The Development of Phosphine-Free "Tethered" Ruthenium(II) Catalysts for the Asymmetric Reduction of Ketones and Imines

Stereoarrayed CF3 -Substituted 1,3-Diols by Dynamic Kinetic Resolution: Ruthenium(II)-Catalyzed Asymmetric Transfer Hydrogenation

(2016) Andrej Emanuel Cotman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective hydrogenation of cyclic imines catalysed by Noyori–Ikariya half-sandwich complexes and their analogues

(2016) B. Vilhanová et al.   CHEMICAL COMMUNICATIONS

The kinetics and mechanism of the organo-iridium-catalysed enantioselective reduction of imines

(2016) Matthew J. Stirling et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Imino Transfer Hydrogenation Reductions

(2016) Martin Wills   Topics in Current Chemistry

ansa-Ruthenium(II) Complexes of R2NSO2DPEN-(CH2)n(η6-Aryl) Conjugate Ligands for Asymmetric Transfer Hydrogenation of Aryl Ketones

(2015) Andrea Kišić et al.   ADVANCED SYNTHESIS & CATALYSIS

Synthesis, characterization and use of a new tethered Rh(III) complex in asymmetric transfer hydrogenation of ketones

(2015) Pierre-Georges Echeverria et al.   CATALYSIS COMMUNICATIONS

Alternative Hydrogen Source for Asymmetric Transfer Hydrogenation in the Reduction of Ketones

(2015) Russell J. Wakeham et al.   ChemCatChem

Enantio- and diastereoselective synthesis of γ-amino alcohols

(2015) Jorge M. M. Verkade et al.   CHEMICAL COMMUNICATIONS

Catalytic Asymmetric Transfer Hydrogenation of Imines: Recent Advances

(2015) Francisco Foubelo et al.   CHEMICAL RECORD

The Golden Age of Transfer Hydrogenation

(2015) Dong Wang et al.   CHEMICAL REVIEWS

Efficient Synthesis of Differentiatedsyn-1,2-Diol Derivatives by Asymmetric Transfer Hydrogenation-Dynamic Kinetic Resolution of α-Alkoxy-Substituted β-Ketoesters

(2015) Laure Monnereau et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asymmetric Reduction of Electron-Rich Ketones with Tethered Ru(II)/TsDPEN Catalysts Using Formic Acid/Triethylamine or Aqueous Sodium Formate

(2015) Rina Soni et al.   JOURNAL OF ORGANIC CHEMISTRY

Highly enantioselective asymmetric transfer hydrogenation (ATH) of α-phthalimide ketones

(2015) Zhou Xu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Dynamic Kinetic Resolution of Phthalides via Asymmetric Transfer Hydrogenation: A Strategy Constructs 1,3-Distereocentered 3-(2-Hydroxy-2-arylethyl)isobenzofuran-1(3H)-one

(2015) Tanyu Cheng et al.   ORGANIC LETTERS

Synthetic Approach to Wortmannilactone C

(2015) Damien Brandt et al.   ORGANIC LETTERS

Evolution of a Manufacturing Route to Omarigliptin, A Long-Acting DPP-4 Inhibitor for the Treatment of Type 2 Diabetes

(2015) John Y. L. Chung et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Diastereoselective synthesis of an advanced intermediate of the crocacin family using asymmetric transfer hydrogenation-DKR and Marshall allenylation as key reactions

(2015) Gullapalli Kumaraswamy et al.   TETRAHEDRON

Asymmetric transfer hydrogenation of α-azido acrylates

(2015) Yang Ji et al.   TETRAHEDRON LETTERS

Catalytic asymmetric transfer hydrogenation of ketones: recent advances

(2015) Francisco Foubelo et al.   TETRAHEDRON-ASYMMETRY

Asymmetric transfer hydrogenation of α-amino β-keto ester hydrochlorides through dynamic kinetic resolution

(2015) Pierre-Georges Echeverria et al.   RSC Advances

ansa-Ruthenium(II) Complexes of DPEN-SO2N(Me)(CH2)n(η6-aryl) Conjugate Ligands for Asymmetric Transfer Hydrogenation of Aryl Ketones

(2014) Andrea Kišić et al.   ADVANCED SYNTHESIS & CATALYSIS

Whyp-Cymene? Conformational Effect in Asymmetric Hydrogenation of Aromatic Ketones with a η6-Arene/Ruthenium(II) Catalyst

(2014) Aki Matsuoka et al.   Chemistry-An Asian Journal

Preparation of Both C5′ Epimers of 5′-C-Methyladenosine: Reagent Control Trumps Substrate Control

