Extracellular Vesicles and Tumor-Immune Escape: Biological Functions and Clinical Perspectives

The role of extracellular vesicles and PD-L1 in glioblastoma-mediated immunosuppressive monocyte induction

(2020) Benjamin T Himes et al.   NEURO-ONCOLOGY

Oncogenic and Non‐Malignant Pancreatic Exosome Cargo Reveal Distinct Expression of Oncogenic and Prognostic Factors Involved in Tumour Invasion and Metastasis

(2019) Aikaterini Emmanouilidi et al.   PROTEOMICS

Hypoxia-induced tumor exosomes promote M2-like macrophage polarization of infiltrating myeloid cells and microRNA-mediated metabolic shift

(2019) Jung Eun Park et al.   ONCOGENE

The functional roles of exosomes-derived long non-coding RNA in human cancer

(2019) Feiyu Chen et al.   CANCER BIOLOGY & THERAPY

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

(2019) Mauro Poggio et al.   CELL

Exosome-Mediated Metastasis: Communication from a Distance

(2019) Inbal Wortzel et al.   DEVELOPMENTAL CELL

RAB27B‐activated secretion of stem‐like tumor exosomes delivers the biomarker microRNA‐146a‐5p, which promotes tumorigenesis and associates with an immunosuppressive tumor microenvironment in colorectal cancer

(2019) Wei‐Chung Cheng et al.   INTERNATIONAL JOURNAL OF CANCER

Efficacy and Safety of Pembrolizumab in Previously Treated Advanced Cervical Cancer: Results From the Phase II KEYNOTE-158 Study

(2019) Hyun Cheol Chung et al.   JOURNAL OF CLINICAL ONCOLOGY

Long non-coding RNA HOTAIR promotes exosome secretion by regulating RAB35 and SNAP23 in hepatocellular carcinoma

(2019) Liang Yang et al.   Molecular Cancer

Circulating exosomes measure responses to therapy in head and neck cancer patients treated with cetuximab, ipilimumab, and IMRT

(2019) Marie-Nicole Theodoraki et al.   OncoImmunology

Exosomal miRNA-107 induces myeloid-derived suppressor cell expansion in gastric cancer

(2019) WeiHong Ren et al.   Cancer Management and Research

Melanoma extracellular vesicles generate immunosuppressive myeloid cells by PD-L1 upregulation via TLR4 signaling

(2019) Viktor Fleming et al.   CANCER RESEARCH

c-Met and PD-L1 on Circulating Exosomes as Diagnostic and Prognostic Markers for Pancreatic Cancer

(2019) Alexander Lux et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma

(2019) Malgorzata Czystowska-Kuzmicz et al.   Nature Communications

T Cell Dysfunction in Cancer Immunity and Immunotherapy

(2019) Anliang Xia et al.   Frontiers in Immunology

The Remarkable Plasticity of Macrophages: A Chance to Fight Cancer

(2019) Nadège Bercovici et al.   Frontiers in Immunology

Tumor-Derived Extracellular Vesicles Inhibit Natural Killer Cell Function in Pancreatic Cancer

(2019) Jiangang Zhao et al.   Cancers

Exosomal PD-L1 promotes tumor growth through immune escape in non-small cell lung cancer

(2019) Dong Ha Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Tumor-derived exosomes, myeloid-derived suppressor cells, and tumor microenvironment

(2019) Xinyu Tian et al.   Journal of Hematology & Oncology

Exosomes Produced by Mesenchymal Stem Cells Drive Differentiation of Myeloid Cells into Immunosuppressive M2-Polarized Macrophages in Breast Cancer

(2019) Subir Biswas et al.   JOURNAL OF IMMUNOLOGY

Clinical significance of PD-L1 expression in serum-derived exosomes in NSCLC patients

(2019) Chuling Li et al.   Journal of Translational Medicine

The role of exosomal PD-L1 in tumor progression and immunotherapy

(2019) Feiting Xie et al.   Molecular Cancer

LncRNA RPPH1 promotes colorectal cancer metastasis by interacting with TUBB3 and by promoting exosomes-mediated macrophage M2 polarization

(2019) Zhen-xing Liang et al.   Cell Death & Disease

Extracellular Vesicles in Cancer Immune Microenvironment and Cancer Immunotherapy

