Hypoxia and HIF Signaling: One Axis with Divergent Effects

Heat shock transcription factor 1 regulates exercise‐induced myocardial angiogenesis after pressure overload via HIF‐1α/VEGF pathway

(2020) Xu Tian et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

P-21-activated kinase 1 contributes to tumor angiogenesis upon photodynamic therapy via the HIF-1α/VEGF pathway

(2020) Shuai Jiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1α Unleashes NK Cell Activity

(2020) Jing Ni et al.   IMMUNITY

Extracellular Vesicles and Tumor-Immune Escape: Biological Functions and Clinical Perspectives

(2020) Stefania Raimondo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hypoxia sensing by hepatic stellate cells leads to VEGF-dependent angiogenesis and may contribute to accelerated liver regeneration

(2020) Konstantin Dirscherl et al.   Scientific Reports

HIF-1α and HIF-2α Differently Regulate the Radiation Sensitivity of NSCLC Cells

(2019) Eloy Moreno Roig et al.   Cells

Hypoxia and Hypoxia-Inducible Factors in Kidney Injury and Repair

(2019) Shaoqun Shu et al.   Cells

Targeting Autophagy to Overcome Human Diseases

(2019) Maria Condello et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Things get broken: the hypoxia-inducible factor prolyl hydroxylases in ischemic heart disease

(2019) Timm Schreiber et al.   BASIC RESEARCH IN CARDIOLOGY

Hypoxia Induced by Vascular Damage at High Doses Could Compromise the Outcome of Radiotherapy

(2019) EMELY KJELLSSON LINDBLOM et al.   ANTICANCER RESEARCH

Hypoxia-inducible factors in CD4+ T cells promote metabolism, switch cytokine secretion, and T cell help in humoral immunity

(2019) Sung Hoon Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Update on mutations in the HIF: EPO pathway and their role in erythrocytosis

(2019) Terence R. Lappin et al.   BLOOD REVIEWS

Hypoxia signaling in human diseases and therapeutic targets

(2019) Jae W. Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Regulation of Gene Expression under Hypoxic Conditions

(2019) Koh Nakayama et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Comprehensive Review of Autophagy and Its Various Roles in Infectious, Non-Infectious, and Lifestyle Diseases: Current Knowledge and Prospects for Disease Prevention, Novel Drug Design, and Therapy

(2019) Rekha Khandia et al.   Cells

Hypoxia‐Inducible Factor (HIF)‐2α Reprograms Liver Macrophages to Protect Against Acute Liver Injury via the Production of Interleukin‐6

(2019) Rachel Y. Gao et al.   HEPATOLOGY

HIF‑1α promotes NLRP3 inflammasome activation in bleomycin‑induced acute lung injury

(2019) Jun‑Jun Huang et al.   Molecular Medicine Reports

Salidroside and FG-4592 ameliorate high glucose-induced glomerular endothelial cells injury via HIF upregulation

(2019) Rui-yan Xie et al.   BIOMEDICINE & PHARMACOTHERAPY

Prolyl hydroxylase inhibition protects the kidneys from ischemia via upregulation of glycogen storage

(2019) Marie Ito et al.   KIDNEY INTERNATIONAL

Role of hypoxia in cancer therapy by regulating the tumor microenvironment

(2019) Xinming Jing et al.   Molecular Cancer

CD146-HIF-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension

(2019) Yongting Luo et al.   Nature Communications

HIF-1α/BNIP3 signaling pathway-induced-autophagy plays protective role during myocardial ischemia-reperfusion injury

(2019) Yanan Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Role of the NF-κB signaling pathway in the pathogenesis of colorectal cancer

(2019) Atena Soleimani et al.   GENE

Current Mechanistic Concepts in Ischemia and Reperfusion Injury

(2018) Meng-Yu Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat (FG-4592) protects against cisplatin-induced acute kidney injury

(2018) Yunwen Yang et al.   CLINICAL SCIENCE

Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury

(2018) Michael Koeppen et al.   Nature Communications

Hypoxia Inducible Factor 1α Plays a Key Role in Remote Ischemic Preconditioning Against Stroke by Modulating Inflammatory Responses in Rats

