Review
Cell Biology
Elena V. Mitroshina, Maria O. Savyuk, Evgeni Ponimaskin, Maria V. Vedunova
Summary: Hypoxia is a common pathological condition induced by various events, with the body's adaptation to it being crucial for health and disease. HIFs, a family of transcription factors, play a key role in cellular responses to hypoxia and are increasingly viewed as potential targets for treating a range of hypoxia-associated diseases. The role of HIFs in adaptation to hypoxia is universal across tissue types, including the CNS, where they are involved in regulating neurogenesis, nerve cell differentiation, and neuronal apoptosis, potentially offering new therapeutic opportunities.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jennifer M. Noto, M. Blanca Piazuelo, Judith Romero-Gallo, Alberto G. Delgado, Giovanni Suarez, Konstantina Akritidou, Miguel Girod Hoffman, Juan Carlos Roa, Cormac T. Taylor, Richard M. Peek Jr
Summary: HIF-1α plays a crucial role in Helicobacter pylori-induced gastric injury and is involved in protecting against inflammation and bacterial virulence.
Article
Obstetrics & Gynecology
Mengkai Du, Zhenghui Cui, Deqin Chen, Yanmin Chen, Zhu Cao, Danqing Chen
Summary: In this study, a total of 6918 known lncRNAs and 3654 novel lncRNAs were identified, and a series of differentially expressed lncRNAs (DELncRNAs) were also identified. Through cis- and trans-regulation analyses, the target genes of DELncRNAs were predicted. Functional analysis demonstrated that the MAPK signalling pathway and adipocytokine signalling pathway were regulated by the DELncRNAs. Additionally, two lncRNAs (Gm12758 and Gm15283) were found to regulate the HIF pathway by targeting specific genes.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Review
Pharmacology & Pharmacy
Zirong Pan, Guodong Ma, Linglei Kong, Guanhua Du
Summary: Stroke is an acute cerebrovascular disease caused by sudden rupture or blockage of blood vessels in the brain, and HIF-1 plays an important role in regulating various pathways in the pathological process. The roles of HIF-1 in stroke are controversial, involving factors such as ischemic time and degree, and its regulatory mechanisms include inflammation, autophagy, oxidative stress, and apoptosis.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Min Kyung Park, Jun Ji, Keeok Haam, Tae-Hee Han, Seona Lim, Mi-Jung Kang, Soon Sung Lim, Hyun Seung Ban
Summary: Licochalcone A, a component of Glycyrrhiza uralensis, demonstrates potential as a therapeutic agent in hypoxic cancer cells by inhibiting HIF-1 alpha accumulation and mitochondrial respiration, leading to increased oxygen content and suppression of cancer cell viability.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Baoqi Yu, Xia Wang, Yanting Song, Guomin Xie, Shiyu Jiao, Li Shi, Xuejie Cao, Xinyao Han, Aijuan Qu
Summary: Cardiovascular diseases are the leading cause of death worldwide, and hypoxia-inducible factors (HIFs) play an important role in their pathogenesis. Recent studies have revealed the role of cell-specific HIFs in various cardiovascular diseases, but the potential clinical application of HIF inhibitors in the treatment of cardiovascular diseases is not well understood.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Anupriya Gupta, Chang Ook Park, Kwonik Oh
Summary: One traditional method for treating allergies is to avoid allergens, which has long been used in high altitude clinics. However, the therapeutic effect of high altitude on allergies is not fully understood. This study examined the role of hypoxia in the development of type 2 lung inflammation. The results showed that the inhibitor DMOG, which mimics hypoxia, had an inhibitory effect on lung inflammation induced by papain or IL-33. The anti-inflammatory effect of DMOG was mediated through the HIF-1 pathway and resulted in a reduction in type 2 lung inflammation. This study highlights the potential of pharmacological inhibition of PHD as a novel therapeutic candidate for type 2 lung inflammation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biology
Xiaowei Zheng, Sampath Narayanan, Cheng Xu, Sofie Eliasson Angelstig, Jacob Grunler, Allan Zhao, Alessandro Di Toro, Luciano Bernardi, Massimiliano Mazzone, Peter Carmeliet, Marianna Del Sole, Giancarlo Solaini, Elisabete A. Forsberg, Ao Zhang, Kerstin Brismar, Tomas A. Schiffer, Neda Rajamand Ekberg, Ileana Ruxandra Botusan, Fredrik Palm, Sergiu-Bogdan Catrina
Summary: Excessive production of mitochondrial reactive oxygen species (ROS) in diabetes complications is mainly caused by impaired responses to hypoxia due to the inhibition of hypoxia-inducible factor-1 (HIF-1) by hyperglycemia. Restoring HIF-1 function can attenuate ROS overproduction, protect cells against apoptosis and renal injury in diabetes. These findings suggest that targeting HIF-1 repression could be a potential therapeutic strategy for diabetic complications.