(2019) Feng Xie et al.   Advanced Science

T Regulatory Cells and Priming the Suppressive Tumor Microenvironment

(2019) Christina M. Paluskievicz et al.   Frontiers in Immunology

Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth

(2018) Yi Yang et al.   CELL RESEARCH

Horizontal transfer of exosomal CXCR4 promotes murine hepatocarcinoma cell migration, invasion and lymphangiogenesis

(2018) Min Li et al.   GENE

Regulation and Function of the PD-L1 Checkpoint

(2018) Chong Sun et al.   IMMUNITY

Tumor exosomes block dendritic cells maturation to decrease the T cell immune response

(2018) Yongling Ning et al.   IMMUNOLOGY LETTERS

Pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib (KEYNOTE-224): a non-randomised, open-label phase 2 trial

(2018) Andrew X Zhu et al.   LANCET ONCOLOGY

Avelumab in metastatic urothelial carcinoma after platinum failure (JAVELIN Solid Tumor): pooled results from two expansion cohorts of an open-label, phase 1 trial

(2018) Manish R Patel et al.   LANCET ONCOLOGY

OUP accepted manuscript

(2018)   NEUROSURGERY

Immunosuppressive effects of hypoxia-induced glioma exosomes through myeloid-derived suppressor cells via the miR-10a/Rora and miR-21/Pten Pathways

(2018) Xiaofan Guo et al.   ONCOGENE

Oral cancer-derived exosomal NAP1 enhances cytotoxicity of natural killer cells via the IRF-3 pathway

(2018) Yingnan Wang et al.   ORAL ONCOLOGY

Tumor-derived exosomes induce PD1+ macrophage population in human gastric cancer that promotes disease progression

(2018) Furong Wang et al.   Oncogenesis

Exosomes and Immune Response in Cancer: Friends or Foes?

(2018) Francisco M. Barros et al.   Frontiers in Immunology

Glioblastoma stem cell-derived exosomes induce M2 macrophages and PD-L1 expression on human monocytes

(2018) Konrad Gabrusiewicz et al.   OncoImmunology

Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles

(2018) Franz L. Ricklefs et al.   Science Advances

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

Exosomes released from pancreatic cancer cells enhance angiogenic activities via dynamin-dependent endocytosis in endothelial cells in vitro

(2018) Mitsuru Chiba et al.   Scientific Reports

Glioma exosomes mediate the expansion and function of myeloid‐derived suppressor cells through microRNA‐29a/ Hbp1 and microRNA‐92a/ Prkar1a pathways

(2018) Xiaofan Guo et al.   INTERNATIONAL JOURNAL OF CANCER

Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer

(2018) Peter Schmid et al.   NEW ENGLAND JOURNAL OF MEDICINE

Exosomes Released from Tumor-Associated Macrophages Transfer miRNAs That Induce a Treg/Th17 Cell Imbalance in Epithelial Ovarian Cancer

(2018) Jieru Zhou et al.   Cancer Immunology Research

Rise of PD-L1 expression during metastasis of colorectal cancer: Implications for immunotherapy

(2017) Huan Bin Wang et al.   Journal of Digestive Diseases

Regulated Polarization of Tumor-Associated Macrophages by miR-145 via Colorectal Cancer–Derived Extracellular Vesicles

(2017) Haruka Shinohara et al.   JOURNAL OF IMMUNOLOGY

The MLL1-H3K4me3 Axis-Mediated PD-L1 Expression and Pancreatic Cancer Immune Evasion

(2017) Chunwan Lu et al.   JNCI-Journal of the National Cancer Institute

Health-related quality-of-life results for pembrolizumab versus chemotherapy in advanced, PD-L1-positive NSCLC (KEYNOTE-024): a multicentre, international, randomised, open-label phase 3 trial

(2017) Julie R Brahmer et al.   LANCET ONCOLOGY

Adjuvant Nivolumab versus Ipilimumab in Resected Stage III or IV Melanoma

(2017) Jeffrey Weber et al.   NEW ENGLAND JOURNAL OF MEDICINE

Aberrant low expression of p85α in stromal fibroblasts promotes breast cancer cell metastasis through exosome-mediated paracrine Wnt10b

(2017) Y Chen et al.   ONCOGENE

Glioma cells enhance angiogenesis and inhibit endothelial cell apoptosis through the release of exosomes that contain long non-coding RNA CCAT2

(2017) Hai-Li Lang et al.   ONCOLOGY REPORTS

Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23

(2017) Yao Wei et al.   Nature Communications

The MLL1-H3K4me3 Axis-Mediated PD-L1 Expression and Pancreatic Cancer Immune Evasion

(2017) Chunwan Lu et al.   JNCI-Journal of the National Cancer Institute

PD-1 and PD-L1 Checkpoint Signaling Inhibition for Cancer Immunotherapy: Mechanism, Combinations, and Clinical Outcome

(2017) Hashem O. Alsaab et al.   Frontiers in Pharmacology

PD-1/PD-L1 Blockade: Have We Found the Key to Unleash the Antitumor Immune Response?