(2018) Jian Yang et al.   Journal of the American Heart Association

Effects of Simultaneous Downregulation of PHD1 and Keap1 on Prevention and Reversal of Liver Fibrosis in Mice

(2018) Jing Liu et al.   Frontiers in Pharmacology

miR-21 Protects Against Ischemia/Reperfusion-Induced Acute Kidney Injury by Preventing Epithelial Cell Apoptosis and Inhibiting Dendritic Cell Maturation

(2018) Nana Song et al.   Frontiers in Physiology

Infarct size-limiting effect of epoxyeicosatrienoic acid analog EET-B is mediated by hypoxia inducible factor-1α via down regulation of prolyl hydroxylase 3

(2018) Jan Neckar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Inflammation stimulates hypoxia-inducible factor-1α regulatory activity in 3T3-L1 adipocytes with conditioned medium from lipopolysaccharide-activated RAW 264.7 macrophages

(2018) Amaya Lopez-Pascual et al.   JOURNAL OF CELLULAR PHYSIOLOGY

PI3K/Akt and HIF‑1 signaling pathway in hypoxia‑ischemia (Review)

(2018) Zhen Zhang et al.   Molecular Medicine Reports

Chronic intermittent hypoxia promotes myocardial ischemia-related ventricular arrhythmias and sudden cardiac death

(2018) Jessica Morand et al.   Scientific Reports

Hypoxia Exacerbates Inflammatory Acute Lung Injury via the Toll-Like Receptor 4 Signaling Pathway

(2018) Gang Wu et al.   Frontiers in Immunology

Identification of a functional antioxidant response element at the HIF1A locus

(2018) Sarah E. Lacher et al.   Redox Biology

MicroRNA-668 represses MTP18 to preserve mitochondrial dynamics in ischemic acute kidney injury

(2018) Qingqing Wei et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia Modifies the Transcriptome of Human NK Cells, Modulates Their Immunoregulatory Profile, and Influences NK Cell Subset Migration

(2018) Monica Parodi et al.   Frontiers in Immunology

Roxadustat in the treatment of anaemia in chronic kidney disease

(2017) Lucia Del Vecchio et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Hypoxia-inducible factor-1α: a promising therapeutic target for autoimmune diseases

(2017) Shi-Yang Guan et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Synergistic effect of HIF-1α and FoxO3a trigger cardiomyocyte apoptosis under hyperglycemic ischemia condition

(2017) Ya-Fang Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hypoxia inducible factor stabilization improves defective ischemia-induced angiogenesis in a rodent model of chronic kidney disease

(2017) Isabel N. Schellinger et al.   KIDNEY INTERNATIONAL

AKI on CKD: heightened injury, suppressed repair, and the underlying mechanisms

(2017) Liyu He et al.   KIDNEY INTERNATIONAL

Hypoxia of the growing liver accelerates regeneration

(2017) Erik Schadde et al.   SURGERY

Renal Protection Mediated by Hypoxia Inducible Factor-1α Depends on Proangiogenesis Function of miR-21 by Targeting Thrombospondin 1

(2017) Xialian Xu et al.   TRANSPLANTATION

Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis

(2017) Ewelina Krzywinska et al.   Nature Communications

Reduction of hepatic fibrosis by overexpression of von Hippel–Lindau protein in experimental models of chronic liver disease

(2017) Jizhou Wang et al.   Scientific Reports

Localized Delivery of shRNA against PHD2 Protects the Heart from Acute Myocardial Infarction through Ultrasound-Targeted Cationic Microbubble Destruction

(2017) Li Zhang et al.   Theranostics

Double Knockdown of PHD1 and Keap1 Attenuated Hypoxia-Induced Injuries in Hepatocytes

(2017) Jing Liu et al.   Frontiers in Physiology

Non-electron transfer chain mitochondrial defects differently regulate HIF-1α degradation and transcription

