Autophagy and LAP in the Fight against Fungal Infections: Regulation and Therapeutics

LC3-Associated Phagocytosis and Inflammation

(2017) Bradlee L. Heckmann et al.   JOURNAL OF MOLECULAR BIOLOGY

Inflammasome and Autophagy Regulation: A Two-way Street

(2017) Qian Sun et al.   MOLECULAR MEDICINE

Melanin targets LC3-associated phagocytosis (LAP): A novel pathogenetic mechanism in fungal disease

(2016) Georgios Chamilos et al.   Autophagy

Aspergillus Cell Wall Melanin Blocks LC3-Associated Phagocytosis to Promote Pathogenicity

(2016) Tonia Akoumianaki et al.   Cell Host & Microbe

Noncanonical Fungal Autophagy Inhibits Inflammation in Response to IFN-γ via DAPK1

(2016) Vasilis Oikonomou et al.   Cell Host & Microbe

LC3-associated phagocytosis: a crucial mechanism for antifungal host defence againstAspergillus fumigatus

(2016) Evelien G. G. Sprenkeler et al.   CELLULAR MICROBIOLOGY

Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells

(2016) Jennifer Martinez et al.   NATURE

Interactions of fungal pathogens with phagocytes

(2016) Lars P. Erwig et al.   NATURE REVIEWS MICROBIOLOGY

Modulation of inflammation by autophagy: Consequences for human disease

(2015) Romana T. Netea-Maier et al.   Autophagy

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins

(2015) Jennifer Martinez et al.   NATURE CELL BIOLOGY

Autophagy and autophagy-related proteins in the immune system

(2015) Shusaku T Shibutani et al.   NATURE IMMUNOLOGY

Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity

(2015) Masashi Kanayama et al.   Nature Communications

Dectin-1–Dependent LC3 Recruitment to Phagosomes Enhances Fungicidal Activity in Macrophages

(2014) Jenny M. Tam et al.   JOURNAL OF INFECTIOUS DISEASES

IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans

(2014) Antonella de Luca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of inflammation by DAPK

(2013) Ming-Zong Lai et al.   APOPTOSIS

The DAP-kinase interactome

(2013) Shani Bialik et al.   APOPTOSIS

Noncanonical autophagy: one small step for LC3, one giant leap for immunity

(2013) Payal Mehta et al.   CURRENT OPINION IN IMMUNOLOGY

Non-autophagic roles of autophagy-related proteins

(2013) Suresh Subramani et al.   EMBO REPORTS

Autophagy is redundant for the host defense against systemic Candida albicans infections

(2013) S. P. Smeekens et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Autophagy in the liver

(2013) Patrice Codogno et al.   JOURNAL OF HEPATOLOGY

Corticosteroids Block Autophagy Protein Recruitment in Aspergillus fumigatus Phagosomes via Targeting Dectin-1/Syk Kinase Signaling

(2013) I. Kyrmizi et al.   JOURNAL OF IMMUNOLOGY

IFNG and autophagy

(2012) Dhananjaya V. Kalvakolanu et al.   Autophagy

Macrophage Autophagy in Immunity to Cryptococcus neoformans and Candida albicans

(2012) André Moraes Nicola et al.   INFECTION AND IMMUNITY

Dectin-1-triggered Recruitment of Light Chain 3 Protein to Phagosomes Facilitates Major Histocompatibility Complex Class II Presentation of Fungal-derived Antigens

(2012) Jun Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

An IFN- -stimulated ATF6-C/EBP- -signaling pathway critical for the expression of Death Associated Protein Kinase 1 and induction of autophagy

(2012) P. Gade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan

(2012) Richard Metz et al.   OncoImmunology

Tumor Suppressor Death-Associated Protein Kinase Attenuates Inflammatory Responses in the Lung

(2011) Sigal Nakav et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Functional Analysis of Host Factors that Mediate the Intracellular Lifestyle of Cryptococcus neoformans

(2011) Qing-Ming Qin et al.   PLoS Pathogens

Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity

(2010) C. Cunha et al.   BLOOD

Regulation of innate immune responses by autophagy-related proteins

(2010) Tatsuya Saitoh et al.   JOURNAL OF CELL BIOLOGY

Requisite Role for the Dectin-1  -Glucan Receptor in Pulmonary Defense against Aspergillus fumigatus

(2009) J. L. Werner et al.   JOURNAL OF IMMUNOLOGY

Intranasally delivered siRNA targeting PI3K/Akt/mTOR inflammatory pathways protects from aspergillosis

(2009) P Bonifazi et al.   Mucosal Immunology

Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease

(2008) Luigina Romani et al.   NATURE

Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance

(2008) Jelena Nedjic et al.   NATURE