Cytosolic Innate Immune Sensing and Signaling upon Infection

STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease

(2015) Nicole Dobbs et al.   Cell Host & Microbe

The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy

(2015) Robert O. Watson et al.   Cell Host & Microbe

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1

(2015) Ruth Wassermann et al.   Cell Host & Microbe

Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis

(2015) Angela C. Collins et al.   Cell Host & Microbe

Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein

(2015) Jian-jun Wu et al.   Cell Host & Microbe

DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway

(2015) L. Lau et al.   SCIENCE

ISG15 counteracts Listeria monocytogenes infection

(2015) Lilliana Radoshevich et al.   eLife

Measles Virus Suppresses RIG-I-like Receptor Activation in Dendritic Cells via DC-SIGN-Mediated Inhibition of PP1 Phosphatases

(2014) Annelies W. Mesman et al.   Cell Host & Microbe

Listeria monocytogenes induces IFN  expression through an IFI16-, cGAS- and STING-dependent pathway

(2014) K. Hansen et al.   EMBO JOURNAL

Hepatitis E Virus Inhibits Type I Interferon Induction by ORF1 Products

(2014) Y. Nan et al.   JOURNAL OF VIROLOGY

The Innate Immune Sensor LGP2 Activates Antiviral Signaling by Regulating MDA5-RNA Interaction and Filament Assembly

(2014) Annie M. Bruns et al.   MOLECULAR CELL

The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling

(2014) Xin Cai et al.   MOLECULAR CELL

Diverse intracellular pathogens activate type III interferon expression from peroxisomes

(2014) Charlotte Odendall et al.   NATURE IMMUNOLOGY

STING-Dependent Type I IFN Production Inhibits Cell-Mediated Immunity to Listeria monocytogenes

(2014) Kristina A. Archer et al.   PLoS Pathogens

Strategies of highly pathogenic RNA viruses to block dsRNA detection by RIG-I-like receptors: Hide, mask, hit

(2013) Luca Zinzula et al.   ANTIVIRAL RESEARCH

Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

(2013) Pu Gao et al.   CELL

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

(2013) Pu Gao et al.   CELL

Human Cytomegalovirus Tegument Protein pUL83 Inhibits IFI16-Mediated DNA Sensing for Immune Evasion

(2013) Tuo Li et al.   Cell Host & Microbe

Immune Sensing of DNA

(2013) Søren R. Paludan et al.   IMMUNITY

Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression

(2013) Xue Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Mycobacterium tuberculosis but Not Nonvirulent Mycobacteria Inhibits IFN-  and AIM2 Inflammasome-Dependent IL-1  Production via Its ESX-1 Secretion System

(2013) S. Shah et al.   JOURNAL OF IMMUNOLOGY

Ebolavirus VP35 Coats the Backbone of Double-Stranded RNA for Interferon Antagonism

(2013) S. Bale et al.   JOURNAL OF VIROLOGY

STING Recognition of Cytoplasmic DNA Instigates Cellular Defense

(2013) Takayuki Abe et al.   MOLECULAR CELL

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

(2013) Xu Zhang et al.   MOLECULAR CELL

Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJ

(2013) Nikolay Burnaevskiy et al.   NATURE

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

(2013) Andrea Ablasser et al.   NATURE

RIG-I Detects Triphosphorylated RNA of Listeria monocytogenes during Infection in Non-Immune Cells

(2013) Cristina Amparo Hagmann et al.   PLoS One

Paramyxovirus V Proteins Disrupt the Fold of the RNA Sensor MDA5 to Inhibit Antiviral Signaling

(2013) C. Motz et al.   SCIENCE

The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING

(2013) Elie J. Diner et al.   Cell Reports

A Mechanism for the Inhibition of DNA-PK-Mediated DNA Sensing by a Virus

(2013) Nicholas E. Peters et al.   PLoS Pathogens

A Distinct Role of Riplet-Mediated K63-Linked Polyubiquitination of the RIG-I Repressor Domain in Human Antiviral Innate Immune Responses

(2013) Hiroyuki Oshiumi et al.   PLoS Pathogens

Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5

(2012) Bin Wu et al.   CELL

Mycobacterium Tuberculosis Activates the DNA-Dependent Cytosolic Surveillance Pathway within Macrophages

(2012) Paolo S. Manzanillo et al.   Cell Host & Microbe

RIG-I detects infection with liveListeriaby sensing secreted bacterial nucleic acids

(2012) Zeinab Abdullah et al.   EMBO JOURNAL

Herpes Simplex Virus 1 Tegument Protein US11 Downmodulates the RLR Signaling Pathway via Direct Interaction with RIG-I and MDA-5

(2012) J. Xing et al.   JOURNAL OF VIROLOGY

Influenza Virus Protein PB1-F2 Inhibits the Induction of Type I Interferon by Binding to MAVS and Decreasing Mitochondrial Membrane Potential

(2012) Zsuzsanna T. Varga et al.   JOURNAL OF VIROLOGY

Paramyxovirus V Proteins Interact with the RNA Helicase LGP2 To Inhibit RIG-I-Dependent Interferon Induction

(2012) K. Childs et al.   JOURNAL OF VIROLOGY

Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes

(2012) Maroof Hasan et al.   NATURE IMMUNOLOGY

Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein

(2012) M. H. Orzalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism

(2012) Shridhar Bale et al.   PLoS Pathogens

DENV Inhibits Type I IFN Production in Infected Cells by Cleaving Human STING

(2012) Sebastian Aguirre et al.   PLoS Pathogens

Structural Basis for the Activation of Innate Immune Pattern-Recognition Receptor RIG-I by Viral RNA

(2011) Eva Kowalinski et al.   CELL

Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity

(2011) Huihui Chen et al.   CELL

MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response

(2011) Fajian Hou et al.   CELL

Inhibition of RIG-I-Mediated Signaling by Kaposi's Sarcoma-Associated Herpesvirus-Encoded Deubiquitinase ORF64

(2011) K.-S. Inn et al.   JOURNAL OF VIROLOGY

Arterivirus and Nairovirus Ovarian Tumor Domain-Containing Deubiquitinases Target Activated RIG-I To Control Innate Immune Signaling

(2011) P. B. van Kasteren et al.   JOURNAL OF VIROLOGY

Structural basis of RNA recognition and activation by innate immune receptor RIG-I

(2011) Fuguo Jiang et al.   NATURE

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5

(2011) Roland Züst et al.   NATURE IMMUNOLOGY

Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity

(2010) Evelyn Dixit et al.   CELL

Reconstitution of the RIG-I Pathway Reveals a Signaling Role of Unanchored Polyubiquitin Chains in Innate Immunity

(2010) Wenwen Zeng et al.   CELL

TheN-Ethyl-N-Nitrosourea-InducedGoldenticketMouse Mutant Reveals an Essential Function ofStingin theIn VivoInterferon Response toListeria monocytogenesand Cyclic Dinucleotides

(2010) John-Demian Sauer et al.   INFECTION AND IMMUNITY

Influenza A Virus Polymerase Inhibits Type I Interferon Induction by Binding to Interferon β Promoter Stimulator 1

(2010) Atsushi Iwai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Short Double-stranded RNAs with an Overhanging 5′ ppp-Nucleotide, as Found in Arenavirus Genomes, Act as RIG-I Decoys

(2010) Jean-Baptiste Marq et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of the RNA polymerase III-mediated dsDNA-sensing pathway of innate immunity by vaccinia virus protein E3

(2010) R. Valentine et al.   JOURNAL OF GENERAL VIROLOGY

Hepatitis C Virus Core Protein Abrogates the DDX3 Function That Enhances IPS-1-Mediated IFN–Beta Induction

(2010) Hiroyuki Oshiumi et al.   PLoS One

c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response

(2010) J. J. Woodward et al.   SCIENCE

SARS-CoV nucleocapsid protein antagonizes IFN-β response by targeting initial step of IFN-β induction pathway, and its C-terminal region is critical for the antagonism

(2010) Xiaolu Lu et al.   VIRUS GENES

Composition and Three-Dimensional Architecture of the Dengue Virus Replication and Assembly Sites

(2009) Sonja Welsch et al.   Cell Host & Microbe

Influenza A Virus NS1 Targets the Ubiquitin Ligase TRIM25 to Evade Recognition by the Host Viral RNA Sensor RIG-I

(2009) Michaela Ulrike Gack et al.   Cell Host & Microbe

DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-κB

(2009) Manuele Rebsamen et al.   EMBO REPORTS

Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus

(2009) Martin Schlee et al.   IMMUNITY

Severe Acute Respiratory Syndrome Coronavirus M Protein Inhibits Type I Interferon Production by Impeding the Formation of TRAF3·TANK·TBK1/IKKϵ Complex

(2009) Kam-Leung Siu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The RIG-I-like Receptor LGP2 Recognizes the Termini of Double-stranded RNA

(2009) Xiaojun Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

(2009) Sarah M. McWhirter et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Z Proteins of New World Arenaviruses Bind RIG-I and Interfere with Type I Interferon Induction

(2009) L. Fan et al.   JOURNAL OF VIROLOGY

A Shared Interface Mediates Paramyxovirus Interference with Antiviral RNA Helicases MDA5 and LGP2

(2009) J.-P. Parisien et al.   JOURNAL OF VIROLOGY

Molecular Determinants for Subcellular Localization of the Severe Acute Respiratory Syndrome Coronavirus Open Reading Frame 3b Protein

(2009) E. C. Freundt et al.   JOURNAL OF VIROLOGY

Key Role of Ubc5 and Lysine-63 Polyubiquitination in Viral Activation of IRF3

(2009) Wenwen Zeng et al.   MOLECULAR CELL

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA

(2009) Diana A. Pippig et al.   NUCLEIC ACIDS RESEARCH

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

(2009) T. Saitoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

5'-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I

(2009) A. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL

Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKɛ-mediated IRF activation

(2008) Martina Schröder et al.   EMBO JOURNAL

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE

Processing of Genome 5′ Termini as a Strategy of Negative-Strand RNA Viruses to Avoid RIG-I-Dependent Interferon Induction

(2008) Matthias Habjan et al.   PLoS One