(2017) Antonina N. Shvetsova et al.   Redox Biology

Hepatocyte Hypoxia Inducible Factor-1 Mediates the Development of Liver Fibrosis in a Mouse Model of Nonalcoholic Fatty Liver Disease

(2017) Omar A. Mesarwi et al.   PLoS One

Hypoxia-inducible factor prolyl-4-hydroxylase-1 is a convergent point in the reciprocal negative regulation of NF-κB and p53 signaling pathways

(2017) Karim Ullah et al.   Scientific Reports

Hypoxia: A Double-Edged Sword in Cancer Therapy

(2016) Hamed Manoochehri Khoshinani et al.   CANCER INVESTIGATION

Hypoxia‐inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype

(2016) Gregg L Semenza   EMBO JOURNAL

Short Term Hypoxia Synergizes with Interleukin 15 Priming in Driving Glycolytic Gene Transcription and Supports Human Natural Killer Cell Activities

(2016) Sonia Y. Velásquez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mortalin-mediated and ERK-controlled targeting of HIF-1α to mitochondria confers resistance to apoptosis under hypoxia

(2016) Ilias Mylonis et al.   JOURNAL OF CELL SCIENCE

Hypoxia-inducible factors: a central link between inflammation and cancer

(2016) Daniel Triner et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF-1 α as a Key Factor in Bile Duct Ligation-Induced Liver Fibrosis in Rats

(2016) Joanna Moczydlowska et al.   JOURNAL OF INVESTIGATIVE SURGERY

Hypoxia-inducible factors as molecular targets for liver diseases

(2016) Cynthia Ju et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Cellular and Molecular Mechanisms of AKI

(2016) A. Agarwal et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Alveolar Hypoxia-Induced Pulmonary Inflammation: From Local Initiation to Secondary Promotion by Activated Systemic Inflammation

(2016) Ting Chen et al.   JOURNAL OF VASCULAR RESEARCH

Transcription factor HIF1A: downstream targets, associated pathways, polymorphic hypoxia response element (HRE) sites, and initiative for standardization of reporting in scientific literature

(2016) Lucija Slemc et al.   TUMOR BIOLOGY

The route to solve the interplay between inflammation, angiogenesis and anti-cancer immune response

(2016) C Botta et al.   Cell Death & Disease

HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity

(2016) Hiroaki Semba et al.   Nature Communications

Mitochondrial autophagy: Origins, significance, and role of BNIP3 and NIX

(2015) Paul A. Ney   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Tumor-Promoting Effects of Myeloid-Derived Suppressor Cells Are Potentiated by Hypoxia-Induced Expression of miR-210

(2015) Muhammad Zaeem Noman et al.   CANCER RESEARCH

Cardiomyocyte-Specific Transgenic Expression of Prolyl-4-Hydroxylase Domain 3 Impairs the Myocardial Response to Ischemia

(2015) Anke Zieseniss et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Protective effects of polydatin on lipopolysaccharide-induced acute lung injury through TLR4-MyD88-NF-κB pathway

(2015) Qi Jiang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Alveolar Epithelial A2B Adenosine Receptors in Pulmonary Protection during Acute Lung Injury

(2015) Sandra Hoegl et al.   JOURNAL OF IMMUNOLOGY

Depletion of PHD3 protects heart from ischemia/reperfusion injury by inhibiting cardiomyocyte apoptosis

(2015) Liang Xie et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer

(2015) Rafik Salama et al.   PLoS One

The p53 family and the hypoxia-inducible factors (HIFs): determinants of cancer progression

(2015) Ivano Amelio et al.   TRENDS IN BIOCHEMICAL SCIENCES

ERβ regulation of NF-kB activation in prostate cancer is mediated by HIF-1

(2015) Paul Mak et al.   Oncotarget

Up-regulation of hypoxia-inducible factor-1  enhanced the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats

(2014) X. Li et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Hypoxia-sensitive pathways in inflammation-driven fibrosis

(2014) Mario C. Manresa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation

(2014) Eric L. Campbell et al.   IMMUNITY

HIF Transcription Factors, Inflammation, and Immunity

(2014) Asis Palazon et al.   IMMUNITY

Hypoxia-inducible factors in regulation of immune responses in tumour microenvironment

