Synergistic effect of HIF-1α and FoxO3a trigger cardiomyocyte apoptosis under hyperglycemic ischemia condition

Hypoxia suppresses myocardial survival pathway through HIF-1α-IGFBP-3-dependent signaling and enhances cardiomyocyte autophagic and apoptotic effects mainly via FoxO3a-induced BNIP3 expression

(2016) Chih-Chung Feng et al.   GROWTH FACTORS

Differentiation of Embryonic Stem Cells into Cardiomyocytes Used to Investigate the Cardioprotective Effect of Salvianolic Acid B through BNIP3 Involved Pathway

(2015) Chih-Yang Huang et al.   CELL TRANSPLANTATION

17β-Estradiol and/or Estrogen Receptor β Attenuate the Autophagic and Apoptotic Effects Induced by Prolonged Hypoxia Through HIF-1α-Mediated BNIP3 and IGFBP-3 Signaling Blockage

(2015) Dennis Jine-Yuan Hsieh et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

FOXO transcription factors: key regulators of cellular quality control

(2014) Ashley E. Webb et al.   TRENDS IN BIOCHEMICAL SCIENCES

Diallyl trisulfide and diallyl disulfide ameliorate cardiac dysfunction by suppressing apoptotic and enhancing survival pathways in experimental diabetic rats

(2012) Yao-Te Huang et al.   JOURNAL OF APPLIED PHYSIOLOGY

Glucose-Induced O2 Consumption Activates Hypoxia Inducible Factors 1 and 2 in Rat Insulin-Secreting Pancreatic Beta-Cells

(2012) Mohammed Bensellam et al.   PLoS One

The Hypoxia-Associated Factor Switches Cells from HIF-1 - to HIF-2 -Dependent Signaling Promoting Stem Cell Characteristics, Aggressive Tumor Growth and Invasion

(2011) M. Y. Koh et al.   CANCER RESEARCH

Hypoxia-Induced Overexpression of BNIP3 is Not Dependent on Hypoxia-Inducible Factor 1α in Mouse Hepatocytes

(2011) Rajaie A. Namas et al.   SHOCK

Hyperglycaemia-induced cardiomyocyte death is mediated via MCP-1 production and induction of a novel zinc-finger protein MCPIP

(2010) Craig W. Younce et al.   CARDIOVASCULAR RESEARCH

High glucose induces apoptosis in AC16 human cardiomyocytes via macrophage migration inhibitory factor and c-Jun N-terminal kinase

(2010) Jia-Liang Liang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

BNIP3 induces IL6 and calcineurin/NFAT3 hypertrophic-related pathways in H9c2 cardiomyoblast cells

(2010) Yi-Jiun Weng et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

BNIP3 subfamily BH3-only proteins: mitochondrial stress sensors in normal and pathological functions

(2009) G Chinnadurai et al.   ONCOGENE

Cardiac reanimation: targeting cardiomyocyte death by BNIP3 and NIX/BNIP3L

(2009) G W Dorn et al.   ONCOGENE

A Role for von Hippel-Lindau Protein in Pancreatic  -Cell Function

(2008) S. Puri et al.   DIABETES

Cardiovascular disease risk in type 2 diabetes mellitus: insights from mechanistic studies

(2008) Theodore Mazzone et al.   LANCET

Hypoxia-induced compensatory effect as related to Shh and HIF-1α in ischemia embryo rat heart

(2008) Jin-Ming Hwang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY