Article
Pharmacology & Pharmacy
Yuanmei Bai, Haimei Wu, Lijie Zheng, Yuhuan Xie, Feifan Liu, Yan Wan, Qiongchao Li, Peixin Guo
Summary: YJSB, a traditional Dai medicine formula, has significant therapeutic effects on liver protection. It can treat CCl4-induced liver fibrosis by regulating the Keap1-Nrf2 signaling pathway and improving liver function.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Santosh Kumar, Qihua Duan, Rongxue Wu, Edward N. Harris, Qiaozhu Su
Summary: Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disease with a spectrum of pathological conditions, involving liver cell injury and signaling pathways such as lipotoxicity, oxidative stress, inflammation, etc., ultimately leading to liver regeneration and fibrogenesis. Targeting specific liver cell types using nanotechnology shows potential as a therapeutic strategy for NASH and liver fibrosis.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Physiology
Wenlong Hao, Minghao Li, Qingmin Cai, Shiying Wu, Xiangyao Li, Quanyu He, Yongbin Hu
Summary: This review discusses the KEAP1/NRF2 signaling mechanisms and recent advances in understanding the role of NRF2 in primary fibrotic lesions. It also explores the therapeutic potential of antioxidant substances and drugs and summarizes the prospects of NRF2 in fibrosis treatment.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shuyu Li, Xi Li, Fangyuan Chen, Min Liu, Liuxin Ning, Yufeng Yan, Shuncai Zhang, Shaoping Huang, Chuantao Tu
Summary: The study demonstrated that nobiletin (NOB) effectively alleviated nonalcoholic steatohepatitis (NASH) and liver fibrosis by reducing hepatic oxidative stress and attenuating mitochondrial dysfunction. This suggests that NOB may be a promising agent for the treatment of NASH and liver fibrosis.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Environmental Sciences
Yuezhu Zhang, Ju Hui, Yan Xu, Yingying Ma, Zhe Sun, Meng Zhang, Lushuang Nie, Lin Ye
Summary: This study revealed that MEHP exposure can inhibit the expression of STAT5A gene by causing oxidative damage, thereby accelerating the expression of key molecules in liver fibrosis. These findings contribute to the understanding of the role of MEHP in the development of liver diseases.
Review
Biochemistry & Molecular Biology
Xinyu Li, Quyan Zhang, Zeyu Wang, Quan Zhuang, Mingyi Zhao
Summary: According to the WHO, cirrhosis of the liver was the 11th leading cause of death globally in 2019. Liver fibrosis, characterized by excessive synthesis and decreased decomposition of extracellular matrix (ECM), is closely related to hepatocyte cell death, hepatic stellate cell (HSC) activation, and inflammation. The process of fibrosis is also influenced by metabolic and immune disorders caused by oxygen imbalance.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Engineering, Biomedical
Meiyu Shao, Yifan Wang, Hongyan Dong, Lu Wang, Xiaoqing Zhang, Xin Han, Xianan Sang, Yini Bao, Mengyun Peng, Gang Cao
Summary: Liver fibrosis and hepatocellular carcinoma are global health threats, and the accumulation of H2O2 plays a crucial role in their development. This review discusses the role of H2O2 in the genesis of liver fibrosis and HCC, and summarizes nanotherapeutics targeting H2O2 as potential therapies.
BIOACTIVE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Huan Yao, Qingman He, Cong Huang, Shujun Wei, Yuanyuan Gong, Xueping Li, Weiwei Liu, Zhiyi Xu, Huihui Wu, Chuan Zheng, Yongxiang Gao
Summary: This study investigated the role of oxidative stress in cardiac fibrosis and the protective effect of panaxatriol saponin (PTS). The results showed that PTS improved cardiac function, reduced cardiac fibrosis, and suppressed oxidative stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
George I. Habeos, Fotini Filippopoulou, Evagelia E. Habeos, Electra Kalaitzopoulou, Marianna Skipitari, Polyxeni Papadea, George Lagoumintzis, Athanasios Niarchos, Christos D. Georgiou, Dionysios V. Chartoumpekis
Summary: This study found that calorie restriction during pregnancy can induce the expression of antioxidant genes in the fetal liver, and this induction is at least partially dependent on the Nrf2 signaling pathway. This finding highlights the importance of further investigating the physiological significance of this phenomenon.