(2014) Vinit Kumar et al.   IMMUNOLOGY

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of Hypoxia-Inducible Factor HIF-1A as Transcriptional Regulator of the A2B Adenosine Receptor during Acute Lung Injury

(2014) T. Eckle et al.   JOURNAL OF IMMUNOLOGY

Chronic inflammation and cancer: potential chemoprevention through nuclear factor kappa B and p53 mutual antagonism

(2014) Srabani Pal et al.   Journal of Inflammation-London

Regulation of Hypoxia-induced Pulmonary Hypertension by Vascular Smooth Muscle Hypoxia-Inducible Factor-1α

(2013) Molly K. Ball et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pulmonary Natural Killer T Cells Play an Essential Role in Mediating Hyperoxic Acute Lung Injury

(2013) Martina Nowak-Machen et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Macrophage A2A Adenosinergic Receptor Modulates Oxygen-Induced Augmentation of Murine Lung Injury

(2013) Neil R. Aggarwal et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Hypoxia-inducible factor 2  regulates key neutrophil functions in humans, mice, and zebrafish

(2013) A. A. R. Thompson et al.   BLOOD

Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity

(2013) Andrea Casazza et al.   CANCER CELL

SIRT1 Limits the Function and Fate of Myeloid-Derived Suppressor Cells in Tumors by Orchestrating HIF-1 -Dependent Glycolysis

(2013) G. Liu et al.   CANCER RESEARCH

Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population

(2013) D. Laoui et al.   CANCER RESEARCH

Crosstalk between the equilibrative nucleoside transporter ENT2 and alveolar Adora2b adenosine receptors dampens acute lung injury

(2013) Tobias Eckle et al.   FASEB JOURNAL

Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen

(2013) Andrew L Doedens et al.   NATURE IMMUNOLOGY

Hypoxia Induced Impairment of NK Cell Cytotoxicity against Multiple Myeloma Can Be Overcome by IL-2 Activation of the NK Cells

(2013) Subhashis Sarkar et al.   PLoS One

Regulation of IL-1 -induced NF- B by hydroxylases links key hypoxic and inflammatory signaling pathways

(2013) C. C. Scholz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia and inflammation are two sides of the same coin

(2013) K. Bartels et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIF1A Reduces Acute Lung Injury by Optimizing Carbohydrate Metabolism in the Alveolar Epithelium

(2013) Tobias Eckle et al.   PLOS BIOLOGY

Transcriptional control of adenosine signaling by hypoxia-inducible transcription factors during ischemic or inflammatory disease

(2012) Jens M. Poth et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

(2012) E. T. Clambey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

Molecular Pathways: Hypoxia Response in Immune Cells Fighting or Promoting Cancer

(2011) Asis Palazón et al.   CLINICAL CANCER RESEARCH

Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia

(2010) P. P. Kapitsinou et al.   BLOOD

Differential activation and antagonistic function of HIF-  isoforms in macrophages are essential for NO homeostasis

(2010) N. Takeda et al.   GENES & DEVELOPMENT

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

(2010) Cesar A. Corzo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-β-dependent mechanisms

(2010) Bryan L. Copple   LIVER INTERNATIONAL

Attenuation of myocardial injury by postconditioning: role of hypoxia inducible factor-1α

(2009) Huan-Xin Zhao et al.   BASIC RESEARCH IN CARDIOLOGY

Adenosine A2A receptor is a unique angiogenic target of HIF-2  in pulmonary endothelial cells

(2009) A. Ahmad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T regulatory cells: hypoxia-adenosinergic suppression and re-direction of the immune response

(2009) Michail V. Sitkovsky   TRENDS IN IMMUNOLOGY

Hypoxia-Inducible Factor-1 Is Central to Cardioprotection

(2008) Tobias Eckle et al.   CIRCULATION

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE

The Adenosine A2b Receptor: Its Role in Inflammation

(2008) J. Ham et al.   Endocrine Metabolic & Immune Disorders-Drug Targets