(2017) Zijun Y. Xu-Monette et al.   Frontiers in Immunology

NK Cell Exhaustion

(2017) Jiacheng Bi et al.   Frontiers in Immunology

Human tumor-derived exosomes (TEX) regulate Treg functions via cell surface signaling rather than uptake mechanisms

(2017) Laurent Muller et al.   OncoImmunology

Efficacy and Safety of Durvalumab in Locally Advanced or Metastatic Urothelial Carcinoma

(2017) Thomas Powles et al.   JAMA Oncology

Tumor-derived exosomes induce CD8+ T cell suppressors

(2017) Brian T. Maybruck et al.   Journal for ImmunoTherapy of Cancer

T-Cell Immunoglobulin and ITIM Domain (TIGIT) Associates with CD8+ T-Cell Exhaustion and Poor Clinical Outcome in AML Patients

(2016) Y. Kong et al.   CLINICAL CANCER RESEARCH

Association of Pembrolizumab With Tumor Response and Survival Among Patients With Advanced Melanoma

(2016) Antoni Ribas et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Exosomes and tumor-mediated immune suppression

(2016) Theresa L. Whiteside   JOURNAL OF CLINICAL INVESTIGATION

Multiple myeloma exosomes establish a favourable bone marrow microenvironment with enhanced angiogenesis and immunosuppression

(2016) Jinheng Wang et al.   JOURNAL OF PATHOLOGY

Predictive Markers for the Efficacy of Anti–PD-1/PD-L1 Antibodies in Lung Cancer

(2016) Takehito Shukuya et al.   Journal of Thoracic Oncology

PD-L1 expression in colorectal cancer is associated with microsatellite instability, BRAF mutation, medullary morphology and cytotoxic tumor-infiltrating lymphocytes

(2016) Matthew W Rosenbaum et al.   MODERN PATHOLOGY

Exosomal Annexin II Promotes Angiogenesis and Breast Cancer Metastasis

(2016) Sayantan Maji et al.   MOLECULAR CANCER RESEARCH

Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck

(2016) Robert L. Ferris et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1

(2016) Chi Lam Au Yeung et al.   Nature Communications

Colorectal cancer cell-derived extracellular vesicles induce phenotypic alteration of T cells into tumor-growth supporting cells with transforming growth factor-β1-mediated suppression

(2016) Nami Yamada et al.   Oncotarget

Tumor-derived exosomes regulate expression of immune function-related genes in human T cell subsets

(2016) Laurent Muller et al.   Scientific Reports

Myeloid derived suppressor cell infiltration of murine and human gliomas is associated with reduction of tumor infiltrating lymphocytes

(2015) Baisakhi Raychaudhuri et al.   JOURNAL OF NEURO-ONCOLOGY

CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA

(2015) Alice Conigliaro et al.   Molecular Cancer

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

Nivolumab and Ipilimumab versus Ipilimumab in Untreated Melanoma

(2015) Michael A. Postow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma

(2015) Robert J. Motzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

(2015) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Upregulation of PD-L1 and APE1 is associated with tumorigenesis and poor prognosis of gastric cancer

(2015) Yi Qing et al.   Drug Design Development and Therapy

Exosomes isolated from plasma of glioma patients enrolled in a vaccination trial reflect antitumor immune activity and might predict survival

(2015) Laurent Muller et al.   OncoImmunology

Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma

(2015) Shu-biao Ye et al.   Oncotarget

Association of PD-L1 overexpression with activating EGFR mutations in surgically resected nonsmall-cell lung cancer

(2014) K. Azuma et al.   ANNALS OF ONCOLOGY

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways

(2014) Mirjam C. Boelens et al.   CELL

Correlation of PD-L1 Tumor Expression and Treatment Outcomes in Patients with Renal Cell Carcinoma Receiving Sunitinib or Pazopanib: Results from COMPARZ, a Randomized Controlled Trial

