Autophagy-regulating protease Atg4: structure, function, regulation and inhibition

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

(2017) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Atg4 plays an important role in efficient expansion of autophagic isolation membranes by cleaving lipidated Atg8 in Saccharomyces cerevisiae

(2017) Eri Hirata et al.   PLoS One

Comparative analyses of ubiquitin-like ATG8 and cysteine protease ATG4 autophagy genes in the plant lineage and cross-kingdom processing of ATG8 by ATG4

(2016) Eunyoung Seo et al.   Autophagy

The 1:2 complex between RavZ and LC3 reveals a mechanism for deconjugation of LC3 on the phagophore membrane

(2016) Do Hoon Kwon et al.   Autophagy

Unraveling the roles of Atg4 proteases from autophagy modulation to targeted cancer therapy

(2016) Lan Zhang et al.   CANCER LETTERS

LC3/GABARAP family proteins: autophagy-(un)related functions

(2016) Marco B. E. Schaaf et al.   FASEB JOURNAL

An Autophagic Flux Probe that Releases an Internal Control

(2016) Takeshi Kaizuka et al.   MOLECULAR CELL

Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors

(2016) Zongxing Qiu et al.   ACS Medicinal Chemistry Letters

O-GlcNAcylation of ATG4B positively regulates autophagy by increasing its hydroxylase activity

(2016) Yoon Kyung Jo et al.   Oncotarget

Mechanisms of Autophagy

(2015) Nobuo N. Noda et al.   Annual Review of Biophysics

AU4S: A novel synthetic peptide to measure the activity of ATG4 in living cells

(2015) Zhenhong Ni et al.   Autophagy

The Legionella Anti-autophagy Effector RavZ Targets the Autophagosome via PI3P- and Curvature-Sensing Motifs

(2015) Florian A. Horenkamp et al.   DEVELOPMENTAL CELL

ATG4B (Autophagin-1) Phosphorylation Modulates Autophagy

(2015) Zhifen Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The functional and pathologic relevance of autophagy proteases

(2015) Álvaro F. Fernández et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy

(2015) Fan Wu et al.   MOLECULAR CELL

Regulation of endoplasmic reticulum turnover by selective autophagy

(2015) Aliaksandr Khaminets et al.   NATURE

Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus

(2015) Keisuke Mochida et al.   NATURE

A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity

(2015) Shuxi Qiao et al.   Nature Communications

Development of Fluorescent Substrates and Assays for the Key Autophagy-Related Cysteine Protease Enzyme, ATG4B

(2014) Thanh G. Nguyen et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

The yeast autophagy protease Atg4 is regulated by thioredoxin

(2014) María Esther Pérez-Pérez et al.   Autophagy

A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors

(2014) Debra Akin et al.   Autophagy

The core autophagy protein ATG4B is a potential biomarker and therapeutic target in CML stem/progenitor cells

(2014) K. Rothe et al.   BLOOD

Self and Nonself: How Autophagy Targets Mitochondria and Bacteria

(2014) Felix Randow et al.   Cell Host & Microbe

Context-dependent role of ATG4B as target for autophagy inhibition in prostate cancer therapy

(2013) Elisa Tran et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Differential processing of Arabidopsis ubiquitin-like Atg8 autophagy proteins by Atg4 cysteine proteases

(2013) J. Woo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual roles of Atg8−PE deconjugation by Atg4 in autophagy

(2012) Zhong-Qiu Yu et al.   Autophagy

A role for Atg8–PE deconjugation in autophagosome biogenesis

(2012) Usha Nair et al.   Autophagy

Atg4 recycles inappropriately lipidated Atg8 to promote autophagosome biogenesis

(2012) Hitoshi Nakatogawa et al.   Autophagy

A high-throughput FRET-based assay for determination of Atg4 activity

(2012) Min Li et al.   Autophagy

Structure of the Atg12–Atg5 conjugate reveals a platform for stimulating Atg8–PE conjugation

(2012) Nobuo N Noda et al.   EMBO REPORTS

Differential Function of the Two Atg4 Homologues in the Aggrephagy Pathway inCaenorhabditis elegans

(2012) Fan Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Legionella Effector RavZ Inhibits Host Autophagy Through Irreversible Atg8 Deconjugation

(2012) A. Choy et al.   SCIENCE

Regulation of ATG4B Stability by RNF5 Limits Basal Levels of Autophagy and Influences Susceptibility to Bacterial Infection

(2012) Ersheng Kuang et al.   PLoS Genetics

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

A monitoring method for Atg4 activation in living cells using peptide-conjugated polymeric nanoparticles

(2011) Kyung-Mi Choi et al.   Autophagy

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Synthetic substrates for measuring activity of autophagy proteases-autophagins (Atg4)

(2010) Chih-Wen Shu et al.   Autophagy

Atg8-family interacting motif crucial for selective autophagy

(2010) Nobuo N. Noda et al.   FEBS LETTERS

Kinetics Comparisons of Mammalian Atg4 Homologues Indicate Selective Preferences toward Diverse Atg8 Substrates

(2010) Min Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles of the Lipid-binding Motifs of Atg18 and Atg21 in the Cytoplasm to Vacuole Targeting Pathway and Autophagy

(2010) Usha Nair et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy is essential for mouse sense of balance

(2010) Guillermo Mariño et al.   JOURNAL OF CLINICAL INVESTIGATION

Histopathological and Neurological Features of Atg4b Knockout Mice

(2010) R. Read et al.   VETERINARY PATHOLOGY

The structure of Atg4B–LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy

(2009) Kenji Satoo et al.   EMBO JOURNAL

Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis

(2009) V. M. S. Betin et al.   JOURNAL OF CELL SCIENCE

Structural basis of target recognition by Atg8/LC3 during selective autophagy

(2008) Nobuo N. Noda et al.   GENES TO CELLS

An Atg4B Mutant Hampers the Lipidation of LC3 Paralogues and Causes Defects in Autophagosome Closure

(2008) Naonobu Fujita et al.   MOLECULAR BIOLOGY OF THE CELL