Article
Environmental Sciences
Meriam N. N. Rezk, Gerges M. Beshreda, Dalia Abdelrahman Meshref, Walaa Yehia Abdelzaher, Gaber El-Saber Batiha, Amin A. Hafiz, Duaa Althumairy, Nada H. Aljarba, Nermeen N. Welson
Summary: This study aimed to investigate the role of hypoxiainducible factor-1 alpha (HIF-1 alpha) in the diagnosis, prediction, and follow-up of Dormex-intoxicated patients. The results showed that HIF-1 alpha can effectively predict and follow up patients within 24 hours after admission. Additionally, blood-related indicators were also significantly abnormal in patients with Dormex intoxication.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Geriatrics & Gerontology
Yingjia Guo, Junpeng Zhou, Xianglong Li, Ying Xiao, Jingyao Zhang, Yutao Yang, Li Feng, Y. James Kang
Summary: Elderly rats show defective recovery from ischemic stroke possibly due to suppressed HIF-1 transcription activity. Overexpression of COMMD1 in aged rats leads to impaired HIF-1 transactivation and affects cerebral recovery.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Zaira Rehman, Ishrat Jabeen, Ammad Fahim, Attya Bhatti, Peter John
Summary: A ligand-based pharmacophore model was developed to identify potential HIF-1α and β dimerization inhibitors, resulting in the identification of six hits with potential anti-cancer chemotherapy activity. These compounds could serve as potential inhibitors of HIF-1 dimerization after further structure optimization.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Toxicology
Michael Aschner, Anatoly V. Skalny, Rongzhu Lu, Abel Santamaria, Ji-Chang Zhou, Tao Ke, Mikhail Yu. Karganov, Aristides Tsatsakis, Kirill S. Golokhvast, Aaron B. Bowman, Alexey A. Tinkov
Summary: This review summarizes the existing data on the effects of toxic metals on HIF-1 signaling and its underlying mechanisms, with a special focus on the prooxidant effect of metals. The effect of metals on HIF-1 pathway varies depending on the cell type, ranging from down-regulation to up-regulation. Inhibition of HIF-1 signaling may contribute to hypoxic damage in cells, while metal-induced activation may promote tumor growth and contribute to the carcinogenic effects of heavy metals.
ARCHIVES OF TOXICOLOGY
(2023)
Review
Pharmacology & Pharmacy
Anwu Huang, Z. L. Wang, Q. Q. Zhang, X. J. Ji, J. Wang, S. J. Chen, W. B. Jiang
Summary: Hypoxia-inducible factor 1-alpha (HIF-1α) is activated by hypoxia as a signal, and plays an influential role in ischemic heart disease. It binds with HIF-1β and initiates downstream processes that promote angiogenesis, glycolysis, and reduce reactive oxygen species. Additionally, reactive oxygen species can also activate HIF-1α as a second messenger. This review discusses the advances in understanding the relationship between HIF-1α and ischemic heart disease.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ioanna E. Stergiou, Konstantinos Kambas, Aikaterini Poulaki, Stavroula Giannouli, Theodora Katsila, Aglaia Dimitrakopoulou, Veroniki Vidali, Vasileios Mouchtouris, Ismini Kloukina, Evangelia Xingi, Stamatis N. Pagakis, Lesley Probert, George P. Patrinos, Konstantinos Ritis, Athanasios G. Tzioufas, Michael Voulgarelis
Summary: Myelodysplastic syndromes (MDS) involve a group of disorders affecting hematopoietic stem and progenitor cells, with a particular focus on the role of the transcription factor HIF-1. Aberrant HIF-1 stabilization and pseudohypoxia are prominent features in MDS pathobiology, showing potential for therapeutic manipulation in benign cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pediatrics
Qingqing Deng, Yanqun Chang, Xiaomao Cheng, Yan Li, Xingang Luo, Xiaoyuan Tang
Summary: This study found that mild hypoxia postconditioning can improve neurobehavioral ability after brain damage, possibly by increasing the expression of HIF-1α. This provides clinical reference for the treatment of infants with HIBD.
IRANIAN JOURNAL OF PEDIATRICS
(2023)