(2014) Cavan M. Bligh et al.   JOURNAL OF ORGANIC CHEMISTRY

Dynamic Kinetic Resolution Based Asymmetric Transfer Hydrogenation of α-Alkoxy-β-Ketophosphonates. Diastereo- and Enantioselective Synthesis of Monoprotected 1,2-Dihydroxyphosphonates

(2014) Se-Mi Son et al.   JOURNAL OF ORGANIC CHEMISTRY

Biomimetic Kinetic Resolution: Highly Enantio- and Diastereoselective Transfer Hydrogenation of Aglain Ketones To Access Flavagline Natural Products

(2014) Steven D. Stone et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Preparation of Enantioenriched γ-Substituted Lactones via Asymmetric Transfer Hydrogenation of β-Azidocyclopropane Carboxylates Using the Ru-TsDPEN Complex

(2014) Yan Su et al.   ORGANIC LETTERS

Asymmetric Synthesis of Highly Functionalized Tetrahydropyran DPP-4 Inhibitor

(2014) Feng Xu et al.   ORGANIC LETTERS

Enantioselective Synthesis of an HCV NS5a Antagonist

(2014) Ian K. Mangion et al.   ORGANIC LETTERS

Scalable Ruthenium-Catalyzed Asymmetric Synthesis of a Key Intermediate for the β2-Adrenergic Receptor Agonist

(2014) Masato Komiyama et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Synthesis and Catalytic Applications of an Extended Range of Tethered Ruthenium(II)/η6-Arene/Diamine Complexes

(2014) Roy Hodgkinson et al.   ORGANOMETALLICS

Computational Studies Explain the Importance of Two Different Substituents on the Chelating Bis(amido) Ligand for Transfer Hydrogenation by Bifunctional Cp*Rh(III) Catalysts

(2014) Ainara Nova et al.   ORGANOMETALLICS

Recent topics in catalytic asymmetric hydrogenation of ketones

(2014) Masahiro Yoshimura et al.   TETRAHEDRON LETTERS

Highly Enantioselective Synthesis of Chiral Tetrahydroquinolines and Tetrahydroisoquinolines by Ruthenium-Catalyzed Asymmetric Hydrogenation in Ionic Liquid

(2013) Zi-Yuan Ding et al.   ADVANCED SYNTHESIS & CATALYSIS

A Practical Access to Highly Enantiomerically Pure Flavanones by Catalytic Asymmetric Transfer Hydrogenation

(2013) Marie-Kristin Lemke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Ruthenium-Catalyzed Hydrogenation of 2- and 2,9-Substituted 1,10-Phenanthrolines

(2013) Tianli Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The NH Functional Group in Organometallic Catalysis

(2013) Baoguo Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of a Stepwise Reductive Deoxygenation Process by Ru-Catalysed Homogeneous Ketone Reduction and Pd-Catalysed Hydrogenolysis in the Presence of Cu Salts

(2013) Damian M. Grainger et al.   ChemCatChem

Trichloromethyl ketones: asymmetric transfer hydrogenation and subsequent Jocic-type reactions with amines

(2013) Michael S. Perryman et al.   CHEMICAL COMMUNICATIONS

New insight into the role of a base in the mechanism of imine transfer hydrogenation on a Ru(ii) half-sandwich complex

(2013) Marek Kuzma et al.   DALTON TRANSACTIONS

Ruthenium-Catalyzed Transfer Hydrogenation of Amino- and Amido-Substituted Acetophenones

(2013) Andrew J. A. Watson et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Transfer Hydrogenation of Functionalized Acetylenic Ketones

(2013) Zhijia Fang et al.   JOURNAL OF ORGANIC CHEMISTRY

Quantum Chemical Calculations with the Inclusion of Nonspecific and Specific Solvation: Asymmetric Transfer Hydrogenation with Bifunctional Ruthenium Catalysts

(2013) Pavel A. Dub et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diametric Stereocontrol in Dynamic Catalytic Reduction of Racemic Acyl Phosphonates: Divergence from α-Keto Ester Congeners

(2013) Michael T. Corbett et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Practical Aspects and Mechanism of Asymmetric Hydrogenation with Chiral Half-Sandwich Complexes

(2013) Jiří Václavík et al.   MOLECULES

Asymmetric Transfer Hydrogenation of 1-Naphthyl Ketones by an ansa-Ru(II) Complex of a DPEN-SO2N(Me)-(CH2)2(η6-p-Tol) Combined Ligand

(2013) Andrea Kišić et al.   ORGANIC LETTERS

Direct Formation of Tethered Ru(II) Catalysts Using Arene Exchange

(2013) Rina Soni et al.   ORGANIC LETTERS

Asymmetric Reduction of Diynones and the Total Synthesis of (S)-Panaxjapyne A

(2013) Zhijia Fang et al.   ORGANIC LETTERS

Asymmetric Hydrogenation of Alkynyl Ketones with the η6-Arene/TsDPEN–Ruthenium(II) Catalyst

(2013) Noriyoshi Arai et al.   ORGANIC LETTERS

Catalytic Asymmetric Reduction of a 3,4-Dihydroisoquinoline for the Large-Scale Production of Almorexant: Hydrogenation or Transfer Hydrogenation?

(2013) Gerard K. M. Verzijl et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Asymmetric reduction of 2,2-dimethyl-6-(2-oxoalkyl/oxoaryl)-1,3-dioxin-4-ones and application to the synthesis of (+)-yashabushitriol

(2013) Zhijia (Amphi) Fang et al.   TETRAHEDRON LETTERS

Stereocontrolled synthesis of a d-amicetose functionalised tetrahydroxanthone related to kigamicin A

(2013) Penelope A. Turner et al.   TETRAHEDRON LETTERS

Enantioselective synthesis of anti-β-amido-α-hydroxy esters via asymmetric transfer hydrogenation coupled with dynamic kinetic resolution

(2013) Marvin Villacrez et al.   TETRAHEDRON LETTERS

Synthesis of (R)-tembamide and (R)-aegeline via asymmetric transfer hydrogenation in water

(2013) Norma A. Cortez et al.   TETRAHEDRON-ASYMMETRY

Application of Tethered Ruthenium Catalysts to Asymmetric Hydrogenation of Ketones, and the Selective Hydrogenation of Aldehydes

(2012) Katherine E. Jolley et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric Hydrogenation of 2,4-Disubstituted 1,5-Benzodiazepines Using Cationic Ruthenium Diamine Catalysts: An Unusual Achiral Counteranion Induced Reversal of Enantioselectivity

(2012) Zi-Yuan Ding et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of (−)-Goniotrionin

(2012) Luiz C. Dias et al.   JOURNAL OF ORGANIC CHEMISTRY

Chiral Surfactant-Type Catalyst for Asymmetric Reduction of Aliphatic Ketones in Water

(2012) Jiahong Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

pH-Independent Transfer Hydrogenation in Water: Catalytic, Enantioselective Reduction of β-Keto Esters

(2012) Martin A. Ariger et al.   ORGANIC LETTERS

Practical Asymmetric Synthesis of (+)-erythro Mefloquine Hydrochloride

(2012) William P. Hems et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Asymmetric Transfer Hydrogenation of Ketones Catalyzed by Rhodium Block Copolymer Complexes in Aqueous Micelles

(2012) Arkadi Vigalok et al.   SYNLETT

New Polymer-Supported Catalysts for the Asymmetric Transfer Hydrogenation of Acetophenone in Water - Kinetic and Mechanistic Investigations

(2011) Jonas Dimroth et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric Total Synthesis of a Pentacyclic Lycopodium Alkaloid: Huperzine-Q

(2011) Atsushi Nakayama et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of water-soluble monotosylated ethylenediamines and their application in ruthenium and iridium-catalyzed transfer hydrogenation of aldehydes

(2011) Zhongqiang Zhou et al.   APPLIED ORGANOMETALLIC CHEMISTRY

Asymmetric Reduction of 2-Chloro-3-oxo Esters by Transfer Hydrogenation

(2011) Jinjin Bai et al.   CHINESE JOURNAL OF CHEMISTRY

The development of aqueous transfer hydrogenation catalysts

(2011) Andrew Robertson et al.   DALTON TRANSACTIONS

Oxo-Tethered Ruthenium(II) Complex as a Bifunctional Catalyst for Asymmetric Transfer Hydrogenation and H2Hydrogenation

(2011) Taichiro Touge et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reaction Development and Mechanistic Study of a Ruthenium Catalyzed Intramolecular Asymmetric Reductive Amination en Route to the Dual Orexin Inhibitor Suvorexant (MK-4305)

(2011) Neil A. Strotman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The importance of the N–H bond in Ru/TsDPEN complexes for asymmetric transfer hydrogenation of ketones and imines

(2011) Rina Soni et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

An Unexpected Directing Effect in the Asymmetric Transfer Hydrogenation of α,α-Disubstituted Ketones

(2011) Rina Soni et al.   ORGANIC LETTERS

Investigation into the enantioselection mechanism of ruthenium–arene–diamine transfer hydrogenation catalysts using fluorinated substrates

(2011) Sigrid Volden Slungård et al.   TETRAHEDRON

Enantioselective synthesis of cyclopropyl δ-lactonealdehydes and dodecyl-5-ene-1-yne-3-ol: advanced intermediates of solandelactone A and B

