, suggesting a potential new approach to managing chronic pain. These findings provide new perspectives for the treatment of patients with chronic pain.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Filipe Renato Pereira Dias, Romulo Rodrigo de Souza Almeida, Vanessa Sovrani, Natalie K. Thomaz, Carlos-Alberto Goncalves, Andre Quincozes-Santos, Larissa Daniele Bobermin
Summary: This study demonstrates for the first time that BMAA directly affects key astroglial functions, contributing to elucidating the cellular and molecular mechanisms of this toxin in the CNS. In addition, we reinforce the glioprotective effects of resveratrol against BMAA-induced astroglial dysfunctions.
NEUROTOXICITY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Romulo Rodrigo de Souza Almeida, Larissa Daniele Bobermin, Belisa Parmeggiani, Krista Mineia Wartchow, Diogo Onofre Souza, Carlos-Alberto Goncalves, Moacir Wajner, Guilhian Leipnitz, Andre Quincozes-Santos
Summary: Methylmalonic acidemia is a neurometabolic disorder characterized by the accumulation of methylmalonic acid in various tissues, including the central nervous system. Astroglial cells play a significant role in maintaining brain homeostasis and are affected by the presence of methylmalonic acid. The study demonstrates the impact of methylmalonic acid on glial parameters, such as redox homeostasis and inflammatory response, and identifies potential mediators and protective molecules, such as melatonin and resveratrol.
Article
Cell Biology
Vanessa Sovrani, Larissa Daniele Bobermin, Camila Leite Santos, Morgana Brondani, Carlos-Alberto Goncalves, Guilhian Leipnitz, Andre Quincozes-Santos
Summary: Aging is associated with metabolic changes, oxidative and inflammatory damage, altered gene expression, and activity of signaling pathways. The hypothalamus, particularly astrocytes, plays a critical role in homeostatic functions during aging. Resveratrol, an anti-inflammatory and antioxidant molecule, was found to prevent the effects of aging on metabolic, oxidative, inflammatory, and senescence parameters in hypothalamic astrocyte cultures from aged rats. The treatment also upregulated key signaling pathways associated with cellular homeostasis.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Cell Biology
Julia Pramio, Mateus Grings, Amanda Gasparin da Rosa, Rafael Teixeira Ribeiro, Nicolas Manzke Glanzel, Marian Flores Signori, Manuela Bianchin Marcuzzo, Larissa Daniele Bobermin, Angela T. S. Wyse, Andre Quincozes-Santos, Moacir Wajner, Guilhian Leipnitz
Summary: Isolated sulfite oxidase (ISOD) and molybdenum cofactor (MoCD) deficiencies are genetic diseases characterized by the accumulation of toxic sulfite in the brain tissues, leading to neurological dysfunction and brain abnormalities in newborns. This study found that sulfite administration caused redox imbalance, mitochondrial dysfunction, and altered signaling proteins in the cerebral cortex of rat pups, which may contribute to the neuropathology of ISOD and MoCD.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Review
Neurosciences
Andre Quincozes-Santos, Larissa Daniele Bobermin, Naithan Ludian Fernandes Costa, Natalie K. Thomaz, Romulo Rodrigo de Souza Almeida, Walter O. Beys-da-Silva, Lucelia Santi, Rafael L. Rosa, Daniela Capra, Juliana M. Coelho-Aguiar, Marcos Fabio DosSantos, Manoela Heringer, Elizabeth O. Cirne-Lima, Jorge Almeida Guimaraes, Lavinia Schuler-Faccini, Carlos-Alberto Goncalves, Vivaldo Moura-Neto, Diogo Onofre Souza
Summary: Zika virus infects glial cells in both the central and peripheral nervous systems, leading to neurological complications and potential neurodevelopmental disorders. Understanding the changes in glial cell functions, including inflammatory response, oxidative stress, mitochondrial dysfunction, calcium and glutamate homeostasis, neural metabolism, and neuron-glia communication, may contribute to the development of preventive and therapeutic strategies against Zika virus-induced neurodegeneration.
Article
Biochemistry & Molecular Biology
Marina C. Leite, Fabiana Galland, Maria Cristina Guerra, Leticia Rodrigues, Jessica Taday, Priscila T. Monteforte, Hanko Hirata, Carmem Gottfried, Rosario Donato, Soraya Smaili, Carlos-Alberto Goncalves
Summary: The secretion of S100B by astrocytes is triggered by the increase in intracellular Ca2+, which is caused by the mobilization of Ca2+ from the endoplasmic reticulum. The widely used solvent DMSO acts as a secretagogue for S100B, promoting its secretion both in vitro and in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Vitor Gayger-Dias, Adriana F. K. Vizuete, Leticia Rodrigues, Krista Mineia Wartchow, Larissa Bobermin, Marina Concli Leite, Andre Quincozes-Santos, Andrea Kleindienst, Carlos-Alberto Goncalves
Summary: This article reviews the interpretation of S100B as a marker of brain injury and discusses the mechanisms by which astrocyte-produced S100B reaches the circulatory system. The article emphasizes the concept of S100B as an alarmin and its dual activity as an inflammatory and neurotrophic molecule. Furthermore, it points out the lack of data supporting S100B as a marker of blood-brain barrier rupture and the need to consider the glymphatic system when interpreting serum changes of S100B.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Immunology
Larissa Daniele Bobermin, Andre Quincozes-Santos
Summary: COVID-19 not only affects the respiratory system, but also leads to extrapulmonary manifestations such as encephalopathy and liver damage. An important point to note is the potential connection between liver and brain dysfunctions, with astrocyte dysfunction possibly resulting in long-term neurological consequences.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2021)