(2014) T. K. Choueiri et al.   CLINICAL CANCER RESEARCH

Regulatory T cells in cancer immunotherapy

(2014) Hiroyoshi Nishikawa et al.   CURRENT OPINION IN IMMUNOLOGY

Correlation between infiltration of FOXP3+ regulatory T cells and expression of B7-H1 in the tumor tissues of gastric cancer

(2014) Jingying Hou et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Human Tumor-Derived Exosomes Down-Modulate NKG2D Expression

(2014) A. Clayton et al.   JOURNAL OF IMMUNOLOGY

Vascular endothelial growth factor-A enhances indoleamine 2,3-dioxygenase expression by dendritic cells and subsequently impacts lymphocyte proliferation

(2014) Luciana Cavalheiro Marti et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

PD-L1 Expression in Triple-Negative Breast Cancer

(2014) E. A. Mittendorf et al.   Cancer Immunology Research

The Immunological Synapse

(2014) M. L. Dustin   Cancer Immunology Research

Exosomes from Murine-derived GL26 Cells Promote Glioblastoma Tumor Growth by Reducing Number and Function of CD8+T Cells

(2013) Zhi-Ming Liu et al.   Asian Pacific Journal of Cancer Prevention

Epidermal Growth Factor Receptor-Containing Exosomes Induce Tumor-Specific Regulatory T Cells

(2013) Shao-hong Huang et al.   CANCER INVESTIGATION

Clinical immunology Gastric cancer increase the percentage of intermediate (CD14++CD16+) and nonclassical (CD14+CD16+) monocytes

(2013) Andrzej Eljaszewicz et al.   Central European Journal of Immunology

Targeting the PD1/PD-L1 axis in melanoma: Biological rationale, clinical challenges and opportunities

(2013) Barbara Merelli et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment

(2013) Joel Crespo et al.   CURRENT OPINION IN IMMUNOLOGY

Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis

(2013) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Dendritic Cells in the Cancer Microenvironment

(2013) Yang Ma et al.   Journal of Cancer

Rab27a Supports Exosome-Dependent and -Independent Mechanisms That Modify the Tumor Microenvironment and Can Promote Tumor Progression

(2012) A. Bobrie et al.   CANCER RESEARCH

Natural killer cell immune escape in acute myeloid leukemia

(2012) E Lion et al.   LEUKEMIA

Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor- 1

(2011) M. J. Szczepanski et al.   HAEMATOLOGICA

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

(2011) Andrea Facciabene et al.   NATURE

Nomenclature of monocytes and dendritic cells in blood

(2010) L. Ziegler-Heitbrock et al.   BLOOD

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Macrophages, innate immunity and cancer: balance, tolerance, and diversity

(2010) Alberto Mantovani et al.   CURRENT OPINION IN IMMUNOLOGY

T regulatory cells in cancer: recent advances and therapeutic potential

(2010) Eyad Elkord et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Designing Vaccines Based on Biology of Human Dendritic Cell Subsets

(2010) Karolina Palucka et al.   IMMUNITY

Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells

(2010) Fanny Chalmin et al.   JOURNAL OF CLINICAL INVESTIGATION

High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation

(2010) Chuan-Yong Mu et al.   MEDICAL ONCOLOGY

Tumor-Derived Microvesicles Induce, Expand and Up-Regulate Biological Activities of Human Regulatory T Cells (Treg)

(2010) Marta Szajnik et al.   PLoS One

Targeting the transforming growth factor-β signaling pathway in human cancer

(2009) Nagathihalli S Nagaraj et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Tumor-Derived Microvesicles Promote Regulatory T Cell Expansion and Induce Apoptosis in Tumor-Reactive Activated CD8+ T Lymphocytes

(2009) E. U. Wieckowski et al.   JOURNAL OF IMMUNOLOGY

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

PD-1 and Its Ligands in Tolerance and Immunity

(2008) Mary E. Keir et al.   Annual Review of Immunology

Induction of myeloid-derived suppressor cells by tumor exosomes

(2008) Xiaoyu Xiang et al.   INTERNATIONAL JOURNAL OF CANCER

B7-H1 up-regulated expression in human pancreatic carcinoma tissue associates with tumor progression

(2008) Lei Geng et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY