Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins

The Atg17-Atg31-Atg29 Complex Coordinates with Atg11 to Recruit the Vam7 SNARE and Mediate Autophagosome-Vacuole Fusion

(2016) Xu Liu et al.   CURRENT BIOLOGY

TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis

(2016) Santosh Chauhan et al.   DEVELOPMENTAL CELL

Dedicated SNAREs and specialized TRIM cargo receptors mediate secretory autophagy

(2016) Tomonori Kimura et al.   EMBO JOURNAL

Facilitation of Endosomal Recycling by an IRG Protein Homolog Maintains Apical Tubule Structure in Caenorhabditis elegans

(2016) Kelly A. Grussendorf et al.   GENETICS

Atg8 family LC3/GABARAP proteins are crucial for autophagosome–lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation

(2016) Thanh Ngoc Nguyen et al.   JOURNAL OF CELL BIOLOGY

Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system

(2016) Gian-Luca McLelland et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial division occurs concurrently with autophagosome formation but independently of Drp1 during mitophagy

(2016) Shun-ichi Yamashita et al.   JOURNAL OF CELL BIOLOGY

Precision autophagy directed by receptor regulators – emerging examples within the TRIM family

(2016) Tomonori Kimura et al.   JOURNAL OF CELL SCIENCE

The Vici Syndrome Protein EPG5 Is a Rab7 Effector that Determines the Fusion Specificity of Autophagosomes with Late Endosomes/Lysosomes

(2016) Zheng Wang et al.   MOLECULAR CELL

The ATG conjugation systems are important for degradation of the inner autophagosomal membrane

(2016) Kotaro Tsuboyama et al.   SCIENCE

Ubiquitin-Dependent And Independent Signals In Selective Autophagy

(2016) Aliaksandr Khaminets et al.   TRENDS IN CELL BIOLOGY

Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway

(2016) Ruud H. Wijdeven et al.   Nature Communications

Facilitation of Endosomal Recycling by an IRG Protein Homolog Maintains Apical Tubule Structure in Caenorhabditis elegans

(2016) Kelly A. Grussendorf et al.   GENETICS

Analysis of the native conformation of the LIR/AIM motif in the Atg8/LC3/GABARAP-binding proteins

(2015) Hana Popelka et al.   Autophagy

A Role for the Ancient SNARE Syntaxin 17 in Regulating Mitochondrial Division

(2015) Kohei Arasaki et al.   DEVELOPMENTAL CELL

The HabcDomain of the SNARE Vam3 Interacts with the HOPS Tethering Complex to Facilitate Vacuole Fusion

(2015) Anna Lürick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity

(2015) Tomonori Kimura et al.   JOURNAL OF CELL BIOLOGY

The functional and pathologic relevance of autophagy proteases

(2015) Álvaro F. Fernández et al.   JOURNAL OF CLINICAL INVESTIGATION

PLEKHM1 Regulates Autophagosome-Lysosome Fusion through HOPS Complex and LC3/GABARAP Proteins

(2015) David G. McEwan et al.   MOLECULAR CELL

IRGM Governs the Core Autophagy Machinery to Conduct Antimicrobial Defense

(2015) Santosh Chauhan et al.   MOLECULAR CELL

ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes

(2015) Jiajie Diao et al.   NATURE

A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly

(2015) R. W. Baker et al.   SCIENCE

Translocation of interleukin-1β into a vesicle intermediate in autophagy-mediated secretion

(2015) Min Zhang et al.   eLife

Sequential Superresolution Imaging of Multiple Targets Using a Single Fluorophore

(2015) Christopher C. Valley et al.   PLoS One

TRIM Proteins Regulate Autophagy and Can Target Autophagic Substrates by Direct Recognition

(2014) Michael A. Mandell et al.   DEVELOPMENTAL CELL

The HOPS complex mediates autophagosome–lysosome fusion through interaction with syntaxin 17