(2011) Gullapalli Kumaraswamy et al.   TETRAHEDRON LETTERS

Ether-tethered Ru(ii)/TsDPEN complexes; synthesis and applications to asymmetric transfer hydrogenation

(2011) Vimal Parekh et al.   Catalysis Science & Technology

Artificial Metalloenzymes Based on the Biotin−Avidin Technology: Enantioselective Catalysis and Beyond

(2010) Thomas R. Ward   ACCOUNTS OF CHEMICAL RESEARCH

Immobilization of a Modified Tethered Rhodium(III)-p-Toluenesulfonyl-1,2-diphenylethylenediamine Catalyst on Soluble and Solid Polymeric Supports and Successful Application to Asymmetric Transfer Hydrogenation of Ketones

(2010) Jonas Dimroth et al.   ADVANCED SYNTHESIS & CATALYSIS

Chiral η6-Arene/N-Tosylethylenediamine-Ruthenium(II) Complexes: Solution Behavior and Catalytic Activity for Asymmetric Hydrogenation

(2010) Christian A. Sandoval et al.   Chemistry-An Asian Journal

The Synthesis of Two Potent β-3 Adrenergic Receptor Agonists

(2010) Paul A. Bradley et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Bifunctional Triflylamide-Tethered Cp′Rh and Cp′Ir Complexes: A New Entry for Asymmetric Hydrogenation Catalysts

(2010) Masato Ito et al.   ORGANOMETALLICS

Asymmetric Transfer Hydrogenation in Water with Platinum Group Metal Catalysts

(2010) Xiaofeng Wu et al.  

Highly enantioselective synthesis of β-hydroxysulfonamides by asymmetric transfer hydrogenation

(2010) Zhicong Geng et al.   TETRAHEDRON LETTERS

Asymmetric transfer hydrogenation of quinolines using tethered Ru(II) catalysts

(2010) Vimal Parekh et al.   TETRAHEDRON-ASYMMETRY

pH-Regulated Asymmetric Transfer Hydrogenation of Quinolines in Water

(2009) Chao Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Water-soluble chiral aminosulfonamides as ligands for ruthenium(II)-catalyzed asymmetric transfer hydrogenation

(2009) Zhongqiang Zhou et al.   CATALYSIS COMMUNICATIONS

Bifunctional transition metal-based molecular catalysts for asymmetric CC and CN bond formation

(2009) Takao Ikariya et al.   CHEMICAL RECORD

Asymmetric hydrogenation, transfer hydrogenation and hydrosilylation of ketones catalyzed by iron complexes

(2009) Robert H. Morris   CHEMICAL SOCIETY REVIEWS

Synthesis and Structure of Novel (η1:η6-Aminoalkylarene)RuIIComplexes

(2009) Masato Ito et al.   CHEMISTRY LETTERS

Kinetic and structural studies on ‘tethered’ Ru(ii) arene ketone reduction catalysts

(2009) Fung Kei (Kathy) Cheung et al.   DALTON TRANSACTIONS

Metal−Brønsted Acid Cooperative Catalysis for Asymmetric Reductive Amination

(2009) Chaoqun Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Total Synthesis of (−)-Awajanomycin

(2009) Rui Fu et al.   ORGANIC LETTERS

Ru(II) Complexes of N-Alkylated TsDPEN Ligands in Asymmetric Transfer Hydrogenation of Ketones and Imines

(2009) José E. D. Martins et al.   ORGANIC LETTERS

Dynamic Kinetic Resolution: Asymmetric Transfer Hydrogenation of α-Alkyl-Substituted β-Ketoamides

(2009) John Limanto et al.   ORGANIC LETTERS

A Multilateral Mechanistic Study into Asymmetric Transfer Hydrogenation in Water

(2008) Xiaofeng Wu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asymmetric Transfer Hydrogenation of CO and CN Bonds by Tethered RhIIICatalysts

(2008) Daljit S. Matharu et al.   Chemistry-An Asian Journal

Broader, Greener, and More Efficient: Recent Advances in Asymmetric Transfer Hydrogenation

(2008) Chao Wang et al.   Chemistry-An Asian Journal

Further ‘tethered’ Ru(II) catalysts for asymmetric transfer hydrogenation (ATH) of ketones; the use of a benzylic linker and a cyclohexyldiamine ligand

(2008) Jose E.D. Martins et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Chiral Counteranion-Aided Asymmetric Hydrogenation of Acyclic Imines

(2008) Chaoqun Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric transfer hydrogenation of imines catalyzed by a polymer-immobilized chiral catalyst

(2008) Naoki Haraguchi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Well-Defined Triflylamide-Tethered Arene−Ru(Tsdpen) Complexes for Catalytic Asymmetric Hydrogenation of Ketones

(2008) Masato Ito et al.   ORGANOMETALLICS