Review
Oncology
Shin Hamada, Ryotaro Matsumoto, Atsushi Masamune
Summary: Pancreatic cancer progression involves interactions between cancer cells and stromal cells in harsh tumor microenvironments characterized by hypoxia, few nutrients, and oxidative stress. Key molecules, such as hypoxia inducible factor-1 and KEAP1-NRF2, play crucial roles in cancer cell adaptation under these conditions. Targeting these molecules may offer novel therapeutic approaches for pancreatic cancer.
Article
Environmental Sciences
Yi-Ting Chu, Bo-Hau Chen, Hsin-Hung Chen, Jui-Chen Lee, Tzu-Jiun Kuo, Hsiang-Chin Chiu, Wen-Hsien Lu
Summary: Early postnatal exposure to hypoxia can negatively affect vital organs, particularly the kidneys. A study comparing neonatal rats housed in either a hypoxic or normoxic chamber found that hypoxic rats had higher expressions of hypoxia-inducible factor-1 in their kidneys. They also exhibited higher hematocrit, serum creatinine, and lactate levels, as well as reduced body weight and protein loss in kidney tissue. Histologically, hypoxic rats showed glomerular atrophy, tubular injury, and renal fibrosis with collagen fiber deposition. The kidneys of hypoxic rats also had enhanced expression of nicotinamide adenine dinucleotide phosphate oxidases, as well as upregulation of proteins involved in apoptosis and pro-inflammatory cytokines. The study suggests that hypoxic kidney injury in neonatal rats is associated with oxidative stress, inflammation, apoptosis, and fibrosis.
Article
Integrative & Complementary Medicine
Hongxia Li, Mingyu Wu, Congying Guo, Rao Zhai, Jun Chen
Summary: This study aimed to explore the mechanism of the protective effects of Tan-IIA on pulmonary fibrosis (PF). The results showed that Tan-IIA can inhibit the activation of myofibroblasts and exert antioxidant stress through the activation of the Sesn2-Nrf2 signaling pathway. These findings provide new candidates for further functional studies of Tan-IIA and reveal the essential role of Sesn2 in PF.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Suvesh Munakarmi, Yamuna Gurau, Juna Shrestha, Prabodh Risal, Ho Sung Park, Hyun Beak Shin, Yeon Jun Jeong
Summary: This study investigates the protective role of 3,3'-diindolylmethane (DIM) in vitro and in a mouse model of liver fibrosis. The results suggest that DIM can inhibit TGF-beta 1-induced epithelial-mesenchymal transition (EMT) and attenuate liver injury and fibrosis caused by CCl4.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Liuxin Ning, Yanting Zou, Shuyu Li, Yue Cao, Beili Xu, Shuncai Zhang, Yu Cai
Summary: The study aimed to investigate the mechanism of anti-PCSK9 treatment on liver fibrosis by inhibiting hypoxia-induced autophagy. The results showed that anti-PCSK9 treatment could alleviate liver inflammation and fibrosis by regulating the AMPK/mTOR/ULK1 signaling pathway to reduce hypoxia-induced autophagy in hepatocytes.
Article
Plant Sciences
Chuanjing Cheng, Jinling Zhang, Kaixin Liu, Yanyan Xu, Fukui Shen, Yanqi Han, Yuanyuan Hou, Tiejun Zhang, Gang Bai
Summary: The study aims to determine the potential therapeutic targets and molecular mechanisms of Ginsenoside CK in improving oxidative stress injury. It was found that CK improves oxidative damage by regulating the KEAP1-NRF2/ARE pathway, and its target protein is KEAP1. CK binds to KEAP1, disrupting the binding between NRF2 and KEAP1, thereby inhibiting oxidative damage induced by LPS or physical mechanical stress.