4.6 Article

Highly enantioselective asymmetric transfer hydrogenation (ATH) of α-phthalimide ketones

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 13, Issue 27, Pages 7513-7516

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ob00568j

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Funding

  1. Natural Science Foundation of Higher Education Institutions of Jiangsu Province, China [10KJB150018]
  2. Project of Science and Technology of Xuzhou Government [XM12B012]
  3. Zhen Xing Project of Xuzhou Medical College

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A mild catalyst system for the synthesis of chiral amino alcohols via asymmetric transfer hydrogenation (ATH) of alpha-phthalimide ketones has been developed by using a chiral Ru-TsDPEN complex as the catalyst in DMF/MeOH at 40 degrees C. The reaction exhibits high reaction activity and excellent enantioselectivity where up to 96% yield and 99% ee of the product were obtained.

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