(2014) Peidu Jiang et al.   MOLECULAR BIOLOGY OF THE CELL

Interaction of the HOPS complex with Syntaxin 17 mediates autophagosome clearance in Drosophila

(2014) Szabolcs Takáts et al.   MOLECULAR BIOLOGY OF THE CELL

Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy

(2014) Vladimir Rogov et al.   MOLECULAR CELL

O-GlcNAc-modification of SNAP-29 regulates autophagosome maturation

(2014) Bin Guo et al.   NATURE CELL BIOLOGY

Directed evolution of APEX2 for electron microscopy and proximity labeling

(2014) Stephanie S Lam et al.   NATURE METHODS

Tethering complexes in the endocytic pathway: CORVET and HOPS

(2013) Jachen A. Solinger et al.   FEBS Journal

Autophagosomal Syntaxin17-dependent lysosomal degradation maintains neuronal function inDrosophila

(2013) Szabolcs Takáts et al.   JOURNAL OF CELL BIOLOGY

Alternative fates of newly formed PrPSc upon prion conversion on the plasma membrane

(2013) R. Goold et al.   JOURNAL OF CELL SCIENCE

CORVET and HOPS tethering complexes - coordinators of endosome and lysosome fusion

(2013) H. J. k. Balderhaar et al.   JOURNAL OF CELL SCIENCE

The ubiquitin ligase parkin mediates resistance to intracellular pathogens

(2013) Paolo S. Manzanillo et al.   NATURE

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

Identification of a candidate therapeutic autophagy-inducing peptide

(2013) Sanae Shoji-Kawata et al.   NATURE

Proteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging

(2013) H.-W. Rhee et al.   SCIENCE

The ER–Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis

(2013) Liang Ge et al.   eLife

The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

(2012) Eisuke Itakura et al.   CELL

ATG8 Family Proteins Act as Scaffolds for Assembly of the ULK Complex

(2012) Endalkachew Ashenafi Alemu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion

(2012) Teresa L. M. Thurston et al.   NATURE

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Autophagic substrate clearance requires activity of the syntaxin-5 SNARE complex

(2011) M. Renna et al.   JOURNAL OF CELL SCIENCE

IRGM Is a Common Target of RNA Viruses that Subvert the Autophagy Network

(2011) Isabel Pombo Grégoire et al.   PLoS Pathogens

LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis

(2010) Hilla Weidberg et al.   EMBO JOURNAL

HOPS prevents the disassembly of trans-SNARE complexes by Sec17p/Sec18p during membrane fusion

(2010) Hao Xu et al.   EMBO JOURNAL

Atg8-family interacting motif crucial for selective autophagy

(2010) Nobuo N. Noda et al.   FEBS LETTERS

Delivery of Cytosolic Components by Autophagic Adaptor Protein p62 Endows Autophagosomes with Unique Antimicrobial Properties

(2010) Marisa Ponpuak et al.   IMMUNITY

Combinational Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor Proteins VAMP8 and Vti1b Mediate Fusion of Antimicrobial and Canonical Autophagosomes with Lysosomes

(2010) Nobumichi Furuta et al.   MOLECULAR BIOLOGY OF THE CELL

Network organization of the human autophagy system

(2010) Christian Behrends et al.   NATURE

Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria

(2010) Sudha B. Singh et al.   NATURE CELL BIOLOGY

Fast, single-molecule localization that achieves theoretically minimum uncertainty

(2010) Carlas S Smith et al.   NATURE METHODS

Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages

(2009) George B. Kyei et al.   JOURNAL OF CELL BIOLOGY

Discovery of Atg5/Atg7-independent alternative macroautophagy

(2009) Yuya Nishida et al.   NATURE

Atg8 Controls Phagophore Expansion during Autophagosome Formation

(2008) Zhiping Xie et al.   MOLECULAR BIOLOGY OF THE CELL

An Atg4B Mutant Hampers the Lipidation of LC3 Paralogues and Causes Defects in Autophagosome Closure

(2008) Naonobu Fujita et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE