Progress and Challenges in the Use of MAP1LC3 as a Legitimate Marker for Measuring Dynamic Autophagy In Vivo

Correction of autophagy impairment inhibits pathology in the NOD.H-2h4 mouse model of primary Sjögren's syndrome

(2020) Elisaveta Voynova et al.   JOURNAL OF AUTOIMMUNITY

Intravenous immunoglobulin mediates anti-inflammatory effects in peripheral blood mononuclear cells by inducing autophagy

(2020) Mrinmoy Das et al.   Cell Death & Disease

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

LC3-associated phagocytosis protects against inflammation and liver fibrosis via immunoreceptor inhibitory signaling

(2020) JingHong Wan et al.   Science Translational Medicine

Activation and targeting of ATG8 protein lipidation

(2020) Sascha Martens et al.   Cell Discovery

Biological Functions of Autophagy Genes: A Disease Perspective

(2019) Beth Levine et al.   CELL

Pharmacological Autophagy Regulators as Therapeutic Agents for Inflammatory Bowel Diseases

(2019) Sruthi Vijaya Retnakumar et al.   TRENDS IN MOLECULAR MEDICINE

Autophagy-Independent Functions of the Autophagy Machinery

(2019) Lorenzo Galluzzi et al.   CELL

LC3-positive structures are prominent in autophagy-deficient cells

(2019) Gautam Runwal et al.   Scientific Reports

Lysosomes as a therapeutic target

(2019) Srinivasa Reddy Bonam et al.   NATURE REVIEWS DRUG DISCOVERY

HSPA8/HSC70 in Immune Disorders: A Molecular Rheostat that Adjusts Chaperone-Mediated Autophagy Substrates

(2019) Bonam et al.   Cells

Autophagosome Biogenesis Machinery

(2019) Simon A. Walker et al.   JOURNAL OF MOLECULAR BIOLOGY

A Diversity of Selective Autophagy Receptors Determines the Specificity of the Autophagy Pathway

(2019) Vladimir Kirkin et al.   MOLECULAR CELL

Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients

(2019) Jean M. Mulcahy Levy et al.   CELL DEATH AND DIFFERENTIATION

Autophagy in hepatic adaptation to stress

(2019) Younis Hazari et al.   JOURNAL OF HEPATOLOGY

Pros and Cons of Chaperone-Mediated Autophagy in Cancer Biology

(2019) Esperanza Arias et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

(2018) Mario Mauthe et al.   Autophagy

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Rescue of autophagy and lysosome defects in salivary glands of MRL/lpr mice by a therapeutic phosphopeptide

(2018) Baihui Li et al.   JOURNAL OF AUTOIMMUNITY

An autophagy-targeting peptide to treat chronic inflammatory demyelinating polyneuropathies

(2018) Susana Brun et al.   JOURNAL OF AUTOIMMUNITY

Autophagy and LAP in the Fight against Fungal Infections: Regulation and Therapeutics

(2018) Vasileios Oikonomou et al.   MEDIATORS OF INFLAMMATION

Cargo recognition and degradation by selective autophagy

(2018) Damián Gatica et al.   NATURE CELL BIOLOGY

Quantifying autophagy using novel LC3B and p62 TR-FRET assays

(2018) Alberto Bresciani et al.   PLoS One

Lupus Regulator Peptide P140 Represses B Cell Differentiation by Reducing HLA Class II Molecule Overexpression

(2018) Maud Wilhelm et al.   Arthritis & Rheumatology

LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance

(2018) Larissa D. Cunha et al.   CELL

Autophagy: A new concept in autoimmunity regulation and a novel therapeutic option

(2018) Srinivasa Reddy Bonam et al.   JOURNAL OF AUTOIMMUNITY

Expression Analysis of Autophagy Related Markers LC3B, p62 and HMGB1 Indicate an Autophagy-Independent Negative Prognostic Impact of High p62 Expression in Pulmonary Squamous Cell Carcinomas

(2018) Rupert Langer et al.   Cancers

Monitoring and Measuring Autophagy

(2017) Saori R. Yoshii et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy-regulating protease Atg4: structure, function, regulation and inhibition

(2017) Tatsuro Maruyama et al.   JOURNAL OF ANTIBIOTICS

Chaperone-mediated autophagy and endosomal microautophagy: Jointed by a chaperone

(2017) Kumsal Tekirdag et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Humanin is an endogenous activator of chaperone-mediated autophagy

(2017) Zhenwei Gong et al.   JOURNAL OF CELL BIOLOGY

LC3-Associated Phagocytosis and Inflammation

(2017) Bradlee L. Heckmann et al.   JOURNAL OF MOLECULAR BIOLOGY

Quantifying autophagy: Measuring LC3 puncta and autolysosome formation in cells using multispectral imaging flow cytometry

(2017) Haley R. Pugsley   METHODS

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

(2017) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease

(2017) Altea Rocchi et al.   PLoS Genetics

Methods for Measuring Autophagy in Mice

(2017) et al.   Cells

Assessing Autophagy in Mouse Models and Patients with Systemic Autoimmune Diseases

(2017) Fengjuan Wang et al.   Cells

Mammalian Autophagy: How Does It Work?

(2016) Carla F. Bento et al.   Annual Review of Biochemistry

iLIR database: A web resource for LIR motif-containing proteins in eukaryotes

(2016) Anne-Claire Jacomin et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Role of the mammalian ATG8/LC3 family in autophagy: differential and compensatory roles in the spatiotemporal regulation of autophagy

(2016) You-Kyung Lee et al.   BMB Reports

An Autophagic Flux Probe that Releases an Internal Control

(2016) Takeshi Kaizuka et al.   MOLECULAR CELL

Prognostic value of the autophagy markers LC3 and p62/SQSTM1 in early-stage non-small cell lung cancer

(2016) Anna M. Schläfli et al.   Oncotarget

Modulation of deregulated chaperone-mediated autophagy by a phosphopeptide

(2015) Christophe Macri et al.   Autophagy

Analysis of the native conformation of the LIR/AIM motif in the Atg8/LC3/GABARAP-binding proteins

(2015) Hana Popelka et al.   Autophagy

Reliable LC3 and p62 autophagy marker detection in formalin fixed paraffin embedded human tissue by immunohistochemistry

(2015) A.M. Schläfli et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

Pharmacologic agents targeting autophagy

(2015) Helin Vakifahmetoglu-Norberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Applications of flow cytometry for measurement of autophagy

(2015) Alik Demishtein et al.   METHODS

Deacetylation of Nuclear LC3 Drives Autophagy Initiation under Starvation

(2015) Rui Huang et al.   MOLECULAR CELL

Phosphorylation of LC3 by the Hippo Kinases STK3/STK4 Is Essential for Autophagy

(2015) Deepti S. Wilkinson et al.   MOLECULAR CELL

Manipulating Autophagic Processes in Autoimmune Diseases: A Special Focus on Modulating Chaperone-Mediated Autophagy, an Emerging Therapeutic Target

(2015) Fengjuan Wang et al.   Frontiers in Immunology

Utilizing flow cytometry to monitor autophagy in living mammalian cells

(2014) Elena Shvets et al.   Autophagy

V-ATPase and osmotic imbalances activate endolysosomal LC3 lipidation

(2014) Oliver Florey et al.   Autophagy

Autophagosomes, phagosomes, autolysosomes, phagolysosomes, autophagolysosomes… Wait, I’m confused

(2014) Daniel J Klionsky et al.   Autophagy

Pharmacological regulators of autophagy and their link with modulators of lupus disease

(2014) Frédéric Gros et al.   BRITISH JOURNAL OF PHARMACOLOGY

VMA21 deficiency prevents vacuolar ATPase assembly and causes autophagic vacuolar myopathy

(2013) Nivetha Ramachandran et al.   ACTA NEUROPATHOLOGICA

Autophagy and human diseases

(2013) Peidu Jiang et al.   CELL RESEARCH

Two ubiquitin-like conjugation systems that mediate membrane formation during autophagy

(2013) Hitoshi Nakatogawa   Essays in Biochemistry

The LC3 interactome at a glance

(2013) P. Wild et al.   JOURNAL OF CELL SCIENCE

New Autophagy Reporter Mice Reveal Dynamics of Proximal Tubular Autophagy

(2013) L. Li et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Identification of a candidate therapeutic autophagy-inducing peptide

(2013) Sanae Shoji-Kawata et al.   NATURE

Lupuzor/P140 peptide in patients with systemic lupus erythematosus: a randomised, double-blind, placebo-controlled phase IIb clinical trial

(2012) Robert Zimmer et al.   ANNALS OF THE RHEUMATIC DISEASES

Interpretation of bafilomycin, pH neutralizing or protease inhibitor treatments in autophagic flux experiments

(2012) Gábor Juhász   Autophagy

A novel method for autophagy detection in primary cells

(2012) Kanchan Phadwal et al.   Autophagy

LC3 immunostaining pitfalls

(2012) Michael I Koukourakis et al.   HISTOPATHOLOGY

mTOR dysfunction contributes to vacuolar pathology and weakness in valosin-containing protein associated inclusion body myopathy

(2012) J. K. Ching et al.   HUMAN MOLECULAR GENETICS

Peptide-based approaches to treat lupus and other autoimmune diseases

(2012) Nicolas Schall et al.   JOURNAL OF AUTOIMMUNITY

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

"Autophagic flux" in normal mouse tissues: Focus on endogenous LC3A processing

(2011) Christos E. Zois et al.   Autophagy

GABARAPL1 (GEC1): Original or copycat?

(2011) Jaclyn Nicole Le Grand et al.   Autophagy

Seeing is believing: The impact of electron microscopy on autophagy research

(2011) Eeva-Liisa Eskelinen et al.   Autophagy

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

HSC70 blockade by the therapeutic peptide P140 affects autophagic processes and endogenous MHCII presentation in murine lupus

(2010) N. Page et al.   ANNALS OF THE RHEUMATIC DISEASES

A novel quantitative flow cytometry-based assay for autophagy

(2010) Kai Er Eng et al.   Autophagy

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Inhibition of Autophagosome Formation by the Benzoporphyrin Derivative Verteporfin

(2010) Elizabeth Donohue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the autophagy protein LC3 by phosphorylation

(2010) Salvatore J. Cherra et al.   JOURNAL OF CELL BIOLOGY

Autophagy: assays and artifacts

(2010) Sandra Barth et al.   JOURNAL OF PATHOLOGY

In search of an “autophagomometer”

(2009) David C. Rubinsztein et al.   Autophagy

Inhibitors of the V0 subunit of the vacuolar H+-ATPase prevent segregation of lysosomal- and secretory-pathway proteins

(2009) J. A. Sobota et al.   JOURNAL OF CELL SCIENCE

Dynamics and diversity in autophagy mechanisms: lessons from yeast

(2009) Hitoshi Nakatogawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes

(2008) E. Shvets et al.   JOURNAL OF CELL SCIENCE